Gut Microbiota in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis: Current Applications and Future Perspectives

Parkinson’s disease from the gut

(2018) Rodger A. Liddle   BRAIN RESEARCH

Gut Dysbiosis and Muscle Aging: Searching for Novel Targets against Sarcopenia

(2018) Anna Picca et al.   MEDIATORS OF INFLAMMATION

The Dynamics of the Gut Microbiome in Multiple Sclerosis in Relation to Disease

(2018) Ellen M. Mowry et al.   NEUROLOGIC CLINICS

Gut microbiome and depression: what we know and what we need to know

(2018) Gal Winter et al.   REVIEWS IN THE NEUROSCIENCES

The Gut Microbiome and Multiple Sclerosis

(2018) Javier Ochoa-Repáraz et al.   Cold Spring Harbor Perspectives in Medicine

Intestinal dysbiosis and probiotic applications in autoimmune diseases

(2017) Gislane Lelis Vilela de Oliveira et al.   IMMUNOLOGY

Gut–CNS-Axis as Possibility to Modulate Inflammatory Disease Activity—Implications for Multiple Sclerosis

(2017) Ann-Katrin Fleck et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The role of exosomes in CNS inflammation and their involvement in multiple sclerosis

(2017) Igor Selmaj et al.   JOURNAL OF NEUROIMMUNOLOGY

The “Gut Feeling”: Breaking Down the Role of Gut Microbiome in Multiple Sclerosis

(2017) Samantha N. Freedman et al.   Neurotherapeutics

Gut microbiota: Implications in Parkinson's disease

(2017) Arun Parashar et al.   PARKINSONISM & RELATED DISORDERS

Gut bacteria from multiple sclerosis patients modulate human T cells and exacerbate symptoms in mouse models

(2017) Egle Cekanaviciute et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice

(2017) Kerstin Berer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gut Microbiota and the Gut-Brain Axis

(2017) Nicolien C. de Clercq et al.   PSYCHOSOMATIC MEDICINE

Helminth-induced Ly6Chi monocyte-derived alternatively activated macrophages suppress experimental autoimmune encephalomyelitis

(2017) Cesar Terrazas et al.   Scientific Reports

Human Gut-Derived Commensal Bacteria Suppress CNS Inflammatory and Demyelinating Disease

(2017) Ashutosh Mangalam et al.   Cell Reports

Oral Multiple Sclerosis Drugs Inhibit the In vitro Growth of Epsilon Toxin Producing Gut Bacterium, Clostridium perfringens

(2017) Kareem R. Rumah et al.   Frontiers in Cellular and Infection Microbiology

Does the Gut Microbiota Influence Immunity and Inflammation in Multiple Sclerosis Pathophysiology?

(2017) Monika Adamczyk-Sowa et al.   Journal of Immunology Research

Editorial: Lymphocytes in MS and EAE: More Than Just a CD4+ World

(2017) Manu Rangachari et al.   Frontiers in Immunology

Modulation of Multiple Sclerosis and Its Animal Model Experimental Autoimmune Encephalomyelitis by Food and Gut Microbiota

(2017) Ward J. van den Hoogen et al.   Frontiers in Immunology

An updated histological classification system for multiple sclerosis lesions

(2016) Tanja Kuhlmann et al.   ACTA NEUROPATHOLOGICA

Associations between the gut microbiota and host immune markers in pediatric multiple sclerosis and controls

(2016) Helen Tremlett et al.   BMC Neurology

Linking the Human Gut Microbiome to Inflammatory Cytokine Production Capacity

(2016) Melanie Schirmer et al.   CELL

Spermidine alleviates experimental autoimmune encephalomyelitis through inducing inhibitory macrophages

(2016) Q Yang et al.   CELL DEATH AND DIFFERENTIATION

Environmental control of autoimmune inflammation in the central nervous system

(2016) Veit Rothhammer et al.   CURRENT OPINION IN IMMUNOLOGY

Formation of propionate and butyrate by the human colonic microbiota

(2016) Petra Louis et al.   ENVIRONMENTAL MICROBIOLOGY

Gut microbiota in early pediatric multiple sclerosis: a case−control study

(2016) H. Tremlett et al.   EUROPEAN JOURNAL OF NEUROLOGY

High salt drives Th17 responses in experimental autoimmune encephalomyelitis without impacting myeloid dendritic cells

(2016) Stefanie Jörg et al.   EXPERIMENTAL NEUROLOGY

Dietary Fatty Acids Directly Impact Central Nervous System Autoimmunity via the Small Intestine

(2016) Aiden Haghikia et al.   IMMUNITY

Sodium chloride promotes pro-inflammatory macrophage polarization thereby aggravating CNS autoimmunity

(2016) Stephanie Hucke et al.   JOURNAL OF AUTOIMMUNITY

A clinical update on the significance of the gut microbiota in systemic autoimmunity

(2016) Elizabeth C. Rosser et al.   JOURNAL OF AUTOIMMUNITY

Higher latitude is significantly associated with an earlier age of disease onset in multiple sclerosis

(2016) Chunrong Tao et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Gut microbiota composition and relapse risk in pediatric MS: A pilot study

(2016) Helen Tremlett et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Breaking down the gut microbiome composition in multiple sclerosis

(2016) Adrian Budhram et al.   Multiple Sclerosis Journal

Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor

(2016) Veit Rothhammer et al.   NATURE MEDICINE

Multiple sclerosis prevalence in the United States commercially insured population

(2016) Piyameth Dilokthornsakul et al.   NEUROLOGY

Gut microbiome in health and disease: Linking the microbiome–gut–brain axis and environmental factors in the pathogenesis of systemic and neurodegenerative diseases

(2016) Shivani Ghaisas et al.   PHARMACOLOGY & THERAPEUTICS

Sex differences in the gut microbiome–brain axis across the lifespan

(2016) Eldin Jašarević et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Gut environment-induced intraepithelial autoreactive CD4+ T cells suppress central nervous system autoimmunity via LAG-3

(2016) Atsushi Kadowaki et al.   Nature Communications

Alterations of the human gut microbiome in multiple sclerosis

(2016) Sushrut Jangi et al.   Nature Communications

Effect of Probiotics on Central Nervous System Functions in Animals and Humans: A Systematic Review

(2016) Huiying Wang et al.   Journal of Neurogastroenterology and Motility

Breaking down the gut microbiome composition in multiple sclerosis

(2016) Adrian Budhram et al.   Multiple Sclerosis Journal

Regulation of prefrontal cortex myelination by the microbiota

(2016) A E Hoban et al.   Translational Psychiatry

KIR4.1: K+ Channel Illusion or Reality in the Autoimmune Pathogenesis of Multiple Sclerosis

(2016) Chen Gu   Frontiers in Molecular Neuroscience

A study of dietary modification: Perceptions and attitudes of patients with multiple sclerosis

(2016) J. Nicholas Brenton et al.   Multiple Sclerosis and Related Disorders

Multiple sclerosis patients have a distinct gut microbiota compared to healthy controls

(2016) Jun Chen et al.   Scientific Reports

Brain microbiota disruption within inflammatory demyelinating lesions in multiple sclerosis

(2016) W. G. Branton et al.   Scientific Reports

Catecholamines and acetylcholine are key regulators of the interaction between microbes and the immune system

(2015) Leon Islas Weinstein et al.   Annals of the New York Academy of Sciences

Indigenous Bacteria from the Gut Microbiota Regulate Host Serotonin Biosynthesis

(2015) Jessica M. Yano et al.   CELL

Dynamics and Stabilization of the Human Gut Microbiome during the First Year of Life

(2015) Fredrik Bäckhed et al.   Cell Host & Microbe

The gut microbiome in autoimmunity: Sex matters

(2015) Andres Gomez et al.   CLINICAL IMMUNOLOGY

The Gut Microbiome in Multiple Sclerosis

(2015) Daniel W. Mielcarz et al.   Current Treatment Options in Neurology

The intestinal microbiota: its role in health and disease

(2015) Luc Biedermann et al.   EUROPEAN JOURNAL OF PEDIATRICS

A review of genome-wide association studies for multiple sclerosis: classical and hypothesis-driven approaches

(2015) V. V. Bashinskaya et al.   HUMAN GENETICS

Gut/brain axis and the microbiota

(2015) Emeran A. Mayer et al.   JOURNAL OF CLINICAL INVESTIGATION

Gut Microbiota in Multiple Sclerosis

(2015) Brandi L. Cantarel et al.   JOURNAL OF INVESTIGATIVE MEDICINE

A comprehensive repertoire of prokaryotic species identified in human beings

(2015) Perrine Hugon et al.   LANCET INFECTIOUS DISEASES

Follicular Helper CD4+T Cells in Human Neuroautoimmune Diseases and Their Animal Models

(2015) Xueli Fan et al.   MEDIATORS OF INFLAMMATION

The role of epidemiology in MS research: Past successes, current challenges and future potential

(2015) Steve Simpson et al.   Multiple Sclerosis Journal

The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment

(2015) Xuan Zhang et al.   NATURE MEDICINE

Host microbiota constantly control maturation and function of microglia in the CNS

(2015) Daniel Erny et al.   NATURE NEUROSCIENCE

Fecal microbiota transplantation broadening its application beyond intestinal disorders

(2015) Meng-Que Xu   WORLD JOURNAL OF GASTROENTEROLOGY

Dietary Gut Microbial Metabolites, Short-chain Fatty Acids, and Host Metabolic Regulation

(2015) Mayu Kasubuchi et al.   Nutrients

The role of epidemiology in MS research: Past successes, current challenges and future potential

(2015) Steve Simpson et al.   Multiple Sclerosis Journal

Dysbiosis in the Gut Microbiota of Patients with Multiple Sclerosis, with a Striking Depletion of Species Belonging to Clostridia XIVa and IV Clusters

(2015) Sachiko Miyake et al.   PLoS One

Rapidly expanding knowledge on the role of the gut microbiome in health and disease

(2014) M.C. Cénit et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Gut microbiome and the risk factors in central nervous system autoimmunity

(2014) Javier Ochoa-Repáraz et al.   FEBS LETTERS

IL-13 Production by Regulatory T Cells Protects against Experimental Autoimmune Encephalomyelitis Independently of Autoantigen

(2014) J. Ochoa-Reparaz et al.   JOURNAL OF IMMUNOLOGY

The Gut Microbiome and the Brain

(2014) Leo Galland   JOURNAL OF MEDICINAL FOOD

Sodium intake is associated with increased disease activity in multiple sclerosis

(2014) Mauricio F Farez et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Digesting the emerging role for the gut microbiome in central nervous system demyelination

(2014) Jennifer Joscelyn et al.   Multiple Sclerosis Journal

An integrated catalog of reference genes in the human gut microbiome

(2014) Junhua Li et al.   NATURE BIOTECHNOLOGY

Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis

(2014) Justin D Crane et al.   NATURE MEDICINE

Epigenetics of Multiple Sclerosis: An Updated Review

(2014) Cem İsmail Küçükali et al.   NEUROMOLECULAR MEDICINE

The gut microbiota influences blood-brain barrier permeability in mice

(2014) V. Braniste et al.   Science Translational Medicine

An intestinal commensal symbiosis factor controls neuroinflammation via TLR2-mediated CD39 signalling

(2014) Yan Wang et al.   Nature Communications

The HPA – Immune Axis and the Immunomodulatory Actions of Glucocorticoids in the Brain

(2014) Marc-André Bellavance et al.   Frontiers in Immunology

Dietary Yeasts Reduce Inflammation in Central Nerve System via Microflora

(2014) Kazushiro Takata et al.   Annals of Clinical and Translational Neurology

Incidence and prevalence of multiple sclerosis in Europe: a systematic review

(2013) Elaine Kingwell et al.   BMC Neurology

The role of microbiome in central nervous system disorders

(2013) Yan Wang et al.   BRAIN BEHAVIOR AND IMMUNITY

Intestinal microbiota, diet and health

(2013) Susan E. Power et al.   BRITISH JOURNAL OF NUTRITION

Amelioration of experimental autoimmune encephalomyelitis by probiotic mixture is mediated by a shift in T helper cell immune response

(2013) Ho-Keun Kwon et al.   CLINICAL IMMUNOLOGY

Gender Bias in Autoimmunity Is Influenced by Microbiota

(2013) Leonid Yurkovetskiy et al.   IMMUNITY

Serine Lipids of Porphyromonas gingivalis Are Human and Mouse Toll-Like Receptor 2 Ligands

(2013) Robert B. Clark et al.   INFECTION AND IMMUNITY

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

(2013) Yukihiro Furusawa et al.   NATURE

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

(2013) Nicholas Arpaia et al.   NATURE

Diet rapidly and reproducibly alters the human gut microbiome

(2013) Lawrence A. David et al.   NATURE

Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells

(2013) Markus Kleinewietfeld et al.   NATURE

Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota

(2013) Koji Atarashi et al.   NATURE

Altered colonic function and microbiota profile in a mouse model of chronic depression

(2013) A. J. Park et al.   NEUROGASTROENTEROLOGY AND MOTILITY

The inflamed axis: The interaction between stress, hormones, and the expression of inflammatory-related genes within key structures comprising the hypothalamic–pituitary–adrenal axis

(2013) Cara M. Hueston et al.   PHYSIOLOGY & BEHAVIOR

Smoking Cessation Induces Profound Changes in the Composition of the Intestinal Microbiota in Humans

(2013) Luc Biedermann et al.   PLoS One

Commensal Akkermansia muciniphila Exacerbates Gut Inflammation in Salmonella Typhimurium-Infected Gnotobiotic Mice

(2013) Bhanu Priya Ganesh et al.   PLoS One

Isolation of Clostridium perfringens Type B in an Individual at First Clinical Presentation of Multiple Sclerosis Provides Clues for Environmental Triggers of the Disease

(2013) Kareem Rashid Rumah et al.   PLoS One

Utilisation of Mucin Glycans by the Human Gut Symbiont Ruminococcus gnavus Is Strain-Dependent

(2013) Emmanuelle H. Crost et al.   PLoS One

Sex Differences in the Gut Microbiome Drive Hormone-Dependent Regulation of Autoimmunity

(2013) J. G. M. Markle et al.   SCIENCE

Microbial Endocrinology in the Microbiome-Gut-Brain Axis: How Bacterial Production and Utilization of Neurochemicals Influence Behavior

(2013) Mark Lyte   PLoS Pathogens

Glucocorticoid regulation of inflammation and its functional correlates: from HPA axis to glucocorticoid receptor dysfunction

(2012) Marni N. Silverman et al.   Annals of the New York Academy of Sciences

Bacteria as vitamin suppliers to their host: a gut microbiota perspective

(2012) Jean Guy LeBlanc et al.   CURRENT OPINION IN BIOTECHNOLOGY

Intestinal microbiota in functional bowel disorders: a Rome foundation report

(2012) Magnus Simrén et al.   GUT

γ-Aminobutyric acid production by culturable bacteria from the human intestine

(2012) E. Barrett et al.   JOURNAL OF APPLIED MICROBIOLOGY

Hsp65-producing Lactococcus lactis prevents experimental autoimmune encephalomyelitis in mice by inducing CD4+LAP+ regulatory T cells

(2012) Rafael M. Rezende et al.   JOURNAL OF AUTOIMMUNITY

1,25-Dihyroxyvitamin D3 Promotes FOXP3 Expression via Binding to Vitamin D Response Elements in Its Conserved Noncoding Sequence Region

(2012) S. W. Kang et al.   JOURNAL OF IMMUNOLOGY

Bystander-mediated stimulation of proteolipid protein-specific regulatory T (Treg) cells confers protection against experimental autoimmune encephalomyelitis (EAE) via TGF-β

(2012) SangMu Jun et al.   JOURNAL OF NEUROIMMUNOLOGY

Human gut microbiome viewed across age and geography

(2012) Tanya Yatsunenko et al.   NATURE

Will the real multiple sclerosis please stand up?

(2012) Peter K. Stys et al.   NATURE REVIEWS NEUROSCIENCE

Prevention of gut leakiness by a probiotic treatment leads to attenuated HPA response to an acute psychological stress in rats

(2012) Afifa Ait-Belgnaoui et al.   PSYCHONEUROENDOCRINOLOGY

Interactions Between the Microbiota and the Immune System

(2012) L. V. Hooper et al.   SCIENCE

A vegan or vegetarian diet substantially alters the human colonic faecal microbiota

(2011) J Zimmer et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Gut microbiota, probiotics, and vitamin D: Interrelated exposures influencing allergy, asthma, and obesity?

(2011) Ngoc P. Ly et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The impact of parasite infections on the course of multiple sclerosis

(2011) Jorge Correale et al.   JOURNAL OF NEUROIMMUNOLOGY

Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination

(2011) Kerstin Berer et al.   NATURE

Human nutrition, the gut microbiome and the immune system

(2011) Andrew L. Kau et al.   NATURE

The Lactic Acid Bacterium Pediococcus acidilactici Suppresses Autoimmune Encephalomyelitis by Inducing IL-10-Producing Regulatory T Cells

(2011) Kazushiro Takata et al.   PLoS One

Modulation of Mucosal Immune Response, Tolerance, and Proliferation in Mice Colonized by the Mucin-Degrader Akkermansia muciniphila

(2011) Muriel Derrien et al.   Frontiers in Microbiology

Why bacteria matter in animal development and evolution

(2010) Sebastian Fraune et al.   BIOESSAYS

Exposure to a social stressor alters the structure of the intestinal microbiota: Implications for stressor-induced immunomodulation

(2010) Michael T. Bailey et al.   BRAIN BEHAVIOR AND IMMUNITY

T cells in multiple sclerosis and experimental autoimmune encephalomyelitis

(2010) J. M. Fletcher et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Epigenetics and autoimmunity

(2010) Wesley H. Brooks et al.   JOURNAL OF AUTOIMMUNITY

Central Nervous System Demyelinating Disease Protection by the Human Commensal Bacteroides fragilis Depends on Polysaccharide A Expression

(2010) J. Ochoa-Reparaz et al.   JOURNAL OF IMMUNOLOGY

A polysaccharide from the human commensal Bacteroides fragilis protects against CNS demyelinating disease

(2010) J Ochoa-Repáraz et al.   Mucosal Immunology

Probiotics and the gut microbiota in intestinal health and disease

(2010) Mélanie G. Gareau et al.   Nature Reviews Gastroenterology & Hepatology

A Novel Probiotic Mixture Exerts a Therapeutic Effect on Experimental Autoimmune Encephalomyelitis Mediated by IL-10 Producing Regulatory T Cells

(2010) Shahram Lavasani et al.   PLoS One

Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis

(2010) Y. K. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota

(2010) J. L. Round et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation

(2010) L. Dethlefsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa

(2010) C. De Filippo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Succession of microbial consortia in the developing infant gut microbiome

(2010) J. E. Koenig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns

(2010) M. G. Dominguez-Bello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species

(2010) K. Atarashi et al.   SCIENCE

Unique Lipids from a Common Human Bacterium Represent a New Class of Toll-Like Receptor 2 Ligands Capable of Enhancing Autoimmunity

(2009) Frank C. Nichols et al.   AMERICAN JOURNAL OF PATHOLOGY

Metagenomic Pyrosequencing and Microbial Identification

(2009) J. F. Petrosino et al.   CLINICAL CHEMISTRY

Role of Gut Commensal Microflora in the Development of Experimental Autoimmune Encephalomyelitis

(2009) J. Ochoa-Reparaz et al.   JOURNAL OF IMMUNOLOGY

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

(2009) Kendle M. Maslowski et al.   NATURE

Influence of microbial environment on autoimmunity

(2009) Alexander V Chervonsky   NATURE IMMUNOLOGY

NKT Cell-Dependent Amelioration of a Mouse Model of Multiple Sclerosis by Altering Gut Flora

(2008) Hiroaki Yokote et al.   AMERICAN JOURNAL OF PATHOLOGY

Caesarean delivery and risk of atopy and allergic disesase: meta-analyses

(2008) P. Bager et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Effects ofBifidobacterium animalisadministered during lactation on allergic and autoimmune responses in rodents

(2008) J. Ezendam et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Molecular analysis of the gut microbiota of identical twins with Crohn's disease

(2008) Johan Dicksved et al.   ISME Journal

Chronic calorie restriction attenuates experimental autoimmune encephalomyelitis

(2008) Laura Piccio et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Inhibition of histone-deacetylase activity by short-chain fatty acids and some polyphenol metabolites formed in the colon

(2008) Markus Waldecker et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Multiple sclerosis

(2008) Alastair Compston et al.   LANCET

A core gut microbiome in obese and lean twins

(2008) Peter J. Turnbaugh et al.   NATURE

Strain-dependent effects of probiotic lactobacilli on EAE autoimmunity

(2008) Catharina B.M. Maassen et al.   VACCINE