Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis

Eosinophils and Type 2 Cytokine Signaling in Macrophages Orchestrate Development of Functional Beige Fat

(2014) Yifu Qiu et al.   CELL

Ablation of PRDM16 and Beige Adipose Causes Metabolic Dysfunction and a Subcutaneous to Visceral Fat Switch

(2014) Paul Cohen et al.   CELL

β-Aminoisobutyric Acid Induces Browning of White Fat and Hepatic β-Oxidation and Is Inversely Correlated with Cardiometabolic Risk Factors

(2014) Lee D. Roberts et al.   Cell Metabolism

A standardized infrared imaging technique that specifically detects UCP1-mediated thermogenesis in vivo

(2014) Justin D. Crane et al.   Molecular Metabolism

Brown-fat paucity due to impaired BMP signalling induces compensatory browning of white fat

(2013) Tim J. Schulz et al.   NATURE

UCP1 in Brite/Beige Adipose Tissue Mitochondria Is Functionally Thermogenic

(2013) Irina G. Shabalina et al.   Cell Reports

PPARγ agonists Induce a White-to-Brown Fat Conversion through Stabilization of PRDM16 Protein

(2012) Haruya Ohno et al.   Cell Metabolism

Gut-Derived Serotonin Is a Multifunctional Determinant to Fasting Adaptation

(2012) Grzegorz Sumara et al.   Cell Metabolism

Deletion of Skeletal Muscle SOCS3 Prevents Insulin Resistance in Obesity

(2012) Sebastian Beck Jorgensen et al.   DIABETES

Retinaldehyde dehydrogenase 1 regulates a thermogenic program in white adipose tissue

(2012) Florian W Kiefer et al.   NATURE MEDICINE

Adipocytes express a functional system for serotonin synthesis, reuptake and receptor activation

(2011) A. K. Stunes et al.   DIABETES OBESITY & METABOLISM

Hematopoietic AMPK β1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity

(2011) Sandra Galic et al.   JOURNAL OF CLINICAL INVESTIGATION

Essential Roles of Enteric Neuronal Serotonin in Gastrointestinal Motility and the Development/Survival of Enteric Dopaminergic Neurons

(2011) Z. Li et al.   JOURNAL OF NEUROSCIENCE

Lrp5 functions in bone to regulate bone mass

(2011) Yajun Cui et al.   NATURE MEDICINE

Sex differences in the expression of serotonin-synthesizing enzymes in mouse trigeminal ganglia

(2011) R. Asghari et al.   NEUROSCIENCE

Association of Variations in TPH1 and HTR2B with Gestational Weight Gain and Measures of Obesity

(2011) Soo Heon Kwak et al.   Obesity

AMP-activated protein kinase (AMPK)  1 2 muscle null mice reveal an essential role for AMPK in maintaining mitochondrial content and glucose uptake during exercise

(2011) H. M. O'Neill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Western Diet Increases Serotonin Availability in Rat Small Intestine

(2010) R. L. Bertrand et al.   ENDOCRINOLOGY

Whole Body Deletion of AMP-activated Protein Kinase β2 Reduces Muscle AMPK Activity and Exercise Capacity

(2010) Gregory R. Steinberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The two faces of serotonin in bone biology

(2010) Patricia Ducy et al.   JOURNAL OF CELL BIOLOGY

Outdoor Temperature, Age, Sex, Body Mass Index, and Diabetic Status Determine the Prevalence, Mass, and Glucose-Uptake Activity of18F-FDG-Detected BAT in Humans

(2010) Veronique Ouellet et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Metabolomic Analysis of Livers and Serum from High-Fat Diet Induced Obese Mice

(2010) Hyun-Jin Kim et al.   JOURNAL OF PROTEOME RESEARCH

Regulation of Adipocyte Differentiation by Activation of Serotonin (5-HT) Receptors 5-HT2AR and 5-HT2CR and Involvement of MicroRNA-448-Mediated Repression of KLF5

(2010) Minako Kinoshita et al.   MOLECULAR ENDOCRINOLOGY

Pharmacological inhibition of gut-derived serotonin synthesis is a potential bone anabolic treatment for osteoporosis

(2010) Vijay K Yadav et al.   NATURE MEDICINE

The Expanded Biology of Serotonin

(2009) Miles Berger et al.   Annual Review of Medicine

UCP1 Ablation Induces Obesity and Abolishes Diet-Induced Thermogenesis in Mice Exempt from Thermal Stress by Living at Thermoneutrality

(2009) Helena M. Feldmann et al.   Cell Metabolism

High Incidence of Metabolically Active Brown Adipose Tissue in Healthy Adult Humans: Effects of Cold Exposure and Adiposity

(2009) M. Saito et al.   DIABETES

Serotonin Has a Key Role in Pathogenesis of Experimental Colitis

(2009) Jean–Eric Ghia et al.   GASTROENTEROLOGY

Identification and Importance of Brown Adipose Tissue in Adult Humans

(2009) Aaron M. Cypess et al.   NEW ENGLAND JOURNAL OF MEDICINE

Growth retardation and altered autonomic control in mice lacking brain serotonin

(2009) N. Alenina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intracellular Serotonin Modulates Insulin Secretion from Pancreatic β-Cells by Protein Serotonylation

(2009) Nils Paulmann et al.   PLOS BIOLOGY

Serotonin Regulates C. elegans Fat and Feeding through Independent Molecular Mechanisms

(2008) Supriya Srinivasan et al.   Cell Metabolism

Serotonin Receptors

(2008) David E. Nichols et al.   CHEMICAL REVIEWS

Defects in Breathing and Thermoregulation in Mice with Near-Complete Absence of Central Serotonin Neurons

(2008) M. R. Hodges et al.   JOURNAL OF NEUROSCIENCE

Discovery and Characterization of Novel Tryptophan Hydroxylase Inhibitors That Selectively Inhibit Serotonin Synthesis in the Gastrointestinal Tract

(2008) Q. Liu et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS