Gut–CNS-Axis as Possibility to Modulate Inflammatory Disease Activity—Implications for Multiple Sclerosis

Akkermansia muciniphila and its role in regulating host functions

(2017) Muriel Derrien et al.   MICROBIAL PATHOGENESIS

Interactions between the microbiota, immune and nervous systems in health and disease

(2017) Thomas C Fung et al.   NATURE NEUROSCIENCE

The role of diet in multiple sclerosis: A review

(2017) Sabrina Esposito et al.   NUTRITIONAL NEUROSCIENCE

Multiple layers of heterogeneity and subset diversity in human MAIT cell responses to distinct microorganisms and to innate cytokines

(2017) Joana Dias et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Gut Microbiota and Autism Spectrum Disorders

(2017) Qinrui Li et al.   Frontiers in Cellular Neuroscience

The effects of probiotics on depressive symptoms in humans: a systematic review

(2017) Caroline J. K. Wallace et al.   Annals of General Psychiatry

Oral Multiple Sclerosis Drugs Inhibit the In vitro Growth of Epsilon Toxin Producing Gut Bacterium, Clostridium perfringens

(2017) Kareem R. Rumah et al.   Frontiers in Cellular and Infection Microbiology

Evolution of gut microbiota composition from birth to 24 weeks in the INFANTMET Cohort

(2017) Cian J. Hill et al.   Microbiome

Low-dose penicillin exposure in early life decreases Th17 and the susceptibility to DSS colitis in mice through gut microbiota modification

(2017) Shuang Jin et al.   Scientific Reports

Fish oil, lard and soybean oil differentially shape gut microbiota of middle-aged rats

(2017) He Li et al.   Scientific Reports

Gut microbiome analysis in neuromyelitis optica reveals overabundance ofClostridium perfringens

(2016) Bruce A. C. Cree et al.   ANNALS OF NEUROLOGY

Neuropathologic, phenotypic and functional analyses of Mucosal Associated Invariant T cells in Multiple Sclerosis

(2016) Marion Salou et al.   CLINICAL IMMUNOLOGY

Gut microbiota in early pediatric multiple sclerosis: a case−control study

(2016) H. Tremlett et al.   EUROPEAN JOURNAL OF NEUROLOGY

Sodium chloride promotes pro-inflammatory macrophage polarization thereby aggravating CNS autoimmunity

(2016) Stephanie Hucke et al.   JOURNAL OF AUTOIMMUNITY

Gut instincts: microbiota as a key regulator of brain development, ageing and neurodegeneration

(2016) Timothy G. Dinan et al.   JOURNAL OF PHYSIOLOGY-LONDON

Gut microbiota composition and relapse risk in pediatric MS: A pilot study

(2016) Helen Tremlett et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Altered intestinal permeability in patients with relapsing–remitting multiple sclerosis: A pilot study

(2016) Maria Chiara Buscarinu et al.   Multiple Sclerosis Journal

Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor

(2016) Veit Rothhammer et al.   NATURE MEDICINE

The Infant Microbiome

(2016) Irene Yang et al.   NURSING RESEARCH

Role of gut microbiota and nutrients in amyloid formation and pathogenesis of Alzheimer disease

(2016) Francesca Pistollato et al.   NUTRITION REVIEWS

The maternal microbiota drives early postnatal innate immune development

(2016) M. Gomez de Aguero et al.   SCIENCE

Alterations of the human gut microbiome in multiple sclerosis

(2016) Sushrut Jangi et al.   Nature Communications

Intestinal microbiome is related to lifetime antibiotic use in Finnish pre-school children

(2016) Katri Korpela et al.   Nature Communications

Altered intestinal permeability in patients with relapsing–remitting multiple sclerosis: A pilot study

(2016) Maria Chiara Buscarinu et al.   Multiple Sclerosis Journal

Multiple sclerosis patients have a distinct gut microbiota compared to healthy controls

(2016) Jun Chen et al.   Scientific Reports

Catecholamines and acetylcholine are key regulators of the interaction between microbes and the immune system

(2015) Leon Islas Weinstein et al.   Annals of the New York Academy of Sciences

Nutrition Facts in Multiple Sclerosis

(2015) Paolo Riccio et al.   ASN Neuro

An IL-23R/IL-22 Circuit Regulates Epithelial Serum Amyloid A to Promote Local Effector Th17 Responses

(2015) Teruyuki Sano et al.   CELL

Th17 Cell Induction by Adhesion of Microbes to Intestinal Epithelial Cells

(2015) Koji Atarashi et al.   CELL

Gut microbes promote colonic serotonin production through an effect of short-chain fatty acids on enterochromaffin cells

(2015) Christopher S. Reigstad et al.   FASEB JOURNAL

Identification of an anti-inflammatory protein fromFaecalibacterium prausnitzii, a commensal bacterium deficient in Crohn’s disease

(2015) E Quévrain et al.   GUT

Dietary Fatty Acids Directly Impact Central Nervous System Autoimmunity via the Small Intestine

(2015) Aiden Haghikia et al.   IMMUNITY

Gut/brain axis and the microbiota

(2015) Emeran A. Mayer et al.   JOURNAL OF CLINICAL INVESTIGATION

Gut Microbiota in Multiple Sclerosis

(2015) Brandi L. Cantarel et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Role of the innate and adaptive immune responses in the course of multiple sclerosis

(2015) Bernhard Hemmer et al.   LANCET NEUROLOGY

Host microbiota constantly control maturation and function of microglia in the CNS

(2015) Daniel Erny et al.   NATURE NEUROSCIENCE

Pathogenesis of Parkinson disease—the gut–brain axis and environmental factors

(2015) Lisa Klingelhoefer et al.   Nature Reviews Neurology

Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders

(2015) John R. Kelly et al.   Frontiers in Cellular Neuroscience

Symbiotic Human Gut Bacteria with Variable Metabolic Priorities for Host Mucosal Glycans

(2015) N. A. Pudlo et al.   mBio

Metagenomic cross-talk: the regulatory interplay between immunogenomics and the microbiome

(2015) Maayan Levy et al.   Genome Medicine

Associations between host gene expression, the mucosal microbiome, and clinical outcome in the pelvic pouch of patients with inflammatory bowel disease

(2015) Xochitl C Morgan et al.   GENOME BIOLOGY

1,25-Dihydroxyvitamin D3-Conditioned CD11c+ Dendritic Cells are Effective Initiators of CNS Autoimmune Disease

(2015) Dario Besusso et al.   Frontiers in Immunology

Mucosal-Associated Invariant T Cells in Multiple Sclerosis: The Jury is Still Out

(2015) Emmanuel Treiner et al.   Frontiers in Immunology

Dysbiosis in the Gut Microbiota of Patients with Multiple Sclerosis, with a Striking Depletion of Species Belonging to Clostridia XIVa and IV Clusters

(2015) Sachiko Miyake et al.   PLoS One

Discovery and Characterization of Gut Microbiota Decarboxylases that Can Produce the Neurotransmitter Tryptamine

(2014) Brianna B. Williams et al.   Cell Host & Microbe

Innate mucosal-associated invariant T (MAIT) cells are activated in inflammatory bowel diseases

(2014) N.-E. Serriari et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis

(2014) Shimpei Kawamoto et al.   IMMUNITY

Host adaptive immunity alters gut microbiota

(2014) Husen Zhang et al.   ISME Journal

IL-13 Production by Regulatory T Cells Protects against Experimental Autoimmune Encephalomyelitis Independently of Autoantigen

(2014) J. Ochoa-Reparaz et al.   JOURNAL OF IMMUNOLOGY

Correction: A β-Lactam Antibiotic Dampens Excitotoxic Inflammatory CNS Damage in a Mouse Model of Multiple Sclerosis

(2014) Nico Melzer et al.   PLoS One

Intestinal Barrier Dysfunction Develops at the Onset of Experimental Autoimmune Encephalomyelitis, and Can Be Induced by Adoptive Transfer of Auto-Reactive T Cells

(2014) Mehrnaz Nouri et al.   PLoS One

The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition

(2014) Pamela V. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The HPA – Immune Axis and the Immunomodulatory Actions of Glucocorticoids in the Brain

(2014) Marc-André Bellavance et al.   Frontiers in Immunology

Role of “Western Diet” in Inflammatory Autoimmune Diseases

(2013) Arndt Manzel et al.   CURRENT ALLERGY AND ASTHMA REPORTS

The Gut Microbiota Reduces Leptin Sensitivity and the Expression of the Obesity-Suppressing Neuropeptides Proglucagon (Gcg) and Brain-Derived Neurotrophic Factor (Bdnf) in the Central Nervous System

(2013) Erik Schéle et al.   ENDOCRINOLOGY

Effects of short chain fatty acid producing bacteria on epigenetic regulation of FFAR3 in type 2 diabetes and obesity

(2013) Marlene Remely et al.   GENE

High Fat Diet Exacerbates Neuroinflammation in an Animal Model of Multiple Sclerosis by Activation of the Renin Angiotensin System

(2013) Silke Timmermans et al.   Journal of Neuroimmune Pharmacology

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

(2013) Yukihiro Furusawa et al.   NATURE

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

(2013) Nicholas Arpaia et al.   NATURE

Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1

(2013) Chuan Wu et al.   NATURE

Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells

(2013) Markus Kleinewietfeld et al.   NATURE

Altered colonic function and microbiota profile in a mouse model of chronic depression

(2013) A. J. Park et al.   NEUROGASTROENTEROLOGY AND MOTILITY

The inflamed axis: The interaction between stress, hormones, and the expression of inflammatory-related genes within key structures comprising the hypothalamic–pituitary–adrenal axis

(2013) Cara M. Hueston et al.   PHYSIOLOGY & BEHAVIOR

Isolation of Clostridium perfringens Type B in an Individual at First Clinical Presentation of Multiple Sclerosis Provides Clues for Environmental Triggers of the Disease

(2013) Kareem Rashid Rumah et al.   PLoS One

Faecalibacterium prausnitzii supernatant improves intestinal barrier function in mice DSS colitis

(2013) Anders H Carlsson et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis

(2013) P. M. Smith et al.   SCIENCE

Critical role of gut microbiota in the production of biologically active, free catecholamines in the gut lumen of mice

(2012) Yasunari Asano et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Glucocorticoid regulation of inflammation and its functional correlates: from HPA axis to glucocorticoid receptor dysfunction

(2012) Marni N. Silverman et al.   Annals of the New York Academy of Sciences

Microbial Translocation Across the GI Tract

(2012) Jason M. Brenchley et al.   Annual Review of Immunology

The Impact of the Gut Microbiota on Human Health: An Integrative View

(2012) Jose C. Clemente et al.   CELL

Priming of Natural Killer Cells by Nonmucosal Mononuclear Phagocytes Requires Instructive Signals from Commensal Microbiota

(2012) Stephanie C. Ganal et al.   IMMUNITY

γ-Aminobutyric acid production by culturable bacteria from the human intestine

(2012) E. Barrett et al.   JOURNAL OF APPLIED MICROBIOLOGY

Microbiota-induced IL-1β, but not IL-6, is critical for the development of steady-state TH17 cells in the intestine

(2012) Michael H. Shaw et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Eicosapentaenoic acid (EPA) induces peroxisome proliferator-activated receptors and ameliorates experimental autoimmune encephalomyelitis

(2012) Kiichi Unoda et al.   JOURNAL OF NEUROIMMUNOLOGY

The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner

(2012) G Clarke et al.   MOLECULAR PSYCHIATRY

NLRC4-driven production of IL-1β discriminates between pathogenic and commensal bacteria and promotes host intestinal defense

(2012) Luigi Franchi et al.   NATURE IMMUNOLOGY

Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour

(2012) John F. Cryan et al.   NATURE REVIEWS NEUROSCIENCE

Of Microbes and Meals

(2012) Caleb J. Kelly et al.   NUTRITION IN CLINICAL PRACTICE

Prevention of gut leakiness by a probiotic treatment leads to attenuated HPA response to an acute psychological stress in rats

(2012) Afifa Ait-Belgnaoui et al.   PSYCHONEUROENDOCRINOLOGY

Innate Lymphoid Cells Promote Anatomical Containment of Lymphoid-Resident Commensal Bacteria

(2012) G. F. Sonnenberg et al.   SCIENCE

The Inhibitory Receptor PD-1 Regulates IgA Selection and Bacterial Composition in the Gut

(2012) S. Kawamoto et al.   SCIENCE

Microbial Exposure During Early Life Has Persistent Effects on Natural Killer T Cell Function

(2012) T. Olszak et al.   SCIENCE

Regulated Virulence Controls the Ability of a Pathogen to Compete with the Gut Microbiota

(2012) N. Kamada et al.   SCIENCE

Analysis of gut microbial regulation of host gene expression along the length of the gut and regulation of gut microbial ecology through MyD88

(2011) Erik Larsson et al.   GUT

Intestinal Bacterial Colonization Induces Mutualistic Regulatory T Cell Responses

(2011) Markus B. Geuking et al.   IMMUNITY

Mucosal-associated invariant T cells regulate Th1 response in multiple sclerosis

(2011) Yusei Miyazaki et al.   INTERNATIONAL IMMUNOLOGY

Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination

(2011) Kerstin Berer et al.   NATURE

RORγt+ innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiota

(2011) Shinichiro Sawa et al.   NATURE IMMUNOLOGY

The anxiolytic effect of Bifidobacterium longum NCC3001 involves vagal pathways for gut-brain communication

(2011) P. Bercik et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve

(2011) J. A. Bravo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Toll-Like Receptor 2 Pathway Establishes Colonization by a Commensal of the Human Microbiota

(2011) J. L. Round et al.   SCIENCE

Intestinal dysbiosis and reduced immunoglobulin-coated bacteria associated with coeliac disease in children

(2010) Giada De Palma et al.   BMC MICROBIOLOGY

Exposure to a social stressor alters the structure of the intestinal microbiota: Implications for stressor-induced immunomodulation

(2010) Michael T. Bailey et al.   BRAIN BEHAVIOR AND IMMUNITY

Central Nervous System Demyelinating Disease Protection by the Human Commensal Bacteroides fragilis Depends on Polysaccharide A Expression

(2010) J. Ochoa-Reparaz et al.   JOURNAL OF IMMUNOLOGY

A polysaccharide from the human commensal Bacteroides fragilis protects against CNS demyelinating disease

(2010) J Ochoa-Repáraz et al.   Mucosal Immunology

A Novel Probiotic Mixture Exerts a Therapeutic Effect on Experimental Autoimmune Encephalomyelitis Mediated by IL-10 Producing Regulatory T Cells

(2010) Shahram Lavasani et al.   PLoS One

Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis

(2010) Y. K. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota

(2010) J. L. Round et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa

(2010) C. De Filippo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species

(2010) K. Atarashi et al.   SCIENCE

Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

(2009) Ivaylo I. Ivanov et al.   CELL

Role of Gut Commensal Microflora in the Development of Experimental Autoimmune Encephalomyelitis

(2009) J. Ochoa-Reparaz et al.   JOURNAL OF IMMUNOLOGY

The role of TLRs, NLRs and RLRs in mucosal innate immunity and homeostasis

(2009) E C Lavelle et al.   Mucosal Immunology

Multiple roles of HDAC inhibition in neurodegenerative conditions

(2009) De-Maw Chuang et al.   TRENDS IN NEUROSCIENCES

NKT Cell-Dependent Amelioration of a Mouse Model of Multiple Sclerosis by Altering Gut Flora

(2008) Hiroaki Yokote et al.   AMERICAN JOURNAL OF PATHOLOGY

Protective effects of Lactobacillus reuteri and Bifidobacterium infantis in murine models for colitis do not involve the vagus nerve

(2008) Hanneke van der Kleij et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Specific Microbiota Direct the Differentiation of IL-17-Producing T-Helper Cells in the Mucosa of the Small Intestine

(2008) Ivaylo I. Ivanov et al.   Cell Host & Microbe

Microbial Flora Drives Interleukin 22 Production in Intestinal NKp46+ Cells that Provide Innate Mucosal Immune Defense

(2008) Naoko Satoh-Takayama et al.   IMMUNITY

ATP drives lamina propria TH17 cell differentiation

(2008) Koji Atarashi et al.   NATURE

Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients

(2008) H. Sokol et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA