The HPA – Immune Axis and the Immunomodulatory Actions of Glucocorticoids in the Brain

Peripheral T Cells Are the Therapeutic Targets of Glucocorticoids in Experimental Autoimmune Encephalomyelitis

(2014) S. Wust et al.   JOURNAL OF IMMUNOLOGY

Glucocorticoid receptor translational isoforms underlie maturational stage-specific glucocorticoid sensitivities of dendritic cells in mice and humans

(2013) Y. Cao et al.   BLOOD

Stress-induced glucocorticoids as a neuroendocrine alarm signal of danger

(2013) Matthew G. Frank et al.   BRAIN BEHAVIOR AND IMMUNITY

Potent and multiple regulatory actions of microglial glucocorticoid receptors during CNS inflammation

(2013) M Á Carrillo-de Sauvage et al.   CELL DEATH AND DIFFERENTIATION

New Insights into the Anti-inflammatory Mechanisms of Glucocorticoids: An Emerging Role for Glucocorticoid-Receptor-Mediated Transactivation

(2013) Sofie Vandevyver et al.   ENDOCRINOLOGY

Endogenous glucocorticoid receptor signaling drives rhythmic changes in human T-cell subset numbers and the expression of the chemokine receptor CXCR4

(2013) Luciana Besedovsky et al.   FASEB JOURNAL

The biology of the glucocorticoid receptor: New signaling mechanisms in health and disease

(2013) Robert H. Oakley et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

CD4+T cells are trigger and target of the glucocorticoid response that prevents lethal immunopathology in toxoplasma infection

(2013) David G. Kugler et al.   JOURNAL OF EXPERIMENTAL MEDICINE

DC-SCRIPT Regulates Glucocorticoid Receptor Function and Expression of Its Target GILZ in Dendritic Cells

(2013) S. Hontelez et al.   JOURNAL OF IMMUNOLOGY

Glucocorticoid Signaling in Myeloid Cells Worsens Acute CNS Injury and Inflammation

(2013) S. F. Sorrells et al.   JOURNAL OF NEUROSCIENCE

The potential role of T cell migration and chemotaxis as targets of glucocorticoids in multiple sclerosis and experimental autoimmune encephalomyelitis

(2013) Henrike J. Fischer et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Glucocorticoid receptor represses proinflammatory genes at distinct steps of the transcription cycle

(2013) Rebecca Gupte et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HES1 Is a Master Regulator of Glucocorticoid Receptor-Dependent Gene Expression

(2013) J. R. Revollo et al.   Science Signaling

Glucocorticoid receptor signaling in health and disease

(2013) Mahita Kadmiel et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Microglia, seen from the CX3CR1 angle

(2013) Yochai Wolf et al.   Frontiers in Cellular Neuroscience

The brain’s best friend: microglial neurotoxicity revisited

(2013) Sabine Hellwig et al.   Frontiers in Cellular Neuroscience

Factors regulating microglia activation

(2013) Katrin Kierdorf et al.   Frontiers in Cellular Neuroscience

Non-genomic inhibitory effect of glucocorticoids on activated peripheral blood basophils through suppression of lipid raft formation

(2012) S. Yamagata et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Proinflammatory Actions of Glucocorticoids: Glucocorticoids and TNFα Coregulate Gene ExpressionIn VitroandIn Vivo

(2012) Erica A. Lannan et al.   ENDOCRINOLOGY

Annexin A1 modulates natural and glucocorticoid-induced resolution of inflammation by enhancing neutrophil apoptosis

(2012) Juliana P. Vago et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Psychological stress in adolescent and adult mice increases neuroinflammation and attenuates the response to LPS challenge

(2012) Christopher J Barnum et al.   Journal of Neuroinflammation

Glucocorticoid receptor dimerization is required for proper recovery of LPS-induced inflammation, sickness behavior and metabolism in mice

(2012) M N Silverman et al.   MOLECULAR PSYCHIATRY

Endothelial glucocorticoid receptor is required for protection against sepsis

(2012) J. E. Goodwin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BDNF and glucocorticoids regulate corticotrophin-releasing hormone (CRH) homeostasis in the hypothalamus

(2012) F. D. Jeanneteau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Origin and functional activity of the membrane-bound glucocorticoid receptor

(2011) Cindy Strehl et al.   ARTHRITIS AND RHEUMATISM

The kaleidoscope of glucorticoid effects on immune system

(2011) Margherita Zen et al.   AUTOIMMUNITY REVIEWS

Widespread Negative Response Elements Mediate Direct Repression by Agonist- Liganded Glucocorticoid Receptor

(2011) Milan Surjit et al.   CELL

Dynamic Exchange at Regulatory Elements during Chromatin Remodeling Underlies Assisted Loading Mechanism

(2011) Ty C. Voss et al.   CELL

Glucocorticoid receptor dimerization is required for survival in septic shock via suppression of interleukin-1 in macrophages

(2011) Anna Kleiman et al.   FASEB JOURNAL

Glucocorticoids Sensitize the Innate Immune System through Regulation of the NLRP3 Inflammasome

(2011) John M. Busillo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glucocorticoid Elevation of Dexamethasone-induced Gene 2 (Dig2/RTP801/REDD1) Protein Mediates Autophagy in Lymphocytes

(2011) Jason K. Molitoris et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recruitment of Prefrontal Cortical Endocannabinoid Signaling by Glucocorticoids Contributes to Termination of the Stress Response

(2011) M. N. Hill et al.   JOURNAL OF NEUROSCIENCE

Mineralocorticoid and glucocorticoid receptors at the neuronal membrane, regulators of nongenomic corticosteroid signalling

(2011) Femke L. Groeneweg et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Minireview: Glucocorticoids in Autoimmunity: Unexpected Targets and Mechanisms

(2011) Jamie R. Flammer et al.   MOLECULAR ENDOCRINOLOGY

The stressed synapse: the impact of stress and glucocorticoids on glutamate transmission

(2011) Maurizio Popoli et al.   NATURE REVIEWS NEUROSCIENCE

New insights into corticosteroid-binding globulin and glucocorticoid delivery

(2011) D.E. Henley et al.   NEUROSCIENCE

Immune system to brain signaling: Neuropsychopharmacological implications

(2011) Lucile Capuron et al.   PHARMACOLOGY & THERAPEUTICS

Nongenomic glucocorticoid receptor action regulates gap junction intercellular communication and neural progenitor cell proliferation

(2011) R. A. Samarasinghe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glucocorticoids target suppressor of cytokine signaling 1 (SOCS1) and type 1 interferons to regulate Toll-like receptor-induced STAT1 activation

(2011) S. Bhattacharyya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microglial glucocorticoid receptors play a pivotal role in regulating dopaminergic neurodegeneration in parkinsonism

(2011) F. Ros-Bernal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glucocorticoid receptor mutants: man-made tools for functional research

(2011) Ilse M. Beck et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Glucocorticoid treatment skews human monocyte differentiation into a hemoglobin-clearance phenotype with enhanced heme-iron recycling and antioxidant capacity

(2010) F. Vallelian et al.   BLOOD

TAK1 targeting by glucocorticoids determines JNK and I B regulation in Toll-like receptor-stimulated macrophages

(2010) S. Bhattacharyya et al.   BLOOD

Classic glucocorticoids versus non-steroidal glucocorticoid receptor modulators: Survival of the fittest regulator of the immune system?

(2010) Karolien De Bosscher et al.   BRAIN BEHAVIOR AND IMMUNITY

Differential effect of glucocorticoids on tumour necrosis factor production in mice: up-regulation by early pretreatment with dexamethasone

(2010) G. FANTUZZI et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Glucocorticoid Receptor-β and Receptor-γ Exert Dominant Negative Effect on Gene Repression But Not on Gene Induction

(2010) Yoshinori Taniguchi et al.   ENDOCRINOLOGY

HPA axis responsiveness to stress: Implications for healthy aging

(2010) Greti Aguilera   EXPERIMENTAL GERONTOLOGY

11β-Hydroxysteroid dehydrogenases and the brain: From zero to hero, a decade of progress

(2010) Caitlin S. Wyrwoll et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Microglia express functional 11β-hydroxysteroid dehydrogenase type 1

(2010) Andres Gottfried-Blackmore et al.   GLIA

Cellular Processing of the Glucocorticoid Receptor Gene and Protein: New Mechanisms for Generating Tissue-specific Actions of Glucocorticoids

(2010) Robert H. Oakley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glucocorticoids Exacerbate Lipopolysaccharide-Induced Signaling in the Frontal Cortex and Hippocampus in a Dose-Dependent Manner

(2010) C. D. Munhoz et al.   JOURNAL OF NEUROSCIENCE

Dexamethasone Enhances ATP-Induced Inflammatory Responses in Endothelial Cells

(2010) Y. Ding et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Mechanisms and resistance in glucocorticoid control of inflammation

(2010) Peter J. Barnes   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

The role of the glucocorticoid receptor in inflammation and immunity

(2010) Ulrike Baschant et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

The crucial role of pulsatile activity of the HPA axis for continuous dynamic equilibration

(2010) Stafford L. Lightman et al.   NATURE REVIEWS NEUROSCIENCE

Dual Roles for Perivascular Macrophages in Immune-to-Brain Signaling

(2010) Jordi Serrats et al.   NEURON

Gene expression changes in the hypothalamus provide evidence for regionally-selective changes in IL-1 and microglial markers after acute stress

(2009) Peter Blandino et al.   BRAIN BEHAVIOR AND IMMUNITY

Prior exposure to glucocorticoids sensitizes the neuroinflammatory and peripheral inflammatory responses to E. coli lipopolysaccharide

(2009) Matthew G. Frank et al.   BRAIN BEHAVIOR AND IMMUNITY

Crosstalk in Inflammation: The Interplay of Glucocorticoid Receptor-Based Mechanisms and Kinases and Phosphatases

(2009) Ilse M. E. Beck et al.   ENDOCRINE REVIEWS

Prednisolone Treatment Induces Tolerogenic Dendritic Cells and a Regulatory Milieu in Myasthenia Gravis Patients

(2009) C. Luther et al.   JOURNAL OF IMMUNOLOGY

Inducible Prostaglandin E2 Synthesis Interacts in a Temporally Supplementary Sequence with Constitutive Prostaglandin-Synthesizing Enzymes in Creating the Hypothalamic-Pituitary-Adrenal Axis Response to Immune Challenge

(2009) L. Elander et al.   JOURNAL OF NEUROSCIENCE

Cerebrovascular Cyclooxygenase-1 Expression, Regulation, and Role in Hypothalamic-Pituitary-Adrenal Axis Activation by Inflammatory Stimuli

(2009) B. Garcia-Bueno et al.   JOURNAL OF NEUROSCIENCE

Ultradian hormone stimulation induces glucocorticoid receptor-mediated pulses of gene transcription

(2009) Diana A. Stavreva et al.   NATURE CELL BIOLOGY

Effects of stress throughout the lifespan on the brain, behaviour and cognition

(2009) Sonia J. Lupien et al.   NATURE REVIEWS NEUROSCIENCE

Neural regulation of endocrine and autonomic stress responses

(2009) Yvonne M. Ulrich-Lai et al.   NATURE REVIEWS NEUROSCIENCE

Stress is critical for LPS-induced activation of microglia and damage in the rat hippocampus

(2009) A.M. Espinosa-Oliva et al.   NEUROBIOLOGY OF AGING

The Stressed CNS: When Glucocorticoids Aggravate Inflammation

(2009) Shawn F. Sorrells et al.   NEURON

DNA Binding Site Sequence Directs Glucocorticoid Receptor Structure and Activity

(2009) S. H. Meijsing et al.   SCIENCE

The human glucocorticoid receptor: Molecular basis of biologic function

(2009) Nicolas C. Nicolaides et al.   STEROIDS

Dexamethasone augments CXCR4-mediated signaling in resting human T cells via the activation of the Src kinase Lck

(2008) M. C. Ghosh et al.   BLOOD

Bone-marrow-derived microglia: myth or reality?

(2008) Denis Soulet et al.   CURRENT OPINION IN PHARMACOLOGY

Steroid hormone receptor expression and function in microglia

(2008) Amanda Sierra et al.   GLIA

Glucocorticoids Inhibit IRF3 Phosphorylation in Response to Toll-like Receptor-3 and -4 by Targeting TBK1 Activation

(2008) Claire E. McCoy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeted ablation reveals a novel role of FKBP52 in gene-specific regulation of glucocorticoid receptor transcriptional activity

(2008) Irene M. Wolf et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

MyD88 signaling in brain endothelial cells is essential for the neuronal activity and glucocorticoid release during systemic inflammation

(2008) D Gosselin et al.   MOLECULAR PSYCHIATRY

Hypothalamic–pituitary–adrenal axis dysregulation and behavioral analysis of mouse mutants with altered glucocorticoid or mineralocorticoid receptor function

(2008) Benedict J. Kolber et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

Genomic and nongenomic effects of glucocorticoids

(2008) Cindy Stahn et al.   Nature clinical practice. Rheumatology

Stress Mediators Regulate Brain Prostaglandin Synthesis and Peroxisome Proliferator-Activated Receptor-γ Activation after Stress in Rats

(2007) Borja García-Bueno et al.   ENDOCRINOLOGY

The effects of non-genomic glucocorticoid mechanisms on bodily functions and the central neural system. A critical evaluation of findings

(2007) József Haller et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Phosphatidylinositol 3-kinase and p38 mitogen-activated protein kinase regulate induction of Mcl-1 and survival in glucocorticoid-treated human neutrophils

(2007) Arash S. Saffar et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The coming out of the brain mineralocorticoid receptor

(2007) Marian Joëls et al.   TRENDS IN NEUROSCIENCES