Towards personalized computational oncology: from spatial models of tumour spheroids, to organoids, to tissues
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Title
Towards personalized computational oncology: from spatial models of tumour spheroids, to organoids, to tissues
Authors
Keywords
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Journal
Journal of the Royal Society Interface
Volume 15, Issue 138, Pages 20170703
Publisher
The Royal Society
Online
2018-01-24
DOI
10.1098/rsif.2017.0703
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Note: Only part of the references are listed.- Pancreatic Tumor Growth Prediction With Elastic-Growth Decomposition, Image-Derived Motion, and FDM-FEM Coupling
- (2017) Ken C. L. Wong et al. IEEE TRANSACTIONS ON MEDICAL IMAGING
- The Use of Endometrial Cancer Patient–Derived Organoid Culture for Drug Sensitivity Testing Is Feasible
- (2017) Eugenia Girda et al. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
- 3D hybrid modelling of vascular network formation
- (2017) Holger Perfahl et al. JOURNAL OF THEORETICAL BIOLOGY
- How tumour-induced vascular changes alter angiogenesis: Insights from a computational model
- (2017) A. Stéphanou et al. JOURNAL OF THEORETICAL BIOLOGY
- A mechanically active heterotypic E-cadherin/N-cadherin adhesion enables fibroblasts to drive cancer cell invasion
- (2017) Anna Labernadie et al. NATURE CELL BIOLOGY
- Precision medicine based on epigenomics: the paradigm of carcinoma of unknown primary
- (2017) Sebastián Moran et al. Nature Reviews Clinical Oncology
- Evaluating fibre orientation dispersion in white matter: Comparison of diffusion MRI, histology and polarized light imaging
- (2017) Jeroen Mollink et al. NEUROIMAGE
- Evaluating optimal therapy robustness by virtual expansion of a sample population, with a case study in cancer immunotherapy
- (2017) Syndi Barish et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Personalized In Vitro and In Vivo Cancer Models to Guide Precision Medicine
- (2017) Chantal Pauli et al. Cancer Discovery
- Quantifying the effects of antiangiogenic and chemotherapy drug combinations on drug delivery and treatment efficacy
- (2017) Sirin Yonucu et al. PLoS Computational Biology
- Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle
- (2017) Lawrence Vernetti et al. Scientific Reports
- Delineation of Tumor Habitats based on Dynamic Contrast Enhanced MRI
- (2017) Yu-Cherng Channing Chang et al. Scientific Reports
- Heralding a new paradigm in 3D tumor modeling
- (2016) Eliza L.S. Fong et al. BIOMATERIALS
- 3D tumor spheroids: an overview on the tools and techniques used for their analysis
- (2016) Elisabete C. Costa et al. BIOTECHNOLOGY ADVANCES
- A reductionist metastasis-on-a-chip platform for in vitro tumor progression modeling and drug screening
- (2016) Aleksander Skardal et al. BIOTECHNOLOGY AND BIOENGINEERING
- PET and MRI: Is the Whole Greater than the Sum of Its Parts?
- (2016) Robert J. Gillies et al. CANCER RESEARCH
- Coarse-Grained Protein Models and Their Applications
- (2016) Sebastian Kmiecik et al. CHEMICAL REVIEWS
- Towards the Design of a Patient-Specific Virtual Tumour
- (2016) Flavien Caraguel et al. Computational and Mathematical Methods in Medicine
- Phase i trials in melanoma: A framework to translate preclinical findings to the clinic
- (2016) Eunjung Kim et al. EUROPEAN JOURNAL OF CANCER
- Stem cell competition in the gut: insights from multi-scale computational modelling
- (2016) Torsten Thalheim et al. Journal of the Royal Society Interface
- Next generation sequencing: implications in personalized medicine and pharmacogenomics
- (2016) Bahareh Rabbani et al. Molecular BioSystems
- Enhanced performance of macrophage-encapsulated nanoparticle albumin-bound-paclitaxel in hypo-perfused cancer lesions
- (2016) Fransisca Leonard et al. Nanoscale
- Cancer therapy: an evolved approach
- (2016) Cassandra Willyard NATURE
- Organoid culture systems for prostate epithelial and cancer tissue
- (2016) Jarno Drost et al. Nature Protocols
- Fusion in diffusion MRI for improved fibre orientation estimation: An application to the 3T and 7T data of the Human Connectome Project
- (2016) Stamatios N. Sotiropoulos et al. NEUROIMAGE
- Three-dimensional culture systems in cancer research: Focus on tumor spheroid model
- (2016) Sritama Nath et al. PHARMACOLOGY & THERAPEUTICS
- Computational Trials: Unraveling Motility Phenotypes, Progression Patterns, and Treatment Options for Glioblastoma Multiforme
- (2016) Fabio Raman et al. PLoS One
- Computational Model for Tumor Oxygenation Applied to Clinical Data on Breast Tumor Hemoglobin Concentrations Suggests Vascular Dilatation and Compression
- (2016) Michael Welter et al. PLoS One
- Tissue-scale, personalized modeling and simulation of prostate cancer growth
- (2016) Guillermo Lorenzo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Radiomics: Images Are More than Pictures, They Are Data
- (2016) Robert J. Gillies et al. RADIOLOGY
- Multimodality imaging and mathematical modelling of drug delivery to glioblastomas
- (2016) Ahmed Boujelben et al. Interface Focus
- Inferring Growth Control Mechanisms in Growing Multi-cellular Spheroids of NSCLC Cells from Spatial-Temporal Image Data
- (2016) Nick Jagiella et al. PLoS Computational Biology
- Leveraging Hypoxia-Activated Prodrugs to Prevent Drug Resistance in Solid Tumors
- (2016) Danika Lindsay et al. PLoS Computational Biology
- Spatial Metrics of Tumour Vascular Organisation Predict Radiation Efficacy in a Computational Model
- (2016) Jacob G. Scott et al. PLoS Computational Biology
- Temporal modulation of collective cell behavior controls vascular network topology
- (2016) Esther Kur et al. eLife
- Mechanotransduction in cancer
- (2016) LiKang Chin et al. Current Opinion in Chemical Engineering
- BioSig3D: High Content Screening of Three-Dimensional Cell Culture Models
- (2016) Cemal Cagatay Bilgin et al. PLoS One
- 3D tumor spheroid models for in vitro therapeutic screening: a systematic approach to enhance the biological relevance of data obtained
- (2016) Michele Zanoni et al. Scientific Reports
- 3D microtumors in vitro supported by perfused vascular networks
- (2016) Agua Sobrino et al. Scientific Reports
- Pathology to Enhance Precision Medicine in Oncology
- (2015) Mark C. Lloyd et al. ADVANCES IN ANATOMIC PATHOLOGY
- Enhanced sampling techniques in molecular dynamics simulations of biological systems
- (2015) Rafael C. Bernardi et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
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- (2015) Jacquelyn A. Brown et al. Biomicrofluidics
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- (2015) Kimberly R. Kanigel Winner et al. CANCER RESEARCH
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- (2015) J. A. Weis et al. CANCER RESEARCH
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- (2015) L. L. Siu et al. CLINICAL CANCER RESEARCH
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- (2015) Heiko Enderling Integrative Biology
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- (2015) Michael Mak et al. Integrative Biology
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- Computational Modeling of Tumor Response to Drug Release from Vasculature-Bound Nanoparticles
- (2015) Louis T. Curtis et al. PLoS One
- The need for complex 3D culture models to unravel novel pathways and identify accurate biomarkers in breast cancer
- (2014) Britta Weigelt et al. ADVANCED DRUG DELIVERY REVIEWS
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- (2014) John A. Hickman et al. Biotechnology Journal
- Local and global dynamics of the basement membrane during branching morphogenesis require protease activity and actomyosin contractility
- (2014) Jill S. Harunaga et al. DEVELOPMENTAL BIOLOGY
- The relevance and potential roles of microphysiological systems in biology and medicine
- (2014) John P Wikswo EXPERIMENTAL BIOLOGY AND MEDICINE
- The formation of tight tumor clusters affects the efficacy of cell cycle inhibitors: A hybrid model study
- (2014) MunJu Kim et al. JOURNAL OF THEORETICAL BIOLOGY
- The role of differential VE-cadherin dynamics in cell rearrangement during angiogenesis
- (2014) Katie Bentley et al. NATURE CELL BIOLOGY
- Generation of cerebral organoids from human pluripotent stem cells
- (2014) Madeline A Lancaster et al. Nature Protocols
- Cancer Systems Biology: a peek into the future of patient care?
- (2014) Henrica M. J. Werner et al. Nature Reviews Clinical Oncology
- Three-dimensional organotypic culture: experimental models of mammalian biology and disease
- (2014) Eliah R. Shamir et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Quantification of Dynamic Morphological Drug Responses in 3D Organotypic Cell Cultures by Automated Image Analysis
- (2014) Ville Härmä et al. PLoS One
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- (2014) Simon D. Angus et al. PLoS One
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- (2014) Robert J. Huebner et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Decoding tumour phenotype by noninvasive imaging using a quantitative radiomics approach
- (2014) Hugo J. W. L. Aerts et al. Nature Communications
- Lattice-Based Model of Ductal Carcinoma In Situ Suggests Rules for Breast Cancer Progression to an Invasive State
- (2014) Eline Boghaert et al. PLoS Computational Biology
- Variation in diffusion of gases through PDMS due to plasma surface treatment and storage conditions
- (2013) Dmitry A. Markov et al. BIOMEDICAL MICRODEVICES
- Three-dimensional culture model to distinguish normal from malignant human bronchial epithelial cells
- (2013) Delphine Fessart et al. EUROPEAN RESPIRATORY JOURNAL
- DCE-MRI analysis methods for predicting the response of breast cancer to neoadjuvant chemotherapy: Pilot study findings
- (2013) Xia Li et al. MAGNETIC RESONANCE IN MEDICINE
- Computational Models Reveal a Passive Mechanism for Cell Migration in the Crypt
- (2013) Sara-Jane Dunn et al. PLoS One
- Cancer Cell Phenotypes, in Fifty Shades of Grey
- (2013) A. Marusyk et al. SCIENCE
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- (2013) Rafael Bravo et al. Theoretical Biology and Medical Modelling
- In Silico Analysis of Cell Cycle Synchronisation Effects in Radiotherapy of Tumour Spheroids
- (2013) Harald Kempf et al. PLoS Computational Biology
- Towards Predicting the Response of a Solid Tumour to Chemotherapy and Radiotherapy Treatments: Clinical Insights from a Computational Model
- (2013) Gibin G. Powathil et al. PLoS Computational Biology
- Chaste: An Open Source C++ Library for Computational Physiology and Biology
- (2013) Gary R. Mirams et al. PLoS Computational Biology
- Angiogenesis: An Adaptive Dynamic Biological Patterning Problem
- (2013) Timothy W. Secomb et al. PLoS Computational Biology
- Design of Optimized Hypoxia-Activated Prodrugs Using Pharmacokinetic/Pharmacodynamic Modeling
- (2013) Annika Foehrenbacher et al. Frontiers in Oncology
- From Patient-Specific Mathematical Neuro-Oncology to Precision Medicine
- (2013) A. L. Baldock et al. Frontiers in Oncology
- The Role of Tumor Tissue Architecture in Treatment Penetration and Efficacy: An Integrative Study
- (2013) Katarzyna A. Rejniak et al. Frontiers in Oncology
- Acute and Fractionated Irradiation Differentially Modulate Glioma Stem Cell Division Kinetics
- (2012) X. Gao et al. CANCER RESEARCH
- Content-Based Microscopic Image Retrieval System for Multi-Image Queries
- (2012) H. C. Akakin et al. IEEE TRANSACTIONS ON INFORMATION TECHNOLOGY IN BIOMEDICINE
- The extracellular matrix: A dynamic niche in cancer progression
- (2012) Pengfei Lu et al. JOURNAL OF CELL BIOLOGY
- Mathematical modeling of monoclonal conversion in the colonic crypt
- (2012) Alexander G. Fletcher et al. JOURNAL OF THEORETICAL BIOLOGY
- Patient-calibrated agent-based modelling of ductal carcinoma in situ (DCIS): From microscopic measurements to macroscopic predictions of clinical progression
- (2012) Paul Macklin et al. JOURNAL OF THEORETICAL BIOLOGY
- Thick-tissue bioreactor as a platform for long-term organotypic culture and drug delivery
- (2012) Dmitry A. Markov et al. LAB ON A CHIP
- Outgrowth of single oncogene-expressing cells from suppressive epithelial environments
- (2012) Cheuk T. Leung et al. NATURE
- Optimization of vascular-targeting drugs in a computational model of tumor growth
- (2012) Jana Gevertz PHYSICAL REVIEW E
- Recent successes in coarse-grained modeling of DNA
- (2012) Davit A. Potoyan et al. Wiley Interdisciplinary Reviews-Computational Molecular Science
- Modeling Protective Anti-Tumor Immunity via Preventative Cancer Vaccines Using a Hybrid Agent-based and Delay Differential Equation Approach
- (2012) Peter S. Kim et al. PLoS Computational Biology
- Mathematical Modeling Predicts Synergistic Antitumor Effects of Combining a Macrophage-Based, Hypoxia-Targeted Gene Therapy with Chemotherapy
- (2011) M. R. Owen et al. CANCER RESEARCH
- Surviving without oxygen: Hypoxia regulation of mammary morphogenesis and anoikis
- (2011) Kelly A. Whelan et al. CELL CYCLE
- Computational Modeling of Tumor Response to Vascular-Targeting Therapies—Part I: Validation
- (2011) Jana L. Gevertz Computational and Mathematical Methods in Medicine
- Phenotypic transition maps of 3D breast acini obtained by imaging-guided agent-based modeling
- (2011) Jonathan Tang et al. Integrative Biology
- In situ force mapping of mammary gland transformation
- (2011) Jose I. Lopez et al. Integrative Biology
- Statistical comparison of dynamic contrast-enhanced MRI pharmacokinetic models in human breast cancer
- (2011) Xia Li et al. MAGNETIC RESONANCE IN MEDICINE
- Multiscale Modelling of Vascular Tumour Growth in 3D: The Roles of Domain Size and Boundary Conditions
- (2011) Holger Perfahl et al. PLoS One
- Integrative physical oncology
- (2011) Haralampos Hatzikirou et al. Wiley Interdisciplinary Reviews-Systems Biology and Medicine
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- (2011) Jesse A. Engelberg et al. PLoS Computational Biology
- A computational approach to resolve cell level contributions to early glandular epithelial cancer progression
- (2010) Sean HJ Kim et al. BMC Systems Biology
- Current trends in mathematical modeling of tumor–microenvironment interactions: a survey of tools and applications
- (2010) Katarzyna A Rejniak et al. EXPERIMENTAL BIOLOGY AND MEDICINE
- Computational investigation of intrinsic and extrinsic mechanisms underlying the formation of carcinoma
- (2010) K. A. Rejniak et al. MATHEMATICAL MEDICINE AND BIOLOGY-A JOURNAL OF THE IMA
- A molecular network for de novo generation of the apical surface and lumen
- (2010) David M. Bryant et al. NATURE CELL BIOLOGY
- Front Instabilities and Invasiveness of Simulated 3D Avascular Tumors
- (2010) Nikodem J. Poplawski et al. PLoS One
- A Sub-Cellular Viscoelastic Model for Cell Population Mechanics
- (2010) Yousef Jamali et al. PLoS One
- Emergent Properties of Tumor Microenvironment in a Real-Life Model of Multicell Tumor Spheroids
- (2010) Edoardo Milotti et al. PLoS One
- Mechanotransduction: a major regulator of homeostasis and development
- (2010) Kevin S. Kolahi et al. Wiley Interdisciplinary Reviews-Systems Biology and Medicine
- Hybrid models of tumor growth
- (2010) Katarzyna A. Rejniak et al. Wiley Interdisciplinary Reviews-Systems Biology and Medicine
- Linking Changes in Epithelial Morphogenesis to Cancer Mutations Using Computational Modeling
- (2010) Katarzyna A. Rejniak et al. PLoS Computational Biology
- Adaptive Therapy
- (2009) R. A. Gatenby et al. CANCER RESEARCH
- Prognostic Significance of Growth Kinetics in Newly Diagnosed Glioblastomas Revealed by Combining Serial Imaging with a Novel Biomathematical Model
- (2009) C. H. Wang et al. CANCER RESEARCH
- An integrative computational model for intestinal tissue renewal
- (2009) I. M. M. van Leeuwen et al. CELL PROLIFERATION
- A 3-D model of tumor progression based on complex automata driven by particle dynamics
- (2009) Rafał Wcisło et al. JOURNAL OF MOLECULAR MODELING
- A quantitative cellular automaton model of in vitro multicellular spheroid tumour growth
- (2009) Monika Joanna Piotrowska et al. JOURNAL OF THEORETICAL BIOLOGY
- A 2D mechanistic model of breast ductal carcinoma in situ (DCIS) morphology and progression
- (2009) Kerri-Ann Norton et al. JOURNAL OF THEORETICAL BIOLOGY
- Comparing the growth kinetics of cell populations in two and three dimensions
- (2009) M. Radszuweit et al. PHYSICAL REVIEW E
- A Computational Approach to Understand In Vitro Alveolar Morphogenesis
- (2009) Sean H. J. Kim et al. PLoS One
- 3D Multi-Cell Simulation of Tumor Growth and Angiogenesis
- (2009) Abbas Shirinifard et al. PLoS One
- A Computational Study of the Development of Epithelial Acini: II. Necessary Conditions for Structure and Lumen Stability
- (2008) Katarzyna A. Rejniak et al. BULLETIN OF MATHEMATICAL BIOLOGY
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- (2008) Katarzyna A. Rejniak et al. BULLETIN OF MATHEMATICAL BIOLOGY
- Anton, a special-purpose machine for molecular dynamics simulation
- (2008) David E. Shaw et al. COMMUNICATIONS OF THE ACM
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- (2008) Alexander R. A. Anderson et al. JOURNAL OF MATHEMATICAL BIOLOGY
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- (2008) Helen Byrne et al. JOURNAL OF MATHEMATICAL BIOLOGY
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