Evaluating optimal therapy robustness by virtual expansion of a sample population, with a case study in cancer immunotherapy

Volume of Preclinical Xenograft Tumors Is More Accurately Assessed by Ultrasound Imaging Than Manual Caliper Measurements

(2017) Gregory D. Ayers et al.   JOURNAL OF ULTRASOUND IN MEDICINE

The memory of a killer T cell: models of CD8+ T cell differentiation

(2016) Bram Gerritsen et al.   IMMUNOLOGY AND CELL BIOLOGY

Translational Implications of Tumor Heterogeneity

(2015) M. Jamal-Hanjani et al.   CLINICAL CANCER RESEARCH

Novel model-based dosing guidelines for gentamicin and tobramycin in preterm and term neonates

(2015) P. A. J. Valitalo et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Regulation of Asymmetric Division and CD8+T Lymphocyte Fate Specification by Protein Kinase Cζ and Protein Kinase Cλ/ι

(2015) Patrick J. Metz et al.   JOURNAL OF IMMUNOLOGY

Mapping spatial heterogeneity in the tumor microenvironment: a new era for digital pathology

(2015) Andreas Heindl et al.   LABORATORY INVESTIGATION

Analyzing the quality robustness of chemotherapy plans with respect to model uncertainties

(2015) Anna Hoffmann et al.   MATHEMATICAL BIOSCIENCES

Generating Virtual Patients by Multivariate and Discrete Re-Sampling Techniques

(2015) D. Teutonico et al.   PHARMACEUTICAL RESEARCH

Optimal radiotherapy dose schedules under parametric uncertainty

(2015) Hamidreza Badri et al.   PHYSICS IN MEDICINE AND BIOLOGY

Extremely high genetic diversity in a single tumor points to prevalence of non-Darwinian cell evolution

(2015) Shaoping Ling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trauma in silico: Individual-specific mathematical models and virtual clinical populations

(2015) David Brown et al.   Science Translational Medicine

Asymmetric Cell Division in T Lymphocyte Fate Diversification

(2015) Janilyn Arsenio et al.   TRENDS IN IMMUNOLOGY

Spatial and Temporal Heterogeneity in High-Grade Serous Ovarian Cancer: A Phylogenetic Analysis

(2015) Roland F. Schwarz et al.   PLOS MEDICINE

Tumor heterogeneity and personalized cancer medicine: are we being outnumbered?

(2014) Geert A Cirkel et al.   Future Oncology

Inter- and Intra-Patient Heterogeneity of Response and Progression to Targeted Therapy in Metastatic Melanoma

(2014) Alexander M. Menzies et al.   PLoS One

Classical Mathematical Models for Description and Prediction of Experimental Tumor Growth

(2014) Sébastien Benzekry et al.   PLoS Computational Biology

Alternate virtual populations elucidate the type I interferon signature predictive of the response to rituximab in rheumatoid arthritis

(2013) Brian J Schmidt et al.   BMC BIOINFORMATICS

Adaptive and robust radiation therapy optimization for lung cancer

(2013) Timothy C.Y. Chan et al.   EUROPEAN JOURNAL OF OPERATIONAL RESEARCH

Personalized medicine in oncology: where have we come from and where are we going?

(2013) Fabrice André et al.   PHARMACOGENOMICS

Non-Darwinian dynamics in therapy-induced cancer drug resistance

(2013) Angela Oliveira Pisco et al.   Nature Communications

Mathematical Model of Naive T Cell Division and Survival IL-7 Thresholds

(2013) Joseph Reynolds et al.   Frontiers in Immunology

Personalising docetaxel and G-CSF schedules in cancer patients by a clinically validated computational model

(2012) O Vainas et al.   BRITISH JOURNAL OF CANCER

Optimization of vascular-targeting drugs in a computational model of tumor growth

(2012) Jana Gevertz   PHYSICAL REVIEW E

A survey of optimization models on cancer chemotherapy treatment planning

(2011) Jinghua Shi et al.   ANNALS OF OPERATIONS RESEARCH

Identification of Critical Molecular Components in a Multiscale Cancer Model Based on the Integration of Monte Carlo, Resampling, and ANOVA

(2011) Zhihui Wang et al.   Frontiers in Physiology

Determination of a quantitative relationship between hepatic CYP3A5*1/*3 and CYP3A4 expression for use in the prediction of metabolic clearance in virtual populations

(2010) Z. E. Barter et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

ODE models for oncolytic virus dynamics

(2010) Natalia L. Komarova et al.   JOURNAL OF THEORETICAL BIOLOGY

Optimal control for resistance and suboptimal response in CML

(2010) Bedr’Eddine Aïnseba et al.   MATHEMATICAL BIOSCIENCES

Optimal control for selected cancer chemotherapy ODE models: A view on the potential of optimal schedules and choice of objective function

(2010) Michael Engelhart et al.   MATHEMATICAL BIOSCIENCES

Oncolytic Viruses for Cancer Therapy: Overcoming the Obstacles

(2010) Han Hsi Wong et al.   Viruses-Basel

Gaussian process regression bootstrapping: exploring the effects of uncertainty in time course data

(2009) Paul D. W. Kirk et al.   BIOINFORMATICS

A Framework for Assessing Inter-individual Variability in Pharmacokinetics Using Virtual Human Populations and Integrating General Knowledge of Physical Chemistry, Biology, Anatomy, Physiology and Genetics: A Tale of ‘Bottom-Up’ vs ‘Top-Down’ Recognition of Covariates

(2009) Masoud Jamei et al.   Drug Metabolism and Pharmacokinetics

Therapeutic and Tumor-specific Immunity Induced by Combination of Dendritic Cells and Oncolytic Adenovirus Expressing IL-12 and 4-1BBL

(2009) Jing-Hua Huang et al.   MOLECULAR THERAPY

Robust Management of Motion Uncertainty in Intensity-Modulated Radiation Therapy

(2009) Thomas Bortfeld et al.   OPERATIONS RESEARCH

Leveraging Prior Quantitative Knowledge to Guide Drug Development Decisions and Regulatory Science Recommendations: Impact of FDA Pharmacometrics During 2004-2006

(2008) Yaning Wang et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Programming with models: modularity and abstraction provide powerful capabilities for systems biology

(2008) A. Mallavarapu et al.   Journal of the Royal Society Interface