Article
Multidisciplinary Sciences
Lucas Venezian Povoa, Carlos Henrique Costa Ribeiro, Israel Tojal da Silva
Summary: This study utilized a Multi Learning Training approach to explore the predictive value of heterogeneous treatment outcomes in Multiple Myeloma. Gene expression values were found to enhance treatment sensitivity prediction and correlate with genetic abnormalities detected by FISH testing. The MuLT performance was evaluated through cross-validation experiments, achieving a 68.70% AUC in predicting treatment sensitivity and suggesting potential for better response to different treatments in a subset of patients.
Article
Computer Science, Interdisciplinary Applications
Nicolas M. Ballarini, Marius Thomas, Gerd K. Rosenkranz, Bjoern Bornkamp
Summary: This paper introduces the subtee R package for subgroup treatment effect estimation in clinical trials, which can be used for various types of outcomes and provides additional functions for building subgroup variables and plotting results using forest plots.
JOURNAL OF STATISTICAL SOFTWARE
(2021)
Article
Critical Care Medicine
Marjorie Z. Imperial, Patrick P. J. Phillips, Payam Nahid, Radojka M. Savic
Summary: This study aimed to develop risk stratification tools for tuberculosis patients to inform optimal treatment durations in clinical trials, leading to high cure rates.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Faiez Zannad, Cynthia Chauhan, Patrick O. Gee, Nick Hartshorne-Evans, Adrian F. Hernandez, Marilyn K. Mann, Robin Martinez, Roxana Mehran
Summary: Patients are crucial end-users in medical therapies and should be actively involved as contributors and decision-makers throughout the product development process. While there is increasing recognition of this, cardiovascular research lags behind in terms of patient involvement and awareness of clinical trials in the field.
EUROPEAN HEART JOURNAL
(2022)
Article
Oncology
Chengyue Wu, Angela M. Jarrett, Zijian Zhou, Nabil Elshafeey, Beatriz E. Adrada, Rosalind P. Candelaria, Rania M. M. Mohamed, Medine Boge, Lei Huo, Jason B. White, Debu Tripathy, Vicente Valero, Jennifer K. Litton, Clinton Yam, Jong Bum Son, Jingfei Ma, Gaiane M. Rauch, Thomas E. Yankeelov
Summary: This study successfully predicts the response of TNBC to neoadjuvant systemic therapy using MRI data and mathematical modeling, providing highly accurate predictions of therapeutic efficacy.
Review
Oncology
Francesca Bonello, Lorenzo Cani, Mattia D'Agostino
Summary: Multiple myeloma is a hematologic malignancy with wide clinical and biological heterogeneity. The application of prognostic tools and treatment monitoring techniques is crucial for guiding clinical treatment decisions.
FRONTIERS IN ONCOLOGY
(2022)
Article
Economics
Bellinda L. King-Kallimanis, Melanie Calvert, David Cella, Kim Cocks, Corneel Coens, Diane Fairclough, Lynn Howie, Pall Jonsson, Nirosha Mahendraratnam, Julia Maues, Sinan Sarac, Jim Shaw, Nichelle Stigger, Peter Trask, Beate Wieseler
Summary: This article summarizes a virtual roundtable held in 2020 by the Food and Drug Administration's Oncology Center of Excellence and the Critical Path Institute to discuss the potential benefits and methodological approaches to collecting patient-reported outcome data after treatment discontinuation.
Article
Mathematical & Computational Biology
Ilya Lipkovich, Bohdana Ratitch, Yongming Qu, Xiang Zhang, Mingyang Shan, Craig Mallinckrodt
Summary: This tutorial aims to provide a coherent and unified description of principal stratification for clinical trialists. It emphasizes the importance of assumptions in estimating effects within principal stratification and provides an overview of key methods for principal stratification analysis. A real clinical trial example is used to illustrate these methods.
STATISTICS IN MEDICINE
(2022)
Review
Oncology
Jie Chen, Ying Lu, Shivaani Kummar
Summary: This paper elaborates on the challenges for patient participation in oncology trials and presents various strategies to increase patient involvement.
Review
Medicine, General & Internal
Perrine Janiaud, Cathrine Axfors, Andreas M. Schmitt, Viktoria Gloy, Fahim Ebrahimi, Matthias Hepprich, Emily R. Smith, Noah A. Haber, Nina Khanna, David Moher, Steven N. Goodman, John P. A. Ioannidis, Lars G. Hemkens
Summary: Convalescent plasma treatment showed no significant decrease in all-cause mortality or benefit for other clinical outcomes compared to placebo or standard of care. The certainty of the evidence ranged from low to moderate for all-cause mortality and remained low for other outcomes.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Pharmacology & Pharmacy
Luana Colloca, Robert H. Dworkin, John T. Farrar, Leslie Tive, Jiyue Yang, Lars Viktrup, Gorana Dasic, Christine R. West, Ed Whalen, Mark T. Brown, Steven A. Gilbert, Kenneth M. Verburg
Summary: This study conducted secondary analyses on data from two clinical trials to identify patient-based variables that predicted responses to placebo or tanezumab. The findings will inform the design of future clinical trials and advance clinical pharmacology and translational science.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Health Care Sciences & Services
Jennifer K. Royle, Andrew Hughes, Laura Stephenson, Donal Landers
Summary: Health care needs continuous development and innovation, and the technology clinical trial is a new solution that integrates various methods to optimize patient health and drive innovation.
Article
Mathematical & Computational Biology
Haifeng Zhang, Jinzhi Lei
Summary: Intratumor heterogeneity poses challenges to anti-cancer treatment by introducing interaction between different types of cells. A mathematical model was developed to study the dynamic interaction between normal, drug-sensitive, and drug-resistant cells in cancer treatment. The model was used to explore the feasibility of optimal treatment strategies that minimize cancer cells count and drug doses.
MATHEMATICAL BIOSCIENCES AND ENGINEERING
(2022)
Article
Biochemistry & Molecular Biology
Chang In Moon, John Michael Elizarraras, Jonathan Thomas Lei, Byron Jia, Bing Zhang
Summary: This study presents a web application called ClinicalOmicsDB, which allows for exploration of molecular associations of oncology drug responses in clinical trials. The database includes transcriptomic data from 40 clinical trial studies, covering 5913 patients with 11 cancer types. Users can explore the molecular associations of oncology drug responses through three options: studies, treatments or genes.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Xuan Zhang, Chongya Dong, Nana Wang, Chunpong Chan, Chung Tai Lau, Juan Wang, Jiangxia Miao, Chen Yao, Youping Li, Aiping Lyu, David Moher, Zhaoxiang Bian
Summary: Due to the frequent inadequate reporting of key details in multicenter clinical trials, the development of guidelines to improve reporting quality is crucial. This study uses the CONSORT and SPIRIT checklists as tools to assist in designing and reporting high-quality clinical research.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Oncology
Gunjan Mandal, Subir Biswas, Carmen M. Anadon, Xiaoqing Yu, Chandler D. Gatenbee, Sandhya Prabhakaran, Kyle K. Payne, Ricardo A. Chaurio, Alexandra Martin, Patrick Innamarato, Carlos Moran, John J. Powers, Carly M. Harro, Jessica A. Mine, Kimberly B. Sprenger, Kristen E. Rigolizzo, Xuefeng Wang, Tyler J. Curiel, Paulo C. Rodriguez, Alexander R. Anderson, Ozlen Saglam, Jose R. Conejo-Garcia
Summary: This study reveals the crucial role of humoral immunity in human endometrial cancer and provides insights for the development of novel immunotherapies against this prevalent malignancy. Coordinated cellular and humoral immune responses, particularly involving B cells and IgA:plgR interactions, determine the progression of endometrial cancer and its response to treatment.
Article
Biotechnology & Applied Microbiology
Calum Gabbutt, Ryan O. Schenck, Daniel J. Weisenberger, Christopher Kimberley, Alison Berner, Jacob Househam, Eszter Lakatos, Mark Robertson-Tessi, Isabel Martin, Roshani Patel, Susan K. Clark, Andrew Latchford, Chris P. Barnes, Simon J. Leedham, Alexander R. A. Anderson, Trevor A. Graham, Darryl Shibata
Summary: Lineage tracing of human stem cells can be achieved by measuring fluctuating DNA methylation, which can serve as clocks that record cell ancestry. This study developed a mathematical model to quantitatively measure the dynamics of human adult stem cells using fluctuating DNA methylation marks. The results showed differences in the number and replacement speed of stem cells in different tissues, and also demonstrated the potential application of fluctuating methylation clocks in diseases.
NATURE BIOTECHNOLOGY
(2022)
Article
Biochemical Research Methods
M. A. Masud, Jae-Young Kim, Cheol-Ho Pan, Eunjung Kim
Summary: Adaptive therapy, a novel treatment strategy that utilizes the competition between drug-sensitive and drug-resistant cells to maintain tumor volume, has shown superiority over continuous therapy depending on the spatial distribution of resistant cells. The spatial architecture of fibroblasts also modulates treatment outcomes. Undetected metastatic lesions play an important role in adaptive therapy outcomes.
PLOS COMPUTATIONAL BIOLOGY
(2022)
Editorial Material
Oncology
Keiran S. M. Smalley
CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
Jill Gallaher, Maximilian Strobl, Jeffrey West, Robert Gatenby, Jingsong Zhang, Mark Robertson-Tessi, Alexander R. A. Anderson
Summary: This study proposed a framework for estimating features of metastases through tumor response dynamics in patients with metastatic castration-resistant prostate cancer undergoing adaptive androgen deprivation treatment. The size of metastases, the proportion of drug-resistant cells, and the cell turnover rate were found to affect the treatment outcomes. The number of metastases, on the other hand, did not have an impact on the treatment cycle times.
Editorial Material
Oncology
Manali S. S. Phadke, Keiran S. M. Smalley
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Editorial Material
Oncology
Jad Chahoud, Alexander R. A. Anderson, Jingsong Zhang, Joel Brown, Robert A. Gatenby
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Review
Oncology
Inna Smalley, Adrienne Boire, Priscilla Brastianos, Harriet M. Kluger, Eva Hernando-Monge, Peter A. Forsyth, Kamran A. Ahmed, Keiran S. M. Smalley, Sherise Ferguson, Michael A. Davies, Isabella C. Glitza Oliva
Summary: Leptomeningeal disease (LMD) is a major challenge in the clinical management of metastatic melanoma patients. Recent trials have demonstrated the feasibility of conducting prospective clinical trials in these patients, and new insights into the pathophysiology of LMD are identifying rational new therapeutic strategies.
PIGMENT CELL & MELANOMA RESEARCH
(2023)
Review
Oncology
Larissa Anastacio DaCosta Carvalho, Flavia C. Aguiar, Keiran S. M. Smalley, Patricia A. Possik
Summary: Acral melanoma is a rare subtype of melanoma that is not linked to sun exposure. Recent studies have begun to explore the genetics and immune features of acral melanoma, which can provide guidance for therapeutic management.
Meeting Abstract
Oncology
Rafael R. Bravo, Brenden K. Peterson, Mark Robertson-Tessi, Daniel M. Faissol, Alexander R. A. Anderson
Meeting Abstract
Oncology
Kimberly A. Luddy, Jeffery West, Mark Robertson-Tessi, Alexander R. A. Anderson, Taylor M. Bursell, Laure Marignol, Cliona O'Farrelly, Robert Gatenby
Meeting Abstract
Oncology
Mark Robertson-Tessi, Joel Brown, Maria Poole, Kimberly Luddy, Andriy Marusyk, Jill Gallaher, Jeffrey West, Matthew Johnson, Heiko Enderling, Rikesh Makanji, Joaquim Farinhas, Robert Gatenby, Damon Reed, Christine Chung, Alexander Anderson
Meeting Abstract
Oncology
Ryan O. Schenck, Niels Asger Jakobsen, Virginia Turati, Darryl Shibata, Paresh Vyas, Simon Leedham, Alexander R. A. Anderson
Meeting Abstract
Oncology
Maximilian Strobl, Mehdi Damaghi, Alexandra Martin, Samantha Byrne, Mark Robertson-Tessi, Robert Gatenby, Robert Wenham, Philip Maini, Alexander R. A. Anderson
Article
Medicine, Research & Experimental
Maximilian A. R. Strobl, Jill Gallaher, Jeffrey West, Mark Robertson-Tessi, Philip K. Maini, Alexander R. A. Anderson
Summary: This theoretical study investigates the intra-tumoral competition during adaptive therapy and finds that adaptive therapy is superior to aggressive treatment in suppressing resistance. The study reveals that competition among resistant cells plays a crucial role in adaptive therapy in solid tumors.
COMMUNICATIONS MEDICINE
(2022)
Article
Oncology
Diego de Miguel-Perez, Edward M. Pickering, Umberto Malapelle, William Grier, Francesco Pepe, Pasquale Pisapia, Gianluca Russo, Joseph A. Pinto, Alessandro Russo, Giancarlo Troncone, Melissa J. Culligan, Katherine A. Scilla, Ranee Mehra, Pranshu Mohindra, Oscar Arrieta, Andres F. Cardona, Marzia Del Re, Ashutosh Sachdeva, Fred R. Hirsch, Andrea Wolf, Joseph S. Friedberg, Christian Rolfo
Summary: In this study, genetic alterations in resectable pleural mesothelioma tissues and blood samples were analyzed, and it was found that high tissue tumor mutational burden, tissue median minor allele frequency, blood tumor mutational burden, and specific mutations were correlated with outcomes in patients with resected PM. These findings suggest that molecular profiling could help identify longer survivors in patients with resected PM.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Davide Melisi, Camilla Zecchetto, Valeria Merz, Giuseppe Malleo, Luca Landoni, Alberto Quinzii, Simona Casalino, Federica Fazzini, Marina Gaule, Camilla Pesoni, Luca Casetti, Alessandro Esposito, Giovanni Marchegiani, Cristiana Piazzola, Mirko D'Onofrio, Riccardo de Robertis, Armando Gabbrielli, Laura Bernardoni, Stefano F. Crino, Silvia Pietrobono, Claudio Luchini, Camillo Aliberti, Guido Martignoni, Stefano Milleri, Giovanni Butturini, Aldo Scarpa, Roberto Salvia, Claudio Bassi
Summary: This study evaluated the safety and activity of liposomal irinotecan in the perioperative treatment of resectable pancreatic ductal adenocarcinoma (rPDAC) patients. The results showed that NALIRIFOX has manageable and active outcomes, and should be further investigated in randomized trials comparing it to standard upfront surgery followed by adjuvant therapy.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Eric Jonasch, Todd M. Bauer, Kyriakos P. Papadopoulos, Elizabeth R. Plimack, Jaime R. Merchan, David F. Mcdermott, M. Dror Michaelson, Leonard J. Appleman, Ananya Roy, Rodolfo F. Perini, Yanfang Liu, Toni K. Choueiri
Summary: After a median follow-up of 41.2 months, belzutifan monotherapy demonstrated durable antitumor activity in patients with advanced ccRCC and acceptable safety.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Patricia A. H. Hamers, Geraldine R. Vink, Marloes A. G. Elferink, Leon M. G. Moons, Cornelis J. A. Punt, Anne M. May, Miriam Koopman
Summary: Screen-detection of the primary tumor is associated with longer overall survival after metachronous metastasis.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Camilla Nero, Nicolo Bizzarri, Stefano Di Berardino, Francesca Sillano, Giuseppe Vizzielli, Francesco Cosentino, Virginia Vargiu, Pierandrea De Iaco, Anna Myriam Perrone, Enrico Vizza, Benito Chiofalo, Stefano Uccella, Fabio Ghezzi, Luigi Carlo Turco, Giacomo Corrado, Diana Giannarelli, Tina Pasciuto, Gian Franco Zannoni, Anna Fagotti, Giovanni Scambia
Summary: This study evaluates the sensitivity and specificity of sentinel-lymph-node mapping compared to systematic lymphadenectomy in detecting lymph node metastasis in early stage ovarian cancer. The results show that sentinel-lymph-node mapping did not reach the expected sensitivity, but ultra-staging protocol improved the accuracy of diagnosis for patients.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Adriana Hepner, Judith M. Versluis, Roslyn Wallace, Clara Allayous, Lauren Julia Brown, Claudia Trojanielloh, Camille Lea Gerardi, Yanina J. L. Jansenj, Prachi Bhave, Bart Neyns, Andrew Haydon, Olivier Michielin, Joanna Manganan Oliver Klein, Alexander N. Shoushtari, Allison Betof Warner, Paolo Antonio Ascierto, Jennifer Leigh McQuade, Matteo S. Carlino, Lisa Zimmer, Celeste Lebbe, Douglas B. Johnson, Shahneen Sandhu, Victoria Atkinson, Christian U. Blank, Serigne N. Lo, Georgina V. Long, Alexander M. Menzies
Summary: Acquired resistance to PD-1 therapy in melanoma is mainly oligometastatic, and patients may have a favorable survival outcome following salvage treatment.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Savannah Roy, Stephanie Lakritz, Anna R. Schreiber, Elizabeth Molina Kuna, Cathy J. Bradley, Lavanya Kondapalli, Jennifer R. Diamond
Summary: This study evaluates major adverse cardiovascular events (MACE) in older women with TNBC treated with anthracycline and taxane-based chemotherapy (ATAX) compared to taxane-based chemotherapy (TAX). The results show that ATAX does not increase the risk of MACE and there is no difference in survival between patients who received TAX and ATAX.
EUROPEAN JOURNAL OF CANCER
(2024)
Letter
Oncology
Pei-Chun Weng, Yau-Li Huang, Chun-Yu Cheng
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Philipp Jansen, Jean Le 'Clerc Arrastia, Daniel Otero Baguer, Maximilian Schmidt, Jennifer Landsberg, Joerg Wenzel, Michael Emberger, Dirk Schadendorf, Eva Hadaschik, Peter Maass, Klaus Georg Griewank
Summary: This study highlights the enormous potential of artificial intelligence in pathology, showing that it can aid in the identification of rare cutaneous adnexal tumors and potentially become a standard tool in routine diagnostics.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Casper W. F. van Eijck, Gaby Strijk, Eveline E. Vietscha, Fleur van der Sijde, Maaike Verheij, Dana A. M. Mustafa, Madelief Vinkc, Joachim G. J. V. Aerts, Casper H. J. van Eijck, Marcella Willemsen
Summary: The study reveals that FOLFIRINOX has immunomodulatory effects, suggesting its potential in immune-based combination therapies for pancreatic cancer. Additionally, certain plasma proteins hold promise as circulating predictive biomarkers for early prediction of FOLFIRINOX response in patients with pancreatic cancer.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Marwan Fakih, Chongkai Wang, Jaideep Sandhu, Jian Ye, Colt Egelston, Xiaochen Li
Summary: This study explores the impact of metastatic sites on treatment outcomes for chemotherapy-refractory colorectal cancer patients. It found that patients with liver or peritoneal metastases had poor treatment outcomes, while those with lung-only metastases showed significant response. The presence of concurrent lymph node or other extrahepatic metastatic disease diminished treatment response in patients with lung metastases. Future checkpoint inhibitor trials should stratify patients based on metastatic locations.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Georgios Christos Tsiatsianis, Candace S. Y. Chan, Ioannis Mouratidis, Nikol Chantzi, Anna Maria Tsiatsiani, Nelson S. Yee, Apostolos Zaravinos, Verena Kantere, Ilias Georgakopoulos-Soares
Summary: The study reveals that nullpeptides can serve as biomarkers for cancer detection and treatment, particularly in highly recurrent cancer patients. These nullpeptides primarily occur in highly expressed genes, particularly in specific loci of oncogenes and tumor suppressors. Recurrent nullpeptides are more likely to be found in neoantigens, which play a significant role in immunotherapy.
EUROPEAN JOURNAL OF CANCER
(2024)