Shared pathological pathways of Alzheimer's disease with specific comorbidities: current perspectives and interventions

Testosterone Plasma Concentration is Associated with Insulin Resistance in Male Hypertensive Patients

(2017) Gian Schianca et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Updating the Evidence on the Association between Serum Cholesterol and Risk of Late-Life Dementia: Review and Meta-Analysis

(2017) Kaarin J. Anstey et al.   JOURNAL OF ALZHEIMERS DISEASE

Neuroprotective Diets Are Associated with Better Cognitive Function: The Health and Retirement Study

(2017) Claire T. McEvoy et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Hyperglycemia and high nitric oxide level induced oxidative stress in the brain and molecular alteration in the neurons and glial cells of laboratory mouse, Mus musculus

(2017) Rashmi Richa et al.   NEUROCHEMISTRY INTERNATIONAL

Long-Term Subclinical Hyperglycemia and Hypoglycemia as Independent Risk Factors for Mild Cognitive Impairment in Elderly People

(2017) Feng Wang et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

Differential associations of plasma lipids with incident dementia and dementia subtypes in the 3C Study: A longitudinal, population-based prospective cohort study

(2017) Sabrina Schilling et al.   PLOS MEDICINE

IGF-II promotes neuroprotection and neuroplasticity recovery in a long-lasting model of oxidative damage induced by glucocorticoids

(2017) E. Martín-Montañez et al.   Redox Biology

Genetic Association between SORL1 Polymorphisms and Alzheimer’s Disease in a Japanese Population

(2017) Nobuto Shibata et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Intranasal Insulin Administration Dose-Dependently Modulates Verbal Memory and Plasma Amyloid-β in Memory-Impaired Older Adults

(2017) Mark A. Reger et al.   JOURNAL OF ALZHEIMERS DISEASE

Leptin Reduces Pathology and Improves Memory in a Transgenic Mouse Model of Alzheimer's Disease

(2017) Steven J. Greco et al.   JOURNAL OF ALZHEIMERS DISEASE

In vivo regulation of glycogen synthase kinase 3β activity in neurons and brains

(2017) Ambika Krishnankutty et al.   Scientific Reports

Insights into the role of neuronal glucokinase

(2016) Ivan De Backer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Nutritional interventions for Alzheimer's prevention: a clinical precision medicine approach

(2016) Matthew W. Schelke et al.   Annals of the New York Academy of Sciences

Predicting diabetes mellitus genes via protein-protein interaction and protein subcellular localization information

(2016) Xiwei Tang et al.   BMC GENOMICS

Integration of bioinformatics and imaging informatics for identifying rare PSEN1 variants in Alzheimer’s disease

(2016) Kwangsik Nho et al.   BMC Medical Genomics

Physiological and pathological roles of the γ-secretase complex

(2016) Courtney M. Carroll et al.   BRAIN RESEARCH BULLETIN

Astrocytic Insulin Signaling Couples Brain Glucose Uptake with Nutrient Availability

(2016) Cristina García-Cáceres et al.   CELL

The Brain–to–Pancreatic Islet Neuronal Map Reveals Differential Glucose Regulation From Distinct Hypothalamic Regions

(2016) Wilfredo Rosario et al.   DIABETES

Brain Insulin Signaling Is Increased in Insulin-Resistant States and Decreases in FOXOs and PGC-1α and Increases in Aβ1–40/42and Phospho-Tau May Abet Alzheimer Development

(2016) Mini Sajan et al.   DIABETES

Increased oxidative stress and apoptosis in the hypothalamus of diabetic male mice in the insulin receptor substrate-2 knockout model

(2016) Eva Baquedano et al.   Disease Models & Mechanisms

Hyperglycemia-associated alterations in cellular signaling and dysregulated mitochondrial bioenergetics in human metabolic disorders

(2016) George B. Stefano et al.   EUROPEAN JOURNAL OF NUTRITION

Rescuing effects of RXR agonist bexarotene on aging-related synapse loss depend on neuronal LRP1

(2016) Masaya Tachibana et al.   EXPERIMENTAL NEUROLOGY

Relationship between oxysterols and mild cognitive impairment in the elderly: a case–control study

(2016) Quanri Liu et al.   Lipids in Health and Disease

Hyperglycemia-Induced Oxidative-Nitrosative Stress Induces Inflammation and Neurodegeneration via Augmented Tuberous Sclerosis Complex-2 (TSC-2) Activation in Neuronal Cells

(2016) Premranjan Kumar et al.   MOLECULAR NEUROBIOLOGY

Analysis of genetics and risk factors of Alzheimer’s Disease

(2016) M. Panpalli Ates et al.   NEUROSCIENCE

RAGE axis in neuroinflammation, neurodegeneration and its emerging role in the pathogenesis of amyotrophic lateral sclerosis

(2016) Rashmi Ray et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Body Mass Index and Decline of Cognitive Function

(2016) Sujin Kim et al.   PLoS One

Chronic hyperglycemia induced via the heterozygous knockout of Pdx1 worsens neuropathological lesion in an Alzheimer mouse model

(2016) Chuang Guo et al.   Scientific Reports

AGE-RAGE signal generates a specific NF-κB RelA “barcode” that directs collagen I expression

(2016) Yunqian Peng et al.   Scientific Reports

Double-blind, placebo-controlled, proof-of-concept trial of bexarotene in moderate Alzheimer’s disease

(2016) Jeffrey L. Cummings et al.   Alzheimers Research & Therapy

Effect of Presenilin Mutations on APP Cleavage; Insights into the Pathogenesis of FAD

(2016) Nuomin Li et al.   Frontiers in Aging Neuroscience

Deep analyses of the associations of a series of biomarkers with insulin resistance, metabolic syndrome, and diabetes risk in nondiabetic middle-aged and elderly individuals: results from a Chinese community-based study

(2016) Shihui Fu et al.   Clinical Interventions in Aging

Systems Nutrigenomics Reveals Brain Gene Networks Linking Metabolic and Brain Disorders

(2016) Qingying Meng et al.   EBioMedicine

Rare coding mutations identified by sequencing of Alzheimer disease genome-wide association studies loci

(2015) Badri N. Vardarajan et al.   ANNALS OF NEUROLOGY

Fyn inhibition rescues established memory and synapse loss in Alzheimer mice

(2015) Adam C. Kaufman et al.   ANNALS OF NEUROLOGY

Dysfunctionally phosphorylated type 1 insulin receptor substrate in neural-derived blood exosomes of preclinical Alzheimer’s disease

(2015) Dimitrios Kapogiannis et al.   FASEB JOURNAL

Blocking IGF Signaling in Adult Neurons Alleviates Alzheimer's Disease Pathology through Amyloid-β Clearance

(2015) Géraldine Gontier et al.   JOURNAL OF NEUROSCIENCE

Obesity, adipokines and neuroinflammation

(2015) Argel Aguilar-Valles et al.   NEUROPHARMACOLOGY

Aberrant insulin signaling in Alzheimer's disease: current knowledge

(2015) Gaurav Bedse et al.   Frontiers in Neuroscience

The Possible Mechanism of Advanced Glycation End Products (AGEs) for Alzheimer’s Disease

(2015) Shun-Yao Ko et al.   PLoS One

MIND DIET SCORE MORE PREDICTIVE THAN DASH OR MEDITERRANEAN DIET SCORES

(2014) Martha Clare Morris et al.   Alzheimers & Dementia

Genomic convergence and network analysis approach to identify candidate genes in Alzheimer's disease

(2014) Puneet Talwar et al.   BMC GENOMICS

Alzheimer's Disease, Cerebrovascular Disease, and the β-amyloid Cascade

(2014) Kie Honjo et al.   CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES

Receptor for AGEs (RAGE) as Mediator of NF-kB Pathway Activation in Neuroinflammation and Oxidative Stress

(2014) Julio Tobon-Velasco et al.   CNS & Neurological Disorders-Drug Targets

Geniposide Attenuates Oligomeric Aβ1-42-Induced Inflammatory Response by Targeting RAGE-Dependent Signaling in BV2 Cells

(2014) Cui Lv et al.   Current Alzheimer Research

Repurposing Diabetes Drugs for Brain Insulin Resistance in Alzheimer Disease

(2014) M. Yarchoan et al.   DIABETES

Association between white matter hyperintensity and medial temporal atrophy at various stages of Alzheimer's disease

(2014) N. Kandiah et al.   EUROPEAN JOURNAL OF NEUROLOGY

Obesity and dementia: Adipokines interact with the brain

(2014) Ilse A.C. Arnoldussen et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Cytokine-Mediated Inhibition of Fibrillar Amyloid-  Peptide Degradation by Human Mononuclear Phagocytes

(2014) M. Yamamoto et al.   JOURNAL OF IMMUNOLOGY

Conditional Overexpression of Insulin-Like Growth Factor-1 Enhances Hippocampal Neurogenesis and Restores Immature Neuron Dendritic Processes After Traumatic Brain Injury

(2014) Shaun W. Carlson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Differential production of reactive oxygen species in distinct brain regions of hypoglycemic mice

(2014) Leticia Amador-Alvarado et al.   METABOLIC BRAIN DISEASE

Polyunsaturated fatty acids and their metabolites in brain function and disease

(2014) Richard P. Bazinet et al.   NATURE REVIEWS NEUROSCIENCE

Integrating Transcriptomics with Metabolic Modeling Predicts Biomarkers and Drug Targets for Alzheimer's Disease

(2014) Shiri Stempler et al.   PLoS One

Epigenetic mechanisms in Alzheimer's disease: Implications for pathogenesis and therapy

(2013) Jun Wang et al.   AGEING RESEARCH REVIEWS

Midlife risk score for the prediction of dementia four decades later

(2013) Lieza G. Exalto et al.   Alzheimers & Dementia

Novel hypoglycemic injury mechanism: N-methyl-D-aspartate receptor-mediated white matter damage

(2013) Xin Yang et al.   ANNALS OF NEUROLOGY

Molecular Mechanisms Responsible for the Differential Effects of ApoE3 and ApoE4 on Plasma Lipoprotein–Cholesterol Levels

(2013) Hui Li et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

High glucose-induced mitochondrial respiration and reactive oxygen species in mouse cerebral pericytes is reversed by pharmacological inhibition of mitochondrial carbonic anhydrases: Implications for cerebral microvascular disease in diabetes

(2013) Gul N. Shah et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Statins more than cholesterol lowering agents in Alzheimer disease: Their pleiotropic functions as potential therapeutic targets

(2013) Eugenio Barone et al.   BIOCHEMICAL PHARMACOLOGY

Hypoglycemia

(2013) Dale Clayton et al.   Canadian Journal of Diabetes

Dyslipidemia and the Risk of Alzheimer’s Disease

(2013) Christiane Reitz   Current Atherosclerosis Reports

Epigenetic Mechanisms Linking Diabetes and Synaptic Impairments

(2013) J. Wang et al.   DIABETES

Diagnosis and Classification of Diabetes Mellitus

(2013)   DIABETES CARE

Streptozotocin-induced diabetes increases amyloid plaque deposition in AD transgenic mice through modulating AGEs/RAGE/NF-κB pathway

(2013) Xu Wang et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Obesity in Aging Exacerbates Blood-Brain Barrier Disruption, Neuroinflammation, and Oxidative Stress in the Mouse Hippocampus: Effects on Expression of Genes Involved in Beta-Amyloid Generation and Alzheimer's Disease

(2013) Z. Tucsek et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

(2013) Chia-Chen Liu et al.   Nature Reviews Neurology

Epigenetics: A novel therapeutic approach for the treatment of Alzheimer's disease

(2013) Lina Adwan et al.   PHARMACOLOGY & THERAPEUTICS

Leptin regulation of hippocampal synaptic function in health and disease

(2013) A. J. Irving et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Glycation Accelerates Fibrillization of the Amyloidogenic W7FW14F Apomyoglobin

(2013) Clara Iannuzzi et al.   PLoS One

Decoding Alzheimer's disease from perturbed cerebral glucose metabolism: Implications for diagnostic and therapeutic strategies

(2013) Zhichun Chen et al.   PROGRESS IN NEUROBIOLOGY

New Hope from an Old Drug: Fighting Alzheimer's Disease with the Cancer Drug Bexarotene (Targretin)?

(2013) Giorgio Aicardi   REJUVENATION RESEARCH

The role of APP and BACE1 trafficking in APP processing and amyloid-β generation

(2013) Xiaojie Zhang et al.   Alzheimers Research & Therapy

Growth hormone and insulin-like growth factor-I alter hippocampal excitatory synaptic transmission in young and old rats

(2012) Doris P. Molina et al.   AGE

Physical exercise modulates peripheral levels of brain-derived neurotrophic factor (BDNF): A systematic review of experimental studies in the elderly

(2012) Flávia Gomes de Melo Coelho et al.   ARCHIVES OF GERONTOLOGY AND GERIATRICS

Insulin resistance in the brain: An old-age or new-age problem?

(2012) Ritchie Williamson et al.   BIOCHEMICAL PHARMACOLOGY

Selective Insulin and Leptin Resistance in Metabolic Disorders

(2012) A. Christine Könner et al.   Cell Metabolism

Translational proteomics in Alzheimer's disease and related disorders

(2012) Roberta Ghidoni et al.   CLINICAL BIOCHEMISTRY

The Role of Glucose Transporters in Brain Disease: Diabetes and Alzheimer's Disease

(2012) Kaushik Shah et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Generation of Alzheimer Disease-associated Amyloid β42/43Peptide by γ-Secretase Can Be Inhibited Directly by Modulation of Membrane Thickness

(2012) Edith Winkler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Resistin protects against 6-hydroxydopamine-induced cell death in dopaminergic-like MES23.5 cells

(2012) Dah-Yuu Lu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

Glucagon-Like Peptide-1 Cleavage Product GLP-1(9-36) Amide Rescues Synaptic Plasticity and Memory Deficits in Alzheimer's Disease Model Mice

(2012) T. Ma et al.   JOURNAL OF NEUROSCIENCE

Drug repositioning for Alzheimer's disease

(2012) Anne Corbett et al.   NATURE REVIEWS DRUG DISCOVERY

Fasting plasma insulin and the default mode network in women at risk for Alzheimer's disease

(2012) Heather Kenna et al.   NEUROBIOLOGY OF AGING

Insulin-induced recurrent hypoglycemia exacerbates diabetic brain mitochondrial dysfunction and oxidative imbalance

(2012) Susana Cardoso et al.   NEUROBIOLOGY OF DISEASE

The Apolipoprotein-E-Mimetic COG112 Protects Amyloid Precursor Protein Intracellular Domain-Overexpressing Animals from Alzheimer's Disease-Like Pathological Features

(2012) Kaushik Ghosal et al.   Neurodegenerative Diseases

Plasma multianalyte profiling in mild cognitive impairment and Alzheimer disease

(2012) W. T. Hu et al.   NEUROLOGY

Epigenetic modifications by dietary phytochemicals: Implications for personalized nutrition

(2012) Sharmila Shankar et al.   PHARMACOLOGY & THERAPEUTICS

Mechanisms Underlying Insulin Deficiency-Induced Acceleration of β-Amyloidosis in a Mouse Model of Alzheimer's Disease

(2012) Latha Devi et al.   PLoS One

Amyloid Precursor Protein and Proinflammatory Changes Are Regulated in Brain and Adipose Tissue in a Murine Model of High Fat Diet-Induced Obesity

(2012) Kendra L. Puig et al.   PLoS One

Targeted proteomics for quantification of histone acetylation in Alzheimer's disease

(2012) Kangling Zhang et al.   PROTEOMICS

GSK3: a key target for the development of novel treatments for type 2 diabetes mellitus and Alzheimer disease

(2012) Chong Gao et al.   REVIEWS IN THE NEUROSCIENCES

ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models

(2012) P. E. Cramer et al.   SCIENCE

The Additive Effects of Type-2 Diabetes on Cognitive Function in Older Adults with Heart Failure

(2012) Michael L. Alosco et al.   Cardiology Research and Practice

Insulin receptor signaling mediates APP processing and β-amyloid accumulation without altering survival in a transgenic mouse model of Alzheimer’s disease

(2011) Oliver Stöhr et al.   AGE

Amyloid Precursor Protein Processing and Alzheimer's Disease

(2011) Richard J. O'Brien et al.   Annual Review of Neuroscience

Insulin-like growth factor-1 receptor activation prevents hydrogen peroxide-induced oxidative stress, mitochondrial dysfunction and apoptosis

(2011) Chang-Ning Hao et al.   APOPTOSIS

Intranasal Insulin Therapy for Alzheimer Disease and Amnestic Mild Cognitive Impairment

(2011) Suzanne Craft   ARCHIVES OF NEUROLOGY

Alzheimer's disease: Cholesterol a menace?

(2011) Anila Mathew et al.   BRAIN RESEARCH BULLETIN

Metabolic Syndrome, Mild Cognitive Impairment and Dementia

(2011) F. Panza et al.   Current Alzheimer Research

Low Testosterone Associated With Obesity and the Metabolic Syndrome Contributes to Sexual Dysfunction and Cardiovascular Disease Risk in Men With Type 2 Diabetes

(2011) C. Wang et al.   DIABETES CARE

Insulin resistance and pathological brain ageing

(2011) B. Cholerton et al.   DIABETIC MEDICINE

Minireview: Glucagon in the Pathogenesis of Hypoglycemia and Hyperglycemia in Diabetes

(2011) Philip E. Cryer   ENDOCRINOLOGY

Roles of ATP-Binding Cassette Transporter A7 in Cholesterol Homeostasis and Host Defense System

(2011) Nobukiyo Tanaka et al.   Journal of Atherosclerosis and Thrombosis

Possible implications of insulin resistance and glucose metabolism in Alzheimer’s disease pathogenesis

(2011) Domenico Bosco et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Obesity is associated with hypothalamic injury in rodents and humans

(2011) Joshua P. Thaler et al.   JOURNAL OF CLINICAL INVESTIGATION

The Diabetes Drug Liraglutide Prevents Degenerative Processes in a Mouse Model of Alzheimer's Disease

(2011) P. L. McClean et al.   JOURNAL OF NEUROSCIENCE

Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes

(2011) Ying Liu et al.   JOURNAL OF PATHOLOGY

The projected effect of risk factor reduction on Alzheimer's disease prevalence

(2011) Deborah E Barnes et al.   LANCET NEUROLOGY

Alzheimer's disease: synapses gone cold

(2011) Robert M Koffie et al.   Molecular Neurodegeneration

Linking lipids to Alzheimer's disease: cholesterol and beyond

(2011) Gilbert Di Paolo et al.   NATURE REVIEWS NEUROSCIENCE

Epigenetic mechanisms in Alzheimer's disease

(2011) Diego Mastroeni et al.   NEUROBIOLOGY OF AGING

Anti-Aβ Therapeutics in Alzheimer's Disease: The Need for a Paradigm Shift

(2011) Todd E. Golde et al.   NEURON

Peripheral insulin-sensitizer drug metformin ameliorates neuronal insulin resistance and Alzheimer’s-like changes

(2011) Amit Gupta et al.   NEUROPHARMACOLOGY

Body mass index in midlife and late-life as a risk factor for dementia: a meta-analysis of prospective studies

(2011) K. J. Anstey et al.   Obesity Reviews

Body Adiposity in Later Life and the Incidence of Dementia: The Health in Men Study

(2011) Brian D. Power et al.   PLoS One

Adiponectin protects rat hippocampal neurons against excitotoxicity

(2010) Guang Qiu et al.   AGE

Meta-analysis Confirms CR1, CLU, and PICALM as Alzheimer Disease Risk Loci and Reveals Interactions With APOE Genotypes

(2010) Gyungah Jun   ARCHIVES OF NEUROLOGY

Insulin Resistance and Alzheimer-like Reductions in Regional Cerebral Glucose Metabolism for Cognitively Normal Adults With Prediabetes or Early Type 2 Diabetes

(2010) Laura D. Baker et al.   ARCHIVES OF NEUROLOGY

Lipid mediators in the nucleus: Their potential contribution to Alzheimer's disease

(2010) Akhlaq A. Farooqui et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Cortical and hippocampal mitochondria bioenergetics and oxidative status during hyperglycemia and/or insulin-induced hypoglycemia

(2010) Susana Cardoso et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Pathogenesis of Fasting and Postprandial Hyperglycemia in Type 2 Diabetes: Implications for Therapy

(2010) R. A. Rizza   DIABETES

Hippocampal neurovascular and hypothalamic–pituitary–adrenal axis alterations in spontaneously type 2 diabetic GK rats

(2010) Juan Beauquis et al.   EXPERIMENTAL NEUROLOGY

Alzheimer's disease amyloid hypothesis at crossroads: where do we go from here?

(2010) Uday Saxena   EXPERT OPINION ON THERAPEUTIC TARGETS

Advanced glycation end products enhance amyloid precursor protein expression by inducing reactive oxygen species

(2010) Shun-Yao Ko et al.   FREE RADICAL BIOLOGY AND MEDICINE

Glycogen synthase kinase-3β, or a link between amyloid and tau pathology?

(2010) D. Muyllaert et al.   GENES BRAIN AND BEHAVIOR

The procognitive effects of leptin in the brain and their clinical implications

(2010) G. Paz-Filho et al.   INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

Executive deficits and regional brain metabolism in Alzheimer's disease

(2010) Benjamin K. P. Woo et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

Statins and serum cholesterol's associations with incident dementia and mild cognitive impairment

(2010) M. A. Beydoun et al.   JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH

NAD+ Depletion Is Necessary and Sufficient forPoly(ADP-Ribose) Polymerase-1-Mediated Neuronal Death

(2010) C. C. Alano et al.   JOURNAL OF NEUROSCIENCE

Microglial Receptor for Advanced Glycation End Product-Dependent Signal Pathway Drives  -Amyloid-Induced Synaptic Depression and Long-Term Depression Impairment in Entorhinal Cortex

(2010) N. Origlia et al.   JOURNAL OF NEUROSCIENCE

Insulin deficiency exacerbates cerebral amyloidosis and behavioral deficits in an Alzheimer transgenic mouse model

(2010) Xu Wang et al.   Molecular Neurodegeneration

Alzheimer's failure raises questions about disease-modifying strategies

(2010) Andy Extance   NATURE REVIEWS DRUG DISCOVERY

AGEs/RAGE complex upregulates BACE1 via NF-κB pathway activation

(2010) Michela Guglielmotto et al.   NEUROBIOLOGY OF AGING

Biomarkers in translational research of Alzheimer’s Disease

(2010) Rawan Tarawneh et al.   NEUROPHARMACOLOGY

Pathways involved in the generation of reactive oxygen and nitrogen species during glucose deprivation and its role on the death of cultured hippocampal neurons

(2010) B. Páramo et al.   NEUROSCIENCE

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Evidence for Sub-Haplogroup H5 of Mitochondrial DNA as a Risk Factor for Late Onset Alzheimer's Disease

(2010) Aurelia Santoro et al.   PLoS One

Glucose Sensing Neurons in the Ventromedial Hypothalamus

(2010) Vanessa Routh   SENSORS

Network-Based Elucidation of Human Disease Similarities Reveals Common Functional Modules Enriched for Pluripotent Drug Targets

(2010) Silpa Suthram et al.   PLoS Computational Biology

Dietary fish and meat intake and dementia in Latin America, China, and India: a 10/66 Dementia Research Group population-based study

(2009) Emiliano Albanese et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Hypertension and Dementia

(2009) M. Nagai et al.   AMERICAN JOURNAL OF HYPERTENSION

Diabetes increases brain damage caused by severe hypoglycemia

(2009) Adam J. Bree et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Recent advances in understanding leptin signaling and leptin resistance

(2009) David L. Morris et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Meta-Analysis of Alzheimer's Disease Risk with Obesity, Diabetes, and Related Disorders

(2009) Louis A. Profenno et al.   BIOLOGICAL PSYCHIATRY

Uncontrolled diabetes increases the risk of Alzheimer’s disease: a population-based cohort study

(2009) W. L. Xu et al.   DIABETOLOGIA

Type 1 diabetes exaggerates features of Alzheimer's disease in APP transgenic mice

(2009) Corinne G. Jolivalt et al.   EXPERIMENTAL NEUROLOGY

RAGE-dependent signaling in microglia contributes to neuroinflammation, Aβ accumulation, and impaired learning/memory in a mouse model of Alzheimer’s disease

(2009) Fang Fang et al.   FASEB JOURNAL

Protective actions of sex steroid hormones in Alzheimer’s disease

(2009) Christian J. Pike et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Association of Plasma Leptin Levels With Incident Alzheimer Disease and MRI Measures of Brain Aging

(2009) Wolfgang Lieb   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Cholesterol metabolism and transport in the pathogenesis of Alzheimer’s disease

(2009) Ian J. Martins et al.   JOURNAL OF NEUROCHEMISTRY

Epigenetic mechanisms in neurological diseases: genes, syndromes, and therapies

(2009) Rocio G Urdinguio et al.   LANCET NEUROLOGY

Mitochondrial DNA variants in a Japanese population of patients with Alzheimer’s disease

(2009) Noriko Tanaka et al.   MITOCHONDRION

Cholesterol involvement in the pathogenesis of neurodegenerative diseases

(2009) Jun-Ping Liu et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Oxysterols and neurodegenerative diseases

(2009) Ingemar Björkhem et al.   MOLECULAR ASPECTS OF MEDICINE

The Insulin/Akt Signaling Pathway Is Targeted by Intracellular β-Amyloid

(2009) Han-Kyu Lee et al.   MOLECULAR BIOLOGY OF THE CELL

Predicting new molecular targets for known drugs

(2009) Michael J. Keiser et al.   NATURE

Advanced glycation endproducts and their receptor RAGE in Alzheimer's disease

(2009) Velandai Srikanth et al.   NEUROBIOLOGY OF AGING

Immunohistochemical analysis of human brain suggests pathological synergism of Alzheimer's disease and diabetes mellitus

(2009) Tony Valente et al.   NEUROBIOLOGY OF DISEASE

Glucose deprivation potentiates toxicity of ouabain and glutamate in cortical neurons cultured for different time periods

(2009) E. R. Lozier et al.   Neurochemical Journal

Plasma Amyloid-β Peptide Levels Correlate with Adipocyte Amyloid Precursor Protein Gene Expression in Obese Individuals

(2009) Yong-Ho Lee et al.   NEUROENDOCRINOLOGY

Association between late-life body mass index and dementia: The Kame Project

(2009) T. F. Hughes et al.   NEUROLOGY

An Overview of APP Processing Enzymes and Products

(2009) Vivian W. Chow et al.   NEUROMOLECULAR MEDICINE

Postnatal Age Influences Hypoglycemia-Induced Poly(ADP-ribose) Polymerase-1 Activation in the Brain Regions of Rats

(2009) Raghavendra Rao et al.   PEDIATRIC RESEARCH

Human Disease-Drug Network Based on Genomic Expression Profiles

(2009) Guanghui Hu et al.   PLoS One

Apolipoprotein E-Mimetics Inhibit Neurodegeneration and Restore Cognitive Functions in a Transgenic Drosophila Model of Alzheimer's Disease

(2009) Svetlana Sarantseva et al.   PLoS One

Adipokines as novel modulators of lipid metabolism

(2009) Francisca Lago et al.   TRENDS IN BIOCHEMICAL SCIENCES

Epigenetic mechanisms in the development of type 2 diabetes

(2009) Sara E. Pinney et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Association of Adiposity Status and Changes in Early to Mid-Adulthood With Incidence of Alzheimer's Disease

(2008) May A. Beydoun et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Association of Duration and Severity of Diabetes Mellitus With Mild Cognitive Impairment

(2008) Rosebud O. Roberts et al.   ARCHIVES OF NEUROLOGY

Insulin resistance and amyloidogenesis as common molecular foundation for type 2 diabetes and Alzheimer's disease

(2008) Wei-Qin Zhao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

(Pre)diabetes, brain aging, and cognition

(2008) Jarbas S. Roriz-Filho et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Association between polymorphisms in the apolipoprotein D gene and sporadic Alzheimer's disease

(2008) Yan Chen et al.   BRAIN RESEARCH

Adipokines: The missing link between insulin resistance and obesity

(2008) B. Antuna-Puente et al.   DIABETES & METABOLISM

Cognitive Dysfunction and Diabetes Mellitus

(2008) Christopher T. Kodl et al.   ENDOCRINE REVIEWS

Leptin Increases Adult Hippocampal Neurogenesisin Vivoandin Vitro

(2008) Jacob C. Garza et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone Code Modifications Repress Glucose Transporter 4 Expression in the Intrauterine Growth-restricted Offspring

(2008) Nupur Raychaudhuri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sequential Release of Nitric Oxide, Zinc, and Superoxide in Hypoglycemic Neuronal Death

(2008) Sang Won Suh et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Low Testosterone Levels Are Common and Associated with Insulin Resistance in Men with Diabetes

(2008) Mathis Grossmann et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice

(2008) Jennifer W. Hill et al.   JOURNAL OF CLINICAL INVESTIGATION

Histone deacetylase 6 interacts with the microtubule-associated protein tau

(2008) Huiping Ding et al.   JOURNAL OF NEUROCHEMISTRY

Statins are associated with a reduced risk of Alzheimer disease regardless of lipophilicity. The Rotterdam Study

(2008) M D M Haag et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Sirtuin 1 Reduction Parallels the Accumulation of Tau in Alzheimer Disease

(2008) Carl Julien et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Defective insulin signaling pathway and increased glycogen synthase kinase-3 activity in the brain of diabetic mice: Parallels with Alzheimer's disease and correction by insulin

(2008) C.G. Jolivalt et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Efficacy and safety of tarenflurbil in mild to moderate Alzheimer's disease: a randomised phase II trial

(2008) Gordon K Wilcock et al.   LANCET NEUROLOGY

Inflammatory markers in AD and MCI patients with different biomarker profiles

(2008) Alie Schuitemaker et al.   NEUROBIOLOGY OF AGING

Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling

(2008) Aileen M. Moloney et al.   NEUROBIOLOGY OF AGING

Oxidative injury and neuropathy in diabetes and impaired glucose tolerance

(2008) James W. Russell et al.   NEUROBIOLOGY OF DISEASE

Insulin Receptor Signaling Regulates Synapse Number, Dendritic Plasticity, and Circuit Function In Vivo

(2008) Shu-Ling Chiu et al.   NEURON

Increased glutamate receptor gene expression in the cerebral cortex of insulin induced hypoglycemic and streptozotocin-induced diabetic rats

(2008) A. Joseph et al.   NEUROSCIENCE

Amyloid Precursor Protein Expression Is Upregulated in Adipocytes in Obesity

(2008) Yong-Ho Lee et al.   Obesity

Hyperglycemia not hypoglycemia alters neuronal dendrites and impairs spatial memory

(2008) John I Malone et al.   PEDIATRIC DIABETES

Age-Specific Epigenetic Drift in Late-Onset Alzheimer's Disease

(2008) Sun-Chong Wang et al.   PLoS One

Androgen cell signaling pathways involved in neuroprotective actions

(2007) Christian J. Pike et al.   HORMONES AND BEHAVIOR

Hippocampal hypometabolism predicts cognitive decline from normal aging

(2007) Lisa Mosconi et al.   NEUROBIOLOGY OF AGING