Reactive oxygen species in haematopoiesis: leukaemic cells take a walk on the wild side

Oxidative stress in normal hematopoietic stem cells and leukemia

(2018) Azin Samimi et al.   APMIS

Role of chemokines in metastatic niche: new insights along with a diagnostic and prognostic approach

(2018) Hadi Rezaeeyan et al.   APMIS

Reactive oxygen species and cancer paradox: To promote or to suppress?

(2017) Sehamuddin Galadari et al.   FREE RADICAL BIOLOGY AND MEDICINE

NOX2-dependent immunosuppression in chronic myelomonocytic leukemia

(2017) Johan Aurelius et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Bortezomib and thalidomide maintenance after stem cell transplantation for multiple myeloma: a PETHEMA/GEM trial

(2017) L Rosiñol et al.   LEUKEMIA

Targeting acute myeloid leukemia stem cell signaling by natural products

(2017) Kodappully Sivaraman Siveen et al.   Molecular Cancer

Vincristine-induced peripheral neuropathy in survivors of childhood acute lymphoblastic leukaemia

(2017) Chee Geap Tay et al.   PEDIATRIC BLOOD & CANCER

Impact of NADPH oxidase functional polymorphisms in acute myeloid leukemia induction chemotherapy

(2017) J E Megías-Vericat et al.   PHARMACOGENOMICS JOURNAL

A novel redox regulator, MnTnBuOE-2-PyP 5+ , enhances normal hematopoietic stem/progenitor cell function

(2017) Y. Zhao et al.   Redox Biology

Hydrogen peroxide as a central redox signaling molecule in physiological oxidative stress: Oxidative eustress

(2017) Helmut Sies   Redox Biology

Brd4 inhibition attenuates unilateral ureteral obstruction-induced fibrosis by blocking TGF-β-mediated Nox4 expression

(2017) Baoshang Zhou et al.   Redox Biology

Update on rational targeted therapy in AML

(2016) Danielle Shafer et al.   BLOOD REVIEWS

The mitochondrial metabolic checkpoint and aging of hematopoietic stem cells

(2016) Mary Mohrin et al.   CURRENT OPINION IN HEMATOLOGY

NOX-driven ROS formation in cell transformation of FLT3-ITD-positive AML

(2016) Ashok Kumar Jayavelu et al.   EXPERIMENTAL HEMATOLOGY

ROS functions as an upstream trigger for autophagy to drive hematopoietic stem cell differentiation

(2016) Yan Cao et al.   Hematology

NADPH Oxidases Are Essential for Macrophage Differentiation

(2016) Qing Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High-throughput screening in niche-based assay identifies compounds to target preleukemic stem cells

(2016) Bastien Gerby et al.   JOURNAL OF CLINICAL INVESTIGATION

Allopurinol Use During Maintenance Therapy for Acute Lymphoblastic Leukemia Avoids Mercaptopurine-related Hepatotoxicity

(2016) Nicole M. Giamanco et al.   JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY

Ataxia telangiectasia: a review

(2016) Cynthia Rothblum-Oviatt et al.   Orphanet Journal of Rare Diseases

Self-renewal of a purified Tie2+ hematopoietic stem cell population relies on mitochondrial clearance

(2016) K. Ito et al.   SCIENCE

Sensitivity of hematopoietic stem cells to mitochondrial dysfunction by SdhD gene deletion

(2016) José Antonio Bejarano-García et al.   Cell Death & Disease

The role of the proteasome in AML

(2016) C M Csizmar et al.   Blood Cancer Journal

CXCR4/CXCL12 axis counteracts hematopoietic stem cell exhaustion through selective protection against oxidative stress

(2016) Yanyan Zhang et al.   Scientific Reports

Clinicopathological Implications of Mitochondrial Genome Alterations in Pediatric Acute Myeloid Leukemia

(2016) Min-Gu Kang et al.   Annals of Laboratory Medicine

A Phase 1 study of intravenous infusions of tigecycline in patients with acute myeloid leukemia

(2016) Gregory A. Reed et al.   Cancer Medicine

Evolution of NADPH Oxidase Inhibitors: Selectivity and Mechanisms for Target Engagement

(2015) Sebastian Altenhöfer et al.   ANTIOXIDANTS & REDOX SIGNALING

Glutathione and Thioredoxin Antioxidant Pathways Synergize to Drive Cancer Initiation and Progression

(2015) Isaac S. Harris et al.   CANCER CELL

Enhancing Hematopoietic Stem Cell Transplantation Efficacy by Mitigating Oxygen Shock

(2015) Charlie R. Mantel et al.   CELL

Selective Toxicity of Investigational Ixazomib for Human Leukemia Cells Expressing Mutant Cytoplasmic NPM1: Role of Reactive Oxygen Species

(2015) J. S. Garcia et al.   CLINICAL CANCER RESEARCH

Molecular Pathways: Mitochondrial Reprogramming in Tumor Progression and Therapy

(2015) M. C. Caino et al.   CLINICAL CANCER RESEARCH

Natural and Synthetic Flavonoids: Structure–Activity Relationship and Chemotherapeutic Potential for the Treatment of Leukemia

(2015) José C. J. M. D. S. Menezes et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Calmangafodipir [Ca4Mn(DPDP)5], mangafodipir (MnDPDP) and MnPLED with special reference to their SOD mimetic and therapeutic properties

(2015) Jan Olof G. Karlsson et al.   DRUG DISCOVERY TODAY

Redox regulation of Rac1 by thiol oxidation

(2015) G. Aaron Hobbs et al.   FREE RADICAL BIOLOGY AND MEDICINE

Myeloid Cell-Derived Reactive Oxygen Species Externally Regulate the Proliferation of Myeloid Progenitors in Emergency Granulopoiesis

(2015) Hyun-Jeong Kwak et al.   IMMUNITY

NADPH Oxidase-generated Hydrogen Peroxide Induces DNA Damage in Mutant FLT3-expressing Leukemia Cells

(2015) Joanna Stanicka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metformin Inhibits the Production of Reactive Oxygen Species from NADH:Ubiquinone Oxidoreductase to Limit Induction of Interleukin-1β (IL-1β) and Boosts Interleukin-10 (IL-10) in Lipopolysaccharide (LPS)-activated Macrophages

(2015) Beth Kelly et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Superoxide-Generating Nox5α Is Functionally Required for the Human T-Cell Leukemia Virus Type 1-Induced Cell Transformation Phenotype

(2015) Tomonari Shigemura et al.   JOURNAL OF VIROLOGY

An MTCH2 pathway repressing mitochondria metabolism regulates haematopoietic stem cell fate

(2015) Maria Maryanovich et al.   Nature Communications

Rationale for revision and proposed changes of the WHO diagnostic criteria for polycythemia vera, essential thrombocythemia and primary myelofibrosis

(2015) T Barbui et al.   Blood Cancer Journal

BA-j as a novel CDK1 inhibitor selectively induces apoptosis in cancer cells by regulating ROS

(2015) Shixuan Zhang et al.   Scientific Reports

Xanthine oxidoreductase in cancer: more than a differentiation marker

(2015) Maria Giulia Battelli et al.   Cancer Medicine

PTPN13 and β-Catenin Regulate the Quiescence of Hematopoietic Stem Cells and Their Interaction with the Bone Marrow Niche

(2015) Guillermo López-Ruano et al.   Stem Cell Reports

CXCL12/SDF-1 and CXCR4

(2015) Takashi Nagasawa   Frontiers in Immunology

STAT5 triggers BCR-ABL1 mutation by mediating ROS production in chronic myeloid leukaemia

(2015) Wolfgang Warsch et al.   Oncotarget

ROS-mediated iron overload injures the hematopoiesis of bone marrow by damaging hematopoietic stem/progenitor cells in mice

(2015) Xiao Chai et al.   Scientific Reports

PTPN13 regulates cellular signalling and β-catenin function during megakaryocytic differentiation

(2014) José L. Sardina et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mitochondrial metabolism contributes to oxidative stress and reveals therapeutic targets in chronic lymphocytic leukemia

(2014) R. Jitschin et al.   BLOOD

BIMELis a key effector molecule in oxidative stress-mediated apoptosis in acute myeloid leukemia cells when combined with arsenic trioxide and buthionine sulfoximine

(2014) Yukie Tanaka et al.   BMC CANCER

Regulation of hematopoietic and leukemic stem cells by the immune system

(2014) C Riether et al.   CELL DEATH AND DIFFERENTIATION

NADPH Oxidases as Therapeutic Targets in Chronic Myelogenous Leukemia

(2014) B. Sanchez-Sanchez et al.   CLINICAL CANCER RESEARCH

The antioxidant paradox: what are antioxidants and how should they be used in a therapeutic context for cancer

(2014) Michael Y Bonner et al.   Future Medicinal Chemistry

Who controls the ATP supply in cancer cells? Biochemistry lessons to understand cancer energy metabolism

(2014) Rafael Moreno-Sánchez et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Arachidonate 15-lipoxygenase is required for chronic myeloid leukemia stem cell survival

(2014) Yaoyu Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

An overview of mechanisms of redox signaling

(2014) Henry Jay Forman et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Metabolic requirements for the maintenance of self-renewing stem cells

(2014) Keisuke Ito et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Impairment of antioxidant defense via glutathione depletion sensitizes acute lymphoblastic leukemia cells for Smac mimetic-induced cell death

(2014) H Schoeneberger et al.   ONCOGENE

TNF and MAP kinase signalling pathways

(2014) Guadalupe Sabio et al.   SEMINARS IN IMMUNOLOGY

Surviving change: the metabolic journey of hematopoietic stem cells

(2014) Latika Kohli et al.   TRENDS IN CELL BIOLOGY

Crucial involvement of xanthine oxidase in the intracellular signalling networks associated with human myeloid cell function

(2014) Maryam Abooali et al.   Scientific Reports

Nuclear receptor-induced transcription is driven by spatially and timely restricted waves of ROS

(2014) Bruno Perillo et al.   Nucleus

Chaetocin antileukemia activity against chronic myelogenous leukemia cells is potentiated by bone marrow stromal factors and overcomes innate imatinib resistance

(2014) L Truitt et al.   Oncogenesis

Overproduction of NOX-derived ROS in AML promotes proliferation and is associated with defective oxidative stress signaling

(2013) P. S. Hole et al.   BLOOD

TXNIP Maintains the Hematopoietic Cell Pool by Switching the Function of p53 under Oxidative Stress

(2013) Haiyoung Jung et al.   Cell Metabolism

Redox regulation of protein kinases

(2013) Aoife Corcoran et al.   FEBS Journal

The copper chelator ATN-224 induces peroxynitrite-dependent cell death in hematological malignancies

(2013) Kristy Lee et al.   FREE RADICAL BIOLOGY AND MEDICINE

Increased reactive oxygen species production and p47phox phosphorylation in neutrophils from myeloproliferative disorders patients with JAK2 (V617F) mutation

(2013) M. Hurtado-Nedelec et al.   HAEMATOLOGICA

Treatment of oxaliplatin-induced peripheral neuropathy by intravenous mangafodipir

(2013) Romain Coriat et al.   JOURNAL OF CLINICAL INVESTIGATION

A role for reactive oxygen species in JAK2 V617F myeloproliferative neoplasm progression

(2013) C Marty et al.   LEUKEMIA

Redox-Dependent Control of FOXO/DAF-16 by Transportin-1

(2013) Marrit Putker et al.   MOLECULAR CELL

A canonical to non-canonical Wnt signalling switch in haematopoietic stem-cell ageing

(2013) Maria Carolina Florian et al.   NATURE

Quantitative imaging of haematopoietic stem and progenitor cell localization and hypoxic status in the bone marrow microenvironment

(2013) César Nombela-Arrieta et al.   NATURE CELL BIOLOGY

Activating Mutations in Protein Tyrosine Phosphatase Ptpn11 (Shp2) Enhance Reactive Oxygen Species Production That Contributes to Myeloproliferative Disorder

(2013) Dan Xu et al.   PLoS One

Redox homeostasis: the linchpin in stem cell self-renewal and differentiation

(2013) Kui Wang et al.   Cell Death & Disease

Redox Control of Leukemia: From Molecular Mechanisms to Therapeutic Opportunities

(2012) Mary E. Irwin et al.   ANTIOXIDANTS & REDOX SIGNALING

Hematopoietic stem cell niche: An interplay among a repertoire of multiple functional niches

(2012) Ayako Nakamura-Ishizu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Rac2-MRC-cIII-generated ROS cause genomic instability in chronic myeloid leukemia stem cells and primitive progenitors

(2012) M. Nieborowska-Skorska et al.   BLOOD

Gliotoxin is a potent NOTCH2 transactivation inhibitor and efficiently induces apoptosis in chronic lymphocytic leukaemia (CLL) cells

(2012) Rainer Hubmann et al.   BRITISH JOURNAL OF HAEMATOLOGY

Hypoxia-Inducible Factors in Physiology and Medicine

(2012) Gregg L. Semenza   CELL

Increased Oxidative Stress in the Nucleus Caused by Nox4 Mediates Oxidation of HDAC4 and Cardiac Hypertrophy

(2012) Shouji Matsushima et al.   CIRCULATION RESEARCH

Chronic myeloid leukemia stem cells display alterations in expression of genes involved in oxidative phosphorylation

(2012) Krzysztof Flis et al.   LEUKEMIA & LYMPHOMA

Connexin-43 prevents hematopoietic stem cell senescence through transfer of reactive oxygen species to bone marrow stromal cells

(2012) E. Taniguchi Ishikawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Do reactive oxygen species play a role in myeloid leukemias?

(2011) P. S. Hole et al.   BLOOD

Inhibition of the NADPH oxidase regulates heme oxygenase 1 expression in chronic myeloid leukemia

(2011) Melissa M. Singh et al.   CANCER

Mitochondrial Subversion in Cancer

(2011) A. Chatterjee et al.   Cancer Prevention Research

Reactive oxygen species: Are they important for haematopoiesis?

(2011) José L. Sardina et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution

(2011) Keiko Taguchi et al.   GENES TO CELLS

Comparative Proteomic Analysis of Blood Eosinophils Reveals Redox Signaling Modifications in Patients with FIP1L1-PDGFRA-Associated Chronic Eosinophilic Leukemia

(2011) Jean-Emmanuel Kahn et al.   JOURNAL OF PROTEOME RESEARCH

Exploiting Mitochondrial Dysfunction for Effective Elimination of Imatinib-Resistant Leukemic Cells

(2011) Jérome Kluza et al.   PLoS One

AKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive oxygen species

(2010) M. M. Juntilla et al.   BLOOD

Enhanced c-Met activity promotes G-CSF-induced mobilization of hematopoietic progenitor cells via ROS signaling

(2010) M. Tesio et al.   BLOOD

Overcoming resistance to histone deacetylase inhibitors in human leukemia with the redox modulating compound  -phenylethyl isothiocyanate

(2010) Y. Hu et al.   BLOOD

Arsenic trioxide — An old drug rediscovered

(2010) Ashkan Emadi et al.   BLOOD REVIEWS

PML/RARA Oxidation and Arsenic Binding Initiate the Antileukemia Response of As2O3

(2010) Marion Jeanne et al.   CANCER CELL

Genetic Analysis of Transforming Events That Convert Chronic Myeloproliferative Neoplasms to Leukemias

(2010) O. Abdel-Wahab et al.   CANCER RESEARCH

p22phox-dependent NADPH oxidase activity is required for megakaryocytic differentiation

(2010) J L Sardina et al.   CELL DEATH AND DIFFERENTIATION

Mdm2 Is Required for Survival of Hematopoietic Stem Cells/Progenitors via Dampening of ROS-Induced p53 Activity

(2010) Hussein A. Abbas et al.   Cell Stem Cell

Polycomb Group Proteins: Multi-Faceted Regulators of Somatic Stem Cells and Cancer

(2010) Martin Sauvageau et al.   Cell Stem Cell

The Distinct Metabolic Profile of Hematopoietic Stem Cells Reflects Their Location in a Hypoxic Niche

(2010) Tugba Simsek et al.   Cell Stem Cell

Regulation of the HIF-1α Level Is Essential for Hematopoietic Stem Cells

(2010) Keiyo Takubo et al.   Cell Stem Cell

Inhibition of the redox function of APE1/Ref-1 in myeloid leukemia cell lines results in a hypersensitive response to retinoic acid-induced differentiation and apoptosis

(2010) Melissa L. Fishel et al.   EXPERIMENTAL HEMATOLOGY

Redox regulation of Wnt signalling via nucleoredoxin

(2010) Yosuke Funato et al.   FREE RADICAL RESEARCH

Involvement of Oxidative Stress in the Relapse of Acute Myeloid Leukemia

(2010) Fu-Ling Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolism and the leukemic stem cell: Figure 1.

(2010) Omar Abdel-Wahab et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Isocitrate Dehydrogenase 1 and 2 Mutations in Cancer: Alterations at a Crossroads of Cellular Metabolism

(2010) Z. J. Reitman et al.   JNCI-Journal of the National Cancer Institute

NADPH oxidases regulate cell growth and migration in myeloid cells transformed by oncogenic tyrosine kinases

(2010) M M Reddy et al.   LEUKEMIA

Redox-Directed Cancer Therapeutics: Molecular Mechanisms and Opportunities

(2009) Georg T. Wondrak   ANTIOXIDANTS & REDOX SIGNALING

NADPH oxidases participate to doxorubicin-induced cardiac myocyte apoptosis

(2009) Mylène Gilleron et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ras-induced reactive oxygen species promote growth factor-independent proliferation in human CD34+ hematopoietic progenitor cells

(2009) P. S. Hole et al.   BLOOD

Constitutively active AKT depletes hematopoietic stem cells and induces leukemia in mice

(2009) M. G. Kharas et al.   BLOOD

Differential expression of NADPH oxidases in megakaryocytes and their role in polyploidy

(2009) D. J. McCrann et al.   BLOOD

Downregulation of thec-MYCtarget gene, peroxiredoxin III, contributes to arsenic trioxide-induced apoptosis in acute promyelocytic leukemia

(2009) Pablo E. Vivas-Mejía et al.   INTERNATIONAL JOURNAL OF CANCER

MAPK signaling pathways in the regulation of hematopoiesis

(2009) Christian R. Geest et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Bcr-Abl-mediated redox regulation of the PI3K/AKT pathway

(2009) R Naughton et al.   LEUKEMIA

Bmi1 regulates mitochondrial function and the DNA damage response pathway

(2009) Jie Liu et al.   NATURE

Reactive oxygen species prime Drosophila haematopoietic progenitors for differentiation

(2009) Edward Owusu-Ansah et al.   NATURE

Loss of the Alox5 gene impairs leukemia stem cells and prevents chronic myeloid leukemia

(2009) Yaoyu Chen et al.   NATURE GENETICS

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY

Recurring Mutations Found by Sequencing an Acute Myeloid Leukemia Genome

(2009) Elaine R. Mardis et al.   NEW ENGLAND JOURNAL OF MEDICINE

Direct Activation of RhoA by Reactive Oxygen Species Requires a Redox-Sensitive Motif

(2009) Amir Aghajanian et al.   PLoS One

High Mitochondrial DNA Stability in B-Cell Chronic Lymphocytic Leukemia

(2009) María Cerezo et al.   PLoS One

The Many Functions of APE1/Ref-1: Not Only a DNA Repair Enzyme

(2008) Gianluca Tell et al.   ANTIOXIDANTS & REDOX SIGNALING

Effective elimination of fludarabine-resistant CLL cells by PEITC through a redox-mediated mechanism

(2008) D. Trachootham et al.   BLOOD

Internal tandem duplication of FLT3 (FLT3/ITD) induces increased ROS production, DNA damage, and misrepair: implications for poor prognosis in AML

(2008) A. Sallmyr et al.   BLOOD

The thioredoxin system: a key target in tumour and endothelial cells

(2008) A Mukherjee et al.   BRITISH JOURNAL OF RADIOLOGY

Genomic instability in myeloid malignancies: Increased reactive oxygen species (ROS), DNA double strand breaks (DSBs) and error-prone repair

(2008) Annahita Sallmyr et al.   CANCER LETTERS

Hematopoiesis: An Evolving Paradigm for Stem Cell Biology

(2008) Stuart H. Orkin et al.   CELL

Targeting Ras in Myeloid Leukemias

(2008) B. S. Braun et al.   CLINICAL CANCER RESEARCH

Targeting Cyclooxygenase-2 in Hematological Malignancies: Rationale and Promise

(2008) M. Bernard et al.   CURRENT PHARMACEUTICAL DESIGN

PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability

(2008) Ana Silva et al.   JOURNAL OF CLINICAL INVESTIGATION

TSC–mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species

(2008) Chong Chen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Effective killing of Gleevec-resistant CML cells with T315I mutation by a natural compound PEITC through redox-mediated mechanism

(2008) H Zhang et al.   LEUKEMIA

Antioxidant status in pediatric acute lymphocytic leukemia (ALL) and solid tumors: The impact of oxidative stress

(2008) Dalia Mazor et al.   PEDIATRIC BLOOD & CANCER