Arachidonate 15-lipoxygenase is required for chronic myeloid leukemia stem cell survival

KIT Signaling Governs Differential Sensitivity of Mature and Primitive CML Progenitors to Tyrosine Kinase Inhibitors

(2013) A. S. Corbin et al.   CANCER RESEARCH

A Pan-BCL2 Inhibitor Renders Bone-Marrow-Resident Human Leukemia Stem Cells Sensitive to Tyrosine Kinase Inhibition

(2013) Daniel J. Goff et al.   Cell Stem Cell

The Blk pathway functions as a tumor suppressor in chronic myeloid leukemia stem cells

(2012) Haojian Zhang et al.   NATURE GENETICS

LSK Derived LSK– Cells Have a High Apoptotic Rate Related to Survival Regulation of Hematopoietic and Leukemic Stem Cells

(2012) Cong Peng et al.   PLoS One

Functional Ramifications for the Loss of P-Selectin Expression on Hematopoietic and Leukemic Stem Cells

(2011) Con Sullivan et al.   PLoS One

Hematopoietic stem cell function requires 12/15-lipoxygenase-dependent fatty acid metabolism

(2010) M. Kinder et al.   BLOOD

TGF-β–FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia

(2010) Kazuhito Naka et al.   NATURE

Regulation of myeloid leukaemia by the cell-fate determinant Musashi

(2010) Takahiro Ito et al.   NATURE

BMS-214662 induces mitochondrial apoptosis in chronic myeloid leukemia (CML) stem/progenitor cells, including CD34+38- cells, through activation of protein kinase C 

(2009) F. Pellicano et al.   BLOOD

PTEN is a tumor suppressor in CML stem cells and BCR-ABL-induced leukemias in mice

(2009) C. Peng et al.   BLOOD

Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia

(2009) Chen Zhao et al.   NATURE

Loss of the Alox5 gene impairs leukemia stem cells and prevents chronic myeloid leukemia

(2009) Yaoyu Chen et al.   NATURE GENETICS

Expansion of Bcr-Abl-Positive Leukemic Stem Cells Is Dependent on Hedgehog Pathway Activation

(2008) Christine Dierks et al.   CANCER CELL

Stems Cells and the Pathways to Aging and Cancer

(2008) Derrick J. Rossi et al.   CELL

β-Catenin is essential for survival of leukemic stem cells insensitive to kinase inhibition in mice with BCR-ABL-induced chronic myeloid leukemia

(2008) Y Hu et al.   LEUKEMIA

PML targeting eradicates quiescent leukaemia-initiating cells

(2008) Keisuke Ito et al.   NATURE

Lipid signalling in disease

(2008) Matthias P. Wymann et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY