Do reactive oxygen species play a role in myeloid leukemias?

Cytosolic phospholipase A2, lipoxygenase metabolites, and reactive oxygen species

(2011) Cheol-Min Kim et al.   BMB Reports

New insight into the Nox4 subcellular localization in HEK293 cells: First monoclonal antibodies against Nox4

(2010) Leilei Zhang et al.   BIOCHIMIE

AKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive oxygen species

(2010) M. M. Juntilla et al.   BLOOD

Enhanced c-Met activity promotes G-CSF-induced mobilization of hematopoietic progenitor cells via ROS signaling

(2010) M. Tesio et al.   BLOOD

Hematopoietic stem cell function requires 12/15-lipoxygenase-dependent fatty acid metabolism

(2010) M. Kinder et al.   BLOOD

Genetic manipulation of AML1-ETO-induced expansion of hematopoietic precursors in a Drosophila model

(2010) S. A. Sinenko et al.   BLOOD

Signatures of polycomb repression and reduced H3K4 trimethylation are associated with p15INK4b DNA methylation in AML

(2010) T. A. Paul et al.   BLOOD

The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate

(2010) Patrick S. Ward et al.   CANCER CELL

PML/RARA Oxidation and Arsenic Binding Initiate the Antileukemia Response of As2O3

(2010) Marion Jeanne et al.   CANCER CELL

Androgen Receptor Requires JunD as a Coactivator to Switch on an Oxidative Stress Generation Pathway in Prostate Cancer Cells

(2010) Farideh Mehraein-Ghomi et al.   CANCER RESEARCH

Expression of heme oxygenase-1 in human leukemic cells and its regulation by transcriptional repressor Bach1

(2010) Takuya Miyazaki et al.   CANCER SCIENCE

The Distinct Metabolic Profile of Hematopoietic Stem Cells Reflects Their Location in a Hypoxic Niche

(2010) Tugba Simsek et al.   Cell Stem Cell

Production of oxygen radicals by fibroblasts and neutrophils from a patient with x-linked chronic granulomatous disease

(2010) Andreas Emmendörffer et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Deferasirox is a powerful NF- B inhibitor in myelodysplastic cells and in leukemia cell lines acting independently from cell iron deprivation by chelation and reactive oxygen species scavenging

(2010) E. Messa et al.   HAEMATOLOGICA

Changes in parameters of oxidative stress and free iron biomarkers during treatment with deferasirox in iron-overloaded patients with myelodysplastic syndromes

(2010) H. Ghoti et al.   HAEMATOLOGICA

Involvement of Oxidative Stress in the Relapse of Acute Myeloid Leukemia

(2010) Fu-Ling Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NADPH oxidases regulate cell growth and migration in myeloid cells transformed by oncogenic tyrosine kinases

(2010) M M Reddy et al.   LEUKEMIA

Iron chelation therapy in MDS: Does it improve survival?

(2010) Heather A. Leitch   LEUKEMIA RESEARCH

Anti-oxidative, anti-cancer and anti-inflammatory actions by thioredoxin 1 and thioredoxin-binding protein-2

(2010) Rie Watanabe et al.   PHARMACOLOGY & THERAPEUTICS

IDH mutations in glioma and acute myeloid leukemia

(2010) Lenny Dang et al.   TRENDS IN MOLECULAR MEDICINE

Tyrosine Kinase Inhibitors: The First Decade

(2010) Meetu Agrawal et al.   Current Hematologic Malignancy Reports

Glutathione dysregulation and the etiology and progression of human diseases

(2009) Nazzareno Ballatori et al.   BIOLOGICAL CHEMISTRY

Ras-induced reactive oxygen species promote growth factor-independent proliferation in human CD34+ hematopoietic progenitor cells

(2009) P. S. Hole et al.   BLOOD

AML at older age: age-related gene expression profiles reveal a paradoxical down-regulation of p16INK4A mRNA with prognostic significance

(2009) H. J. M. de Jonge et al.   BLOOD

In vivo cellular imaging pinpoints the role of reactive oxygen species in the early steps of adult hematopoietic reconstitution

(2009) D. Lewandowski et al.   BLOOD

Constitutively active AKT depletes hematopoietic stem cells and induces leukemia in mice

(2009) M. G. Kharas et al.   BLOOD

Oxidative stress-specific interaction between FANCD2 and FOXO3a

(2009) J. Li et al.   BLOOD

Repression of BMI1 in normal and leukemic human CD34+ cells impairs self-renewal and induces apoptosis

(2009) A. Rizo et al.   BLOOD

Cancer Stem Cells: The Emerging Challenge of Drug Targeting

(2009) Roger Besancon et al.   CURRENT MEDICINAL CHEMISTRY

Frequent genomic abnormalities in acute myeloid leukemia/myelodysplastic syndrome with normal karyotype

(2009) T. Akagi et al.   HAEMATOLOGICA

Oxidative Stress Promotes Transcriptional Up-regulation of Fyn in BCR-ABL1-expressing Cells

(2009) Yin Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The hematopoietic stem cell niche: Low in oxygen but a nice place to be

(2009) Pernilla Eliasson et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Bcr-Abl-mediated redox regulation of the PI3K/AKT pathway

(2009) R Naughton et al.   LEUKEMIA

The gene encoding thioredoxin-interacting protein (TXNIP) is a frequent virus integration site in virus-induced mouse leukemia and is overexpressed in a subset of AML patients

(2009) Stefan J. Erkeland et al.   LEUKEMIA RESEARCH

Amifostine has the potential to induce haematologic responses and decelerate disease progression in individual patients with low- and intermediate-1-risk myelodysplastic syndromes

(2009) Julie Schanz et al.   LEUKEMIA RESEARCH

Enhancement of arsenic trioxide cytotoxicity by dietary isothiocyanates in human leukemic cells via a reactive oxygen species-dependent mechanism

(2009) Nicole A. Doudican et al.   LEUKEMIA RESEARCH

Association of reactive oxygen species levels and radioresistance in cancer stem cells

(2009) Maximilian Diehn et al.   NATURE

Reactive oxygen species prime Drosophila haematopoietic progenitors for differentiation

(2009) Edward Owusu-Ansah et al.   NATURE

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY

An 8-oxo-guanine repair pathway coordinated by MUTYH glycosylase and DNA polymerase  

(2009) B. van Loon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tks5-Dependent, Nox-Mediated Generation of Reactive Oxygen Species Is Necessary for Invadopodia Formation

(2009) B. Diaz et al.   Science Signaling

Neither Too Much Nor Too Little: Reactive Oxygen Species Levels Regulate Drosophila Hematopoiesis

(2009) A. Vincent et al.   Journal of Molecular Cell Biology

Cell Cycle Regulation by Oncogenic Tyrosine Kinases in Myeloid Neoplasias: From Molecular Redox Mechanisms to Health Implications

(2008) Margret S. Rodrigues et al.   ANTIOXIDANTS & REDOX SIGNALING

Protein Tyrosine Phosphorylation and Protein Tyrosine Nitration in Redox Signaling

(2008) Hugo P. Monteiro et al.   ANTIOXIDANTS & REDOX SIGNALING

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Effective elimination of fludarabine-resistant CLL cells by PEITC through a redox-mediated mechanism

(2008) D. Trachootham et al.   BLOOD

Internal tandem duplication of FLT3 (FLT3/ITD) induces increased ROS production, DNA damage, and misrepair: implications for poor prognosis in AML

(2008) A. Sallmyr et al.   BLOOD

Acute promyelocytic leukemia: from highly fatal to highly curable

(2008) Z.-Y. Wang et al.   BLOOD

Signal cross talks for sustained MAPK activation and cell migration: the potential role of reactive oxygen species

(2008) Wen-Sheng Wu et al.   CANCER AND METASTASIS REVIEWS

Reactive oxygen species in tumor metastasis

(2008) Makiya Nishikawa   CANCER LETTERS

Mechanisms of ROS modulated cell survival during carcinogenesis

(2008) J.S. Clerkin et al.   CANCER LETTERS

Genomic instability in myeloid malignancies: Increased reactive oxygen species (ROS), DNA double strand breaks (DSBs) and error-prone repair

(2008) Annahita Sallmyr et al.   CANCER LETTERS

Oxidative Stress Is Inherent in Prostate Cancer Cells and Is Required for Aggressive Phenotype

(2008) B. Kumar et al.   CANCER RESEARCH

Induction of apoptosis by shikonin through a ROS/JNK-mediated process in Bcr/Abl-positive chronic myelogenous leukemia (CML) cells

(2008) Xin Mao et al.   CELL RESEARCH

Role of Nox2-Based NADPH Oxidase in Bone Marrow and Progenitor Cell Function Involved in Neovascularization Induced by Hindlimb Ischemia

(2008) Norifumi Urao et al.   CIRCULATION RESEARCH

Measurement of oxidative stress and antioxidant status in acute lymphoblastic leukemia patients

(2008) Vanessa Battisti et al.   CLINICAL BIOCHEMISTRY

Induction of apoptosis in a human leukemic cell line via reactive oxygen species modulation by antioxidants

(2008) Tullia Maraldi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Editorial

(2008) Michael Davies et al.   FREE RADICAL RESEARCH

Impact of antioxidant supplementation on chemotherapeutic toxicity: A systematic review of the evidence from randomized controlled trials

(2008) Keith I. Block et al.   INTERNATIONAL JOURNAL OF CANCER

Effective killing of Gleevec-resistant CML cells with T315I mutation by a natural compound PEITC through redox-mediated mechanism

(2008) H Zhang et al.   LEUKEMIA

Oxidative DNA damage in bone marrow cells of patients with low-risk myelodysplastic syndrome

(2008) Bozena Novotna et al.   LEUKEMIA RESEARCH

Amifostine Protection Against Mitomycin-induced Chromosomal Breakage in Fanconi Anaemia Lymphocytes

(2008) Ricardo Camelo et al.   MOLECULES

The reactive oxygen-driven tumor: relevance to melanoma

(2008) Levi Fried et al.   Pigment Cell & Melanoma Research

NADPH oxidase-derived reactive oxygen species are responsible for the high susceptibility to arsenic cytotoxicity in acute promyelocytic leukemia cells

(2007) Jie Wang et al.   LEUKEMIA RESEARCH