Redox Control of Leukemia: From Molecular Mechanisms to Therapeutic Opportunities

Protection of acute myeloid leukaemia cells from apoptosis induced by front-line chemotherapeutics is mediated by haem oxygenase-1

(2015) Sally-Anne Heasman et al.   Oncotarget

An Atypical NF- B-Regulated Pathway Mediates Phorbol Ester-Dependent Heme Oxygenase-1 Gene Activation in Monocytes

(2014) S. Naidu et al.   JOURNAL OF IMMUNOLOGY

Lipopolysaccharide-Induced Expression of NAD(P)H:Quinone Oxidoreductase 1 and Heme Oxygenase-1 Protects against Excessive Inflammatory Responses in Human Monocytes

(2014) S. A. Rushworth et al.   JOURNAL OF IMMUNOLOGY

The roles of CYP450 epoxygenases and metabolites, epoxyeicosatrienoic acids, in cardiovascular and malignant diseases

(2011) Xizhen Xu et al.   ADVANCED DRUG DELIVERY REVIEWS

Superoxide Dismutases: Role in Redox Signaling, Vascular Function, and Diseases

(2011) Tohru Fukai et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial Regulation of Cell Cycle and Proliferation

(2011) Valeria Gabriela Antico Arciuch et al.   ANTIOXIDANTS & REDOX SIGNALING

Regulation of mitochondrial metabolism: yet another facet in the biology of the oncoprotein Bcl-2

(2011) Shefali Krishna et al.   BIOCHEMICAL JOURNAL

Accumulation of oxidative DNA damage restricts the self-renewal capacity of human hematopoietic stem cells

(2011) T. Yahata et al.   BLOOD

Do reactive oxygen species play a role in myeloid leukemias?

(2011) P. S. Hole et al.   BLOOD

Genome-wide analysis of histone H3 acetylation patterns in AML identifies PRDX2 as an epigenetically silenced tumor suppressor gene

(2011) S. Agrawal-Singh et al.   BLOOD

From an old remedy to a magic bullet: molecular mechanisms underlying the therapeutic effects of arsenic in fighting leukemia

(2011) S.-J. Chen et al.   BLOOD

The histone methyltransferase inhibitor, DZNep, up-regulates TXNIP, increases ROS production, and targets leukemia cells in AML

(2011) J. Zhou et al.   BLOOD

Inhibition of the NADPH oxidase regulates heme oxygenase 1 expression in chronic myeloid leukemia

(2011) Melissa M. Singh et al.   CANCER

High Basal Nuclear Levels of Nrf2 in Acute Myeloid Leukemia Reduces Sensitivity to Proteasome Inhibitors

(2011) S. A. Rushworth et al.   CANCER RESEARCH

Current understanding of the mechanism of benzene-induced leukemia in humans: implications for risk assessment

(2011) C. M. McHale et al.   CARCINOGENESIS

HDAC Inhibitors Potentiate the Activity of the BCR/ABL Kinase Inhibitor KW-2449 in Imatinib-Sensitive or -Resistant BCR/ABL+ Leukemia Cells In Vitro and In Vivo

(2011) T. Nguyen et al.   CLINICAL CANCER RESEARCH

NADPH oxidase inhibitors: a patent review

(2011) Jung-Ae Kim et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Signal transduction by reactive oxygen species

(2011) Toren Finkel   JOURNAL OF CELL BIOLOGY

Intracellular uptake and behavior of two types zinc protoporphyrin (ZnPP) micelles, SMA-ZnPP and PEG-ZnPP as anticancer agents; unique intracellular disintegration of SMA micelles

(2011) Hideaki Nakamura et al.   JOURNAL OF CONTROLLED RELEASE

Inhibition of heme oxygenase-1 enhances anti-cancer effects of arsenic trioxide on glioma cells

(2011) Yaohua Liu et al.   JOURNAL OF NEURO-ONCOLOGY

Targeting the translational apparatus to improve leukemia therapy: roles of the PI3K/PTEN/Akt/mTOR pathway

(2011) A M Martelli et al.   LEUKEMIA

Intracellular reactive oxygen species are essential for PI3K/Akt/mTOR-dependent IL-7-mediated viability of T-cell acute lymphoblastic leukemia cells

(2011) A Silva et al.   LEUKEMIA

Targeting the disturbed redox equilibrium in chronic lymphocytic leukemia by novel reactive oxygen species-catalytic ‘sensor/effector’ compounds

(2011) Nils Lilienthal et al.   LEUKEMIA & LYMPHOMA

NADPH oxidase inhibition attenuates total body irradiation-induced haematopoietic genomic instability

(2011) S. K. Pazhanisamy et al.   MUTAGENESIS

Selective killing of cancer cells by a small molecule targeting the stress response to ROS

(2011) Lakshmi Raj et al.   NATURE

Cytarabine Dose for Acute Myeloid Leukemia

(2011) Bob Löwenberg et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Antioxidant Protein Peroxiredoxin 4 Is Epigenetically Down Regulated in Acute Promyelocytic Leukemia

(2011) Karishma K. Palande et al.   PLoS One

Effects of Stem Cell Factor on Hypoxia-Inducible Factor 1 Alpha Accumulation in Human Acute Myeloid Leukaemia and LAD2 Mast Cells

(2011) Bernhard F. Gibbs et al.   PLoS One

Phenethyl isothiocyanate exhibits antileukemic activity in vitro and in vivo by inactivation of Akt and activation of JNK pathways

(2011) N Gao et al.   Cell Death & Disease

Modulation of reactive oxygen species by antioxidants in chronic myeloid leukemia cells enhances imatinib sensitivity through survivin downregulation

(2010) Jolie Kiemlian Kwee et al.   ANTI-CANCER DRUGS

Structure, Function, and Mechanism of Thioredoxin Proteins

(2010) Jean-Francois Collet et al.   ANTIOXIDANTS & REDOX SIGNALING

Cancer Chemoprevention Mechanisms Mediated Through the Keap1–Nrf2 Pathway

(2010) John D. Hayes et al.   ANTIOXIDANTS & REDOX SIGNALING

Multiple Functions of Peroxiredoxins: Peroxidases, Sensors and Regulators of the Intracellular Messenger H2O2, and Protein Chaperones

(2010) Sue Goo Rhee et al.   ANTIOXIDANTS & REDOX SIGNALING

Overcoming resistance to histone deacetylase inhibitors in human leukemia with the redox modulating compound  -phenylethyl isothiocyanate

(2010) Y. Hu et al.   BLOOD

FLT3 as a therapeutic target in AML: still challenging after all these years

(2010) T. Kindler et al.   BLOOD

NF-κB–Inhibited Acute Myeloid Leukemia Cells Are Rescued from Apoptosis by Heme Oxygenase-1 Induction

(2010) Stuart A. Rushworth et al.   CANCER RESEARCH

Expression of heme oxygenase-1 in human leukemic cells and its regulation by transcriptional repressor Bach1

(2010) Takuya Miyazaki et al.   CANCER SCIENCE

Current and emerging therapies for acute myeloid leukemia

(2010) Tadeusz Robak et al.   CLINICAL THERAPEUTICS

Association of Glutathione S-Transferase, EPHX, and p53 codon 72 Gene Polymorphisms with Adult Acute Myeloid Leukemia

(2010) Pradeep Singh Chauhan et al.   DNA AND CELL BIOLOGY

The sites and topology of mitochondrial superoxide production

(2010) Martin D. Brand   EXPERIMENTAL GERONTOLOGY

Role of Ras/Raf/MEK/ERK signaling in physiological hematopoiesis and leukemia development

(2010) Eva Chung et al.   IMMUNOLOGIC RESEARCH

Involvement of Oxidative Stress in the Relapse of Acute Myeloid Leukemia

(2010) Fu-Ling Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of AMP-activated protein kinase is involved in vincristine-induced cell apoptosis in B16 melanoma cell

(2010) Min-Bin Chen et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Adaphostin toxicity in a sensitive non-small cell lung cancer model is mediated through Nrf2 signaling and heme oxygenase 1

(2010) Nicole D Fer et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Cytochrome P450 2J2 Is Highly Expressed in Hematologic Malignant Diseases and Promotes Tumor Cell Growth

(2010) C. Chen et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Myeloperoxidase Expression as a Potential Determinant of Parthenolide-Induced Apoptosis in Leukemia Bulk and Leukemia Stem Cells

(2010) Y. R. Kim et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

NADPH oxidases regulate cell growth and migration in myeloid cells transformed by oncogenic tyrosine kinases

(2010) M M Reddy et al.   LEUKEMIA

Arsenic trioxide and ascorbic acid demonstrate promising activity against primary human CLL cells in vitro

(2010) Sabyasachi Biswas et al.   LEUKEMIA RESEARCH

Cytotoxicity of arsenic trioxide is enhanced by (−)-epigallocatechin-3-gallate via suppression of ferritin in cancer cells

(2010) Te-Chang Lee et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Therapeutic strategies by modulating oxygen stress in cancer and inflammation

(2009) Jun Fang et al.   ADVANCED DRUG DELIVERY REVIEWS

Mammalian Mitochondrial Complex I: Biogenesis, Regulation, and Reactive Oxygen Species Generation

(2009) Werner J.H. Koopman et al.   ANTIOXIDANTS & REDOX SIGNALING

Blockade of the ERK or PI3K–Akt signaling pathway enhances the cytotoxicity of histone deacetylase inhibitors in tumor cells resistant to gefitinib or imatinib

(2009) Kei-ichi Ozaki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ras-induced reactive oxygen species promote growth factor-independent proliferation in human CD34+ hematopoietic progenitor cells

(2009) P. S. Hole et al.   BLOOD

ABT-737, a BH3 mimetic, induces glutathione depletion and oxidative stress

(2009) Adrienne N. Howard et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Selenite is a potent cytotoxic agent for human primary AML cells

(2009) Eric Olm et al.   CANCER LETTERS

Gene Transfer of Inducible Nitric Oxide Synthase Affords Cardioprotection by Upregulating Heme Oxygenase-1 Via a Nuclear Factor-κB-Dependent Pathway

(2009) Qianhong Li et al.   CIRCULATION

Targeting of Hsp32 in Solid Tumors and Leukemias: A Novel Approach to Optimize Anticancer Therapy (Supplementry Material)

(2009) K. Gleixner et al.   CURRENT CANCER DRUG TARGETS

NAD(P)H oxidase isoform Nox2 plays a prosurvival role in human leukaemia cells

(2009) Tullia Maraldi et al.   FREE RADICAL RESEARCH

Downregulation of thec-MYCtarget gene, peroxiredoxin III, contributes to arsenic trioxide-induced apoptosis in acute promyelocytic leukemia

(2009) Pablo E. Vivas-Mejía et al.   INTERNATIONAL JOURNAL OF CANCER

Oxidative Stress Promotes Transcriptional Up-regulation of Fyn in BCR-ABL1-expressing Cells

(2009) Yin Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bcr-Abl-mediated redox regulation of the PI3K/AKT pathway

(2009) R Naughton et al.   LEUKEMIA

The gene encoding thioredoxin-interacting protein (TXNIP) is a frequent virus integration site in virus-induced mouse leukemia and is overexpressed in a subset of AML patients

(2009) Stefan J. Erkeland et al.   LEUKEMIA RESEARCH

Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

(2009) C. Choudhary et al.   SCIENCE

Clinical implications of c-Kit mutations in acute myelogenous leukemia

(2009) Muriel Malaise et al.   Current Hematologic Malignancy Reports

Evolution of Catalases from Bacteria to Humans

(2008) Marcel Zamocky et al.   ANTIOXIDANTS & REDOX SIGNALING

Redox Regulation of Cell Survival

(2008) Dunyaporn Trachootham et al.   ANTIOXIDANTS & REDOX SIGNALING

Kinetic and Thermodynamic Aspects of Cellular Thiol–Disulfide Redox Regulation

(2008) Kristine Steen Jensen et al.   ANTIOXIDANTS & REDOX SIGNALING

BCR-ABL1 mediates up-regulation of Fyn in chronic myelogenous leukemia

(2008) K. Ban et al.   BLOOD

Effective elimination of fludarabine-resistant CLL cells by PEITC through a redox-mediated mechanism

(2008) D. Trachootham et al.   BLOOD

HO-1 underlies resistance of AML cells to TNF-induced apoptosis

(2008) S. A. Rushworth et al.   BLOOD

Internal tandem duplication of FLT3 (FLT3/ITD) induces increased ROS production, DNA damage, and misrepair: implications for poor prognosis in AML

(2008) A. Sallmyr et al.   BLOOD

Nuclear factor-κB as a potential therapeutic target for the novel cytotoxic agent LC-1 in acute myeloid leukaemia

(2008) Christopher Jenkins et al.   BRITISH JOURNAL OF HAEMATOLOGY

Signal cross talks for sustained MAPK activation and cell migration: the potential role of reactive oxygen species

(2008) Wen-Sheng Wu et al.   CANCER AND METASTASIS REVIEWS

Measurement of oxidative stress and antioxidant status in acute lymphoblastic leukemia patients

(2008) Vanessa Battisti et al.   CLINICAL BIOCHEMISTRY

Targeting Ras in Myeloid Leukemias

(2008) B. S. Braun et al.   CLINICAL CANCER RESEARCH

Classical Inhibitors of NOX NAD(P)H Oxidases Are Not Specific

(2008) Elisabetta Aldieri et al.   CURRENT DRUG METABOLISM

Targeting of heat-shock protein 32/heme oxygenase-1 in canine mastocytoma cells is associated with reduced growth and induction of apoptosis

(2008) Emir Hadzijusufovic et al.   EXPERIMENTAL HEMATOLOGY

Inhibition of the thioredoxin system is a basis for the antileukemic potential of 13-hydroxy-15-oxo-zoapatlin

(2008) Patrizia Nigro et al.   FREE RADICAL BIOLOGY AND MEDICINE

Effective killing of Gleevec-resistant CML cells with T315I mutation by a natural compound PEITC through redox-mediated mechanism

(2008) H Zhang et al.   LEUKEMIA

MtDNA mutation associated with mitochondrial dysfunction in megakaryoblastic leukaemic cells

(2008) C Piccoli et al.   LEUKEMIA

Catalase activity and arsenic sensitivity in acute leukemia

(2008) Emma Coe et al.   LEUKEMIA & LYMPHOMA

Tannic acid-induced apoptosis and -enhanced sensitivity to arsenic trioxide in human leukemia HL-60 cells

(2008) Kuo-Shuen Chen et al.   LEUKEMIA RESEARCH

Role of histone deacetylase inhibitor-induced reactive oxygen species and DNA damage in LAQ-824/fludarabine antileukemic interactions

(2008) Roberto R. Rosato et al.   MOLECULAR CANCER THERAPEUTICS

Mammalian Rho GTPases: new insights into their functions from in vivo studies

(2008) Sarah J. Heasman et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Bcl-2 family proteins as regulators of oxidative stress

(2008) Nathan Susnow et al.   SEMINARS IN CANCER BIOLOGY

Therapy-Related Myeloid Leukemia

(2008) Lucy A. Godley et al.   SEMINARS IN ONCOLOGY

Quiescent Human Hematopoietic Stem Cells in the Bone Marrow Niches Organize the Hierarchical Structure of Hematopoiesis

(2008) Takashi Yahata et al.   STEM CELLS

NADPH oxidase-derived reactive oxygen species are responsible for the high susceptibility to arsenic cytotoxicity in acute promyelocytic leukemia cells

(2007) Jie Wang et al.   LEUKEMIA RESEARCH

Potentiation of reactive oxygen species is a marker for synergistic cytotoxicity of MS-275 and 5-azacytidine in leukemic cells

(2007) Shan Gao et al.   LEUKEMIA RESEARCH