Rac2-MRC-cIII-generated ROS cause genomic instability in chronic myeloid leukemia stem cells and primitive progenitors

Rac GTPases in Human Diseases

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Persistence of leukemia stem cells in chronic myelogenous leukemia patients in prolonged remission with imatinib treatment

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Hallmarks of Cancer: The Next Generation

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Exploiting Mitochondrial Dysfunction for Effective Elimination of Imatinib-Resistant Leukemic Cells

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Rac2 GTPase deficiency depletes BCR-ABL+ leukemic stem cells and progenitors in vivo

(2010) A. Sengupta et al.   BLOOD

BCR/ABL Stimulates WRN to Promote Survival and Genomic Instability

(2010) A. Slupianek et al.   CANCER RESEARCH

The Distinct Metabolic Profile of Hematopoietic Stem Cells Reflects Their Location in a Hypoxic Niche

(2010) Tugba Simsek et al.   Cell Stem Cell

Chronic myeloid leukemia: mechanisms of blastic transformation

(2010) Danilo Perrotti et al.   JOURNAL OF CLINICAL INVESTIGATION

Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity

(2010) Amie S. Corbin et al.   JOURNAL OF CLINICAL INVESTIGATION

Insights into the stem cells of chronic myeloid leukemia

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TGF-β–FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia

(2010) Kazuhito Naka et al.   NATURE

Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans

(2009) Ethan J. Anderson et al.   JOURNAL OF CLINICAL INVESTIGATION

Similar patterns of chromosome abnormalities in CML occur in addition to the Philadelphia chromosome with or without tyrosine kinase inhibitor treatment

(2009) C Haferlach et al.   LEUKEMIA

Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth

(2009) T. Hitosugi et al.   Science Signaling

Internal tandem duplication of FLT3 (FLT3/ITD) induces increased ROS production, DNA damage, and misrepair: implications for poor prognosis in AML

(2008) A. Sallmyr et al.   BLOOD

Effects of Dasatinib on Src Kinase Activity and Downstream Intracellular Signaling in Primitive Chronic Myelogenous Leukemia Hematopoietic Cells

(2008) H. Konig et al.   CANCER RESEARCH

Superoxide Flashes in Single Mitochondria

(2008) Wang Wang et al.   CELL

Early mitochondrial dysfunction in electron transfer activity and reactive oxygen species generation after cardiac arrest

(2008) Fei Han et al.   CRITICAL CARE MEDICINE

BCR/ABL promotes accumulation of chromosomal aberrations induced by oxidative and genotoxic stress

(2008) M Koptyra et al.   LEUKEMIA

Inhibition of mitochondrial metabolism by methyl-2-cyano-3,12-dioxooleana-1,9-diene-28-oate induces apoptotic or autophagic cell death in chronic myeloid leukemia cells

(2008) I. Samudio et al.   MOLECULAR CANCER THERAPEUTICS