Sweet Mitochondria: A Shortcut to Alzheimer’s Disease

Brain functional alterations in Type 2 Diabetes – A systematic review of fMRI studies

(2017) Helen Macpherson et al.   FRONTIERS IN NEUROENDOCRINOLOGY

NMR-based metabolomics reveals brain region-specific metabolic alterations in streptozotocin-induced diabetic rats with cognitive dysfunction

(2017) Hong Zheng et al.   METABOLIC BRAIN DISEASE

Brain GLP-1/IGF-1 Signaling and Autophagy Mediate Exendin-4 Protection Against Apoptosis in Type 2 Diabetic Rats

(2017) Emanuel Candeias et al.   MOLECULAR NEUROBIOLOGY

Uncoupling Protein 2 Inhibition Exacerbates Glucose Fluctuation-Mediated Neuronal Effects

(2017) Susana Cardoso et al.   NEUROTOXICITY RESEARCH

Hydrogen sulfide ameliorates cognitive dysfunction in streptozotocin-induced diabetic rats: involving suppression in hippocampal endoplasmic reticulum stress

(2017) Wei Zou et al.   Oncotarget

A Multi-Center Randomized Proof-of-Concept Clinical Trial Applying [18F]FDG-PET for Evaluation of Metabolic Therapy with Rosiglitazone XR in Mild to Moderate Alzheimer's Disease

(2017) Sofia Tzimopoulou et al.   JOURNAL OF ALZHEIMERS DISEASE

Long-term treatment with intranasal insulin ameliorates cognitive impairment, tau hyperphosphorylation and microglial activation in a streptozotocin-induced Alzheimer’s rat model

(2017) Zhangyu Guo et al.   Scientific Reports

Mitochondrial traffic jams in Alzheimer's disease - pinpointing the roadblocks

(2016) Sónia C. Correia et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Alzheimer's Disease: From Mitochondrial Perturbations to Mitochondrial Medicine

(2016) Susana Cardoso et al.   BRAIN PATHOLOGY

Mitochondria as a target for neuroprotection: implications for Alzheimer´s disease

(2016) Susana Cardoso et al.   Expert Review of Neurotherapeutics

Humans with Type-2 Diabetes Show Abnormal Long-Term Potentiation-Like Cortical Plasticity Associated with Verbal Learning Deficits

(2016) Peter J. Fried et al.   JOURNAL OF ALZHEIMERS DISEASE

Mitochondrial dysfunction precedes depression of AMPK/AKT signaling in insulin resistance induced by high glucose in primary cortical neurons

(2016) Yunhua Peng et al.   JOURNAL OF NEUROCHEMISTRY

Exendin-4 reduces tau hyperphosphorylation in type 2 diabetic rats via increasing brain insulin level

(2016) Yan Yang et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Elevated glucose and oligomeric β-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation

(2016) Mohd Waseem Akhtar et al.   Nature Communications

Chronic hyperglycemia induced via the heterozygous knockout of Pdx1 worsens neuropathological lesion in an Alzheimer mouse model

(2016) Chuang Guo et al.   Scientific Reports

In Alzheimer’s Disease, 6-Month Treatment with GLP-1 Analog Prevents Decline of Brain Glucose Metabolism: Randomized, Placebo-Controlled, Double-Blind Clinical Trial

(2016) Michael Gejl et al.   Frontiers in Aging Neuroscience

Mitochondria as a target for neuroprotection: implications for Alzheimer´s disease

(2016) Susana Cardoso et al.   Expert Review of Neurotherapeutics

Alzheimer's disease and type 2 diabetes-related alterations in brain mitochondria, autophagy and synaptic markers

(2015) Cristina Carvalho et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

High-fat diet-induced deregulation of hippocampal insulin signaling and mitochondrial homeostasis deficiences contribute to Alzheimer disease pathology in rodents

(2015) Dmitry Petrov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Increased Oxidative Stress and Mitochondrial Dysfunction in Zucker Diabetic Rat Liver and Brain

(2015) Haider Raza et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Mitochondrial Deficits Accompany Cognitive Decline Following Single Bilateral Intracerebroventricular Streptozotocin

(2015) Ramesh Paidi et al.   Current Alzheimer Research

Clinically Relevant Cognitive Impairment in Middle-Aged Adults With Childhood-Onset Type 1 Diabetes

(2015) Karen A. Nunley et al.   DIABETES CARE

Risk of dementia in patients hospitalised with type 1 and type 2 diabetes in England, 1998–2011: a retrospective national record linkage cohort study

(2015) Kate Smolina et al.   DIABETOLOGIA

Exenatide reduces TNF-α expression and improves hippocampal neuron numbers and memory in streptozotocin treated rats

(2015) Volkan Solmaz et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Exendin-4, a Glucagon-Like Peptide-1 Receptor Agonist, Reduces Alzheimer Disease-Associated Tau Hyperphosphorylation in the Hippocampus of Rats With Type 2 Diabetes

(2015) Weijie Xu et al.   JOURNAL OF INVESTIGATIVE MEDICINE

The Impact of Diabetes on Cerebral Structure and Function

(2015) Elizabeth R. Seaquist   PSYCHOSOMATIC MEDICINE

Insulin therapy modulates mitochondrial dynamics and biogenesis, autophagy and tau protein phosphorylation in the brain of type 1 diabetic rats

(2014) R.X. Santos et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

AMPK at the Nexus of Energetics and Aging

(2014) Kristopher Burkewitz et al.   Cell Metabolism

Metabolic effects of resveratrol: addressing the controversies

(2014) Jacob L. Bitterman et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Vascular, Oxidative, and Synaptosomal Abnormalities During Aging and the Progression of Type 2 Diabetes

(2014) Cristina Carvalho et al.   CURRENT NEUROVASCULAR RESEARCH

Inflammation, Defective Insulin Signaling, and Mitochondrial Dysfunction as Common Molecular Denominators Connecting Type 2 Diabetes to Alzheimer Disease

(2014) F. G. De Felice et al.   DIABETES

Drp1-Mediated Mitochondrial Abnormalities Link to Synaptic Injury in Diabetes Model

(2014) Shengbin Huang et al.   DIABETES

Ventral Striatum, but Not Cortical Volume Loss, Is Related to Cognitive Dysfunction in Type 1 Diabetic Patients With and Without Microangiopathy

(2014) Eelco van Duinkerken et al.   DIABETES CARE

Peroxisome Proliferator-Activated Receptor-Gamma Agonists for Alzheimer’s Disease and Amnestic Mild Cognitive Impairment: A Systematic Review and Meta-Analysis

(2014) Jia Liu et al.   DRUGS & AGING

Perspectives on mitochondrial uncoupling proteins-mediated neuroprotection

(2014) Susana Cardoso et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Pioglitazone ameliorates memory deficits in streptozotocin-induced diabetic mice by reducing brain β-amyloid through PPARγ activation

(2013) Li-ping Liu et al.   ACTA PHARMACOLOGICA SINICA

Geniposide Ameliorates Learning Memory Deficits, Reduces Tau Phosphorylation and Decreases Apoptosis via GSK3β Pathway in Streptozotocin-Induced Alzheimer Rat Model

(2013) Chong Gao et al.   BRAIN PATHOLOGY

Mitochondrial Abnormalities in a Streptozotocin-Induced Rat Model of Sporadic Alzheimer's Disease

(2013) Sonia C. Correia et al.   Current Alzheimer Research

Hyperglycemia, Hypoglycemia and Dementia: Role of Mitochondria and Uncoupling Proteins

(2013) S. Cardoso et al.   CURRENT MOLECULAR MEDICINE

UCP2 and ANT differently modulate proton-leak in brain mitochondria of long-term hyperglycemic and recurrent hypoglycemic rats

(2013) Susana Cardoso et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

DPP-4 inhibitors improve cognition and brain mitochondrial function of insulin-resistant rats

(2013) Hiranya Pintana et al.   JOURNAL OF ENDOCRINOLOGY

Mechanisms of Diabetic Complications

(2013) Josephine M. Forbes et al.   PHYSIOLOGICAL REVIEWS

Presynaptic mitochondrial morphology in monkey prefrontal cortex correlates with working memory and is improved with estrogen treatment

(2013) Y. Hara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diabetes exacerbates amyloid and neurovascular pathology in aging-accelerated mice

(2012) Antonio Currais et al.   AGING CELL

Parkinson's disease, insulin resistance and novel agents of neuroprotection

(2012) Iciar Aviles-Olmos et al.   BRAIN

Metabolic Alterations Induced by Sucrose Intake and Alzheimer’s Disease Promote Similar Brain Mitochondrial Abnormalities

(2012) Cristina Carvalho et al.   DIABETES

An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers

(2012) Theresa R. Bomfim et al.   JOURNAL OF CLINICAL INVESTIGATION

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

Effects of metformin on learning and memory behaviors and brain mitochondrial functions in high fat diet induced insulin resistant rats

(2012) Hiranya Pintana et al.   LIFE SCIENCES

Insulin-induced recurrent hypoglycemia exacerbates diabetic brain mitochondrial dysfunction and oxidative imbalance

(2012) Susana Cardoso et al.   NEUROBIOLOGY OF DISEASE

Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis

(2012) D. Sebastian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intranasal Insulin Therapy for Alzheimer Disease and Amnestic Mild Cognitive Impairment

(2011) Suzanne Craft   ARCHIVES OF NEUROLOGY

Effects of streptozotocin-induced diabetes on tau phosphorylation in the rat brain

(2011) Zhongsen Qu et al.   BRAIN RESEARCH

Type 2 Diabetes and Late-Onset Alzheimer’s Disease

(2011) D. Cheng et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Cerebral amyloid angiopathy in streptozotocin rat model of sporadic Alzheimer’s disease: a long-term follow up study

(2011) Melita Salkovic-Petrisic et al.   JOURNAL OF NEURAL TRANSMISSION

Recurrent Hypoglycemia Exacerbates Cerebral Ischemic Damage in Streptozotocin-Induced Diabetic Rats

(2011) Kunjan R. Dave et al.   STROKE

Cortical and hippocampal mitochondria bioenergetics and oxidative status during hyperglycemia and/or insulin-induced hypoglycemia

(2010) Susana Cardoso et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Diabetes, Alzheimer disease, and vascular dementia: A population-based neuropathologic study

(2010) S. Ahtiluoto et al.   NEUROLOGY

Impact of STZ-induced hyperglycemia and insulin-induced hypoglycemia in plasma amino acids and cortical synaptosomal neurotransmitters

(2010) Susana Cardoso et al.   SYNAPSE

Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology

(2009) Paula I. Moreira et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Contribution of Impaired Myocardial Insulin Signaling to Mitochondrial Dysfunction and Oxidative Stress in the Heart

(2009) Sihem Boudina et al.   CIRCULATION

Prolonged Exposure to Insulin Suppresses Mitochondrial Production in Primary Hepatocytes

(2009) Hui-Yu Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insulin Signaling Regulates Mitochondrial Function in Pancreatic β-Cells

(2009) Siming Liu et al.   PLoS One

Glucose Homeostasis in Huntington Disease

(2008) Nebojša M. Lalić et al.   ARCHIVES OF NEUROLOGY

Enhanced Risk for Alzheimer Disease in Persons With Type 2 Diabetes and APOE ε4

(2008) Fumiko Irie et al.   ARCHIVES OF NEUROLOGY

Type 2 diabetes mellitus, hypertension, dyslipidemia and obesity: A systematic comparison of their impact on cognition

(2008) Esther van den Berg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mid- and Late-Life Diabetes in Relation to the Risk of Dementia: A Population-Based Twin Study

(2008) W. Xu et al.   DIABETES

Investigation on the relationship between diabetes mellitus type 2 and cognitive impairment

(2008) S.A. Ebady et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Molecular Bases of Caloric Restriction Regulation of Neuronal Synaptic Plasticity

(2008) Ángela Fontán-Lozano et al.   MOLECULAR NEUROBIOLOGY

Vascular risk factors and dementia in the general population aged >85 years

(2008) Sari Rastas et al.   NEUROBIOLOGY OF AGING

Mitochondria in Neuroplasticity and Neurological Disorders

(2008) Mark P. Mattson et al.   NEURON

Effects of prior hypoglycemia and hyperglycemia on cognition in children with type 1 diabetes mellitus

(2008) Dana C Perantie et al.   PEDIATRIC DIABETES