Perspectives on mitochondrial uncoupling proteins-mediated neuroprotection

How the mitochondrion was shaped by radical differences in substrates

(2014) Dave Speijer   BIOESSAYS

Mitochondrial respiration as a target for neuroprotection and cognitive enhancement

(2013) F. Gonzalez-Lima et al.   BIOCHEMICAL PHARMACOLOGY

UCP2, a mitochondrial protein regulated at multiple levels

(2013) Massimo Donadelli et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

UCP2 and ANT differently modulate proton-leak in brain mitochondria of long-term hyperglycemic and recurrent hypoglycemic rats

(2013) Susana Cardoso et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

A microRNA-30e/mitochondrial uncoupling protein 2 axis mediates TGF-β1-induced tubular epithelial cell extracellular matrix production and kidney fibrosis

(2013) Lei Jiang et al.   KIDNEY INTERNATIONAL

UCP2 overexpression worsens mitochondrial dysfunction and accelerates disease progression in a mouse model of amyotrophic lateral sclerosis

(2013) Pablo M. Peixoto et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Uncoupling protein 2 deficiency aggravates astrocytic endoplasmic reticulum stress and nod-like receptor protein 3 inflammasome activation

(2013) Ming Lu et al.   NEUROBIOLOGY OF AGING

Unearthing the secrets of mitochondrial ROS and glutathione in bioenergetics

(2013) Ryan J. Mailloux et al.   TRENDS IN BIOCHEMICAL SCIENCES

The Neuroprotection of Hydrogen Sulfide Against MPTP-Induced Dopaminergic Neuron Degeneration Involves Uncoupling Protein 2 Rather Than ATP-Sensitive Potassium Channels

(2012) Ming Lu et al.   ANTIOXIDANTS & REDOX SIGNALING

Toward Understanding the Mechanism of Ion Transport Activity of Neuronal Uncoupling Proteins UCP2, UCP4, and UCP5

(2012) Tuan Hoang et al.   BIOCHEMISTRY

Mitochondria-targeted antioxidants and metabolic modulators as pharmacological interventions to slow ageing

(2012) Jan Gruber et al.   BIOTECHNOLOGY ADVANCES

Altered gene expression profiles in the hippocampus and prefrontal cortex of type 2 diabetic rats

(2012) Omar Abdul-Rahman et al.   BMC GENOMICS

UCP4 is a target effector of the NF-κB c-Rel prosurvival pathway against oxidative stress

(2012) Jessica Wing-Man Ho et al.   FREE RADICAL BIOLOGY AND MEDICINE

Glutathionylation State of Uncoupling Protein-2 and the Control of Glucose-stimulated Insulin Secretion

(2012) Ryan J. Mailloux et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondria targeted therapeutic approaches in Parkinson's and Huntington's diseases

(2012) Rajnish K. Chaturvedi et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Upregulation of UCP2 by Adiponectin: The Involvement of Mitochondrial Superoxide and hnRNP K

(2012) Mingyan Zhou et al.   PLoS One

Uncoupling Protein-4 (UCP4) Increases ATP Supply by Interacting with Mitochondrial Complex II in Neuroblastoma Cells

(2012) Philip Wing-Lok Ho et al.   PLoS One

Ucp2 Induced by Natural Birth Regulates Neuronal Differentiation of the Hippocampus and Related Adult Behavior

(2012) Julia Simon-Areces et al.   PLoS One

Mitochondrial proticity and ROS signaling: lessons from the uncoupling proteins

(2012) Ryan J. Mailloux et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Human neuronal uncoupling proteins 4 and 5 (UCP4 and UCP5): structural properties, regulation, and physiological role in protection against oxidative stress and mitochondrial dysfunction

(2012) David B. Ramsden et al.   Brain and Behavior

A/ASP/VAL allele combination of IGF1R, IRS2, and UCP2 genes is associated with better metabolic profile, preserved energy expenditure parameters, and low mortality rate in longevity

(2011) Michelangela Barbieri et al.   AGE

Caenorhabditis elegansUCP4 Protein Controls Complex II-mediated Oxidative Phosphorylation through Succinate Transport

(2011) Matthew Pfeiffer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Whole genome siRNA cell-based screen links mitochondria to Akt signaling network through uncoupling of electron transport chain

(2011) William T. Senapedis et al.   MOLECULAR BIOLOGY OF THE CELL

Uncoupling protein 2 knockout exacerbates depression-like behaviors in mice via enhancing inflammatory response

(2011) X.-L. Sun et al.   NEUROSCIENCE

The Regulation and Physiology of Mitochondrial Proton Leak

(2011) Ajit S. Divakaruni et al.   PHYSIOLOGY

Further Support to the Uncoupling-to-Survive Theory: The Genetic Variation of Human UCP Genes Is Associated with Longevity

(2011) Giuseppina Rose et al.   PLoS One

Mitochondrial uncoupling protein 2 (UCP2) in glucose and lipid metabolism

(2011) Sabrina Diano et al.   TRENDS IN MOLECULAR MEDICINE

Mitochondrial proton and electron leaks

(2010) Martin Jastroch et al.   Essays in Biochemistry

Mitochondrial UCP5 is neuroprotective by preserving mitochondrial membrane potential, ATP levels, and reducing oxidative stress in MPP+ and dopamine toxicity

(2010) Ken Hon-Hung Kwok et al.   FREE RADICAL BIOLOGY AND MEDICINE

Metabolic Depression and Increased Reactive Oxygen Species Production by Isolated Mitochondria at Moderately Lower Temperatures

(2010) Sameh S. Ali et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of calcium/calmodulin-dependent protein kinase IV and peroxisome proliferator-activated receptor γ coactivator-1α signaling pathway protects against neuronal injury and promotes mitochondrial biogenesis in the hippocampal CA1 subfield after tra

(2010) Shang-Der Chen et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Mosaic origin of the mitochondrial proteome

(2010) Radek Szklarczyk et al.   PROTEOMICS

Effects of long-term calorie restriction and endurance exercise on glucose tolerance, insulin action, and adipokine production

(2009) Luigi Fontana et al.   AGE

Compromised respiratory adaptation and thermoregulation in aging and age-related diseases

(2009) Sic L. Chan et al.   AGEING RESEARCH REVIEWS

Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity

(2009) Ludmila Pawlikowska et al.   AGING CELL

Coupled with uncouplers: the curious case of lifespan

(2009) Sarah Haas Lockie et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Uncoupling protein-2 regulates lifespan in mice

(2009) Zane B. Andrews et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Uncoupling proteins: A complex journey to function discovery

(2009) Federica Cioffi et al.   BIOFACTORS

Resveratrol pretreatment protects rat brain from cerebral ischemic damage via a sirtuin 1–uncoupling protein 2 pathway

(2009) D. Della-Morte et al.   NEUROSCIENCE

The Brain Uncoupling Protein UCP4 Attenuates Mitochondrial Toxin-Induced Cell Death: Role of Extracellular Signal-Regulated Kinases in Bioenergetics Adaptation and Cell Survival

(2009) Zelan Wei et al.   NEUROTOXICITY RESEARCH

The role of mitochondrial uncoupling proteins in lifespan

(2009) Marcelo O. Dietrich et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Mild mitochondrial uncoupling in mice affects energy metabolism, redox balance and longevity

(2008) Camille C. Caldeira da Silva et al.   AGING CELL

Characterization of survival and phenotype throughout the life span in UCP2/UCP3 genetically altered mice

(2008) Roger B. McDonald et al.   EXPERIMENTAL GERONTOLOGY

Sex-dependent differences in aged rat brain mitochondrial function and oxidative stress

(2008) Rocío Guevara et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial UCP4 attenuates MPP+- and dopamine-induced oxidative stress, mitochondrial depolarization, and ATP deficiency in neurons and is interlinked with UCP2 expression

(2008) Andrew Chi-Yuen Chu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Insulin-Like Signaling, Nutrient Homeostasis, and Life Span

(2007) Akiko Taguchi et al.   Annual Review of Physiology

Uncoupling protein-2 accumulates rapidly in the inner mitochondrial membrane during mitochondrial reactive oxygen stress in macrophages

(2007) Tindaro M. Giardina et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

BMCP1: a mitochondrial uncoupling protein in neurons which regulates mitochondrial function and oxidant production

(2003) Jeong Sook Kim-Han et al.   JOURNAL OF NEUROCHEMISTRY