Alzheimer's Disease: From Mitochondrial Perturbations to Mitochondrial Medicine

From Aging to Alzheimer's Disease: Unveiling “The Switch” with the Senescence-Accelerated Mouse Model (SAMP8)

(2017) Merce Pallas et al.   JOURNAL OF ALZHEIMERS DISEASE

Antioxidants in Central Nervous System Diseases: Preclinical Promise and Translational Challenges

(2017) Chandrashekhar D. Kamat et al.   JOURNAL OF ALZHEIMERS DISEASE

The Neurodegenerative Mitochondriopathies

(2017) Russell H. Swerdlow   JOURNAL OF ALZHEIMERS DISEASE

Exercise Plays a Preventive Role Against Alzheimer's Disease

(2017) Zsolt Radak et al.   JOURNAL OF ALZHEIMERS DISEASE

Mitochondrial Amyloid-β Levels are Associated with the Extent of Mitochondrial Dysfunction in Different Brain Regions and the Degree of Cognitive Impairment in Alzheimer's Transgenic Mice

(2017) Natasa Dragicevic et al.   JOURNAL OF ALZHEIMERS DISEASE

The Alzheimer's Disease Mitochondrial Cascade Hypothesis

(2017) Russell H. Swerdlow et al.   JOURNAL OF ALZHEIMERS DISEASE

Mitochondria-Targeted Antioxidants Protect Against Amyloid-β Toxicity in Alzheimer's Disease Neurons

(2017) Maria Manczak et al.   JOURNAL OF ALZHEIMERS DISEASE

Exercise as a pro-cognitive, pro-neurogenic and anti-inflammatory intervention in transgenic mouse models of Alzheimer’s disease

(2016) Sinéad M. Ryan et al.   AGEING RESEARCH REVIEWS

Opportunities and challenges in developing relevant animal models for Alzheimer’s disease

(2016) Fernanda G. De Felice et al.   AGEING RESEARCH REVIEWS

Can ketones compensate for deteriorating brain glucose uptake during aging? Implications for the risk and treatment of Alzheimer's disease

(2016) Stephen C. Cunnane et al.   Annals of the New York Academy of Sciences

Dietary DHA supplementation causes selective changes in phospholipids from different brain regions in both wild type mice and the Tg2576 mouse model of Alzheimer's disease

(2016) Cécile Bascoul-Colombo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Neuroprotective Role of Nanoparticles Against Alzheimer';s Disease

(2016) Magisetty Obulesu et al.   CURRENT DRUG METABOLISM

Alzheimer's Disease Risk and Progression: The Role of Nutritional Supplements and their Effect on Drug Therapy Outcome

(2016) A. Giulietti et al.   Current Neuropharmacology

Progress in drug development for Alzheimer's disease: An overview in relation to mitochondrial energy metabolism

(2016) Jana Hroudová et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Altered brain energetics induces mitochondrial fission arrest in Alzheimer’s Disease

(2016) Liang Zhang et al.   Scientific Reports

Glucose deprivation increases tau phosphorylation via P38 mitogen-activated protein kinase

(2015) Elisabetta Lauretti et al.   AGING CELL

Alzheimer's disease and type 2 diabetes-related alterations in brain mitochondria, autophagy and synaptic markers

(2015) Cristina Carvalho et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mitochondrial quality control: Easy come, easy go

(2015) Aleksandr Stotland et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mitochondrial dysfunction: the missing link between aging and sporadic Alzheimer’s disease

(2015) Amandine Grimm et al.   BIOGERONTOLOGY

UCP2 protects against amyloid beta toxicity and oxidative stress in primary neuronal culture

(2015) Zhang Jun et al.   BIOMEDICINE & PHARMACOTHERAPY

Alzheimer's Disease-Related Misfolded Proteins and Dysfunctional Organelles on Autophagy Menu

(2015) Sónia C. Correia et al.   DNA AND CELL BIOLOGY

Masitinib for the treatment of mild to moderate Alzheimer’s disease

(2015) Jaume Folch et al.   Expert Review of Neurotherapeutics

The role of mitochondrial disturbances in Alzheimer, Parkinson and Huntington diseases

(2015) Cristina Carvalho et al.   Expert Review of Neurotherapeutics

Alzheimer’s Disease: Mechanism and Approach to Cell Therapy

(2015) Takashi Amemori et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Loss of mitofusin 2 links beta-amyloid-mediated mitochondrial fragmentation and Cdk5-induced oxidative stress in neuron cells

(2015) Junghyung Park et al.   JOURNAL OF NEUROCHEMISTRY

The case for rejecting the amyloid cascade hypothesis

(2015) Karl Herrup   NATURE NEUROSCIENCE

Neural stem cell transplantation enhances mitochondrial biogenesis in a transgenic mouse model of Alzheimer's disease–like pathology

(2015) Wei Zhang et al.   NEUROBIOLOGY OF AGING

A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease

(2015) R. Scott Turner et al.   NEUROLOGY

Physical exercise improves brain cortex and cerebellum mitochondrial bioenergetics and alters apoptotic, dynamic and auto(mito)phagy markers

(2015) I. Marques-Aleixo et al.   NEUROSCIENCE

Masitinib for the treatment of mild to moderate Alzheimer’s disease

(2015) Jaume Folch et al.   Expert Review of Neurotherapeutics

The role of mitochondrial disturbances in Alzheimer, Parkinson and Huntington diseases

(2015) Cristina Carvalho et al.   Expert Review of Neurotherapeutics

Neurodegenerative lysosomal disorders: A continuum from development to late age

(2014) Ralph A. Nixon et al.   Autophagy

Mitochondrial import and degradation of amyloid-β peptide

(2014) Catarina Moreira Pinho et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

CR6-interacting factor 1 is a key regulator in Aβ-induced mitochondrial disruption and pathogenesis of Alzheimer’s disease

(2014) J Byun et al.   CELL DEATH AND DIFFERENTIATION

Calorie Restriction and Dietary Restriction Mimetics: A Strategy for Improving Healthy Aging and Longevity

(2014) Gabriella Testa et al.   CURRENT PHARMACEUTICAL DESIGN

PGC-1α overexpression exacerbates β-amyloid and tau deposition in a transgenic mouse model of Alzheimer's disease

(2014) Magali Dumont et al.   FASEB JOURNAL

The mitochondria-targeted antioxidant MitoQ extends lifespan and improves healthspan of a transgenic Caenorhabditis elegans model of Alzheimer disease

(2014) Li Fang Ng et al.   FREE RADICAL BIOLOGY AND MEDICINE

Caloric Restriction Impedes Age-Related Decline of Mitochondrial Function and Neuronal Activity

(2014) Ai-Ling Lin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Axonal Transport Defects in Alzheimer’s Disease

(2014) Zi-Xuan Wang et al.   MOLECULAR NEUROBIOLOGY

Neural Stem Cell Transplants Improve Cognitive Function Without Altering Amyloid Pathology in an APP/PS1 Double Transgenic Model of Alzheimer’s Disease

(2014) Wei Zhang et al.   MOLECULAR NEUROBIOLOGY

Mitochondria-targeting particles

(2014) Amaraporn Wongrakpanich et al.   Nanomedicine

Mitochondrial form and function

(2014) Jonathan R. Friedman et al.   NATURE

Disturbed mitochondrial dynamics and neurodegenerative disorders

(2014) Florence Burté et al.   Nature Reviews Neurology

Dietary restriction in cerebral bioenergetics and redox state

(2014) Ignacio Amigo et al.   Redox Biology

On the origin of Alzheimer's disease. Trials and tribulations of the amyloid hypothesis

(2013) Michael A. Castello et al.   AGEING RESEARCH REVIEWS

The global prevalence of dementia: A systematic review and metaanalysis

(2013) Martin Prince et al.   Alzheimers & Dementia

The Alzheimer's disease mitochondrial cascade hypothesis: Progress and perspectives

(2013) Russell H. Swerdlow et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Oxidative stress and mitochondrial dysfunction in Alzheimer's disease

(2013) Xinglong Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Inhibition of ERK-DLP1 signaling and mitochondrial division alleviates mitochondrial dysfunction in Alzheimer's disease cybrid cell

(2013) Xueqi Gan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Alzheimer’s as a metabolic disease

(2013) Lloyd A. Demetrius et al.   BIOGERONTOLOGY

Bioenergetic flux, mitochondrial mass and mitochondrial morphology dynamics in AD and MCI cybrid cell lines

(2013) D. F. Silva et al.   HUMAN MOLECULAR GENETICS

Resveratrol Induces a Mitochondrial Complex I-dependent Increase in NADH Oxidation Responsible for Sirtuin Activation in Liver Cells

(2013) Valérie Desquiret-Dumas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pharmacological approaches to restore mitochondrial function

(2013) Pénélope A. Andreux et al.   NATURE REVIEWS DRUG DISCOVERY

Axonal transport deficits and neurodegenerative diseases

(2013) Stéphanie Millecamps et al.   NATURE REVIEWS NEUROSCIENCE

Inhibition of mitochondrial fission attenuates Aβ-induced microglia apoptosis

(2013) N. Xie et al.   NEUROSCIENCE

Rapamycin Attenuates the Progression of Tau Pathology in P301S Tau Transgenic Mice

(2013) Sefika Ozcelik et al.   PLoS One

Does exercise reduce brain oxidative stress? A systematic review

(2013) D. Camiletti-Moirón et al.   SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS

Neuropathological Alterations in Alzheimer Disease

(2013) A. Serrano-Pozo et al.   Cold Spring Harbor Perspectives in Medicine

Mitochondrion-Derived Reactive Oxygen Species Lead to Enhanced Amyloid Beta Formation

(2012) Kristina Leuner et al.   ANTIOXIDANTS & REDOX SIGNALING

Inhibition of amyloid-beta peptide aggregation rescues the autophagic deficits in the TgCRND8 mouse model of Alzheimer disease

(2012) Aaron Y. Lai et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

An inverse-Warburg effect and the origin of Alzheimer’s disease

(2012) Lloyd A. Demetrius et al.   BIOGERONTOLOGY

CRIF1 Is Essential for the Synthesis and Insertion of Oxidative Phosphorylation Polypeptides in the Mammalian Mitochondrial Membrane

(2012) Soung Jung Kim et al.   Cell Metabolism

Metabolic Alterations Induced by Sucrose Intake and Alzheimer’s Disease Promote Similar Brain Mitochondrial Abnormalities

(2012) Cristina Carvalho et al.   DIABETES

Mitochondrial quality control: a matter of life and death for neurons

(2012) Elena I Rugarli et al.   EMBO JOURNAL

Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer's disease

(2012) M. Manczak et al.   HUMAN MOLECULAR GENETICS

The axonal transport of mitochondria

(2012) W. M. Saxton et al.   JOURNAL OF CELL SCIENCE

Role of mitochondrial homeostasis and dynamics in Alzheimer's disease

(2012) J. Eva Selfridge et al.   NEUROBIOLOGY OF DISEASE

Elevated Oxidative Stress and Decreased Antioxidant Function in the Human Hippocampus and Frontal Cortex with Increasing Age: Implications for Neurodegeneration in Alzheimer’s Disease

(2012) C. Venkateshappa et al.   NEUROCHEMICAL RESEARCH

Engineering of blended nanoparticle platform for delivery of mitochondria-acting therapeutics

(2012) S. Marrache et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Physical exercise as a possible strategy for brain protection: Evidence from mitochondrial-mediated mechanisms

(2012) Inês Marques-Aleixo et al.   PROGRESS IN NEUROBIOLOGY

Neurodegeneration as a consequence of failed mitochondrial maintenance

(2011) Mariusz Karbowski et al.   ACTA NEUROPATHOLOGICA

Insights into Mitochondrial Dysfunction: Aging, Amyloid-β, and Tau–A Deleterious Trio

(2011) Karen Schmitt et al.   ANTIOXIDANTS & REDOX SIGNALING

Therapeutic effects of remediating autophagy failure in a mouse model of Alzheimer disease by enhancing lysosomal proteolysis

(2011) Dun-Sheng Yang et al.   Autophagy

Amyloid beta impairs mitochondrial anterograde transport and degenerates synapses in Alzheimer's disease neurons

(2011) Marcus J. Calkins et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Brain aging, Alzheimer's disease, and mitochondria

(2011) Russell H. Swerdlow   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Abnormal mitochondrial dynamics and synaptic degeneration as early events in Alzheimer's disease: Implications to mitochondria-targeted antioxidant therapeutics

(2011) P. Hemachandra Reddy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Antioxidant clinical trials in mild cognitive impairment and Alzheimer's disease

(2011) Patrizia Mecocci et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Role of Sirtuins and Calorie Restriction in Neuroprotection: Implications in Alzheimers and Parkinsons Diseases

(2011) Sarika Srivastava et al.   CURRENT PHARMACEUTICAL DESIGN

Principles and Therapeutic Relevance for Targeting Mitochondria in Aging and Neurodegenerative Diseases

(2011) Gaetano Serviddio et al.   CURRENT PHARMACEUTICAL DESIGN

Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage

(2011) Maria Manczak et al.   HUMAN MOLECULAR GENETICS

Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease

(2011) M. J. Calkins et al.   HUMAN MOLECULAR GENETICS

Exercise training increases mitochondrial biogenesis in the brain

(2011) Jennifer L. Steiner et al.   JOURNAL OF APPLIED PHYSIOLOGY

Effects of rapamycin and TOR on aging and memory: implications for Alzheimer’s disease

(2011) Renato X. Santos et al.   JOURNAL OF NEUROCHEMISTRY

Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimer’s disease

(2011) Baiyang Sheng et al.   JOURNAL OF NEUROCHEMISTRY

The Mitochondria-Targeted Antioxidant MitoQ Prevents Loss of Spatial Memory Retention and Early Neuropathology in a Transgenic Mouse Model of Alzheimer's Disease

(2011) M. J. McManus et al.   JOURNAL OF NEUROSCIENCE

Coenzyme Q10 protects against amyloid beta-induced neuronal cell death by inhibiting oxidative stress and activating the P13K pathway

(2011) Hojin Choi et al.   NEUROTOXICOLOGY

Inducing Autophagy by Rapamycin Before, but Not After, the Formation of Plaques and Tangles Ameliorates Cognitive Deficits

(2011) Smita Majumder et al.   PLoS One

2-Deoxy-D-Glucose Treatment Induces Ketogenesis, Sustains Mitochondrial Function, and Reduces Pathology in Female Mouse Model of Alzheimer's Disease

(2011) Jia Yao et al.   PLoS One

The future of Alzheimer's disease: The next 10 years

(2011) Harald Hampel et al.   PROGRESS IN NEUROBIOLOGY

Development of Mitochondria-targeted Aromatic-cationic Peptides for Neurodegenerative Diseases

(2010) Hazel H. Szeto   Annals of the New York Academy of Sciences

Calorie restriction: what recent results suggest for the future of ageing research

(2010) Daniel L. Smith et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Novel synthetic small-molecule activators of AMPK as enhancers of autophagy and amyloid-β peptide degradation

(2010) Valérie Vingtdeux et al.   FASEB JOURNAL

Comparative Studies of Oxidative Stress and Mitochondrial Function in Aging

(2010) Y. Shi et al.   INTEGRATIVE AND COMPARATIVE BIOLOGY

The combination of exercise training and α-lipoic acid treatment has therapeutic effects on the pathogenic phenotypes of Alzheimer's disease in NSE/APPsw-transgenic mice

(2010) Cho   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Current Challenges for the Early Detection of Alzheimer's Disease: Brain Imaging and CSF Studies

(2010) Rachel Mistur et al.   Journal of Clinical Neurology

Oxidative Stress in the Progression of Alzheimer Disease in the Frontal Cortex

(2010) Mubeen A. Ansari et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Expression of  -Amyloid Induced Age-Dependent Presynaptic and Axonal Changes in Drosophila

(2010) X.-L. Zhao et al.   JOURNAL OF NEUROSCIENCE

Mitofusin 2 Is Necessary for Transport of Axonal Mitochondria and Interacts with the Miro/Milton Complex

(2010) A. Misko et al.   JOURNAL OF NEUROSCIENCE

Dietary Interventions to Extend Life Span and Health Span Based on Calorie Restriction

(2010) R. K. Minor et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Resveratrol, sirtuins, and the promise of a DR mimetic

(2010) Joseph A. Baur   MECHANISMS OF AGEING AND DEVELOPMENT

Alzheimer's disease: Effects of β-amyloid on mitochondria

(2010) Laurent Tillement et al.   MITOCHONDRION

Abnormal Mitochondrial Dynamics—A Novel Therapeutic Target for Alzheimer's Disease?

(2010) Bo Su et al.   MOLECULAR NEUROBIOLOGY

Treadmill exercise represses neuronal cell death in an aged transgenic mouse model of Alzheimer's disease

(2010) Hyun-Sub Um et al.   NEUROSCIENCE RESEARCH

Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model

(2010) H. Du et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PGC-1α Expression Decreases in the Alzheimer Disease Brain as a Function of Dementia

(2009) Weiping Qin et al.   ARCHIVES OF NEUROLOGY

Autophagy protects neuron from Aβ-induced cytotoxicity

(2009) Shih-Ya Hung et al.   Autophagy

Aβ exacerbates the neuronal dysfunction caused by human tau expression in a Drosophila model of Alzheimer's disease

(2009) James Folwell et al.   EXPERIMENTAL NEUROLOGY

Overexpression of Tfam protects mitochondria against β-amyloid-induced oxidative damage in SH-SY5Y cells

(2009) Shangcheng Xu et al.   FEBS Journal

The role of abnormal mitochondrial dynamics in the pathogenesis of Alzheimer’s disease

(2009) Xinglong Wang et al.   JOURNAL OF NEUROCHEMISTRY

Impaired Balance of Mitochondrial Fission and Fusion in Alzheimer's Disease

(2009) X. Wang et al.   JOURNAL OF NEUROSCIENCE

Systematic gene expression profile of hypothalamus in calorie-restricted mice implicates the involvement of mTOR signaling in neuroprotective activity

(2009) Pu Wu et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Caloric restriction attenuates amyloid deposition in middle-aged dtg APP/PS1 mice

(2009) Peter R. Mouton et al.   NEUROSCIENCE LETTERS

Disruption of fast axonal transport is a pathogenic mechanism for intraneuronal amyloid beta

(2009) G. Pigino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease

(2009) M. Blurton-Jones et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease

(2009) J. Yao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid-  and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice

(2009) V. Rhein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

S-Nitrosylation of Drp1 Mediates β-Amyloid-Related Mitochondrial Fission and Neuronal Injury

(2009) Dong-Hyung Cho et al.   SCIENCE

Mitochondrial fusion and division: Regulation and role in cell viability

(2009) Giovanni Benard et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Control of mitochondrial transport and localization in neurons

(2009) Andrew F. MacAskill et al.   TRENDS IN CELL BIOLOGY

Hippocampal metabolic proteins are modulated in voluntary and treadmill exercise rats

(2008) Lieselotte Kirchner et al.   EXPERIMENTAL NEUROLOGY

Brain oxidative stress in a triple-transgenic mouse model of Alzheimer disease

(2008) Rosa Resende et al.   FREE RADICAL BIOLOGY AND MEDICINE

Exercise-Induced Synaptogenesis in the Hippocampus Is Dependent on UCP2-Regulated Mitochondrial Adaptation

(2008) M. O. Dietrich et al.   JOURNAL OF NEUROSCIENCE

Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease

(2008) Saravanan S. Karuppagounder et al.   NEUROCHEMISTRY INTERNATIONAL

Mitochondrial Medicine for Aging and Neurodegenerative Diseases

(2008) P. Hemachandra Reddy   NEUROMOLECULAR MEDICINE

Phosphorylation of the Translation Initiation Factor eIF2α Increases BACE1 Levels and Promotes Amyloidogenesis

(2008) Tracy O'Connor et al.   NEURON

Mitochondria in Neuroplasticity and Neurological Disorders

(2008) Mark P. Mattson et al.   NEURON

Amyloid-  overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins

(2008) X. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The amyloid  -peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae

(2008) C. A. Hansson Petersen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Calorie restriction ameliorates neurodegenerative phenotypes in forebrain-specific presenilin-1 and presenilin-2 double knockout mice

(2007) Pu Wu et al.   NEUROBIOLOGY OF AGING