Brain GLP-1/IGF-1 Signaling and Autophagy Mediate Exendin-4 Protection Against Apoptosis in Type 2 Diabetic Rats

Evidence for Cortical Neuronal Loss in Male Type 2 Diabetic Goto-Kakizaki Rats

(2018) Shafaat Hussain et al.   JOURNAL OF ALZHEIMERS DISEASE

Structural and Functional Brain Changes in Middle-Aged Type 2 Diabetic Patients: A Cross-Sectional Study

(2018) Natalia García-Casares et al.   JOURNAL OF ALZHEIMERS DISEASE

AMPK Activation Ameliorates Alzheimer's Disease-Like Pathology and Spatial Memory Impairment in a Streptozotocin-Induced Alzheimer's Disease Model in Rats

(2018) Lai-Ling Du et al.   JOURNAL OF ALZHEIMERS DISEASE

Exenatide exerts direct protective effects on endothelial cells through the AMPK/Akt/eNOS pathway in a GLP-1 receptor-dependent manner

(2016) Rui Wei et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The GLP-1 receptor agonists exendin-4 and liraglutide alleviate oxidative stress and cognitive and micturition deficits induced by middle cerebral artery occlusion in diabetic mice

(2016) Ping-Chia Li et al.   BMC NEUROSCIENCE

Therapeutic Development of Interrelated Metabolic and Neurodegenerative Disorders

(2016) Xuan Thi-Anh Nguyen et al.   CURRENT PHARMACEUTICAL DESIGN

The ubiquitin signal and autophagy: an orchestrated dance leading to mitochondrial degradation

(2016) Koji Yamano et al.   EMBO REPORTS

Long-Term Exposure of Pancreatic β-Cells to Palmitate Results in SREBP-1C-Dependent Decreases in GLP-1 Receptor Signaling via CREB and AKT and Insulin Secretory Response

(2016) Annalisa Natalicchio et al.   ENDOCRINOLOGY

Exenatide enhances cognitive performance and upregulates neurotrophic factor gene expression levels in diabetic mice

(2016) Esen Gumuslu et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Exendin-4 protects bone marrow-derived mesenchymal stem cells against oxygen/glucose and serum deprivation-induced apoptosis through the activation of the cAMP/PKA signaling pathway and the attenuation of ER stress

(2016) JIEQIONG HE et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Hyperglycemic Conditions Prime Cells for RIP1-dependent Necroptosis

(2016) Timothy J. LaRocca et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insulin signalling in Alzheimer′s disease and diabetes: from epidemiology to molecular links

(2016) E. M. Ribe et al.   JOURNAL OF INTERNAL MEDICINE

Mechanisms of Selective Autophagy

(2016) Gabriele Zaffagnini et al.   JOURNAL OF MOLECULAR BIOLOGY

Exendin-4 reduces tau hyperphosphorylation in type 2 diabetic rats via increasing brain insulin level

(2016) Yan Yang et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Brain-Defective Insulin Signaling Is Associated to Late Cognitive Impairment in Post-Septic Mice

(2016) Fernanda S. Neves et al.   MOLECULAR NEUROBIOLOGY

Middle-Aged Diabetic Females and Males Present Distinct Susceptibility to Alzheimer Disease-like Pathology

(2016) E. Candeias et al.   MOLECULAR NEUROBIOLOGY

Brain Insulin Resistance at the Crossroads of Metabolic and Cognitive Disorders in Humans

(2016) Stephanie Kullmann et al.   PHYSIOLOGICAL REVIEWS

Type 2 diabetes-induced neuronal pathology in the piriform cortex of the rat is reversed by the GLP-1 receptor agonist exendin-4

(2016) Grazyna Lietzau et al.   Oncotarget

Exenatide Activates the APPL1-AMPK-PPARαAxis to Prevent Diabetic Cardiomyocyte Apoptosis

(2016) Lei XiaoTian et al.   Journal of Diabetes Research

mTOR's role in ageing: protein synthesis or autophagy?

(2016) Sarah L. Hands et al.   Aging-US

The receptor proteins: pivotal roles in selective autophagy

(2015) Zhijie Xu et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Optical Control of Insulin Secretion Using an Incretin Switch

(2015) Johannes Broichhagen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

GLP-1 Receptor Agonist Exenatide Increases Capillary Perfusion Independent of Nitric Oxide in Healthy Overweight Men

(2015) M. M. Smits et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

BAX and BAK1 are dispensable for ABT-737-induced dissociation of the BCL2-BECN1 complex and autophagy

(2015) Jose Manuel Bravo-San Pedro et al.   Autophagy

Exendin-4 attenuates cardiac hypertrophy via AMPK/mTOR signaling pathway activation

(2015) Yue Zhou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Alzheimer's disease and type 2 diabetes-related alterations in brain mitochondria, autophagy and synaptic markers

(2015) Cristina Carvalho et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Long-term changes in cardiovascular risk markers during administration of exenatide twice daily or glimepiride: results from the European exenatide study

(2015) Rafael Simó et al.   Cardiovascular Diabetology

Exendin-4 Promotes Beta Cell Proliferation via PI3k/Akt Signalling Pathway

(2015) Chaoxun Wang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Effects of exenatide therapy on insulin resistance in the skeletal muscles of high-fat diet and low-dose streptozotocin-induced diabetic rats

(2015) Hui Wu et al.   ENDOCRINE RESEARCH

Exenatide reduces TNF-α expression and improves hippocampal neuron numbers and memory in streptozotocin treated rats

(2015) Volkan Solmaz et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Chronic Treatment with a Water-Soluble Extract from the Culture Medium ofGanoderma lucidumMycelia Prevents Apoptosis and Necroptosis in Hypoxia/Ischemia-Induced Injury of Type 2 Diabetic Mouse Brain

(2015) Meiyan Xuan et al.   Evidence-based Complementary and Alternative Medicine

p62/SQSTM1 functions as a signaling hub and an autophagy adaptor

(2015) Yoshinori Katsuragi et al.   FEBS Journal

Exendin-4-Loaded PLGA Microspheres Relieve Cerebral Ischemia/Reperfusion Injury and Neurologic Deficits through Long-Lasting Bioactivity-Mediated Phosphorylated Akt/eNOS Signaling in Rats

(2015) Chiang-Ting Chien et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Exendin-4, a Glucagon-Like Peptide-1 Receptor Agonist, Reduces Alzheimer Disease-Associated Tau Hyperphosphorylation in the Hippocampus of Rats With Type 2 Diabetes

(2015) Weijie Xu et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Sitagliptin alleviated myocardial remodeling of the left ventricle and improved cardiac diastolic dysfunction in diabetic rats

(2015) Yu-Sheng Liu et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Five-Year Efficacy and Safety Data of Exenatide Once Weekly

(2015) Carol H. Wysham et al.   MAYO CLINIC PROCEEDINGS

Brain GLP-1 and insulin sensitivity

(2015) Darleen Sandoval et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Epac is Required for GLP-1R-Mediated Inhibition of Oxidative Stress and Apoptosis in Cardiomyocytes

(2015) Supachoke Mangmool et al.   MOLECULAR ENDOCRINOLOGY

Exendin-4 Enhances Motor Function Recovery via Promotion of Autophagy and Inhibition of Neuronal Apoptosis After Spinal Cord Injury in Rats

(2015) Hao-Tian Li et al.   MOLECULAR NEUROBIOLOGY

Compromised autophagy and neurodegenerative diseases

(2015) Fiona M. Menzies et al.   NATURE REVIEWS NEUROSCIENCE

Modulation of insulin signaling rescues BDNF transport defects independent of tau in amyloid-β oligomer-treated hippocampal neurons

(2015) Oliver Takach et al.   NEUROBIOLOGY OF AGING

Necroptosis: Pathway diversity and characteristics

(2015) M. Cristina de Almagro et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Role and Importance of IGF-1 in Traumatic Brain Injuries

(2015) Annunziato Mangiola et al.   Biomed Research International

Endoplasmic Reticulum Stress Impairs Insulin Receptor Signaling in the Brains of Obese Rats

(2015) Lina Liang et al.   PLoS One

p62/SQSTM1 at the interface of aging, autophagy, and disease

(2014) Alessandro Bitto et al.   AGE

Mitigation of autophagy ameliorates hepatocellular damage following ischemia-reperfusion injury in murine steatotic liver

(2014) Nitika A. Gupta et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Insulin therapy modulates mitochondrial dynamics and biogenesis, autophagy and tau protein phosphorylation in the brain of type 1 diabetic rats

(2014) R.X. Santos et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Increased protein aggregation in Zucker Diabetic Fatty rat brain: identification of key mechanistic targets and the therapeutic application of hydrogen sulfide

(2014) Fatemeh Talaei et al.   BMC CELL BIOLOGY

Acute metformin preconditioning confers neuroprotection against focal cerebral ischaemia by pre-activation of AMPK-dependent autophagy

(2014) Teng Jiang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Exendin-4 Alleviates High Glucose-Induced Rat Mesangial Cell Dysfunction through the AMPK Pathway

(2014) Wen-Wei Xu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Vascular, Oxidative, and Synaptosomal Abnormalities During Aging and the Progression of Type 2 Diabetes

(2014) Cristina Carvalho et al.   CURRENT NEUROVASCULAR RESEARCH

Intranasal Insulin Enhanced Resting-State Functional Connectivity of Hippocampal Regions in Type 2 Diabetes

(2014) Hui Zhang et al.   DIABETES

Insulin and insulin-like growth factor receptors in the brain: Physiological and pathological aspects

(2014) Haim Werner et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Exenatide protects against hypoxia/reoxygenation-induced apoptosis by improving mitochondrial function in H9c2 cells

(2014) Guanglei Chang et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Exendin-4 alleviates retinal vascular leakage by protecting the blood–retinal barrier and reducing retinal vascular permeability in diabetic Goto-Kakizaki rats

(2014) Yichao Fan et al.   EXPERIMENTAL EYE RESEARCH

(–)-Epigallocatechin-3-gallate attenuated myocardial mitochondrial dysfunction and autophagy in diabetic Goto–Kakizaki rats

(2014) J. Liu et al.   FREE RADICAL RESEARCH

METABOLIC PHENOTYPING GUIDELINES: Assessing glucose homeostasis in rodent models

(2014) James E Bowe et al.   JOURNAL OF ENDOCRINOLOGY

Mitochondrial quality control systems sustain brain mitochondrial bioenergetics in early stages of type 2 diabetes

(2014) R. X. Santos et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Nitric oxide show its survival role by NO-PKC pathway through cGMP-dependent or independent on the culture of cerebella granular neurons

(2014) Lin Wang et al.   NEUROSCIENCE LETTERS

Exendin-4 reduces glycemia by increasing liver glucokinase activity: an insulin independent effect

(2014) Nirav Dhanesha et al.   Pharmacological Reports

Chronic Exposure to GLP-1 Increases GLP-1 Synthesis and Release in a Pancreatic Alpha Cell Line (α-TC1): Evidence of a Direct Effect of GLP-1 on Pancreatic Alpha Cells

(2014) Salvatore Piro et al.   PLoS One

Exendin-4 Reduces Ischemic Brain Injury in Normal and Aged Type 2 Diabetic Mice and Promotes Microglial M2 Polarization

(2014) Vladimer Darsalia et al.   PLoS One

Neuronal necrosis is regulated by a conserved chromatin-modifying cascade

(2014) K. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Parkin and PINK1: much more than mitophagy

(2014) Leslie A. Scarffe et al.   TRENDS IN NEUROSCIENCES

CREB mediates the insulinotropic and anti-apoptotic effects of GLP-1 signaling in adult mouse β-cells

(2014) Soona Shin et al.   Molecular Metabolism

Insulin as a Bridge between Type 2 Diabetes and Alzheimer Disease – How Anti-Diabetics Could be a Solution for Dementia

(2014) Inês Sebastião et al.   Frontiers in Endocrinology

Aging aggravates ischemic stroke-induced brain damage in mice with chronic peripheral infection

(2013) Hiramani Dhungana et al.   AGING CELL

Crosstalk between diabetes and brain: Glucagon-like peptide-1 mimetics as a promising therapy against neurodegeneration

(2013) A.I. Duarte et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Exendin-4 decreases liver inflammation and atherosclerosis development simultaneously by reducing macrophage infiltration

(2013) Y Wang et al.   BRITISH JOURNAL OF PHARMACOLOGY

The effect of chronic twice daily exenatide treatment on β-cell function in new onset type 2 diabetes

(2013) Amalia Gastaldelli et al.   CLINICAL ENDOCRINOLOGY

The extra-pancreatic effects of GLP-1 receptor agonists: a focus on the cardiovascular, gastrointestinal and central nervous systems

(2013) J. Seufert et al.   DIABETES OBESITY & METABOLISM

Exendin-4 protects pancreatic beta cells from palmitate-induced apoptosis by interfering with GPR40 and the MKK4/7 stress kinase signalling pathway

(2013) Annalisa Natalicchio et al.   DIABETOLOGIA

Exendin-4 Improves β-Cell Function in Autophagy-Deficient β-Cells

(2013) Hiroko Abe et al.   ENDOCRINOLOGY

Selective autophagy

(2013) Steingrim Svenning et al.   Essays in Biochemistry

Selective hepatic insulin resistance in a murine model heterozygous for a mitochondrial trifunctional protein defect

(2013) R. Scott Rector et al.   HEPATOLOGY

Central effects of GLP-1: new opportunities for treatments of neurodegenerative diseases

(2013) Christian Hölscher   JOURNAL OF ENDOCRINOLOGY

Mechanism of the beneficial and protective effects of exenatide in diabetic rats

(2013) Mohamed Lotfy et al.   JOURNAL OF ENDOCRINOLOGY

DPP-4 inhibitors improve cognition and brain mitochondrial function of insulin-resistant rats

(2013) Hiranya Pintana et al.   JOURNAL OF ENDOCRINOLOGY

Exendin-4 Ameliorates Traumatic Brain Injury-Induced Cognitive Impairment in Rats

(2013) Katharine Eakin et al.   PLoS One

Impaired MEK Signaling and SERCA Expression Promote ER Stress and Apoptosis in Insulin-Resistant Macrophages and Are Reversed by Exenatide Treatment

(2012) C.-P. Liang et al.   DIABETES

Antiapoptotic Actions of Exendin-4 against Hypoxia and Cytokines Are Augmented by CREB

(2012) Kalpana Velmurugan et al.   ENDOCRINOLOGY

The impairment of insulin signaling in Alzheimer's disease

(2012) Emanuel Candeias et al.   IUBMB LIFE

An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers

(2012) Theresa R. Bomfim et al.   JOURNAL OF CLINICAL INVESTIGATION

Roles of AMP-activated Protein Kinase in Alzheimer’s Disease

(2012) Zhiyou Cai et al.   NEUROMOLECULAR MEDICINE

Exendin-4 improved rat cortical neuron survival under oxygen/glucose deprivation through PKA pathway

(2012) M.-D. Wang et al.   NEUROSCIENCE

The crosstalk between autophagy and apoptosis: where does this lead?

(2012) Claire Gordy et al.   Protein & Cell

Amelioration of neurodegenerative changes in cellular and rat models of diabetes-related Alzheimer’s disease by exendin-4

(2011) Song Chen et al.   AGE

AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network

(2011) Antero Salminen et al.   AGEING RESEARCH REVIEWS

Brain activation following peripheral administration of the GLP-1 receptor agonist exendin-4

(2011) Elena-Dana Baraboi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Intracellular Signals Mediating the Food Intake-Suppressive Effects of Hindbrain Glucagon-like Peptide-1 Receptor Activation

(2011) Matthew R. Hayes et al.   Cell Metabolism

GLP-1 signals via ERK in peripheral nerve and prevents nerve dysfunction in diabetic mice

(2011) C. G. Jolivalt et al.   DIABETES OBESITY & METABOLISM

Peripheral and Central GLP-1 Receptor Populations Mediate the Anorectic Effects of Peripherally Administered GLP-1 Receptor Agonists, Liraglutide and Exendin-4

(2011) Scott E. Kanoski et al.   ENDOCRINOLOGY

Exenatide or glimepiride added to metformin on metabolic control and on insulin resistance in type 2 diabetic patients

(2011) Giuseppe Derosa et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

IGF-1 protects against diabetic features in an in vivo model of Huntington's disease

(2011) A.I. Duarte et al.   EXPERIMENTAL NEUROLOGY

Novel GLP-1 mimetics developed to treat type 2 diabetes promote progenitor cell proliferation in the brain

(2011) A. Hamilton et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes

(2011) Ying Liu et al.   JOURNAL OF PATHOLOGY

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

GLP-1 Analogs Reduce Hepatocyte Steatosis and Improve Survival by Enhancing the Unfolded Protein Response and Promoting Macroautophagy

(2011) Shvetank Sharma et al.   PLoS One

The emerging role of autophagy in the pathophysiology of diabetes mellitus

(2010) Claudio D. Gonzalez et al.   Autophagy

Cortical and hippocampal mitochondria bioenergetics and oxidative status during hyperglycemia and/or insulin-induced hypoglycemia

(2010) Susana Cardoso et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Role of autophagy in suppression of inflammation and cancer

(2010) Eileen White et al.   CURRENT OPINION IN CELL BIOLOGY

Exendin-4 Suppresses Src Activation and Reactive Oxygen Species Production in Diabetic Goto-Kakizaki Rat Islets in an Epac-Dependent Manner

(2010) E. Mukai et al.   DIABETES

Autophagy in Alzheimer’s disease

(2010) Paula I Moreira et al.   Expert Review of Neurotherapeutics

Does autophagy take a front seat in lifespan extension?

(2010) Goran Petrovski et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Exendin-4 Protects Oxidative Stress-Induced β-Cell Apoptosis through Reduced JNK and GSK3β Activity

(2010) Ju-Young Kim et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

Autophagy gone awry in neurodegenerative diseases

(2010) Esther Wong et al.   NATURE NEUROSCIENCE

The Beclin 1–VPS34 complex – at the crossroads of autophagy and beyond

(2010) Sarah F. Funderburk et al.   TRENDS IN CELL BIOLOGY

Role and regulation of autophagy in cancer

(2009) Ning Chen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Role of the JNK-interacting protein 1/islet brain 1 in cell degeneration in Alzheimer disease and diabetes

(2009) Nicole Beeler et al.   BRAIN RESEARCH BULLETIN

High Fat and Highly Thermolyzed Fat Diets Promote Insulin Resistance and Increase DNA Damage in Rats

(2009) Adriano M. de Assis et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Forkhead class O transcription factor 3a activation and Sirtuin1 overexpression in the hypertrophied myocardium of the diabetic Goto-Kakizaki rat

(2009) Erik Vahtola et al.   JOURNAL OF HYPERTENSION

More Choces Than Ever Before

(2008) R. Keith Campbell et al.   DIABETES EDUCATOR

Autophagic cell death: the story of a misnomer

(2008) Guido Kroemer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling

(2008) Aileen M. Moloney et al.   NEUROBIOLOGY OF AGING

Peptide hormone exendin-4 stimulates subventricular zone neurogenesis in the adult rodent brain and induces recovery in an animal model of parkinson's disease

(2007) Göran Bertilsson et al.   JOURNAL OF NEUROSCIENCE RESEARCH