Molecular Pharmacology of Rosmarinic and Salvianolic Acids: Potential Seeds for Alzheimer’s and Vascular Dementia Drugs

Mechanism of salvianolic acid B neuroprotection against ischemia/reperfusion induced cerebral injury

(2018) Yong Fan et al.   BRAIN RESEARCH

Iridoids and Other Monoterpenes in the Alzheimer’s Brain: Recent Development and Future Prospects

(2018) Solomon Habtemariam   MOLECULES

Formal total synthesis of salvianolic acid N

(2018) Kong Wu et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Apigenin as neuroprotective agent: Of mice and men

(2018) Seyed Fazel Nabavi et al.   PHARMACOLOGICAL RESEARCH

Structure–activity relations of rosmarinic acid derivatives for the amyloid β aggregation inhibition and antioxidant properties

(2017) Riho Taguchi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synaptic dysfunction in Alzheimer's disease: From the role of amyloid β-peptide to the α-secretase ADAM10

(2017) Stefano Musardo et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Plants-Derived Neuroprotective Agents: Cutting the Cycle of Cell Death through Multiple Mechanisms

(2017) Taiwo Olayemi Elufioye et al.   Evidence-based Complementary and Alternative Medicine

Post-stroke Dementia: Epidemiology, Mechanisms and Management

(2017) Gwo-Chi Hu et al.   International Journal of Gerontology

The Role of ADAM10 in Alzheimer’s Disease

(2017) Xiang-Zhen Yuan et al.   JOURNAL OF ALZHEIMERS DISEASE

Rosmarinic acid prevents fibrillization and diminishes vibrational modes associated to β sheet in tau protein linked to Alzheimer’s disease

(2017) Alberto Cornejo et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Salvianolic Acids for Injection (SAFI) suppresses inflammatory responses in activated microglia to attenuate brain damage in focal cerebral ischemia

(2017) Pengwei Zhuang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Combined in Vitro Cell-Based/in Silico Screening of Naturally Occurring Flavonoids and Phenolic Compounds as Potential Anti-Alzheimer Drugs

(2017) Alba Espargaró et al.   JOURNAL OF NATURAL PRODUCTS

Salvianolic acids enhance cerebral angiogenesis and neurological recovery by activating JAK2/STAT3 signaling pathway after ischemic stroke in mice

(2017) Yaoru Li et al.   JOURNAL OF NEUROCHEMISTRY

Protective Effects of Caffeic Acid and the Alzheimer's Brain: An Update

(2017) Solomon Habtemariam   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Recent Advances in the Inhibition of p38 MAPK as a Potential Strategy for the Treatment of Alzheimer’s Disease

(2017) Jong Kil Lee et al.   MOLECULES

Review: Astrocytes in Alzheimer's disease and other age-associated dementias: a supporting player with a central role

(2017) C. J. Garwood et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Selective in vitro and in silico butyrylcholinesterase inhibitory activity of diterpenes and rosmarinic acid isolated from Perovskia atriplicifolia Benth. and Salvia glutinosa L.

(2017) F. Sezer Senol et al.   PHYTOCHEMISTRY

Salvianolic acid A inhibits calpain activation and eNOS uncoupling during focal cerebral ischemia in mice

(2017) Qaisar Mahmood et al.   PHYTOMEDICINE

Evaluation of brain targeting in rats of Salvianolic acid B nasal delivery by the microdialysis technique

(2017) Suiling Zhang et al.   XENOBIOTICA

Inflammatory Aspects of Alzheimer Disease and Other Neurodegenerative Disorders

(2017) Claudia Schwab et al.   JOURNAL OF ALZHEIMERS DISEASE

In Vitro and In Vivo Activation of Astrocytes by Amyloid-β is Potentiated by Pro-Oxidant Agents

(2017) Silvia García-Matas et al.   JOURNAL OF ALZHEIMERS DISEASE

Amelioration of cognitive impairments in APPswe/PS1dE9 mice is associated with metabolites alteration induced by total salvianolic acid

(2017) Li Shen et al.   PLoS One

Targeting Tumor Necrosis Factor Alpha for Alzheimer’s Disease

(2016) Boris Decourt et al.   Current Alzheimer Research

Rutin as a Natural Therapy for Alzheimer’s Disease: Insights into its Mechanisms of Action

(2016) Solomon Habtemariam   CURRENT MEDICINAL CHEMISTRY

Neuroprotective Effects of Fisetin in Alzheimer's and Parkinson's Diseases: From Chemistry to Medicine

(2016) Seyed Fazel Nabavi et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

The Therapeutic Potential of Rosemary (Rosmarinus officinalis) Diterpenes for Alzheimer’s Disease

(2016) Solomon Habtemariam   Evidence-based Complementary and Alternative Medicine

Effects of rosmarinic acid on cognitive and biochemical alterations in ovariectomized rats treated with D-galactose

(2016) Deniz Kantar Gok et al.   FOLIA HISTOCHEMICA ET CYTOBIOLOGICA

Salvianolic acid A alleviates ischemic brain injury through the inhibition of inflammation and apoptosis and the promotion of neurogenesis in mice

(2016) Mei-Yin Chien et al.   FREE RADICAL BIOLOGY AND MEDICINE

Microglial Priming and Alzheimer’s Disease: A Possible Role for (Early) Immune Challenges and Epigenetics?

(2016) Lianne Hoeijmakers et al.   Frontiers in Human Neuroscience

Salvianolic Acid B Ameliorates Cerebral Ischemia/Reperfusion Injury Through Inhibiting TLR4/MyD88 Signaling Pathway

(2016) Yujue Wang et al.   INFLAMMATION

Effects of the Nrf2 Protein Modulator Salvianolic Acid A Alone or Combined with Metformin on Diabetes-associated Macrovascular and Renal Injury

(2016) Ping Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Preparation of salvianolic acid A by the degradation reaction of salvianolic acid B in subcritical water integrated with pH-zone-refining counter-current chromatography

(2016) Huaizhi Li et al.   JOURNAL OF CHROMATOGRAPHY A

Upstream regulators and downstream effectors of NF-κB in Alzheimer's disease

(2016) Zhe-Min Shi et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Salvianolic acid B protects the myelin sheath around injured spinal cord axons

(2016) Hong-fu Wu et al.   Neural Regeneration Research

Perilla frutescensvar.japonicaand rosmarinic acid improve amyloid-β25-35induced impairment of cognition and memory function

(2016) Ah Young Lee et al.   Nutrition Research and Practice

The asymmetric total synthesis of (+)-salvianolic acid A

(2016) Yong Zheng et al.   TETRAHEDRON

Association between alcohol and Alzheimer's disease

(2016) Wen-Juan Huang et al.   Experimental and Therapeutic Medicine

Salvianolic Acid B Inhibits Aβ Generation by Modulating BACE1 Activity in SH-SY5Y-APPsw Cells

(2016) Ying Tang et al.   Nutrients

Combination Therapy of Salvianolic Acid and Fluoxetine Improves the Cognitive Function of Rats with Chronic Stress-induced Depression

(2016) Lulu Yu et al.   World Neurosurgery

Anticholinesterase activity of selected phenolic acids and flavonoids – interaction testing in model solutions

(2015) Dominik Szwajgier   ANNALS OF AGRICULTURAL AND ENVIRONMENTAL MEDICINE

Compromised MAPK signaling in human diseases: an update

(2015) Eun Kyung Kim et al.   ARCHIVES OF TOXICOLOGY

Salvianolic acid B attenuates apoptosis and inflammation via SIRT1 activation in experimental stroke rats

(2015) Hongdi Lv et al.   BRAIN RESEARCH BULLETIN

The Therapeutic Potential of Rutin for Diabetes: An Update

(2015) Solomon Habtemariam et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Immune attack: the role of inflammation in Alzheimer disease

(2015) Frank L. Heppner et al.   NATURE REVIEWS NEUROSCIENCE

Neuroprotective effects of chrysin: From chemistry to medicine

(2015) Seyed Fazel Nabavi et al.   NEUROCHEMISTRY INTERNATIONAL

Molecular docking and ex vivo and in vitro anticholinesterase activity studies ofSalvia sp. and highlighted rosmarinic acid

(2015) Lütfiye Ömür DEMİREZER et al.   Turkish Journal Of Medical Sciences

Antioxidant effect of salvianolic acid B on hippocampal CA1 neurons in mice with cerebral ischemia and reperfusion injury

(2014) Yu-feng Jiang et al.   Chinese Journal of Integrative Medicine

The Antidiabetic Therapeutic Potential of Dietary Polyphenols

(2014) Solomon Habtemariam et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Salvianolic acid A protects RPE cells against oxidative stress through activation of Nrf2/HO-1 signaling

(2014) Hui Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Role of NADPH Oxidase in Total Salvianolic Acid Injection Attenuating Ischemia-Reperfusion Impaired Cerebral Microcirculation and Neurons: Implication of AMPK/Akt/PKC

(2014) Hao Tang et al.   MICROCIRCULATION

Conversion of salvianolic acid B into salvianolic acid A in tissues of Radix Salviae Miltiorrhizae using high temperature, high pressure and high humidity

(2014) Hongrui Xia et al.   PHYTOMEDICINE

A Novel Diterpene Skeleton: Identification of a Highly Aromatic, Cytotoxic and Antioxidant 5-Methyl-10-demethyl-abietane-type Diterpene fromPremna serratifolia

(2014) Solomon Habtemariam et al.   PHYTOTHERAPY RESEARCH

Microglia actions in Alzheimer’s disease

(2013) Stefan Prokop et al.   ACTA NEUROPATHOLOGICA

Neuroprotective effects of salvianolic acid B on an Aβ25–35 peptide-induced mouse model of Alzheimer's disease

(2013) Young Woo Lee et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

SMND-309, a novel derivative of salvianolic acid B, protects rat brains ischemia and reperfusion injury by targeting the JAK2/STAT3 pathway

(2013) Haibo Zhu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Rosmarinus officinalis L. leaf extract improves memory impairment and affects acetylcholinesterase and butyrylcholinesterase activities in rat brain

(2013) Marcin Ozarowski et al.   FITOTERAPIA

Impact of caffeic acid on aluminium chloride-induced dementia in rats

(2013) Kafeel A. Khan et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Salvianolic acid A, a polyphenolic derivative from Salvia miltiorrhiza bunge, as a multifunctional agent for the treatment of Alzheimer’s disease

(2013) Ying Ying Cao et al.   MOLECULAR DIVERSITY

Total synthesis of (+)-pentamethylsalvianolic acid C

(2013) Benjamin L. Alford et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Associations Between Serum Cholesterol Levels and Cerebral Amyloidosis

(2013) Bruce Reed et al.   JAMA Neurology

Tau Oligomers as Potential Targets for Alzheimer’s Diagnosis and Novel Drugs

(2013) Leonardo Guzmán-Martinez et al.   Frontiers in Neurology

Effects of salvianolic acid B on survival, self-renewal and neuronal differentiation of bone marrow derived neural stem cells

(2012) Nan Zhang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Antidiabetic components ofCassia alataleaves: Identification through α-glucosidase inhibition studies

(2012) George Kadakasseril Varghese et al.   PHARMACEUTICAL BIOLOGY

Antioxidant and Anti-α-glucosidase Compounds from the Rhizome ofPeltiphyllum peltatum(Torr.) Engl

(2012) Solomon Habtemariam et al.   PHYTOTHERAPY RESEARCH

Antihyperlipidemic Components ofCassia auriculataAerial Parts: Identification ThroughIn VitroStudies

(2012) Solomon Habtemariam   PHYTOTHERAPY RESEARCH

Direct Stimulation of Adult Neural Stem/Progenitor Cells In Vitro and Neurogenesis In Vivo by Salvianolic Acid B

(2012) Pengwei Zhuang et al.   PLoS One

New pharmacological strategies for treatment of Alzheimer's disease: focus on disease modifying drugs

(2011) Salvatore Salomone et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Astrocytes: Implications for Neuroinflammatory Pathogenesis of Alzheimers Disease

(2011) Chuanyu Li et al.   Current Alzheimer Research

In Salvia miltiorrhiza, phenolic acids possess protective properties against amyloid β-induced cytotoxicity, and tanshinones act as acetylcholinesterase inhibitors

(2011) Yongqiang Zhou et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

SOD1 (Copper/Zinc Superoxide Dismutase) Deficiency Drives Amyloid β Protein Oligomerization and Memory Loss in Mouse Model of Alzheimer Disease

(2011) Kazuma Murakami et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Methyl-3-O-Methyl Gallate and Gallic Acid from the Leaves of Peltiphyllum peltatum: Isolation and Comparative Antioxidant, Prooxidant, and Cytotoxic Effects in Neuronal Cells

(2011) Solomon Habtemariam   JOURNAL OF MEDICINAL FOOD

Recent advances in the multitarget-directed ligands approach for the treatment of Alzheimer's disease

(2011) Rafael León et al.   MEDICINAL RESEARCH REVIEWS

Cognitive dysfunctions induced by a cholinergic blockade and Aβ25–35 peptide are attenuated by salvianolic acid B

(2011) Dong Hyun Kim et al.   NEUROPHARMACOLOGY

Phytochemical, Antioxidant and Anti-α-glucosidase Activity Evaluations of Bergenia cordifolia

(2011) Mariagrazia Roselli et al.   PHYTOTHERAPY RESEARCH

Investigation of the binding of Salvianolic acid B to human serum albumin and the effect of metal ions on the binding

(2011) Tingting Chen et al.   SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

Aging Brain: Prevention of Oxidative Stress by Vitamin E and Exercise

(2011) Sambe Asha Devi   TheScientificWorldJOURNAL

Pathological roles of MAPK signaling pathways in human diseases

(2010) Eun Kyung Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Salvianolic acid B attenuates brain damage and inflammation after traumatic brain injury in mice

(2010) Tao Chen et al.   BRAIN RESEARCH BULLETIN

Antioxidant compounds from a South Asian beverage and medicinal plant, Cassia auriculata

(2010) Malindra Juan-Badaturuge et al.   FOOD CHEMISTRY

Anti-inflammatory Activity of Salvianolic Acid B in Microglia Contributes to its Neuroprotective Effect

(2010) Shao-Xia Wang et al.   NEUROCHEMICAL RESEARCH

In vitro anti HSV-1 and HSV-2 activity of Tanacetum vulgare extracts and isolated compounds: An approach to their mechanisms of action

(2010) Ángel L. Álvarez et al.   PHYTOTHERAPY RESEARCH

Effects of salvianolic acid B on proliferation, neurite outgrowth and differentiation of neural stem cells derived from the cerebral cortex of embryonic mice

(2010) GuoQing Guo et al.   Science China-Life Sciences

Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology

(2009) Paula I. Moreira et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

SMND-309, a novel derivate of salvianolic acid B, ameliorates cerebral infarction in rats: Characterization and role

(2009) Jingwei Tian et al.   BRAIN RESEARCH

Targeting p38 MAPK pathway for the treatment of Alzheimer's disease

(2009) Lenka Munoz et al.   NEUROPHARMACOLOGY

Evolution of rosmarinic acid biosynthesis

(2009) Maike Petersen et al.   PHYTOCHEMISTRY

Protections of SMND-309, a novel derivate of salvianolic acid B, on brain mitochondria contribute to injury amelioration in cerebral ischemia rats

(2009) Jingwei Tian et al.   PHYTOMEDICINE

Comparative Antioxidant, Prooxidant and Cytotoxic Activity of Sigmoidin A and Eriodictyol

(2009) Solomon Habtemariam et al.   PLANTA MEDICA

SMND-309, a Novel Derivate of Salvianolic Acid B, Attenuates Apoptosis and Ameliorates Mitochondrial Energy Metabolism in Rat Cortical Neurons

(2008) Jingwei Tian et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Acetylcholinesterase inhibitory guided fractionation of Melissa officinalis L.

(2008) Keyvan Dastmalchi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Salvianolic acids prevent acute doxorubicin cardiotoxicity in mice through suppression of oxidative stress

(2008) Baohong Jiang et al.   FOOD AND CHEMICAL TOXICOLOGY

Peripheral levels of glutathione and protein oxidation as markers in the development of Alzheimer's disease from Mild Cognitive Impairment

(2008) Paloma Bermejo et al.   FREE RADICAL RESEARCH

Characterization of the radical scavenging and antioxidant activities of danshensu and salvianolic acid B

(2007) Guang-Rong Zhao et al.   FOOD AND CHEMICAL TOXICOLOGY

Salvianolic acid B inhibits Aβ fibril formation and disaggregates preformed fibrils and protects against Aβ-induced cytotoxicty

(2007) Siva Sundara Kumar Durairajan et al.   NEUROCHEMISTRY INTERNATIONAL