Recent advances in the multitarget-directed ligands approach for the treatment of Alzheimer's disease

Selective Acetylcholinesterase Inhibitor Activated by Acetylcholinesterase Releases an Active Chelator with Neurorescuing and Anti-Amyloid Activities

(2010) Hailin Zheng et al.   ACS Chemical Neuroscience

Strategies for the Inhibition of Protein Aggregation in Human Diseases

(2010) Manuela Bartolini et al.   CHEMBIOCHEM

Development of an Efficient Therapeutic Agent for Alzheimer's Disease: Design and Synthesis of Dual Inhibitors of Acetylcholinesterase and Serotonin Transporter

(2010) Narihiro Toda et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Tacrine-based dual binding site acetylcholinesterase inhibitors as potential disease-modifying anti-Alzheimer drug candidates

(2010) Pelayo Camps et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Immune-Inflammatory Responses and Oxidative Stress in Alzheimers Disease: Therapeutic Implications

(2010) D. Bona et al.   CURRENT PHARMACEUTICAL DESIGN

Calcium Signaling and Amyloid Toxicity in Alzheimer Disease

(2010) Angelo Demuro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hybrid Molecules from Xanomeline and Tacrine: Enhanced Tacrine Actions on Cholinesterases and Muscarinic M1Receptors

(2010) Lei Fang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, Biological Properties, and Molecular Modeling Investigations of Novel Tacrine Derivatives with a Combination of Acetylcholinesterase Inhibition and Cannabinoid CB1Receptor Antagonism

(2010) Jos H. M. Lange et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Biological Evaluation of a Novel Class of γ-Secretase Modulators with PPARγ Activity

(2010) Martina Hieke et al.   JOURNAL OF MEDICINAL CHEMISTRY

Bivalent β-Carbolines as Potential Multitarget Anti-Alzheimer Agents

(2010) Yvonne Rook et al.   JOURNAL OF MEDICINAL CHEMISTRY

Calcium Signalling and Alzheimer’s Disease

(2010) Michael J. Berridge   NEUROCHEMICAL RESEARCH

Proteases and Proteolysis in Alzheimer Disease: A Multifactorial View on the Disease Process

(2010) Bart De Strooper   PHYSIOLOGICAL REVIEWS

ER Calcium and Alzheimer's Disease: In a State of Flux

(2010) M. P. Mattson   Science Signaling

Drug development for Alzheimer's disease: Where are we now and where are we headed?

(2009) Marwan N. Sabbagh   American Journal Geriatric Pharmacotherapy

Alzheimer's Disease: From Pathology to Therapeutic Approaches

(2009) Roland Jakob-Roetne et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Design, synthesis and biological evaluation of novel dual inhibitors of acetylcholinesterase and β-secretase

(2009) Yiping Zhu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Medicinal Inorganic Chemistry Approaches to Passivation and Removal of Aberrant Metal Ions in Disease

(2009) Lauren E. Scott et al.   CHEMICAL REVIEWS

Amitriptyline is a TrkA and TrkB Receptor Agonist that Promotes TrkA/TrkB Heterodimerization and Has Potent Neurotrophic Activity

(2009) Sung-Wuk Jang et al.   CHEMISTRY & BIOLOGY

Searching for Disease Modifiers-PKC Activation and HDAC Inhibition-A Dual Drug Approach to Alzheimer's Disease that Decreases Aβ Production while Blocking Oxidative Stress

(2009) Alan P. Kozikowski et al.   ChemMedChem

Tacrine-Melatonin Hybrids as Multifunctional Agents for Alzheimer's Disease, with Cholinergic, Antioxidant, and Neuroprotective Properties

(2009) María Isabel Fernández-Bachiller et al.   ChemMedChem

Cholinesterase inhibition: is there evidence for disease-modifying effects?

(2009) Michael Shanks et al.   CURRENT MEDICAL RESEARCH AND OPINION

Glycosylated tetrahydrosalens as multifunctional molecules for Alzheimer's therapy

(2009) Tim Storr et al.   DALTON TRANSACTIONS

GSK3: A possible link between beta amyloid peptide and tau protein

(2009) Félix Hernández et al.   EXPERIMENTAL NEUROLOGY

Brain mitochondria as a primary target in the development of treatment strategies for Alzheimer disease

(2009) Gjumrakch Aliev et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Novel piperazine derivative PMS1339 exhibits tri-functional properties and cognitive improvement in mice

(2009) Jean Marc Miezan Ezoulin et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

The Crystal Structure of a Complex of Acetylcholinesterase with a Bis-(−)-nor-meptazinol Derivative Reveals Disruption of the Catalytic Triad

(2009) Aviv Paz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Biological Evaluation of New 5-HT4Receptor Agonists: Application as Amyloid Cascade Modulators and Potential Therapeutic Utility in Alzheimer’s Disease

(2009) Olivier Russo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Site-Activated Multifunctional Chelator with Acetylcholinesterase and Neuroprotective−Neurorestorative Moieties for Alzheimer’s Therapy

(2009) Hailin Zheng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Neuroprotective and Cholinergic Properties of Multifunctional Glutamic Acid Derivatives for the Treatment of Alzheimer’s Disease

(2009) Mariana P. Arce et al.   JOURNAL OF MEDICINAL CHEMISTRY

Tacripyrines, the First Tacrine−Dihydropyridine Hybrids, as Multitarget-Directed Ligands for the Treatment of Alzheimer’s Disease

(2009) José Marco-Contelles et al.   JOURNAL OF MEDICINAL CHEMISTRY

Toward a Rational Design of Multitarget-Directed Antioxidants: Merging Memoquin and Lipoic Acid Molecular Frameworks

(2009) Maria Laura Bolognesi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Naturally occurring phytochemicals for the prevention of Alzheimer’s disease

(2009) Jiyoung Kim et al.   JOURNAL OF NEUROCHEMISTRY

Drug Development Targeting the Glycogen Synthase Kinase-3β (GSK-3β)-Mediated Signal Transduction Pathway: Role of GSK-3β in Adult Brain

(2009) Akihiko Takashima   JOURNAL OF PHARMACOLOGICAL SCIENCES

Design, Selection, and Characterization of Thioflavin-Based Intercalation Compounds with Metal Chelating Properties for Application in Alzheimer’s Disease

(2009) Cristina Rodríguez-Rodríguez et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Small Molecule Modulators of Copper-Induced Aβ Aggregation

(2009) Sarmad S. Hindo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies

(2009) Kurt R. Brunden et al.   NATURE REVIEWS DRUG DISCOVERY

Natural Antioxidants Protect Neurons in Alzheimer’s Disease and Parkinson’s Disease

(2009) Baolu Zhao   NEUROCHEMICAL RESEARCH

Soluble Oligomers of Amyloid β Protein Facilitate Hippocampal Long-Term Depression by Disrupting Neuronal Glutamate Uptake

(2009) Shaomin Li et al.   NEURON

The Role of Apolipoprotein E in Alzheimer's Disease

(2009) Jungsu Kim et al.   NEURON

A New Tacrine–Melatonin Hybrid Reduces Amyloid Burden and Behavioral Deficits in a Mouse Model of Alzheimer’s Disease

(2009) Carlos Spuch et al.   NEUROTOXICITY RESEARCH

Multiple roles of HDAC inhibition in neurodegenerative conditions

(2009) De-Maw Chuang et al.   TRENDS IN NEUROSCIENCES

Cognitive Function Over Time in the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT)

(2008)   ARCHIVES OF NEUROLOGY

Current approaches in the treatment of Alzheimer's disease

(2008) Reena S. Shah et al.   BIOMEDICINE & PHARMACOTHERAPY

New tacrine-dihydropyridine hybrids that inhibit acetylcholinesterase, calcium entry, and exhibit neuroprotection properties

(2008) Rafael León et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Rational design of novel, potent piperazinone and imidazolidinone BACE1 inhibitors

(2008) J.N. Cumming et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design and synthesis of tacrine–ferulic acid hybrids as multi-potent anti-Alzheimer drug candidates

(2008) Lei Fang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Beta-Secretase: Structure, Function, and Evolution

(2008) Chitra Venugopal et al.   CNS & Neurological Disorders-Drug Targets

Mechanism of Tau-Induced Neurodegeneration in Alzheimer Disease and Related Tauopathies

(2008) Alejandra del Alonso et al.   Current Alzheimer Research

Metals in Alzheimer's and Parkinson's Diseases

(2008) Kevin J Barnham et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Treatment Options in Alzheimer’s Disease: Maximizing Benefit, Managing Expectations

(2008) Martin R. Farlow et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Effects of Grape Seed-derived Polyphenols on Amyloid β-Protein Self-assembly and Cytotoxicity

(2008) Kenjiro Ono et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pharmacotherapeutic targets in Alzheimer's disease

(2008) Yif'at Biran et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Roscovitine-Derived, Dual-Specificity Inhibitors of Cyclin-Dependent Kinases and Casein Kinases 1

(2008) Nassima Oumata et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure−Activity Relationships of Acetylcholinesterase Noncovalent Inhibitors Based on a Polyamine Backbone. 4. Further Investigation on the Inner Spacer

(2008) Vincenzo Tumiatti et al.   JOURNAL OF MEDICINAL CHEMISTRY

Benzofuran-Based Hybrid Compounds for the Inhibition of Cholinesterase Activity, β Amyloid Aggregation, and Aβ Neurotoxicity

(2008) Stefano Rizzo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Novel Donepezil-Based Inhibitors of Acetyl- and Butyrylcholinesterase and Acetylcholinesterase-Induced β-Amyloid Aggregation

(2008) Pelayo Camps et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inhibition of Acetylcholinesterase, β-Amyloid Aggregation, and NMDA Receptors in Alzheimer’s Disease: A Promising Direction for the Multi-target-Directed Ligands Gold Rush

(2008) Michela Rosini et al.   JOURNAL OF MEDICINAL CHEMISTRY

Bis-(−)-nor-meptazinols as Novel Nanomolar Cholinesterase Inhibitors with High Inhibitory Potency on Amyloid-β Aggregation

(2008) Qiong Xie et al.   JOURNAL OF MEDICINAL CHEMISTRY

Multi-target-Directed Ligands To Combat Neurodegenerative Diseases

(2008) Andrea Cavalli et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Novel Cholinesterase–Monoamine Oxidase Inhibitor and Antioxidant, Ladostigil, Confers Neuroprotection in Neuroblastoma Cells and Aged Rats

(2008) Orit Bar-Am et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Preclinical efficacy on GSK-3 inhibitors: Towards a future generation of powerful drugs

(2008) Ana Martinez   MEDICINAL RESEARCH REVIEWS

EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers

(2008) Dagmar E Ehrnhoefer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

M1 Muscarinic Agonists Target Major Hallmarks of Alzheimer’s Disease – The Pivotal Role of Brain M1 Receptors

(2008) Abraham Fisher   Neurodegenerative Diseases

Linking Calcium to Aβ and Alzheimer's Disease

(2008) Kim N. Green et al.   NEURON

PPARγ agonists as therapeutics for the treatment of Alzheimer’s disease

(2008) Gary Landreth et al.   Neurotherapeutics

Memoquin: A multi-target-directed ligand as an innovative therapeutic opportunity for Alzheimer’s disease

(2008) Maria Laura Bolognesi et al.   Neurotherapeutics

Promising anti-Alzheimer’s dimer bis(7)-tacrine reduces β-amyloid generation by directly inhibiting BACE-1 activity

(2007) Hongjun Fu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Lead identification of acetylcholinesterase inhibitors–histamine H3 receptor antagonists from molecular modeling

(2007) Scott D. Bembenek et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Potent memapsin 2 (β-secretase) inhibitors: Design, synthesis, protein-ligand X-ray structure, and in vivo evaluation

(2007) Arun K. Ghosh et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Multi-target-directed coumarin derivatives: hAChE and BACE1 inhibitors as potential anti-Alzheimer compounds

(2007) Lorna Piazzi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of 6-amino-1,4-dihydropyridines that prevent calcium overload and neuronal death

(2007) Rafael León et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Targeting multiple Alzheimer’s disease etiologies with multimodal neuroprotective and neurorestorative iron chelators

(2007) Tamar Amit et al.   FASEB JOURNAL

Characterization of Copper Interactions with Alzheimer Amyloid β Peptides

(2003) Craig S. Atwood et al.   JOURNAL OF NEUROCHEMISTRY