The Therapeutic Potential of Rosemary (Rosmarinus officinalis) Diterpenes for Alzheimer’s Disease

Mitochondrial Alterations, Oxidative Stress and Neuroinflammation in Alzheimer's Disease

(2017) M. Verri et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

Rosemary tea consumption results to anxiolytic- and anti-depressant-like behavior of adult male mice and inhibits all cerebral area and liver cholinesterase activity; phytochemical investigation and in silico studies

(2015) Anastasia-Varvara Ferlemi et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Carnosic acid protects against 6-hydroxydopamine-induced neurotoxicity in in vivo and in vitro model of Parkinson’s disease: Involvement of antioxidative enzymes induction

(2015) Chi-Rei Wu et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Protection from cyanide-induced brain injury by the Nrf2 transcriptional activator carnosic acid

(2015) Dongxian Zhang et al.   JOURNAL OF NEUROCHEMISTRY

Carnosic acid

(2015) Simona Birtić et al.   PHYTOCHEMISTRY

Molecular Interaction of Acetylcholinesterase with Carnosic Acid Derivatives: A Neuroinformatics Study

(2014) M. Merad et al.   CNS & Neurological Disorders-Drug Targets

The Antidiabetic Therapeutic Potential of Dietary Polyphenols

(2014) Solomon Habtemariam et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

New terpenoid glycosides obtained from Rosmarinus officinalis L. aerial parts

(2014) Yi Zhang et al.   FITOTERAPIA

Characterization of two genes for the biosynthesis of abietane-type diterpenes in rosemary (Rosmarinus officinalis) glandular trichomes

(2014) Kathleen Brückner et al.   PHYTOCHEMISTRY

A Novel Diterpene Skeleton: Identification of a Highly Aromatic, Cytotoxic and Antioxidant 5-Methyl-10-demethyl-abietane-type Diterpene fromPremna serratifolia

(2014) Solomon Habtemariam et al.   PHYTOTHERAPY RESEARCH

Microglia actions in Alzheimer’s disease

(2013) Stefan Prokop et al.   ACTA NEUROPATHOLOGICA

Rosmarinus officinalis L. leaf extract improves memory impairment and affects acetylcholinesterase and butyrylcholinesterase activities in rat brain

(2013) Marcin Ozarowski et al.   FITOTERAPIA

Nrf2/ARE-mediated antioxidant actions of pro-electrophilic drugs

(2013) Takumi Satoh et al.   FREE RADICAL BIOLOGY AND MEDICINE

Role of Metal Ions in the Self-assembly of the Alzheimer’s Amyloid-β Peptide

(2013) Peter Faller et al.   INORGANIC CHEMISTRY

Carnosol inhibits cell adhesion molecules and chemokine expression by tumor necrosis factor-α in human umbilical vein endothelial cells through the nuclear factor-κB and mitogen-activated protein kinase pathways

(2013) HUI YAO et al.   Molecular Medicine Reports

Bioavailability of the major bioactive diterpenoids in a rosemary extract: Metabolic profile in the intestine, liver, plasma, and brain of Zucker rats

(2013) María Romo Vaquero et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Carnosic acid suppresses the production of amyloid-β 1-42 and 1-43 by inducing an α-secretase TACE/ADAM17 in U373MG human astrocytoma cells

(2013) Hidemi Yoshida et al.   NEUROSCIENCE RESEARCH

Small molecule activators of the Nrf2-HO-1 antioxidant axis modulate heme metabolism and inflammation in BV2 microglia cells

(2013) Roberta Foresti et al.   PHARMACOLOGICAL RESEARCH

The Protective Role of Carnosic Acid against Beta-Amyloid Toxicity in Rats

(2013) H. Rasoolijazi et al.   TheScientificWorldJOURNAL

Soluble amyloid precursor proteins and secretases as Alzheimer's disease biomarkers

(2013) Robert Perneczky et al.   TRENDS IN MOLECULAR MEDICINE

Anticholinesterase Activity of Phenolic Acids and their Derivatives

(2013) Dominik Szwajgier   ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES

Neuropathological Alterations in Alzheimer Disease

(2013) A. Serrano-Pozo et al.   Cold Spring Harbor Perspectives in Medicine

Carnosic Acid Prevents 6-Hydroxydopamine-Induced Cell Death in SH-SY5Y Cells via Mediation of Glutathione Synthesis

(2012) Jing-Hsien Chen et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Enhanced Phenolic Diterpenes Antioxidant Levels Through Non-transgenic Approaches

(2012) T. Tounekti et al.   CRITICAL REVIEWS IN PLANT SCIENCES

Novel AβIsoforms in Alzheimer's Disease - Their Role in Diagnosis and Treatment

(2012) Erik Portelius et al.   CURRENT PHARMACEUTICAL DESIGN

Carnosic acid attenuates lipopolysaccharide-induced liver injury in rats via fortifying cellular antioxidant defense system

(2012) Qisen Xiang et al.   FOOD AND CHEMICAL TOXICOLOGY

New insights into antibacterial and antioxidant activities of rosemary essential oils and their main components

(2012) Adriana M. Ojeda-Sana et al.   FOOD CONTROL

Rosmarinus officinalis L. hydroalcoholic extract, similar to fluoxetine, reverses depressive-like behavior without altering learning deficit in olfactory bulbectomized mice

(2012) Daniele G. Machado et al.   JOURNAL OF ETHNOPHARMACOLOGY

Carnosic acid suppresses the production of amyloid-β 1–42 by inducing the metalloprotease gene TACE/ADAM17 in SH-SY5Y human neuroblastoma cells

(2012) Pengfei Meng et al.   NEUROSCIENCE RESEARCH

Neuroprotective effects of carnosic acid on neuronal cells under ischemic and hypoxic stress

(2012) Chien-Wei Hou et al.   NUTRITIONAL NEUROSCIENCE

Carnosic acid protects against ROS/RNS-induced protein damage and upregulates HO-1 expression in RAW264.7 macrophages

(2012) Qisen Xiang et al.   Journal of Functional Foods

Carnosic acid, a pro-electrophilic compound, inhibits LPS-induced activation of microglia

(2011) Mika Yanagitai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Chemical composition and antimicrobial activity of the essential oil of Rosemary

(2011) Yang Jiang et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

SOD1 (Copper/Zinc Superoxide Dismutase) Deficiency Drives Amyloid β Protein Oligomerization and Memory Loss in Mouse Model of Alzheimer Disease

(2011) Kazuma Murakami et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Methyl-3-O-Methyl Gallate and Gallic Acid from the Leaves of Peltiphyllum peltatum: Isolation and Comparative Antioxidant, Prooxidant, and Cytotoxic Effects in Neuronal Cells

(2011) Solomon Habtemariam   JOURNAL OF MEDICINAL FOOD

Rosmarinus officinalis L. Essential Oil Inhibits In Vivo and In Vitro Leukocyte Migration

(2011) Gessilda Alcantara Nogueira de Melo et al.   JOURNAL OF MEDICINAL FOOD

Dynamic action of neurometals at the synapse

(2011) Haruna Tamano et al.   Metallomics

Interactions of Zn(ii) and Cu(ii) ions with Alzheimer's amyloid-beta peptide. Metal ion binding, contribution to fibrillization and toxicity

(2011) Vello Tõugu et al.   Metallomics

Phytochemical, Antioxidant and Anti-α-glucosidase Activity Evaluations of Bergenia cordifolia

(2011) Mariagrazia Roselli et al.   PHYTOTHERAPY RESEARCH

Absorption, Distribution and Elimination of Carnosic Acid, A Natural Antioxidant from Rosmarinus officinalis, in Rats

(2011) Evelyne H. A. Doolaege et al.   PLANT FOODS FOR HUMAN NUTRITION

Aging Brain: Prevention of Oxidative Stress by Vitamin E and Exercise

(2011) Sambe Asha Devi   TheScientificWorldJOURNAL

Essential oils composition in two Rosmarinus officinalis L. varieties and incidence for antimicrobial and antioxidant activities

(2010) Yosr Zaouali et al.   FOOD AND CHEMICAL TOXICOLOGY

Antioxidant compounds from a South Asian beverage and medicinal plant, Cassia auriculata

(2010) Malindra Juan-Badaturuge et al.   FOOD CHEMISTRY

Flavonoids and Phenolic Compounds from Rosmarinus officinalis

(2010) Naisheng Bai et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Inhibitory Effects of Rosemary Extracts, Carnosic Acid and Rosmarinic Acid on the Growth of Various Human Cancer Cell Lines

(2010) Ozlem Yesil-Celiktas et al.   PLANT FOODS FOR HUMAN NUTRITION

Dual mechanisms of NF-κB inhibition in carnosol-treated endothelial cells

(2010) Kai-Cheng Lian et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology

(2009) Paula I. Moreira et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Carnosic acid reduces cytokine-induced adhesion molecules expression and monocyte adhesion to endothelial cells

(2009) Ya-Mei Yu et al.   EUROPEAN JOURNAL OF NUTRITION

Relationship between the Antioxidant Capacity and Effect of Rosemary (Rosmarinus officinalis L.) Polyphenols on Membrane Phospholipid Order

(2009) Laura Pérez-Fons et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Role of Nrf2 and p62/ZIP in the neurite outgrowth by carnosic acid in PC12h cells

(2009) Kunio Kosaka et al.   JOURNAL OF BIOCHEMISTRY

Comparative Antioxidant, Prooxidant and Cytotoxic Activity of Sigmoidin A and Eriodictyol

(2009) Solomon Habtemariam et al.   PLANTA MEDICA

Carnosic acid and carnosol potently inhibit human 5-lipoxygenase and suppress pro-inflammatory responses of stimulated human polymorphonuclear leukocytes

(2008) Daniel Poeckel et al.   BIOCHEMICAL PHARMACOLOGY

Peripheral levels of glutathione and protein oxidation as markers in the development of Alzheimer's disease from Mild Cognitive Impairment

(2008) Paloma Bermejo et al.   FREE RADICAL RESEARCH

Neurological Benefits of Omega-3 Fatty Acids

(2008) S. C. Dyall et al.   NEUROMOLECULAR MEDICINE

Carnosic acid protects neuronal HT22 Cells through activation of the antioxidant-responsive element in free carboxylic acid- and catechol hydroxyl moieties-dependent manners

(2008) Takumi Satoh et al.   NEUROSCIENCE LETTERS

In vivo assessment of antidiabetic and antioxidant activities of rosemary (Rosmarinus officinalis) in alloxan-diabetic rabbits

(2007) Tülay Bakırel et al.   JOURNAL OF ETHNOPHARMACOLOGY

Carnosic acid, acatechol-typeelectrophilic compound, protects neurons bothin vitroandin vivothrough activation of the Keap1/Nrf2 pathway viaS-alkylation of targeted cysteines on Keap1

(2007) Takumi Satoh et al.   JOURNAL OF NEUROCHEMISTRY