Aberrant REDD1-mTORC1 responses to insulin in skeletal muscle from Type 2 diabetics
Published 2015 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Aberrant REDD1-mTORC1 responses to insulin in skeletal muscle from Type 2 diabetics
Authors
Keywords
-
Journal
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
Volume 309, Issue 8, Pages R855-R863
Publisher
American Physiological Society
Online
2015-08-13
DOI
10.1152/ajpregu.00285.2015
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Effect of obesity and type 2 diabetes on protein anabolic response to insulin in elderly women
- (2015) Jessica Murphy et al. EXPERIMENTAL GERONTOLOGY
- Effect of age on basal muscle protein synthesis and mTORC1 signaling in a large cohort of young and older men and women
- (2015) Melissa M. Markofski et al. EXPERIMENTAL GERONTOLOGY
- Nutrient-sensing mechanisms and pathways
- (2015) Alejo Efeyan et al. NATURE
- Effects of acute glucocorticoid blockade on metabolic dysfunction in patients with Type 2 diabetes with and without fatty liver
- (2014) D. P. Macfarlane et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Lack of REDD1 reduces whole body glucose and insulin tolerance, and impairs skeletal muscle insulin signaling
- (2014) Cory M. Dungan et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- 2. Classification and Diagnosis of Diabetes
- (2014) DIABETES CARE
- Altered nutrient response of mTORC1 as a result of changes in REDD1 expression: effect of obesity vs. REDD1 deficiency
- (2014) David L. Williamson et al. JOURNAL OF APPLIED PHYSIOLOGY
- Therapeutic Targeting of Cellular Metabolism in Cells with Hyperactive mTORC1: A Paradigm Shift
- (2014) Doug Medvetz et al. MOLECULAR CANCER RESEARCH
- Protein and glucose metabolic responses to hyperinsulinemia, hyperglycemia, and hyperaminoacidemia in obese men
- (2014) Stéphanie Chevalier et al. Obesity
- REDD1 enhances protein phosphatase 2A-mediated dephosphorylation of Akt to repress mTORC1 signaling
- (2014) M. D. Dennis et al. Science Signaling
- United States Adults Meeting 2010 American College of Rheumatology Criteria for Treatment and Prevention of Glucocorticoid-Induced Osteoporosis
- (2014) Robert A. Overman et al. ARTHRITIS CARE & RESEARCH
- IRS1Ser307 phosphorylation does not mediate mTORC1-induced insulin resistance
- (2013) Hilde Herrema et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Regulated in DNA damage and development 1 (REDD1) promotes cell survival during serum deprivation by sustaining repression of signaling through the mechanistic target of rapamycin in complex 1 (mTORC1)
- (2013) Michael D. Dennis et al. CELLULAR SIGNALLING
- Influence of glucocorticoids and growth hormone on insulin sensitivity in humans
- (2013) K. C. J. Yuen et al. DIABETIC MEDICINE
- Abnormal protein turnover and anabolic resistance to exercise in sarcopenic obesity
- (2013) Mats I. Nilsson et al. FASEB JOURNAL
- The mTORC1 signaling repressors REDD1/2 are rapidly induced and activation of p70S6K1 by leucine is defective in skeletal muscle of an immobilized rat hindlimb
- (2012) Andrew R. Kelleher et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- mTOR Signaling in Growth Control and Disease
- (2012) Mathieu Laplante et al. CELL
- Muscle-Specific Deletion of Carnitine Acetyltransferase Compromises Glucose Tolerance and Metabolic Flexibility
- (2012) Deborah M. Muoio et al. Cell Metabolism
- 11β-Hydroxysteroid dehydrogenase type 1: relevance of its modulation in the pathophysiology of obesity, the metabolic syndrome and type 2 diabetes mellitus
- (2012) C. D. Pereira et al. DIABETES OBESITY & METABOLISM
- Coupling nutrient sensing to metabolic homoeostasis: the role of the mammalian target of rapamycin complex 1 pathway
- (2012) Caroline André et al. PROCEEDINGS OF THE NUTRITION SOCIETY
- Prevalence of oral glucocorticoid usage in the United States: A general population perspective
- (2012) Robert A. Overman et al. ARTHRITIS CARE & RESEARCH
- Intramyocellular lipid content and insulin sensitivity are increased following a short-term low-glycemic index diet and exercise intervention
- (2011) Jacob M. Haus et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- REDD1 (regulated in development and DNA damage response 1) expression in skeletal muscle as a surrogate biomarker of the efficiency of glucocorticoid receptor blockade
- (2011) Rashmi Kumari et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Rapid induction of REDD1 expression by endurance exercise in rat skeletal muscle
- (2011) Taro Murakami et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Insulin resistance of amino acid and protein metabolism in type 2 diabetes
- (2011) Paolo Tessari et al. CLINICAL NUTRITION
- Oxidative DNA damage and obesity in type 2 diabetes mellitus
- (2011) Hayder A Al-Aubaidy et al. EUROPEAN JOURNAL OF ENDOCRINOLOGY
- Relative Muscle Mass Is Inversely Associated with Insulin Resistance and Prediabetes. Findings from The Third National Health and Nutrition Examination Survey
- (2011) Preethi Srikanthan et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- A 7-d Exercise Program Increases High–Molecular Weight Adiponectin in Obese Adults
- (2011) KAREN R. KELLY et al. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
- Intermittent Hypoxia Exacerbates Metabolic Effects of Diet-Induced Obesity
- (2011) Luciano F. Drager et al. Obesity
- Downregulation of Akt/mammalian target of rapamycin pathway in skeletal muscle is associated with increased REDD1 expression in response to chronic hypoxia
- (2010) François B. Favier et al. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
- AICAR treatment for 14 days normalizes obesity-induced dysregulation of TORC1 signaling and translational capacity in fasted skeletal muscle
- (2010) Joshua C. Drake et al. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
- Unknown
- (2010) Anita Ost et al. MOLECULAR MEDICINE
- Cortisol, energy intake, and food frequency in overweight/obese women
- (2010) Valentina Vicennati et al. NUTRITION
- Sarcopenia Exacerbates Obesity-Associated Insulin Resistance and Dysglycemia: Findings from the National Health and Nutrition Examination Survey III
- (2010) Preethi Srikanthan et al. PLoS One
- Randomized trial on the effects of a 7-d low-glycemic diet and exercise intervention on insulin resistance in older obese humans
- (2009) Thomas PJ Solomon et al. AMERICAN JOURNAL OF CLINICAL NUTRITION
- Insulin Induces REDD1 Expression through Hypoxia-inducible Factor 1 Activation in Adipocytes
- (2009) Claire Regazzetti et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Regulation of REDD1 by insulin-like growth factor-I in skeletal muscle and myotubes
- (2009) Robert A. Frost et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- The Pathogenetic Role of Cortisol in the Metabolic Syndrome: A Hypothesis
- (2009) Panagiotis Anagnostis et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Free Fatty Acid-Induced Hepatic Insulin Resistance is Attenuated Following Lifestyle Intervention in Obese Individuals with Impaired Glucose Tolerance
- (2009) Jacob M. Haus et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Lipid-induced mTOR activation in rat skeletal muscle reversed by exercise and 5′-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside
- (2009) Donato A Rivas et al. JOURNAL OF ENDOCRINOLOGY
- Elevated Corticosterone Associated with Food Deprivation Upregulates Expression in Rat Skeletal Muscle of the mTORC1 Repressor, REDD1
- (2009) Nora K. McGhee et al. JOURNAL OF NUTRITION
- A Mek1–Mek2 heterodimer determines the strength and duration of the Erk signal
- (2009) Federica Catalanotti et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Hepatic Gene Expression in Morbidly Obese Women: Implications for Disease Susceptibility
- (2009) Marshall B. Elam et al. Obesity
- Acute Alcohol Intoxication Increases REDD1 in Skeletal Muscle
- (2008) Charles H. Lang et al. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
- Lower growth hormone and higher cortisol are associated with greater visceral adiposity, intramyocellular lipids, and insulin resistance in overweight girls
- (2008) Madhusmita Misra et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Sarcopenic obesity: definition, cause and consequences
- (2008) Sari Stenholm et al. CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
- Plasma Ceramides Are Elevated in Obese Subjects With Type 2 Diabetes and Correlate With the Severity of Insulin Resistance
- (2008) J. M. Haus et al. DIABETES
- Hypoxia regulates TSC1/2 mTOR signaling and tumor suppression through REDD1-mediated 14 3 3 shuttling
- (2008) M. P. DeYoung et al. GENES & DEVELOPMENT
- Growth inhibition of colon cancer cells by polyisoprenylated benzophenones is associated with induction of the endoplasmic reticulum response
- (2008) Petr Protiva et al. INTERNATIONAL JOURNAL OF CANCER
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started