标题
Role of mTOR in Glucose and Lipid Metabolism
作者
关键词
-
出版物
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 19, Issue 7, Pages 2043
出版商
MDPI AG
发表日期
2018-07-16
DOI
10.3390/ijms19072043
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- mTORC1 Signaling: A Double-Edged Sword in Diabetic β Cells
- (2018) Amin Ardestani et al. Cell Metabolism
- Kaempferol alleviates palmitic acid-induced lipid stores, endoplasmic reticulum stress and pancreatic β-cell dysfunction through AMPK/mTOR-mediated lipophagy
- (2018) Ritu Varshney et al. JOURNAL OF NUTRITIONAL BIOCHEMISTRY
- Brain Somatic Mutations in MTOR Disrupt Neuronal Ciliogenesis, Leading to Focal Cortical Dyslamination
- (2018) Sang Min Park et al. NEURON
- Liver Reptin/RUVBL2 controls glucose and lipid metabolism with opposite actions on mTORC1 and mTORC2 signalling
- (2017) Joaquim Javary et al. GUT
- mTOR controls ChREBP transcriptional activity and pancreatic β cell survival under diabetic stress
- (2017) Gia Cac Chau et al. JOURNAL OF CELL BIOLOGY
- Loss of mTORC1 signaling alters pancreatic α cell mass and impairs glucagon secretion
- (2017) Nadejda Bozadjieva et al. JOURNAL OF CLINICAL INVESTIGATION
- EPRS is a critical mTORC1–S6K1 effector that influences adiposity in mice
- (2017) Abul Arif et al. NATURE
- Raptor regulates functional maturation of murine beta cells
- (2017) Qicheng Ni et al. Nature Communications
- Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing
- (2017) Manuel Blandino-Rosano et al. Nature Communications
- mTORC1 in AGRP neurons integrates exteroceptive and interoceptive food-related cues in the modulation of adaptive energy expenditure in mice
- (2017) Luke K Burke et al. eLife
- Role of nutrients and mTOR signaling in the regulation of pancreatic progenitors development
- (2017) Lynda Elghazi et al. Molecular Metabolism
- Rapamycin treatment benefits glucose metabolism in mouse models of type 2 diabetes
- (2016) Peter C. Reifsnyder et al. Aging-US
- Hypothalamic roles of mTOR complex I: integration of nutrient and hormone signals to regulate energy homeostasis
- (2016) Fang Hu et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- DEPTOR in POMC neurons affects liver metabolism but is dispensable for the regulation of energy balance
- (2016) Alexandre Caron et al. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
- Rapamycin Blocks Induction of the Thermogenic Program in White Adipose Tissue
- (2016) Cassie M. Tran et al. DIABETES
- Adipocyte-specific deletion of mTOR inhibits adipose tissue development and causes insulin resistance in mice
- (2016) Tizhong Shan et al. DIABETOLOGIA
- Pharmacological inhibition of S6K1 increases glucose metabolism and Akt signalling in vitro and in diet-induced obese mice
- (2016) Michael Shum et al. DIABETOLOGIA
- Reciprocal regulation of mTOR complexes in pancreatic islets from humans with type 2 diabetes
- (2016) Ting Yuan et al. DIABETOLOGIA
- mTORC2 sustains thermogenesis via Akt-induced glucose uptake and glycolysis in brown adipose tissue
- (2016) V. Albert et al. EMBO Molecular Medicine
- The TORC1-activated Proteins, p70S6K and GRB10, Regulate IL-4 Signaling and M2 Macrophage Polarization by Modulating Phosphorylation of Insulin Receptor Substrate-2
- (2016) Kristi J. Warren et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Activation of mTORC1 is essential for β-adrenergic stimulation of adipose browning
- (2016) Dianxin Liu et al. JOURNAL OF CLINICAL INVESTIGATION
- TSC1-mTOR signaling determines the differentiation of islet cells
- (2016) Li Ding et al. JOURNAL OF ENDOCRINOLOGY
- An evolutionarily conserved pathway controls proteasome homeostasis
- (2016) Adrien Rousseau et al. NATURE
- mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle
- (2016) I. Ben-Sahra et al. SCIENCE
- Is REDD1 a Metabolic Éminence Grise ?
- (2016) Christopher Lipina et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Adipose tissue mTORC2 regulates ChREBP-driven de novo lipogenesis and hepatic glucose metabolism
- (2016) Yuefeng Tang et al. Nature Communications
- mTORC1-independent Raptor prevents hepatic steatosis by stabilizing PHLPP2
- (2016) KyeongJin Kim et al. Nature Communications
- mTORC2 and AMPK differentially regulate muscle triglyceride content via Perilipin 3
- (2016) Maximilian Kleinert et al. Molecular Metabolism
- Mediobasal hypothalamic overexpression of DEPTOR protects against high-fat diet-induced obesity
- (2016) Alexandre Caron et al. Molecular Metabolism
- Alterations to mTORC1 signaling in the skeletal muscle differentially affect whole-body metabolism
- (2016) Maitea Guridi et al. Skeletal Muscle
- Aberrant REDD1-mTORC1 responses to insulin in skeletal muscle from Type 2 diabetics
- (2015) David L. Williamson et al. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
- Raptor ablation in skeletal muscle decreases Cav1.1 expression and affects the function of the excitation–contraction coupling supramolecular complex
- (2015) Rubén J. Lopez et al. BIOCHEMICAL JOURNAL
- Muscle-specific 4E-BP1 signaling activation improves metabolic parameters during aging and obesity
- (2015) Shihyin Tsai et al. JOURNAL OF CLINICAL INVESTIGATION
- The CREB coactivator CRTC2 controls hepatic lipid metabolism by regulating SREBP1
- (2015) Jinbo Han et al. NATURE
- Brain somatic mutations in MTOR cause focal cortical dysplasia type II leading to intractable epilepsy
- (2015) Jae Seok Lim et al. NATURE MEDICINE
- mTOR in Brain Physiology and Pathologies
- (2015) Joël Bockaert et al. PHYSIOLOGICAL REVIEWS
- mTOR inhibition activates overall protein degradation by the ubiquitin proteasome system as well as by autophagy
- (2015) Jinghui Zhao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Activation of mTORC1 in skeletal muscle regulates whole-body metabolism through FGF21
- (2015) Maitea Guridi et al. Science Signaling
- Ribosomal S6K1 in POMC and AgRP Neurons Regulates Glucose Homeostasis but Not Feeding Behavior in Mice
- (2015) Mark A. Smith et al. Cell Reports
- Glucagon Couples Hepatic Amino Acid Catabolism to mTOR-Dependent Regulation of α-Cell Mass
- (2015) Mark J. Solloway et al. Cell Reports
- Activation of mTORC1 in skeletal muscle regulates whole-body metabolism through FGF21
- (2015) Maitea Guridi et al. Science Signaling
- Sestrin 3 Protein Enhances Hepatic Insulin Sensitivity by Direct Activation of the mTORC2-Akt Signaling
- (2014) Rongya Tao et al. DIABETES
- Tuberous Sclerosis Complex 1–Mechanistic Target of Rapamycin Complex 1 Signaling Determines Brown-to-White Adipocyte Phenotypic Switch
- (2014) Xinxin Xiang et al. DIABETES
- Pancreatic -Cell Failure Mediated by mTORC1 Hyperactivity and Autophagic Impairment
- (2014) A. Bartolome et al. DIABETES
- Altered nutrient response of mTORC1 as a result of changes in REDD1 expression: effect of obesity vs. REDD1 deficiency
- (2014) David L. Williamson et al. JOURNAL OF APPLIED PHYSIOLOGY
- Hepatic mTORC1 controls locomotor activity, body temperature, and lipid metabolism through FGF21
- (2014) M. Cornu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Ghrelin promotes hepatic lipogenesis by activation of mTOR-PPAR signaling pathway
- (2014) Z. Li et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- mTORC1 Promotes Denervation-Induced Muscle Atrophy Through a Mechanism Involving the Activation of FoxO and E3 Ubiquitin Ligases
- (2014) H. Tang et al. Science Signaling
- Hepatoprotective role of Sestrin2 against chronic ER stress
- (2014) Hwan-Woo Park et al. Nature Communications
- Rictor/mTORC2 Loss in the Myf5 Lineage Reprograms Brown Fat Metabolism and Protects Mice against Obesity and Metabolic Disease
- (2014) Chien-Min Hung et al. Cell Reports
- Acute mTOR inhibition induces insulin resistance and alters substrate utilization in vivo
- (2014) Maximilian Kleinert et al. Molecular Metabolism
- Rictor/mTORC2 facilitates central regulation of energy and glucose homeostasis
- (2014) Heidi E. Kocalis et al. Molecular Metabolism
- Sustained Activation of mTORC1 in Skeletal Muscle Inhibits Constitutive and Starvation-Induced Autophagy and Causes a Severe, Late-Onset Myopathy
- (2013) Perrine Castets et al. Cell Metabolism
- mTOR in aging, metabolism, and cancer
- (2013) Marion Cornu et al. CURRENT OPINION IN GENETICS & DEVELOPMENT
- Evidence for Rapamycin Toxicity in Pancreatic β-Cells and a Review of the Underlying Molecular Mechanisms
- (2013) Adam D. Barlow et al. DIABETES
- Ablation of the mTORC2 component rictor in brain or Purkinje cells affects size and neuron morphology
- (2013) Venus Thomanetz et al. JOURNAL OF CELL BIOLOGY
- Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis
- (2013) Pengda Liu et al. NATURE CELL BIOLOGY
- mTORC1 Dependent Regulation of REDD1 Protein Stability
- (2013) Chia Yee Tan et al. PLoS One
- BSTA Promotes mTORC2-Mediated Phosphorylation of Akt1 to Suppress Expression of FoxC2 and Stimulate Adipocyte Differentiation
- (2013) Y. Yao et al. Science Signaling
- mTOR Signaling in Growth Control and Disease
- (2012) Mathieu Laplante et al. CELL
- Hepatic mTORC2 Activates Glycolysis and Lipogenesis through Akt, Glucokinase, and SREBP1c
- (2012) Asami Hagiwara et al. Cell Metabolism
- Maintenance of Metabolic Homeostasis by Sestrin2 and Sestrin3
- (2012) Jun Hee Lee et al. Cell Metabolism
- A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB
- (2012) Carmine Settembre et al. EMBO JOURNAL
- Identification of Akt-independent Regulation of Hepatic Lipogenesis by Mammalian Target of Rapamycin (mTOR) Complex 2
- (2012) Minsheng Yuan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- mTOR inhibition with rapamycin causes impaired insulin signalling and glucose uptake in human subcutaneous and omental adipocytes
- (2012) Maria J. Pereira et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Rapamycin Ameliorates Age-Dependent Obesity Associated with Increased mTOR Signaling in Hypothalamic POMC Neurons
- (2012) Shi-Bing Yang et al. NEURON
- Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity
- (2012) D. W. Lamming et al. SCIENCE
- Rapamycin has a biphasic effect on insulin sensitivity in C2C12 myotubes due to sequential disruption of mTORC1 and mTORC2
- (2012) Lan Ye et al. Frontiers in Genetics
- Chronic mTOR inhibition by rapamycin induces muscle insulin resistance despite weight loss in rats
- (2011) N Deblon et al. BRITISH JOURNAL OF PHARMACOLOGY
- mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway
- (2011) Timothy R. Peterson et al. CELL
- Rictor/mTORC2 Is Essential for Maintaining a Balance Between β-Cell Proliferation and Cell Size
- (2011) Yanyun Gu et al. DIABETES
- AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
- (2011) Joungmok Kim et al. NATURE CELL BIOLOGY
- Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1)
- (2010) Laura R. Pearce et al. BIOCHEMICAL JOURNAL
- Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids
- (2010) Yasemin Sancak et al. CELL
- Fat Cell-Specific Ablation of Rictor in Mice Impairs Insulin-Regulated Fat Cell and Whole-Body Glucose and Lipid Metabolism
- (2010) A. Kumar et al. DIABETES
- Chronic Rapamycin Treatment Causes Glucose Intolerance and Hyperlipidemia by Upregulating Hepatic Gluconeogenesis and Impairing Lipid Deposition in Adipose Tissue
- (2010) V. P. Houde et al. DIABETES
- Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1
- (2010) Katrin Düvel et al. MOLECULAR CELL
- mTORC1 controls fasting-induced ketogenesis and its modulation by ageing
- (2010) Shomit Sengupta et al. NATURE
- Critical Role for Hypothalamic mTOR Activity in Energy Balance
- (2009) Hiroyuki Mori et al. Cell Metabolism
- mTORC1-Activated S6K1 Phosphorylates Rictor on Threonine 1135 and Regulates mTORC2 Signaling
- (2009) L.-A. Julien et al. MOLECULAR AND CELLULAR BIOLOGY
- Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
- (2009) David E. Harrison et al. NATURE
- mTOR complex 2 in adipose tissue negatively controls whole-body growth
- (2009) N. Cybulski et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mediobasal Hypothalamic p70 S6 Kinase 1 Modulates the Control of Energy Homeostasis
- (2008) Clémence Blouet et al. Cell Metabolism
- Skeletal Muscle-Specific Ablation of raptor, but Not of rictor, Causes Metabolic Changes and Results in Muscle Dystrophy
- (2008) C. Florian Bentzinger et al. Cell Metabolism
- Regulation of TORC1 by Rag GTPases in nutrient response
- (2008) Eunjung Kim et al. NATURE CELL BIOLOGY
- Disruption of Tsc2 in pancreatic cells induces cell mass expansion and improved glucose tolerance in a TORC1-dependent manner
- (2008) L. Rachdi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started