mTORC1 Promotes Denervation-Induced Muscle Atrophy Through a Mechanism Involving the Activation of FoxO and E3 Ubiquitin Ligases

Sustained Activation of mTORC1 in Skeletal Muscle Inhibits Constitutive and Starvation-Induced Autophagy and Causes a Severe, Late-Onset Myopathy

(2013) Perrine Castets et al.   Cell Metabolism

Differential response of skeletal muscles to mTORC1 signaling during atrophy and hypertrophy

(2013) C Bentzinger et al.   Skeletal Muscle

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Cellular and molecular mechanisms of muscle atrophy

(2012) P. Bonaldo et al.   Disease Models & Mechanisms

A unifying model for mTORC1-mediated regulation of mRNA translation

(2012) Carson C. Thoreen et al.   NATURE

The translational landscape of mTOR signalling steers cancer initiation and metastasis

(2012) Andrew C. Hsieh et al.   NATURE

Systems biology of skeletal muscle: fiber type as an organizing principle

(2012) Sarah M. Greising et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Rapamycin treatment augments motor neuron degeneration in SOD1G93Amouse model of amyotrophic lateral sclerosis

(2011) Xiaojie Zhang et al.   Autophagy

Recent progress toward understanding the molecular mechanisms that regulate skeletal muscle mass

(2011) Craig A. Goodman et al.   CELLULAR SIGNALLING

mTOR signaling in disease

(2011) Eva Dazert et al.   CURRENT OPINION IN CELL BIOLOGY

Inhibition of FoxO transcriptional activity prevents muscle fiber atrophy during cachexia and induces hypertrophy

(2011) Sarah A. Reed et al.   FASEB JOURNAL

Mechanotransduction and the regulation of mTORC1 signaling in skeletal muscle

(2011) Troy A. Hornberger   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Myogenin regulates denervation-dependent muscle atrophy in mouse soleus muscle

(2011) Peter C. D. Macpherson et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Reduction of ribosome biogenesis with activation of the mTOR pathway in denervated atrophic muscle

(2011) Masanao Machida et al.   JOURNAL OF CELLULAR PHYSIOLOGY

mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice

(2011) Ken Inoki et al.   JOURNAL OF CLINICAL INVESTIGATION

Phosphoproteomic Analysis Identifies Grb10 as an mTORC1 Substrate That Negatively Regulates Insulin Signaling

(2011) Y. Yu et al.   SCIENCE

The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling

(2011) P. P. Hsu et al.   SCIENCE

Regulation of skeletal muscle growth by the IGF1-Akt/PKB pathway: insights from genetic models

(2011) Stefano Schiaffino et al.   Skeletal Muscle

Intracellular signaling pathways regulating net protein balance following diaphragm muscle denervation

(2010) Heather M. Argadine et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Motor Neuron Diversity in Development and Disease

(2010) Kevin C. Kanning et al.   Annual Review of Neuroscience

Motor neuron disease: systematic reviews of treatment for ALS and SMA

(2010) R. W. Orrell   BRITISH MEDICAL BULLETIN

Myogenin and Class II HDACs Control Neurogenic Muscle Atrophy by Inducing E3 Ubiquitin Ligases

(2010) Viviana Moresi et al.   CELL

FOXO signaling is required for disuse muscle atrophy and is directly regulated by Hsp70

(2009) Sarah M. Senf et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Regulation of mTOR Complex 1 (mTORC1) by Raptor Ser863and Multisite Phosphorylation

(2009) Kathryn G. Foster et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy

(2009) Valérie Risson et al.   JOURNAL OF CELL BIOLOGY

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

(2009) David E. Harrison et al.   NATURE

Skeletal Muscle-Specific Ablation of raptor, but Not of rictor, Causes Metabolic Changes and Results in Muscle Dystrophy

(2008) C. Florian Bentzinger et al.   Cell Metabolism

S6K Directly Phosphorylates IRS-1 on Ser-270 to Promote Insulin Resistance in Response to TNF-α Signaling through IKK2

(2008) Jin Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Histone Deacetylase 4/Myogenin Positive Feedback Loop Coordinates Denervation-dependent Gene Induction and Suppression

(2008) Huibin Tang et al.   MOLECULAR BIOLOGY OF THE CELL