The TORC1-activated Proteins, p70S6K and GRB10, Regulate IL-4 Signaling and M2 Macrophage Polarization by Modulating Phosphorylation of Insulin Receptor Substrate-2

The adaptor protein insulin receptor substrate 2 inhibits alternative macrophage activation and allergic lung inflammation

(2016) Preeta Dasgupta et al.   Science Signaling

Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation

(2016) Anthony J Covarrubias et al.   eLife

The adaptor protein insulin receptor substrate 2 inhibits alternative macrophage activation and allergic lung inflammation

(2016) Preeta Dasgupta et al.   Science Signaling

Control of macrophage metabolism and activation by mTOR and Akt signaling

(2015) Anthony J. Covarrubias et al.   SEMINARS IN IMMUNOLOGY

Insulin and Metabolic Stress Stimulate Multisite Serine/Threonine Phosphorylation of Insulin Receptor Substrate 1 and Inhibit Tyrosine Phosphorylation

(2014) Nancy J. Hançer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Myeloid-Specific Rictor Deletion Induces M1 Macrophage Polarization and Potentiates In Vivo Pro-Inflammatory Response to Lipopolysaccharide

(2014) William T. Festuccia et al.   PLoS One

TSC1 controls macrophage polarization to prevent inflammatory disease

(2014) Linnan Zhu et al.   Nature Communications

Rapamycin unbalances the polarization of human macrophages to M1

(2013) Alessia Mercalli et al.   IMMUNOLOGY

The TSC-mTOR pathway regulates macrophage polarization

(2013) Vanessa Byles et al.   Nature Communications

Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2

(2012) K. D. Copps et al.   DIABETOLOGIA

The Extracellular and Transmembrane Domains of the γC and Interleukin (IL)-13 Receptor α1 Chains, Not Their Cytoplasmic Domains, Dictate the Nature of Signaling Responses to IL-4 and IL-13

(2012) Nicola M. Heller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphoproteomic Analysis Identifies Grb10 as an mTORC1 Substrate That Negatively Regulates Insulin Signaling

(2011) Y. Yu et al.   SCIENCE

The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling

(2011) P. P. Hsu et al.   SCIENCE

Insulin-induced serine phosphorylation of IRS-2 via ERK1/2 and mTOR: studies on the function of Ser675 and Ser907

(2010) Louise Fritsche et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1)

(2010) Laura R. Pearce et al.   BIOCHEMICAL JOURNAL

Mechanism of Activation of PKB/Akt by the Protein Phosphatase Inhibitor Calyculin A

(2010) Mercedes Pozuelo-Rubio et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

More alternative activation of macrophages in lungs of asthmatic patients

(2010) Barbro N. Melgert et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

NEDD4-2 associates with γc and regulates its degradation rate

(2009) Valérie Malardé et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A multi-centre study of candidate genes for wheeze and allergy: the International Study of Asthma and Allergies in Childhood Phase 2

(2009) J. Genuneit et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Alveolar Macrophage Subpopulations in Bronchoalveolar Lavage and Induced Sputum of Asthmatic and Control Subjects

(2009) Julie St-Laurent et al.   JOURNAL OF ASTHMA

mTOR signaling at a glance

(2009) M. Laplante et al.   JOURNAL OF CELL SCIENCE

Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2

(2009) Morris E Feldman et al.   PLOS BIOLOGY

Phosphorylation of IRS proteins, insulin action, and insulin resistance

(2008) Sigalit Boura-Halfon et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Advances in asthma and allergy genetics in 2007

(2008) Donata Vercelli   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Grb10/Nedd4-mediated multiubiquitination of the insulin-like growth factor receptor regulates receptor internalization

(2008) Giada Monami et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Type I IL-4Rs Selectively Activate IRS-2 to Induce Target Gene Expression in Macrophages

(2008) N. M. Heller et al.   Science Signaling