Altered nutrient response of mTORC1 as a result of changes in REDD1 expression: effect of obesity vs. REDD1 deficiency

Regulated in DNA damage and development 1 (REDD1) promotes cell survival during serum deprivation by sustaining repression of signaling through the mechanistic target of rapamycin in complex 1 (mTORC1)

(2013) Michael D. Dennis et al.   CELLULAR SIGNALLING

Insulin Stimulates Mitochondrial Fusion and Function in Cardiomyocytes via the Akt-mTOR-NF B-Opa-1 Signaling Pathway

(2013) V. Parra et al.   DIABETES

Influence of glucocorticoids and growth hormone on insulin sensitivity in humans

(2013) K. C. J. Yuen et al.   DIABETIC MEDICINE

Abnormal protein turnover and anabolic resistance to exercise in sarcopenic obesity

(2013) Mats I. Nilsson et al.   FASEB JOURNAL

Branched chain amino acids are novel biomarkers for discrimination of metabolic wellness

(2013) Bryan C. Batch et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

The mTORC1 signaling repressors REDD1/2 are rapidly induced and activation of p70S6K1 by leucine is defective in skeletal muscle of an immobilized rat hindlimb

(2012) Andrew R. Kelleher et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Sarcopenia in the aging high-fat fed rat: a pilot study for modeling sarcopenic obesity in rodents

(2012) L. Cornelius Bollheimer et al.   BIOGERONTOLOGY

Muscle-Specific Deletion of Carnitine Acetyltransferase Compromises Glucose Tolerance and Metabolic Flexibility

(2012) Deborah M. Muoio et al.   Cell Metabolism

Rheb is a Critical Regulator of Autophagy During Myocardial Ischemia

(2012) Sebastiano Sciarretta et al.   CIRCULATION

mTORC1 and mTORC2 regulate insulin secretion through Akt in INS-1 cells

(2012) Olivier Le Bacquer et al.   JOURNAL OF ENDOCRINOLOGY

Erratum: Regulation of cytoplasmic mRNA decay

(2012) Daniel R. Schoenberg et al.   NATURE REVIEWS GENETICS

Metabolic Consequences of High-Fat Diet Are Attenuated by Suppression of HIF-1α

(2012) Mi-Kyung Shin et al.   PLoS One

Altered REDD1, myostatin, and Akt/mTOR/FoxO/MAPK signaling in streptozotocin-induced diabetic muscle atrophy

(2011) Juha J. Hulmi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Rapid induction of REDD1 expression by endurance exercise in rat skeletal muscle

(2011) Taro Murakami et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

BMI and the risk of renal cell carcinoma

(2011) Barry B. McGuire et al.   CURRENT OPINION IN UROLOGY

Oxidative DNA damage and obesity in type 2 diabetes mellitus

(2011) Hayder A Al-Aubaidy et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Mechanisms Involved in the Coordinate Regulation of mTORC1 by Insulin and Amino Acids

(2011) Michael D. Dennis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Relative Muscle Mass Is Inversely Associated with Insulin Resistance and Prediabetes. Findings from The Third National Health and Nutrition Examination Survey

(2011) Preethi Srikanthan et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Interplay Between pVHL and mTORC1 Pathways in Clear-Cell Renal Cell Carcinoma

(2011) B. Kucejova et al.   MOLECULAR CANCER RESEARCH

Intermittent Hypoxia Exacerbates Metabolic Effects of Diet-Induced Obesity

(2011) Luciano F. Drager et al.   Obesity

Downregulation of Akt/mammalian target of rapamycin pathway in skeletal muscle is associated with increased REDD1 expression in response to chronic hypoxia

(2010) François B. Favier et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

AICAR treatment for 14 days normalizes obesity-induced dysregulation of TORC1 signaling and translational capacity in fasted skeletal muscle

(2010) Joshua C. Drake et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

(2010) Katrin Düvel et al.   MOLECULAR CELL

Sarcopenia Exacerbates Obesity-Associated Insulin Resistance and Dysglycemia: Findings from the National Health and Nutrition Examination Survey III

(2010) Preethi Srikanthan et al.   PLoS One

AMPK inhibits myoblast differentiation through a PGC-1α-dependent mechanism

(2009) David L. Williamson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance

(2009) Christopher B. Newgard et al.   Cell Metabolism

Morphological and biochemical alterations of skeletal muscles from the genetically obese (ob/ob) mouse

(2009) J G Kemp et al.   INTERNATIONAL JOURNAL OF OBESITY

Insulin Induces REDD1 Expression through Hypoxia-inducible Factor 1 Activation in Adipocytes

(2009) Claire Regazzetti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of REDD1 by insulin-like growth factor-I in skeletal muscle and myotubes

(2009) Robert A. Frost et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The Pathogenetic Role of Cortisol in the Metabolic Syndrome: A Hypothesis

(2009) Panagiotis Anagnostis et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Lipid-induced mTOR activation in rat skeletal muscle reversed by exercise and 5′-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside

(2009) Donato A Rivas et al.   JOURNAL OF ENDOCRINOLOGY

Elevated Corticosterone Associated with Food Deprivation Upregulates Expression in Rat Skeletal Muscle of the mTORC1 Repressor, REDD1

(2009) Nora K. McGhee et al.   JOURNAL OF NUTRITION

Chronic high fat feeding attenuates load-induced hypertrophy in mice

(2009) Mitchell Sitnick et al.   JOURNAL OF PHYSIOLOGY-LONDON

Human Muscle Gene Expression following Resistance Exercise and Blood Flow Restriction

(2009) MICAH J. DRUMMOND et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Obesity Increases Vascular Senescence and Susceptibility to Ischemic Injury Through Chronic Activation of Akt and mTOR

(2009) C.-Y. Wang et al.   Science Signaling

Acute Alcohol Intoxication Increases REDD1 in Skeletal Muscle

(2008) Charles H. Lang et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Satellite cell proliferation is reduced in muscles of obese Zucker rats but restored with loading

(2008) Jonathan M. Peterson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Lower growth hormone and higher cortisol are associated with greater visceral adiposity, intramyocellular lipids, and insulin resistance in overweight girls

(2008) Madhusmita Misra et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Rapamycin does not improve insulin sensitivity despite elevated mammalian target of rapamycin complex 1 activity in muscles of ob/ob mice

(2008) Andrew M. Miller et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

SKAR Links Pre-mRNA Splicing to mTOR/S6K1-Mediated Enhanced Translation Efficiency of Spliced mRNAs

(2008) Xiaoju Max Ma et al.   CELL

Hypoxia regulates TSC1/2 mTOR signaling and tumor suppression through REDD1-mediated 14 3 3 shuttling

(2008) M. P. DeYoung et al.   GENES & DEVELOPMENT

Growth inhibition of colon cancer cells by polyisoprenylated benzophenones is associated with induction of the endoplasmic reticulum response

(2008) Petr Protiva et al.   INTERNATIONAL JOURNAL OF CANCER

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE