Halfway between 2D and Animal Models: Are 3D Cultures the Ideal Tool to Study Cancer-Microenvironment Interactions?

PEG–peptide hydrogels reveal differential effects of matrix microenvironmental cues on melanoma drug sensitivity

(2017) Emi Y. Tokuda et al.   Integrative Biology

The Role of Tumor Microenvironment in Chemoresistance: To Survive, Keep Your Enemies Closer

(2017) Dimakatso Alice Senthebane et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Fine Tuning Cell Migration by a Disintegrin and Metalloproteinases

(2017) D. Dreymueller et al.   MEDIATORS OF INFLAMMATION

Induction of anti-VEGF therapy resistance by upregulated expression of microseminoprotein (MSMP)

(2017) T Mitamura et al.   ONCOGENE

Mimicking the Acute Myeloid Leukemia Niche for Molecular Study and Drug Screening

(2017) Mohammad Houshmand et al.   TISSUE ENGINEERING PART C-METHODS

BRAF inhibitors: resistance and the promise of combination treatments for melanoma

(2017) Merope Griffin et al.   Oncotarget

Organ Bioprinting: Are We There Yet?

(2017) Guifang Gao et al.   Advanced Healthcare Materials

Biomimetic Model of Tumor Microenvironment on Microfluidic Platform

(2017) Minhwan Chung et al.   Advanced Healthcare Materials

3D bioprinting and the current applications in tissue engineering

(2017) Ying Huang et al.   Biotechnology Journal

Three-Dimensional Cell Cultures in Drug Discovery and Development

(2017) Ye Fang et al.   SLAS Discovery

Microfluidic Biopsy Trapping Device for the Real-Time Monitoring of Tumor Microenvironment

(2017) Angela Babetski Holton et al.   PLoS One

3D bioprinting for engineering complex tissues

(2016) Christian Mandrycky et al.   BIOTECHNOLOGY ADVANCES

Molecular imaging and cancer gene therapy

(2016) Z Saadatpour et al.   CANCER GENE THERAPY

Three-Dimensional Breast Cancer Models Mimic Hallmarks of Size-Induced Tumor Progression

(2016) Manjulata Singh et al.   CANCER RESEARCH

Recent advances in hyaluronic acid hydrogels for biomedical applications

(2016) Christopher B Highley et al.   CURRENT OPINION IN BIOTECHNOLOGY

Adaptable stirred-tank culture strategies for large scale production of multicellular spheroid-based tumor cell models

(2016) Vítor E. Santo et al.   JOURNAL OF BIOTECHNOLOGY

Evaluation of assays for drug efficacy in a three-dimensional model of the lung

(2016) Julia M. Huber et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Single cell dual adherent-suspension co-culture micro-environment for studying tumor–stromal interactions with functionally selected cancer stem-like cells

(2016) Yu-Chih Chen et al.   LAB ON A CHIP

A framework for understanding and targeting residual disease in oncogene-driven solid cancers

(2016) Trever G Bivona et al.   NATURE MEDICINE

A practical guide to hydrogels for cell culture

(2016) Steven R Caliari et al.   NATURE METHODS

Three-dimensional culture systems in cancer research: Focus on tumor spheroid model

(2016) Sritama Nath et al.   PHARMACOLOGY & THERAPEUTICS

Printing Technologies for Medical Applications

(2016) Ashkan Shafiee et al.   TRENDS IN MOLECULAR MEDICINE

Culture on 3D Chitosan-Hyaluronic Acid Scaffolds Enhances Stem Cell Marker Expression and Drug Resistance in Human Glioblastoma Cancer Stem Cells

(2016) Kui Wang et al.   Advanced Healthcare Materials

Bioprinting the Cancer Microenvironment

(2016) Yu Shrike Zhang et al.   ACS Biomaterials-Science & Engineering

Bioprinting the Cancer Microenvironment

(2016) Yu Shrike Zhang et al.   ACS Biomaterials Science & Engineering

Drug testing and flow cytometry analysis on a large number of uniform sized tumor spheroids using a microfluidic device

(2016) Bishnubrata Patra et al.   Scientific Reports

Microenvironment complexity and matrix stiffness regulate breast cancer cell activity in a 3D in vitro model

(2016) Marta Cavo et al.   Scientific Reports

SDF-1alpha concentration dependent modulation of RhoA and Rac1 modifies breast cancer and stromal cells interaction

(2015) Jennifer Pasquier et al.   BMC CANCER

Co-targeting EGFR and Autophagy Impairs Ovarian Cancer Cell Survival during Detachment from the ECM

(2015) Zongyuan Yang et al.   CURRENT CANCER DRUG TARGETS

TGFβ signaling regulates epithelial–mesenchymal plasticity in ovarian cancer ascites-derived spheroids

(2015) Samah Rafehi et al.   ENDOCRINE-RELATED CANCER

Formation of stable small cell number three-dimensional ovarian cancer spheroids using hanging drop arrays for preclinical drug sensitivity assays

(2015) Shreya Raghavan et al.   GYNECOLOGIC ONCOLOGY

Breast cancer cells promote a notch-dependent mesenchymal phenotype in endothelial cells participating to a pro-tumoral niche

(2015) Pegah Ghiabi et al.   Journal of Translational Medicine

Precision medicine: lessons learned from the SHIVA trial – Authors' reply

(2015) Christophe Le Tourneau et al.   LANCET ONCOLOGY

Advances in Anticancer Immunotoxin Therapy

(2015) C. Alewine et al.   ONCOLOGIST

Bioprinting for cancer research

(2015) Stephanie Knowlton et al.   TRENDS IN BIOTECHNOLOGY

Local 3D matrix microenvironment regulates cell migration through spatiotemporal dynamics of contractility-dependent adhesions

(2015) Andrew D. Doyle et al.   Nature Communications

Intact LKB1 activity is required for survival of dormant ovarian cancer spheroids

(2015) Teresa Peart et al.   Oncotarget

Formation and manipulation of cell spheroids using a density adjusted PEG/DEX aqueous two phase system

(2015) Chungmin Han et al.   Scientific Reports

High-Throughput Cancer Cell Sphere Formation for Characterizing the Efficacy of Photo Dynamic Therapy in 3D Cell Cultures

(2015) Yu-Chih Chen et al.   Scientific Reports

Epithelial to Mesenchymal Transition in a Clinical Perspective

(2015) Jennifer Pasquier et al.   Journal of Oncology

Fibroblasts Influence Survival and Therapeutic Response in a 3D Co-Culture Model

(2015) Meher Majety et al.   PLoS One

A microfluidic 3D in vitro model for specificity of breast cancer metastasis to bone

(2014) Simone Bersini et al.   BIOMATERIALS

Hanging drop cultures of human testis and testis cancer samples: a model used to investigate activin treatment effects in a preserved niche

(2014) A Jørgensen et al.   BRITISH JOURNAL OF CANCER

Three-dimensional constructs using hyaluronan cell carrier as a tool for the study of cancer stem cells

(2014) Cristina Martínez-Ramos et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS

Akt-Activated Endothelium Constitutes the Niche for Residual Disease and Resistance to Bevacizumab in Ovarian Cancer

(2014) B. S. Guerrouahen et al.   MOLECULAR CANCER THERAPEUTICS

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

3D bioprinting of tissues and organs

(2014) Sean V Murphy et al.   NATURE BIOTECHNOLOGY

Endothelial Cells Provide a Notch-Dependent Pro-Tumoral Niche for Enhancing Breast Cancer Survival, Stemness and Pro-Metastatic Properties

(2014) Pegah Ghiabi et al.   PLoS One

Animal models and therapeutic molecular targets of cancer: utility and limitations

(2014) Maria Cekanova et al.   Drug Design Development and Therapy

Versican regulates metastasis of epithelial ovarian carcinoma cells and spheroids

(2014) Mark Desjardins et al.   Journal of Ovarian Research

Three-Dimensional In Vitro Co-Culture Model of Breast Tumor using Magnetic Levitation

(2014) Hamsa Jaganathan et al.   Scientific Reports

Apoptosis and Molecular Targeting Therapy in Cancer

(2014) Mohamed Hassan et al.   Biomed Research International

Strategies for directing the structure and function of three-dimensional collagen biomaterials across length scales

(2013) B.D. Walters et al.   Acta Biomaterialia

Mathematical Modeling of Eukaryotic Cell Migration: Insights Beyond Experiments

(2013) Gaudenz Danuser et al.   Annual Review of Cell and Developmental Biology

Chemokine receptor expression on integrin-mediated stellate projections of prostate cancer cells in 3D culture

(2013) Debra L. Kiss et al.   CYTOKINE

Regulation of contact inhibition of locomotion by Eph-ephrin signalling

(2013) J. BATSON et al.   JOURNAL OF MICROSCOPY

Skin and hair on-a-chip: in vitro skin models versus ex vivo tissue maintenance with dynamic perfusion

(2013) Beren Ataç et al.   LAB ON A CHIP

The role of tumour–stromal interactions in modifying drug response: challenges and opportunities

(2013) Douglas W. McMillin et al.   NATURE REVIEWS DRUG DISCOVERY

Assembly of a Three-Dimensional Multitype Bronchiole Coculture Model Using Magnetic Levitation

(2013) Hubert Tseng et al.   TISSUE ENGINEERING PART C-METHODS

Carbonic Anhydrase IX Promotes Tumor Growth and Necrosis In Vivo and Inhibition Enhances Anti-VEGF Therapy

(2012) A. McIntyre et al.   CLINICAL CANCER RESEARCH

The contribution of oxidative stress to drug-induced organ toxicity and its detectionin vitroandin vivo

(2012) Claudia V Pereira et al.   Expert Opinion on Drug Metabolism & Toxicology

Microengineered physiological biomimicry: Organs-on-Chips

(2012) Dongeun Huh et al.   LAB ON A CHIP

Hyaluronic acid modified mesoporous silica nanoparticles for targeted drug delivery to CD44-overexpressing cancer cells

(2012) Meihua Yu et al.   Nanoscale

New dimensions in cell migration

(2012) Peter Friedl et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Circumventing Cancer Drug Resistance in the Era of Personalized Medicine

(2012) Levi A. Garraway et al.   Cancer Discovery

Engineering the Regenerative Microenvironment with Biomaterials

(2012) Jeffrey J. Rice et al.   Advanced Healthcare Materials

Role of the Microenvironment in Ovarian Cancer Stem Cell Maintenance

(2012) Jennifer Pasquier et al.   Biomed Research International

A Microfluidic System for Testing the Responses of Head and Neck Squamous Cell Carcinoma Tissue Biopsies to Treatment with Chemotherapy Drugs

(2011) Samantha M. Hattersley et al.   ANNALS OF BIOMEDICAL ENGINEERING

Self-assembled nanoparticles based on hyaluronic acid-ceramide (HA-CE) and Pluronic® for tumor-targeted delivery of docetaxel

(2011) Hyun-Jong Cho et al.   BIOMATERIALS

The enhancement of cancer stem cell properties of MCF-7 cells in 3D collagen scaffolds for modeling of cancer and anti-cancer drugs

(2011) Lei Chen et al.   BIOMATERIALS

Micro-ring structures stabilize microdroplets to enable long term spheroid culture in 384 hanging drop array plates

(2011) Amy Y. Hsiao et al.   BIOMEDICAL MICRODEVICES

384 hanging drop arrays give excellent Z-factors and allow versatile formation of co-culture spheroids

(2011) Amy Y. Hsiao et al.   BIOTECHNOLOGY AND BIOENGINEERING

Cancer Invasion and the Microenvironment: Plasticity and Reciprocity

(2011) Peter Friedl et al.   CELL

Ovarian cancer cells with the CD117 phenotype are highly tumorigenic and are related to chemotherapy outcome

(2011) Lijing Luo et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

High-throughput 3D spheroid culture and drug testing using a 384 hanging drop array

(2010) Yi-Chung Tung et al.   ANALYST

A complex 3D human tissue culture system based on mammary stromal cells and silk scaffolds for modeling breast morphogenesis and function

(2010) Xiuli Wang et al.   BIOMATERIALS

Bioengineered 3D platform to explore cell–ECM interactions and drug resistance of epithelial ovarian cancer cells

(2010) Daniela Loessner et al.   BIOMATERIALS

Hallmarks of cancer: Interactions with the tumor stroma

(2010) Kristian Pietras et al.   EXPERIMENTAL CELL RESEARCH

Targeting Aldehyde Dehydrogenase Cancer Stem Cells in Ovarian Cancer

(2010) C. N. Landen et al.   MOLECULAR CANCER THERAPEUTICS

Competition amongst Eph receptors regulates contact inhibition of locomotion and invasiveness in prostate cancer cells

(2010) Jonathan W. Astin et al.   NATURE CELL BIOLOGY

Three-dimensional tissue culture based on magnetic cell levitation

(2010) Glauco R. Souza et al.   Nature Nanotechnology

CD24+ cells from hierarchically organized ovarian cancer are enriched in cancer stem cells

(2010) M-Q Gao et al.   ONCOGENE

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

High-throughput laser printing of cells and biomaterials for tissue engineering

(2009) F. Guillemot et al.   Acta Biomaterialia

Collagen Structure and Stability

(2009) Matthew D. Shoulders et al.   Annual Review of Biochemistry

Microfluidic system for formation of PC-3 prostate cancer co-culture spheroids

(2009) Amy Y. Hsiao et al.   BIOMATERIALS

Hydrogels as extracellular matrix mimics for 3D cell culture

(2009) Mark W. Tibbitt et al.   BIOTECHNOLOGY AND BIOENGINEERING

Cancer Statistics, 2009

(2009) A. Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Tissue architecture and function: dynamic reciprocity via extra- and intra-cellular matrices

(2009) Ren Xu et al.   CANCER AND METASTASIS REVIEWS

The extracellular matrix in development and morphogenesis: A dynamic view

(2009) Tania Rozario et al.   DEVELOPMENTAL BIOLOGY

Multicellular spheroids in ovarian cancer metastases: Biology and pathology

(2009) Kristy Shield et al.   GYNECOLOGIC ONCOLOGY

Three-Dimensional Overlay Culture Models of Human Breast Cancer Reveal a Critical Sensitivity to Mitogen-Activated Protein Kinase Kinase Inhibitors

(2009) Q. Li et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

A microfluidic 3D hepatocyte chip for drug toxicity testing

(2009) Yi-Chin Toh et al.   LAB ON A CHIP

Snail and Slug Mediate Radioresistance and Chemoresistance by Antagonizing p53-Mediated Apoptosis and Acquiring a Stem-Like Phenotype in Ovarian Cancer Cells

(2009) Nawneet K. Kurrey et al.   STEM CELLS

Bcl-2 Family Proteins Contribute to Apoptotic Resistance in Lung Cancer Multicellular Spheroids

(2008) Tsung-Ming Yang et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Recent advances in three-dimensional multicellular spheroid culture for biomedical research

(2008) Ruei-Zhen Lin et al.   Biotechnology Journal

Identification and Characterization of Ovarian Cancer-Initiating Cells from Primary Human Tumors

(2008) S. Zhang et al.   CANCER RESEARCH

Change in cell shape is required for matrix metalloproteinase-induced epithelial-mesenchymal transition of mammary epithelial cells

(2008) Celeste M. Nelson et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

An integrated microfluidic system for long-term perfusion culture and on-line monitoring of intestinal tissue models

(2008) Hiroshi Kimura et al.   LAB ON A CHIP

Epidermal Growth Factor–induced Enhancement of Glioblastoma Cell Migration in 3D Arises from an Intrinsic Increase in Speed But an Extrinsic Matrix- and Proteolysis-dependent Increase in Persistence

(2008) Hyung-Do Kim et al.   MOLECULAR BIOLOGY OF THE CELL

Comparison of 3D and 2D tumor models reveals enhanced HER2 activation in 3D associated with an increased response to trastuzumab

(2008) M Pickl et al.   ONCOGENE

Epigenetic regulation of CD133 and tumorigenicity of CD133+ ovarian cancer cells

(2008) T Baba et al.   ONCOGENE

Three-Dimensional Cell Culture Matrices: State of the Art

(2008) Jungwoo Lee et al.   TISSUE ENGINEERING PART B-REVIEWS