Apoptosis and Molecular Targeting Therapy in Cancer

Histone Deacetylase Inhibitors Sensitize Lung Cancer Cells to Hyperthermia: Involvement of Ku70/SirT-1 in Thermo-Protection

(2014) Mohamed K. Hassan et al.   PLoS One

Targeting Inhibitor of Apoptosis Proteins (IAPs) for Cancer Therapy

(2012) Simone Fulda   Anti-Cancer Agents in Medicinal Chemistry

Weekly paclitaxel plus trastuzumab in metastatic breast cancer pretreated with anthracyclines-a phase II multipractice study

(2012) Matthias John et al.   BMC CANCER

Clusterin is a potential molecular predictor for ovarian cancer patient's survival: targeting Clusterin improves response to paclitaxel

(2011) Mohamed K Hassan et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Efficient Elimination of Cancer Cells by Deoxyglucose-ABT-263/737 Combination Therapy

(2011) Ryuji Yamaguchi et al.   PLoS One

DNA repair and synthetic lethality

(2011) Gong‐she Guo et al.   International Journal of Oral Science

Novel HSP90 inhibitors, NVP-AUY922 and NVP-BEP800, radiosensitise tumour cells through cell-cycle impairment, increased DNA damage and repair protraction

(2010) L Stingl et al.   BRITISH JOURNAL OF CANCER

Mitochondrial signaling in cell death via the Bcl-2 family

(2010) Brian Leibowitz et al.   CANCER BIOLOGY & THERAPY

Crossing paths: interactions between the cell death machinery and growth factor survival signals

(2010) Gabriela Brumatti et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Targeting the Bcl-2

(2010) Mehul P Patel et al.   CURRENT OPINION IN ONCOLOGY

IAP antagonists: promising candidates for cancer therapy

(2010) Raimund Mannhold et al.   DRUG DISCOVERY TODAY

Targeting mitochondria for cancer therapy

(2010) David M. Hockenbery   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Inhibition of NF-κB Signaling by Quinacrine Is Cytotoxic to Human Colon Carcinoma Cell Lines and Is Synergistic in Combination with Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) or Oxaliplatin

(2010) Tanvi S. Jani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human Mutations That Confer Paclitaxel Resistance

(2010) S. Yin et al.   MOLECULAR CANCER THERAPEUTICS

Homing in on delivery

(2010) Monya Baker   NATURE

Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles

(2010) Mark E. Davis et al.   NATURE

Genomic instability — an evolving hallmark of cancer

(2010) Simona Negrini et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cancer Cells Acquire Mitotic Drug Resistance Properties Through Beta I-Tubulin Mutations and Alterations in the Expression of Beta-Tubulin Isotypes

(2010) Chun Hei Antonio Cheung et al.   PLoS One

Survivin: A new target for anti-cancer therapy

(2009) Bríd M. Ryan et al.   CANCER TREATMENT REVIEWS

Procaspase 8 overexpression in non-small-cell lung cancer promotes apoptosis induced by FLIP silencing

(2009) T R Wilson et al.   CELL DEATH AND DIFFERENTIATION

Bcl-2 Inhibitors: Targeting Mitochondrial Apoptotic Pathways in Cancer Therapy

(2009) M. H. Kang et al.   CLINICAL CANCER RESEARCH

Overcoming Drug Resistance by Enhancing Apoptosis of Tumor Cells

(2009) Pepita Gimenez-Bonafe et al.   CURRENT CANCER DRUG TARGETS

Anti-Apoptotic Mechanisms of Drug Resistance in Cancer

(2009) T. Wilson et al.   CURRENT CANCER DRUG TARGETS

Defining the DNA mismatch repair-dependent apoptotic pathway in primary cells: Evidence for p53-independence and involvement of centrosomal caspase 2

(2009) Kelly A.D. Narine et al.   DNA REPAIR

Life and death by death receptors

(2009) Maria Eugenia Guicciardi et al.   FASEB JOURNAL

Cellular FLICE-inhibitory protein (c-FLIP) signalling: A key regulator of receptor-mediated apoptosis in physiologic context and in cancer

(2009) Marina Bagnoli et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Puma strikes Bax: Figure 1.

(2009) Anthony Letai   JOURNAL OF CELL BIOLOGY

Bax activation by the BH3-only protein Puma promotes cell dependence on antiapoptotic Bcl-2 family members

(2009) Tristan Gallenne et al.   JOURNAL OF CELL BIOLOGY

Expression and biological significance of c-FLIP in human hepatocellular carcinomas

(2009) Xilin Du et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Combining Hit Identification Strategies: Fragment-Based and in Silico Approaches to Orally Active 2-Aminothieno[2,3-d]pyrimidine Inhibitors of the Hsp90 Molecular Chaperone

(2009) Paul A. Brough et al.   JOURNAL OF MEDICINAL CHEMISTRY

RNA Interference in Cancer: Targeting the Anti-Apoptotic Protein c-FLIP for Drug Discovery

(2009) Travis Day et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

The First Targeted Delivery of siRNA in Humans via a Self-Assembling, Cyclodextrin Polymer-Based Nanoparticle: From Concept to Clinic

(2009) Mark E. Davis   MOLECULAR PHARMACEUTICS

Knocking down barriers: advances in siRNA delivery

(2009) Kathryn A. Whitehead et al.   NATURE REVIEWS DRUG DISCOVERY

Differential Expression of NUDT9 at Different Phases of The Menstrual Cycle and in Different Components of Normal and Neoplastic Human Endometrium

(2009) Ling-Yun Chen et al.   Taiwanese Journal of Obstetrics & Gynecology

Heat shock protein inhibitors, 17-DMAG and KNK437, enhance arsenic trioxide-induced mitotic apoptosis

(2009) Yi-Chen Wu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The life of a cell: apoptosis regulation by the PI3K/PKB pathway

(2008) Vincent Duronio   BIOCHEMICAL JOURNAL

TRAIL and cancer therapy

(2008) Frank A.E. Kruyt   CANCER LETTERS

ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor

(2008) C. Tse et al.   CANCER RESEARCH

Therapeutic Efficacy of ABT-737, a Selective Inhibitor of BCL-2, in Small Cell Lung Cancer

(2008) C. L. Hann et al.   CANCER RESEARCH

NVP-AUY922: A Novel Heat Shock Protein 90 Inhibitor Active against Xenograft Tumor Growth, Angiogenesis, and Metastasis

(2008) S. A. Eccles et al.   CANCER RESEARCH

TRAIL receptor signalling and modulation: Are we on the right TRAIL?

(2008) Devalingam Mahalingam et al.   CANCER TREATMENT REVIEWS

Cellular FLICE-Like Inhibitory Protein (C-FLIP): A Novel Target for Cancer Therapy

(2008) Ahmad Safa et al.   CURRENT CANCER DRUG TARGETS

Targeting the extrinsic apoptosis pathway in cancer

(2008) Avi Ashkenazi   CYTOKINE & GROWTH FACTOR REVIEWS

Clusterin expression predicts survival of invasive cervical cancer patients treated with radical hysterectomy and systematic lymphadenectomy

(2008) Hidemichi Watari et al.   GYNECOLOGIC ONCOLOGY

Tumor resistance to apoptosis

(2008) Simone Fulda   INTERNATIONAL JOURNAL OF CANCER

Dysregulation of apoptotic signaling in cancer: Molecular mechanisms and therapeutic opportunities

(2008) Jessica Plati et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Inhibitor of apoptosis proteins in hematological malignancies

(2008) S Fulda   LEUKEMIA

Is NF-κB a good target for cancer therapy? Hopes and pitfalls

(2008) Véronique Baud et al.   NATURE REVIEWS DRUG DISCOVERY

IAP-targeted therapies for cancer

(2008) E C LaCasse et al.   ONCOGENE

An Oncogene-Induced DNA Damage Model for Cancer Development

(2008) T. D. Halazonetis et al.   SCIENCE

4,5-Diarylisoxazole Hsp90 Chaperone Inhibitors: Potential Therapeutic Agents for the Treatment of Cancer

(2007) Paul A. Brough et al.   JOURNAL OF MEDICINAL CHEMISTRY