Microenvironment complexity and matrix stiffness regulate breast cancer cell activity in a 3D in vitro model

Bioreactor-engineered cancer tissue-like structures mimic phenotypes, gene expression profiles and drug resistance patterns observed “in vivo”

(2015) Christian Hirt et al.   BIOMATERIALS

Alginate core-shell beads for simplified three-dimensional tumor spheroid culture and drug screening

(2015) Linfen Yu et al.   BIOMEDICAL MICRODEVICES

Elastin-Coated Biodegradable Photopolymer Scaffolds for Tissue Engineering Applications

(2014) Rossella Barenghi et al.   Biomed Research International

Micropatterning Alginate Substrates for In Vitro Cardiovascular Muscle on a Chip

(2013) Ashutosh Agarwal et al.   ADVANCED FUNCTIONAL MATERIALS

Engineered Culture Models for Studies of Tumor-Microenvironment Interactions

(2013) David W. Infanger et al.   Annual Review of Biomedical Engineering

Atomic force microscopy to investigate spatial patterns of response to interleukin-1beta in engineered cartilage tissue elasticity

(2013) Leonardo Peñuela et al.   JOURNAL OF BIOMECHANICS

Characterizing the micro-scale elastic modulus of hydrogels for use in regenerative medicine

(2013) Chad D. Markert et al.   Journal of the Mechanical Behavior of Biomedical Materials

Peptide Hydrogelation and Cell Encapsulation for 3D Culture of MCF-7 Breast Cancer Cells

(2013) Hongzhou Huang et al.   PLoS One

Matrix Stiffness in Three-Dimensional Systems Effects on the Behavior of C3A Cells

(2012) Xiaobo Huang et al.   ARTIFICIAL ORGANS

Engineering three-dimensional cell mechanical microenvironment with hydrogels

(2012) Guoyou Huang et al.   Biofabrication

Order versus Disorder: in vivo bone formation within osteoconductive scaffolds

(2012) Silvia Scaglione et al.   Scientific Reports

3D in vitro bioengineered tumors based on collagen I hydrogels

(2011) Christopher S. Szot et al.   BIOMATERIALS

Live cell division dynamics monitoring in 3D large spheroid tumor models using light sheet microscopy

(2011) Corinne Lorenzo et al.   Cell Division

Mechanical Properties of Cellularly Responsive Hydrogels and Their Experimental Determination

(2010) April M. Kloxin et al.   ADVANCED MATERIALS

A complex 3D human tissue culture system based on mammary stromal cells and silk scaffolds for modeling breast morphogenesis and function

(2010) Xiuli Wang et al.   BIOMATERIALS

Replication of the 3D architecture of tissues

(2010) R. Perez-Castillejos   Materials Today

Can tissue engineering concepts advance tumor biology research?

(2010) Dietmar W. Hutmacher et al.   TRENDS IN BIOTECHNOLOGY

Biomechanics: Cell Research and Applications for the Next Decade

(2009) Dennis Discher et al.   ANNALS OF BIOMEDICAL ENGINEERING

Probing cellular mechanobiology in three-dimensional culture with collagen–agarose matrices

(2009) Theresa A. Ulrich et al.   BIOMATERIALS

Hydrogels as extracellular matrix mimics for 3D cell culture

(2009) Mark W. Tibbitt et al.   BIOTECHNOLOGY AND BIOENGINEERING

The Mechanical Rigidity of the Extracellular Matrix Regulates the Structure, Motility, and Proliferation of Glioma Cells

(2009) T. A. Ulrich et al.   CANCER RESEARCH

Intrinsic extracellular matrix properties regulate stem cell differentiation

(2009) Gwendolen C. Reilly et al.   JOURNAL OF BIOMECHANICS

New dimensions in tumor immunology: what does 3D culture reveal?

(2008) Chantal Feder-Mengus et al.   TRENDS IN MOLECULAR MEDICINE

Maintaining dimensions and mechanical properties of ionically crosslinked alginate hydrogel scaffoldsin vitro

(2007) Catherine K. Kuo et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A