Multifaced Roles of the αvβ3 Integrin in Ehlers–Danlos and Arterial Tortuosity Syndromes’ Dermal Fibroblasts

Dermal fibroblast-to-myofibroblast transition sustained by αvß3 integrin-ILK-Snail1/Slug signaling is a common feature for hypermobile Ehlers-Danlos syndrome and hypermobility spectrum disorders

(2018) Nicoletta Zoppi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Connective tissue growth factor regulates transition of primary bronchial fibroblasts to myofibroblasts in asthmatic subjects

(2018) Katarzyna Wójcik-Pszczoła et al.   CYTOKINE

Transcriptome analysis of skin fibroblasts with dominant negative COL3A1 mutations provides molecular insights into the etiopathology of vascular Ehlers-Danlos syndrome

(2018) Nicola Chiarelli et al.   PLoS One

GLUT10—Lacking in Arterial Tortuosity Syndrome—Is Localized to the Endoplasmic Reticulum of Human Fibroblasts

(2017) Alessandra Gamberucci et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Osteogenesis imperfecta

(2017) Joan C. Marini et al.   Nature Reviews Disease Primers

Exploring the Role of RGD-Recognizing Integrins in Cancer

(2017) Markus Nieberler et al.   Cancers

Integrin αvβ3 Signaling in Tumor-Induced Bone Disease

(2017) Kristin Kwakwa et al.   Cancers

Extracellular matrix structure

(2016) Achilleas D. Theocharis et al.   ADVANCED DRUG DELIVERY REVIEWS

αv integrins: key regulators of tissue fibrosis

(2016) Kylie P. Conroy et al.   CELL AND TISSUE RESEARCH

Molecular insights into prolyl and lysyl hydroxylation of fibrillar collagens in health and disease

(2016) Rutger A. F. Gjaltema et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Transforming growth factor-β-dependent Wnt secretion controls myofibroblast formation and myocardial fibrosis progression in experimental autoimmune myocarditis

(2016) Przemyslaw Blyszczuk et al.   EUROPEAN HEART JOURNAL

The journey of integrins and partners in a complex interactions landscape studied by super-resolution microscopy and single protein tracking

(2016) Olivier Rossier et al.   EXPERIMENTAL CELL RESEARCH

Myofibroblasts

(2016) Boris Hinz   EXPERIMENTAL EYE RESEARCH

Glucose transporter type 10-lacking in arterial tortuosity syndrome-facilitates dehydroascorbic acid transport

(2016) Csilla E. Németh et al.   FEBS LETTERS

Integrin-mediated mechanotransduction

(2016) Zhiqi Sun et al.   JOURNAL OF CELL BIOLOGY

Regulation of epithelial-mesenchymal transition through epigenetic and post-translational modifications

(2016) Silvia Juliana Serrano-Gomez et al.   Molecular Cancer

RNAi-Mediated Downregulation of FKBP14 Suppresses the Growth of Human Ovarian Cancer Cells

(2016) Meng Lu et al.   ONCOLOGY RESEARCH

Transcriptome-Wide Expression Profiling in Skin Fibroblasts of Patients with Joint Hypermobility Syndrome/Ehlers-Danlos Syndrome Hypermobility Type

(2016) Nicola Chiarelli et al.   PLoS One

The phenotype of the musculocontractural type of Ehlers-Danlos syndrome due toCHST14mutations

(2015) Andreas R. Janecke et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Differential diagnosis and diagnostic flow chart of joint hypermobility syndrome/ehlers-danlos syndrome hypermobility type compared to other heritable connective tissue disorders

(2015) Marina Colombi et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS

The Genetics of Soft Connective Tissue Disorders

(2015) Olivier Vanakker et al.   Annual Review of Genomics and Human Genetics

GLUT10 deficiency leads to oxidative stress and non-canonical αvβ3 integrin-mediated TGFβ signalling associated with extracellular matrix disarray in arterial tortuosity syndrome skin fibroblasts

(2015) Nicoletta Zoppi et al.   HUMAN MOLECULAR GENETICS

Bruch’s membrane abnormalities in PRDM5-related brittle cornea syndrome

(2015) Louise F. Porter et al.   Orphanet Journal of Rare Diseases

The role of the extracellular matrix in chronic pain following injury

(2015) Maral Tajerian et al.   PAIN

A new role for the PI3K/Akt signaling pathway in the epithelial-mesenchymal transition

(2015) Wenting Xu et al.   Cell Adhesion & Migration

Damage-Associated Molecular Patterns Generated in Osteoarthritis Directly Excite Murine Nociceptive Neurons Through Toll-like Receptor 4

(2015) Rachel E. Miller et al.   Arthritis & Rheumatology

Oxidative exposure impairs TGF-β pathway via reduction of type II receptor and SMAD3 in human skin fibroblasts

(2014) Tianyuan He et al.   AGE

Osteogenesis imperfecta: Clinical diagnosis, nomenclature and severity assessment

(2014) F.S. Van Dijk et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

The anti-fibrotic effects of CCN1/CYR61 in primary portal myofibroblasts are mediated through induction of reactive oxygen species resulting in cellular senescence, apoptosis and attenuated TGF-β signaling

(2014) Erawan Borkham-Kamphorst et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Integrins αvβ5 and αvβ3 promote latent TGF-β1 activation by human cardiac fibroblast contraction

(2014) Vincent Sarrazy et al.   CARDIOVASCULAR RESEARCH

The extracellular matrix modulates the hallmarks of cancer

(2014) M. W. Pickup et al.   EMBO REPORTS

4-Hydroxynonenal impairs transforming growth factor-β1-induced elastin synthesis via epidermal growth factor receptor activation in human and murine fibroblasts

(2014) Pauline Larroque-Cardoso et al.   FREE RADICAL BIOLOGY AND MEDICINE

A Substrate Preference for the Rough Endoplasmic Reticulum Resident Protein FKBP22 during Collagen Biosynthesis

(2014) Yoshihiro Ishikawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Beyond Tissue Injury--Damage-Associated Molecular Patterns, Toll-Like Receptors, and Inflammasomes Also Drive Regeneration and Fibrosis

(2014) H.-J. Anders et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Scleroderma dermal fibroblasts overexpress vascular endothelial growth factor due to autocrine transforming growth factorβsignaling

(2014) Ikko Kajihara et al.   Modern Rheumatology

Remodelling the extracellular matrix in development and disease

(2014) Caroline Bonnans et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

FibronectinEDA Promotes Chronic Cutaneous Fibrosis Through Toll-Like Receptor Signaling

(2014) S. Bhattacharyya et al.   Science Translational Medicine

Transcription Factor Snail Regulates Tumor Necrosis Factor α-Mediated Synovial Fibroblast Activation in the Rheumatoid Joint

(2014) Shih-Yao Chen et al.   Arthritis & Rheumatology

Re-writing the natural history of pain and related symptoms in the joint hypermobility syndrome/Ehlers-Danlos syndrome, hypermobility type

(2013) Marco Castori et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Extracellular matrix signaling in morphogenesis and repair

(2013) Kelly C Clause et al.   CURRENT OPINION IN BIOTECHNOLOGY

Bax Exists in a Dynamic Equilibrium between the Cytosol and Mitochondria to Control Apoptotic Priming

(2013) Barbara Schellenberg et al.   MOLECULAR CELL

Snail as a Potential Target Molecule in Cardiac Fibrosis: Paracrine Action of Endothelial Cells on Fibroblasts Through Snail and CTGF Axis

(2013) Sae-Won Lee et al.   MOLECULAR THERAPY

Clinical and molecular characterization of 40 patients with classic Ehlers–Danlos syndrome: identification of 18 COL5A1 and 2 COL5A2 novel mutations

(2013) Marco Ritelli et al.   Orphanet Journal of Rare Diseases

Focal Adhesion Kinase: A Key Mediator of Transforming Growth Factor Beta Signaling in Fibroblasts

(2013) Andrew Leask   Advances in Wound Care

Mutations in FKBP14 Cause a Variant of Ehlers-Danlos Syndrome with Progressive Kyphoscoliosis, Myopathy, and Hearing Loss

(2012) Matthias Baumann et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Recent Developments in Myofibroblast Biology

(2012) Boris Hinz et al.   AMERICAN JOURNAL OF PATHOLOGY

Host Responses in Tissue Repair and Fibrosis

(2012) Jeremy S. Duffield et al.   Annual Review of Pathology-Mechanisms of Disease

Extracellular Matrix Remodeling: The Common Denominator in Connective Tissue DiseasesPossibilities for Evaluation and Current Understanding of the Matrix as More Than a Passive Architecture, but a Key Player in Tissue Failure

(2012) Morten A. Karsdal et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Type III and V collagens modulate the expression and assembly of EDA+ fibronectin in the extracellular matrix of defective Ehlers–Danlos syndrome fibroblasts

(2012) Nicoletta Zoppi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Educational paper

(2012) Lut Van Laer et al.   EUROPEAN JOURNAL OF PEDIATRICS

Comprehensive molecular analysis demonstrates type V collagen mutations in over 90% of patients with classic EDS and allows to refine diagnostic criteria

(2012) Sofie Symoens et al.   HUMAN MUTATION

The extracellular matrix: A dynamic niche in cancer progression

(2012) Pengfei Lu et al.   JOURNAL OF CELL BIOLOGY

Mechanisms of fibrosis: therapeutic translation for fibrotic disease

(2012) Thomas A Wynn et al.   NATURE MEDICINE

Mutations in PRDM5 in Brittle Cornea Syndrome Identify a Pathway Regulating Extracellular Matrix Development and Maintenance

(2011) Emma M.M. Burkitt Wright et al.   AMERICAN JOURNAL OF HUMAN GENETICS

CCN1/CYR61: the very model of a modern matricellular protein

(2011) Lester F. Lau   CELLULAR AND MOLECULAR LIFE SCIENCES

The role of β3-integrins in tumor angiogenesis: context is everything

(2011) Stephen D Robinson et al.   CURRENT OPINION IN CELL BIOLOGY

Functional Cooperation between Snail1 and Twist in the Regulation ofZEB1Expression during Epithelial to Mesenchymal Transition

(2011) Natàlia Dave et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification and Characterization of a Novel Integrin-Linked Kinase Inhibitor

(2011) Su-Lin Lee et al.   JOURNAL OF MEDICINAL CHEMISTRY

Dangers Within: DAMP Responses to Damage and Cell Death in Kidney Disease

(2011) D. L. Rosin et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Wnt3a Induces Myofibroblast Differentiation by Upregulating TGF-β Signaling Through SMAD2 in a β-Catenin-Dependent Manner

(2011) Jon M. Carthy et al.   PLoS One

CCN2 Is Required for the TGF-β Induced Activation of Smad1 - Erk1/2 Signaling Network

(2011) Sashidhar S. Nakerakanti et al.   PLoS One

Regulation of membrane traffic by integrin signaling

(2011) Sara A. Wickström et al.   TRENDS IN CELL BIOLOGY

Cross Talk among TGF-  Signaling Pathways, Integrins, and the Extracellular Matrix

(2011) J. S. Munger et al.   Cold Spring Harbor Perspectives in Biology

Cell-Extracellular Matrix Interactions in Normal and Diseased Skin

(2011) F. M. Watt et al.   Cold Spring Harbor Perspectives in Biology

Integrins in Cell Migration

(2011) A. Huttenlocher et al.   Cold Spring Harbor Perspectives in Biology

Molecular Architecture and Function of Matrix Adhesions

(2011) B. Geiger et al.   Cold Spring Harbor Perspectives in Biology

Integrin Structure, Activation, and Interactions

(2011) I. D. Campbell et al.   Cold Spring Harbor Perspectives in Biology

Overview of the Matrisome--An Inventory of Extracellular Matrix Constituents and Functions

(2011) R. O. Hynes et al.   Cold Spring Harbor Perspectives in Biology

TNF-α/NF-κB/Snail pathway in cancer cell migration and invasion

(2010) Y Wu et al.   BRITISH JOURNAL OF CANCER

Synovial fluid of patients with rheumatoid arthritis induces α-smooth muscle actin in human adipose tissue-derived mesenchymal stem cells through a TGF-β1-dependent mechanism

(2010) Hae Young Song et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Glucose transporter 10 and arterial tortuosity syndrome: The vitamin C connection

(2010) Fernando Segade   FEBS LETTERS

Mitochondrial GLUT10 facilitates dehydroascorbic acid import and protects cells against oxidative stress: mechanistic insight into arterial tortuosity syndrome

(2010) Yi-Ching Lee et al.   HUMAN MOLECULAR GENETICS

The extracellular matrix at a glance

(2010) C. Frantz et al.   JOURNAL OF CELL SCIENCE

Integrins and Extracellular Matrix in Mechanotransduction

(2010) M. A. Schwartz   Cold Spring Harbor Perspectives in Biology

The extracellular matrix in development and morphogenesis: A dynamic view

(2009) Tania Rozario et al.   DEVELOPMENTAL BIOLOGY

Genetic diseases of connective tissues: cellular and extracellular effects of ECM mutations

(2009) John F. Bateman et al.   NATURE REVIEWS GENETICS

Matrix mechanics and receptor–ligand interactions in cell adhesion

(2009) Dewi Harjanto et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

The Tail of Integrins, Talin, and Kindlins

(2009) M. Moser et al.   SCIENCE

The Extracellular Matrix: Not Just Pretty Fibrils

(2009) R. O. Hynes   SCIENCE

FAK-independent αvβ3 integrin-EGFR complexes rescue from anoikis matrix-defective fibroblasts

(2008) Nicoletta Zoppi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Proteases: Multifunctional Enzymes in Life and Disease

(2008) Carlos López-Otín et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kindlin-2 (Mig-2): a co-activator of β3integrins

(2008) Yan-Qing Ma et al.   JOURNAL OF CELL BIOLOGY

The ADAM metalloproteinases

(2008) D EDWARDS et al.   MOLECULAR ASPECTS OF MEDICINE

TGF-β1 increases motility and αvβ3 integrin up-regulation via PI3K, Akt and NF-κB-dependent pathway in human chondrosarcoma cells

(2007) Ying-Yi Yeh et al.   BIOCHEMICAL PHARMACOLOGY

Fibroblasts as novel therapeutic targets in chronic inflammation

(2007) S J Flavell et al.   BRITISH JOURNAL OF PHARMACOLOGY