Exploring the Role of RGD-Recognizing Integrins in Cancer

Hypoxia Selectively Enhances Integrin α 5 β 1 Receptor Expression in Breast Cancer to Promote Metastasis

(2017) Julia A. Ju et al.   MOLECULAR CANCER RESEARCH

Force interacts with macromolecular structure in activation of TGF-β

(2017) Xianchi Dong et al.   NATURE

Perspective of αvβ6-Integrin Imaging for Clinical Management of Pancreatic Carcinoma and Its Precursor Lesions

(2017) Katja Steiger et al.   Molecular Imaging

RGD-Binding Integrins in Head and Neck Cancers

(2017) Hanadi Ahmedah et al.   Cancers

A Comprehensive Evaluation of the Activity and Selectivity Profile of Ligands for RGD-binding Integrins

(2017) Tobias G. Kapp et al.   Scientific Reports

αvβ3- or α5β1-Integrin-Selective Peptidomimetics for Surface Coating

(2016) Carlos Mas-Moruno et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

99mTc-HisoDGR as a Potential SPECT Probe for Orthotopic Glioma Detection via Targeting of Integrin α5β1

(2016) Haitao Zhao et al.   BIOCONJUGATE CHEMISTRY

The complexity of integrins in cancer and new scopes for therapeutic targeting

(2016) Hellyeh Hamidi et al.   BRITISH JOURNAL OF CANCER

The role of integrins in TGFβ activation in the tumour stroma

(2016) Zareen Khan et al.   CELL AND TISSUE RESEARCH

Synergistic growth factor microenvironments

(2016) Manuel Salmerón-Sánchez et al.   CHEMICAL COMMUNICATIONS

Exploring Novel Methods for Modulating Tumor Blood Vessels in Cancer Treatment

(2016) Ping-Pui Wong et al.   CURRENT BIOLOGY

αvβ3 Integrin and tumour blood vessels—learning from the past to shape the future

(2016) Fevzi Demircioglu et al.   CURRENT OPINION IN CELL BIOLOGY

Molecular Basis of the Ligand Binding Specificity of αvβ8 Integrin

(2016) Akio Ozawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In Vivo PET Imaging of the Cancer Integrin αvβ6 Using 68 Ga-Labeled Cyclic RGD Nonapeptides

(2016) Johannes Notni et al.   JOURNAL OF NUCLEAR MEDICINE

Variation of Specific Activities of 68Ga-Aquibeprin and 68Ga-Avebetrin Enables Selective PET Imaging of Different Expression Levels of Integrins  5 1 and  v 3

(2016) J. Notni et al.   JOURNAL OF NUCLEAR MEDICINE

ITGA6 is directly regulated by hypoxia-inducible factors and enriches for cancer stem cell activity and invasion in metastatic breast cancer models

(2016) Danielle L. Peacock Brooks et al.   Molecular Cancer

The Cytoskeletal Adapter Protein Spinophilin Regulates Invadopodia Dynamics and Tumor Cell Invasion in Glioblastoma

(2016) Mujeeburahiman Cheerathodi et al.   MOLECULAR CANCER RESEARCH

Integrin-based therapeutics: biological basis, clinical use and new drugs

(2016) Klaus Ley et al.   NATURE REVIEWS DRUG DISCOVERY

Regulation of the Bioavailability of TGF-β and TGF-β-Related Proteins

(2016) Ian B. Robertson et al.   Cold Spring Harbor Perspectives in Biology

Clinical Application of Radiolabeled RGD Peptides for PET Imaging of Integrin αvβ3

(2016) Haojun Chen et al.   Theranostics

Role of EMT in Metastasis and Therapy Resistance

(2016) Bethany Smith et al.   Journal of Clinical Medicine

Amplification of TGFβ Induced ITGB6 Gene Transcription May Promote Pulmonary Fibrosis

(2016) Amanda L. Tatler et al.   PLoS One

Substrate engagement of integrins α5β1 and αvβ3 is necessary, but not sufficient, for high directional persistence in migration on fibronectin

(2016) Dimitris Missirlis et al.   Scientific Reports

Stable Peptides Instead of Stapled Peptides: Highly Potent αvβ6-Selective Integrin Ligands

(2015) Oleg V. Maltsev et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Regulation of integrin and growth factor signaling in biomaterials for osteodifferentiation

(2015) Qiang Wei et al.   Beilstein Journal of Organic Chemistry

Dual-Action Combination Therapy Enhances Angiogenesis while Reducing Tumor Growth and Spread

(2015) Ping-Pui Wong et al.   CANCER CELL

Integrin α5β1 and p53 convergent pathways in the control of anti-apoptotic proteins PEA-15 and survivin in high-grade glioma

(2015) G Renner et al.   CELL DEATH AND DIFFERENTIATION

Alternative splicing of KAI1 abrogates its tumor-suppressive effects on integrin αvβ3-mediated ovarian cancer biology

(2015) Sina Upheber et al.   CELLULAR SIGNALLING

Avβ3 integrin: Pathogenetic role in osteotropic tumors

(2015) Stefania Stucci et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

18 F-Alfatide II PET/CT in healthy human volunteers and patients with brain metastases

(2015) Chunjing Yu et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

In vivo biokinetic and metabolic characterization of the 68Ga-labelled α5β1-selective peptidomimetic FR366

(2015) Calogero D’Alessandria et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Integrin αvβ8-Mediated TGF-β Activation by Effector Regulatory T Cells Is Essential for Suppression of T-Cell-Mediated Inflammation

(2015) John J. Worthington et al.   IMMUNITY

Transforming Growth Factor-β and Interleukin-1β Signaling Pathways Converge on the Chemokine CCL20 Promoter

(2015) Oliver J. Brand et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

α5β1 integrin recycling promotes Arp2/3-independent cancer cell invasion via the formin FHOD3

(2015) Nikki R. Paul et al.   JOURNAL OF CELL BIOLOGY

TGF-β–Dependent Dendritic Cell Chemokinesis in Murine Models of Airway Disease

(2015) Mitsuo Hashimoto et al.   JOURNAL OF IMMUNOLOGY

68Ga-NOTA-PRGD2 PET/CT for Integrin Imaging in Patients with Lung Cancer

(2015) K. Zheng et al.   JOURNAL OF NUCLEAR MEDICINE

Complementary, Selective PET Imaging of Integrin Subtypes  5 1 and  v 3 Using 68Ga-Aquibeprin and 68Ga-Avebetrin

(2015) J. Notni et al.   JOURNAL OF NUCLEAR MEDICINE

The Effect of Bi-Terminal PEGylation of an Integrin  v 6-Targeted 18F Peptide on Pharmacokinetics and Tumor Uptake

(2015) S. H. Hausner et al.   JOURNAL OF NUCLEAR MEDICINE

Simultaneous β1 integrin-EGFR Targeting and Radiosensitization of Human Head and Neck Cancer

(2015) Iris Eke et al.   JNCI-Journal of the National Cancer Institute

Integrin endosomal signalling suppresses anoikis

(2015) Jonna Alanko et al.   NATURE CELL BIOLOGY

End of the road: confounding results of the CORE trial terminate the arduous journey of cilengitide for glioblastoma

(2015) W. P. Mason   NEURO-ONCOLOGY

Two cilengitide regimens in combination with standard treatment for patients with newly diagnosed glioblastoma and unmethylated MGMT gene promoter: results of the open-label, controlled, randomized phase II CORE study

(2015) L. Burt Nabors et al.   NEURO-ONCOLOGY

Dissociation of HSV gL from gH by αvβ6- or αvβ8-integrin promotes gH activation and virus entry

(2015) Tatiana Gianni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrin αvβ6 sustains and promotes tumor invasive growth in colon cancer progression

(2015) Guang-Yun Yang   WORLD JOURNAL OF GASTROENTEROLOGY

A novel HIF-1α-integrin-linked kinase regulatory loop that facilitates hypoxia-induced HIF-1α expression and epithelial-mesenchymal transition in cancer cells

(2015) Chih-Chien Chou et al.   Oncotarget

Simultaneous β1 integrin-EGFR Targeting and Radiosensitization of Human Head and Neck Cancer

(2015) Iris Eke et al.   JNCI-Journal of the National Cancer Institute

Correlation between the expression of integrins in prostate cancer and clinical outcome in 1284 patients

(2014) Katharina Heß et al.   Annals of Diagnostic Pathology

Redefining the role(s) of endothelial αvβ3-integrin in angiogenesis: Figure 1

(2014) Samuel J. Atkinson et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Single cell tracking assay reveals an opposite effect of selective small non-peptidic α5β1 or αvβ3/β5 integrin antagonists in U87MG glioma cells

(2014) Anne-Marie Ray et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Cytoplasmic salt bridge formation in integrin αvß3 stabilizes its inactive state affecting integrin-mediated cell biological effects

(2014) Martina A. Müller et al.   CELLULAR SIGNALLING

αvβ3, αvβ5 and αvβ6 integrins in brain metastases of lung cancer

(2014) Anna Sophie Berghoff et al.   CLINICAL & EXPERIMENTAL METASTASIS

Directed migration of mesenchymal cells: where signaling and the cytoskeleton meet

(2014) James E Bear et al.   CURRENT OPINION IN CELL BIOLOGY

Excessive vascular sprouting underlies cerebral hemorrhage in mice lacking  V 8-TGF  signaling in the brain

(2014) T. D. Arnold et al.   DEVELOPMENT

Switch from αvβ5 to αvβ6 integrin is required for CD9-regulated keratinocyte migration and MMP-9 activation

(2014) Xupin Jiang et al.   FEBS LETTERS

Integrins αvβ3 and αvβ5 as prognostic, diagnostic, and therapeutic targets in gastric cancer

(2014) Christine Böger et al.   Gastric Cancer

Overexpression of integrin αv facilitates proliferation and invasion of oral squamous cell carcinoma cells via MEK/ERK signaling pathway that is activated by interaction of integrin αvβ8 with type I collagen

(2014) YASUTAKA HAYASHIDO et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Release of Active TGF-β1 from the Latent TGF-β1/GARP Complex on T Regulatory Cells Is Mediated by Integrin β8

(2014) Justin P. Edwards et al.   JOURNAL OF IMMUNOLOGY

Pharmacophoric Modifications Lead to Superpotent αvβ3 Integrin Ligands with Suppressed α5β1 Activity

(2014) Stefanie Neubauer et al.   JOURNAL OF MEDICINAL CHEMISTRY

Strategies To Inhibit Tumor Associated Integrin Receptors: Rationale for Dual and Multi-Antagonists

(2014) Helen M. Sheldrake et al.   JOURNAL OF MEDICINAL CHEMISTRY

Integrin  v 6-Targeted SPECT Imaging for Pancreatic Cancer Detection

(2014) Z. Liu et al.   JOURNAL OF NUCLEAR MEDICINE

Therapeutic Targeting of Integrin αvβ6 in Breast Cancer

(2014) Kate M. Moore et al.   JNCI-Journal of the National Cancer Institute

99mTc-Labeled Cystine Knot Peptide Targeting Integrin αvβ6 for Tumor SPECT Imaging

(2014) Xiaohua Zhu et al.   MOLECULAR PHARMACEUTICS

An integrin β3–KRAS–RalB complex drives tumour stemness and resistance to EGFR inhibition

(2014) Laetitia Seguin et al.   NATURE CELL BIOLOGY

Structural basis for pure antagonism of integrin αVβ3 by a high-affinity form of fibronectin

(2014) Johannes F Van Agthoven et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dimerization of a Phage-Display Selected Peptide for Imaging of αvβ6- Integrin: Two Approaches to the Multivalent Effect

(2014) Ajay N. Singh et al.   Theranostics

H-CRRETAWAC-OH, a Lead Structure for the Development of Radiotracer Targeting Integrinα5β1?

(2014) Roland Haubner et al.   Biomed Research International

Hydrogel Micropillars with Integrin Selective Peptidomimetic Functionalized Nanopatterned Tops: A New Tool for the Measurement of Cell Traction Forces Transmitted through αvβ3- or α5β1-Integrins

(2013) Sabri Rahmouni et al.   ADVANCED MATERIALS

Selective Imaging of the Angiogenic Relevant Integrins α5β1 and αvβ3

(2013) Stefanie Neubauer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Anoikis molecular pathways and its role in cancer progression

(2013) Paolo Paoli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Bi-Directional Signaling: Extracellular Matrix and Integrin Regulation of Breast Tumor Progression

(2013) Scott Gehler et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Complete integrin headpiece opening in eight steps

(2013) Jieqing Zhu et al.   JOURNAL OF CELL BIOLOGY

The Glycophorin A Transmembrane Sequence within Integrin αvβ3 Creates a Non-Signaling Integrin with Low Basal Affinity That Is Strongly Adhesive under Force

(2013) Martina A. Müller et al.   JOURNAL OF MOLECULAR BIOLOGY

Preclinical SPECT/CT Imaging of  v 6 Integrins for Molecular Stratification of Idiopathic Pulmonary Fibrosis

(2013) A. E. John et al.   JOURNAL OF NUCLEAR MEDICINE

First Experience of 18F-Alfatide in Lung Cancer Patients Using a New Lyophilized Kit for Rapid Radiofluorination

(2013) W. Wan et al.   JOURNAL OF NUCLEAR MEDICINE

β1- and αv-class integrins cooperate to regulate myosin II during rigidity sensing of fibronectin-based microenvironments

(2013) Herbert B. Schiller et al.   NATURE CELL BIOLOGY

In vitro and in vivo evaluation of the effects of aluminum [18F]fluoride radiolabeling on an integrin αvβ6-specific peptide

(2013) Sven H. Hausner et al.   NUCLEAR MEDICINE AND BIOLOGY

Integrins and their ligands are expressed in non-small cell lung cancer but not correlated with parameters of disease progression

(2013) Christine Böger et al.   VIRCHOWS ARCHIV

Induction of Partial Protection against Foot and Mouth Disease Virus in Guinea Pigs by Neutralization with the Integrin β6-1 Subunit

(2013) Yan Zhang et al.   Viruses-Basel

FAK-heterozygous mice display enhanced tumour angiogenesis

(2013) Vassiliki Kostourou et al.   Nature Communications

Integrins and metastasis

(2013) Kirat Kumar Ganguly et al.   Cell Adhesion & Migration

 v Integrins in Angiogenesis and Cancer

(2013) S. M. Weis et al.   Cold Spring Harbor Perspectives in Medicine

Tumor Targeting via Integrin Ligands

(2013) Udaya Kiran Marelli et al.   Frontiers in Oncology

N-Methylation of Peptides and Proteins: An Important Element for Modulating Biological Functions

(2012) Jayanta Chatterjee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Defining the Role of Integrin αvβ6 in Cancer

(2012) A. Bandyopadhyay et al.   CURRENT DRUG TARGETS

Crystal structure of α5β1 integrin ectodomain: Atomic details of the fibronectin receptor

(2012) Masamichi Nagae et al.   JOURNAL OF CELL BIOLOGY

Finding the weakest link – exploring integrin-mediated mechanical molecular pathways

(2012) Pere Roca-Cusachs et al.   JOURNAL OF CELL SCIENCE

Biodistribution and Radiation Dosimetry of the Integrin Marker 18F-RGD-K5 Determined from Whole-Body PET/CT in Monkeys and Humans

(2012) M. Doss et al.   JOURNAL OF NUCLEAR MEDICINE

PEGylated Liposomal Doxorubicin Targeted to α5β1-Expressing MDA-MB-231 Breast Cancer Cells

(2012) Kamlesh Shroff et al.   LANGMUIR

Guiding plant virus particles to integrin-displaying cells

(2012) Marisa L. Hovlid et al.   Nanoscale

The origins of the molecular era of adhesion research

(2012) Alan Rick Horwitz   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Evaluation of an integrin αvβ6-specific peptide labeled with [18F]fluorine by copper-free, strain-promoted click chemistry

(2012) Sven H. Hausner et al.   NUCLEAR MEDICINE AND BIOLOGY

Integrins as therapeutic targets

(2012) Simon L. Goodman et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Why Integrin as a Primary Target for Imaging and Therapy

(2012) Gang Niu et al.   Theranostics

Cilengitide: The First Anti-Angiogenic Small Molecule Drug Candidate. Design, Synthesis and Clinical Evaluation

(2011) Carlos Mas-Moruno et al.   Anti-Cancer Agents in Medicinal Chemistry

E/N-cadherin switch mediates cancer progression via TGF-β-induced epithelial-to-mesenchymal transition in extrahepatic cholangiocarcinoma

(2011) K Araki et al.   BRITISH JOURNAL OF CANCER

Whole-Body Distribution and Radiation Dosimetry of 68Ga-NOTA-RGD, a Positron Emission Tomography Agent for Angiogenesis Imaging

(2011) Joong Hyun Kim et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Pharmacokinetically Stabilized Cystine Knot Peptides That Bind Alpha-v-Beta-6 Integrin with Single-Digit Nanomolar Affinities for Detection of Pancreatic Cancer

(2011) R. H. Kimura et al.   CLINICAL CANCER RESEARCH

The astrocyte-expressed integrin  v 8 governs blood vessel sprouting in the developing retina

(2011) S. Hirota et al.   DEVELOPMENT

βPix plays a dual role in cerebral vascular stability and angiogenesis, and interacts with integrin αvβ8

(2011) Jing Liu et al.   DEVELOPMENTAL BIOLOGY

Cilengitide: an RGD pentapeptide ανβ3 and ανβ5 integrin inhibitor in development for glioblastoma and other malignancies

(2011) David A Reardon et al.   Future Oncology

Integrin  5 1 facilitates cancer cell invasion through enhanced contractile forces

(2011) C. T. Mierke et al.   JOURNAL OF CELL SCIENCE

aV integrins and TGF-β-induced EMT: a circle of regulation

(2011) Fahmy A. Mamuya et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Mouse and human lung fibroblasts regulate dendritic cell trafficking, airway inflammation, and fibrosis through integrin αvβ8–mediated activation of TGF-β

(2011) Hideya Kitamura et al.   JOURNAL OF CLINICAL INVESTIGATION

Latent TGF-β structure and activation

(2011) Minlong Shi et al.   NATURE

Pilot Pharmacokinetic and Dosimetric Studies of18F-FPPRGD2: A PET Radiopharmaceutical Agent for Imaging αvβ3Integrin Levels

(2011) Erik S. Mittra et al.   RADIOLOGY

Integrin-Mediated Cell-Matrix Interaction in Physiological and Pathological Blood Vessel Formation

(2011) Stephan Niland et al.   Journal of Oncology

Endothelial  5 and  v integrins cooperate in remodeling of the vasculature during development

(2010) A. van der Flier et al.   DEVELOPMENT

Characteristics of the level-of-evidence-1 disease forecast cancer biomarkers uPA and its inhibitor PAI-1

(2010) Karin Mengele et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

The αvβ6 integrin is a highly specific immunohistochemical marker for cholangiocarcinoma

(2010) E. Patsenker et al.   JOURNAL OF HEPATOLOGY

Cell adhesion: integrating cytoskeletal dynamics and cellular tension

(2010) J. Thomas Parsons et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A mosaic mouse model of astrocytoma identifies αvβ8 integrin as a negative regulator of tumor angiogenesis

(2010) J H Tchaicha et al.   ONCOGENE

Transforming growth factor-β-induced epithelial–mesenchymal transition facilitates epidermal growth factor-dependent breast cancer progression

(2010) M K Wendt et al.   ONCOGENE

TGFβ: a sleeping giant awoken by integrins

(2010) John J. Worthington et al.   TRENDS IN BIOCHEMICAL SCIENCES

Immunohistochemical analysis of integrins αvβ3, αvβ5 and α5β1, and their ligands, fibrinogen, fibronectin, osteopontin and vitronectin, in frozen sections of human oral head and neck squamous cell carcinomas

(2010) EVA-MARIA FABRICIUS et al.   Experimental and Therapeutic Medicine

Integrins as triggers of Epstein-Barr virus fusion and epithelial cell infection

(2010) Lindsey M. Hutt-Fletcher et al.   Virulence

Reduced Expression of Integrin αvβ8 Is Associated with Brain Arteriovenous Malformation Pathogenesis

(2009) Hua Su et al.   AMERICAN JOURNAL OF PATHOLOGY

The Transmembrane Structure of Integrin αIIbβ3: Significance for Signal Transduction

(2009) Martin Hoefling et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Signal co-operation between integrins and other receptor systems

(2009) Charles H. Streuli et al.   BIOCHEMICAL JOURNAL

Targeted In vivo Imaging of Integrin  v 6 with an Improved Radiotracer and Its Relevance in a Pancreatic Tumor Model

(2009) S. H. Hausner et al.   CANCER RESEARCH

Function and Antagonism of β Integrins in the Development of Cancer Therapy

(2009) H. Sheldrake et al.   CURRENT CANCER DRUG TARGETS

Giving off mixed signals-Distinct functions of α5β1and αvβ3integrins in regulating cell behaviour

(2009) Mark R. Morgan et al.   IUBMB LIFE

Mice that lack activity of  v 6- and  v 8-integrins reproduce the abnormalities of Tgfb1- and Tgfb3-null mice

(2009) P. Aluwihare et al.   JOURNAL OF CELL SCIENCE

Linking integrin conformation to function

(2009) J. A. Askari et al.   JOURNAL OF CELL SCIENCE

Adhesion signaling - crosstalk between integrins, Src and Rho

(2009) S. Huveneers et al.   JOURNAL OF CELL SCIENCE

The basics of epithelial-mesenchymal transition

(2009) Raghu Kalluri et al.   JOURNAL OF CLINICAL INVESTIGATION

Synthesis and characterization of a high-affinity  v 6-specific ligand for in vitro and in vivo applications

(2009) S. Li et al.   MOLECULAR CANCER THERAPEUTICS

Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors

(2009) Andrew R Reynolds et al.   NATURE MEDICINE

Fusion of epithelial cells by Epstein-Barr virus proteins is triggered by binding of viral glycoproteins gHgL to integrins  v 6 or  v 8

(2009) L. S. Chesnokova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Tail of Integrins, Talin, and Kindlins

(2009) M. Moser et al.   SCIENCE

Identification of Vitronectin as an Extrinsic Inducer of Cancer Stem Cell Differentiation and Tumor Formation

(2009) Elaine M. Hurt et al.   STEM CELLS

In vitro and in vivo evidence for shear-induced activation of latent transforming growth factor- 1

(2008) J. Ahamed et al.   BLOOD

The GPIIb/IIIa (integrin  IIb 3) odyssey: a technology-driven saga of a receptor with twists, turns, and even a bend

(2008) B. S. Coller et al.   BLOOD

Expression of Integrin αvβ3in Gliomas Correlates with Tumor Grade and Is not Restricted to Tumor Vasculature

(2008) Oliver Schnell et al.   BRAIN PATHOLOGY

Signaling and regulatory mechanisms of integrin ανβ6 on the apoptosis of colon cancer cells

(2008) Zhang Zhao-yang et al.   CANCER LETTERS

Loss of E-Cadherin Promotes Ovarian Cancer Metastasis via  5-Integrin, which Is a Therapeutic Target

(2008) K. Sawada et al.   CANCER RESEARCH

 v 6 Integrin Promotes the Invasion of Morphoeic Basal Cell Carcinoma through Stromal Modulation

(2008) D. Marsh et al.   CANCER RESEARCH

Integrin alphavbeta6 mediates the potential for colon cancer cells to colonize in and metastasize to the liver

(2008) Guang-Yun Yang et al.   CANCER SCIENCE

Hypoxia-inducible factor (HIF)-1  directly enhances the transcriptional activity of stem cell factor (SCF) in response to hypoxia and epidermal growth factor (EGF)

(2008) Z.-B. Han et al.   CARCINOGENESIS

Rational Design of Highly Active and Selective Ligands for the α5β1 Integrin Receptor

(2008) Dominik Heckmann et al.   CHEMBIOCHEM

Integrins and the activation of latent transforming growth factor β1 – An intimate relationship

(2008) P WIPFF et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Selective induction of integrin β1 by hypoxia-inducible factor: implications for wound healing

(2008) Simon Keely et al.   FASEB JOURNAL

Integrin αvβ3 mediates upregulation of epidermal growth-factor receptor expression and activity in human ovarian cancer cells

(2008) Daniela Lössner et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Transforming Growth Factor β1 Induces αvβ3 Integrin Expression in Human Lung Fibroblasts via a β3 Integrin-, c-Src-, and p38 MAPK-dependent Pathway

(2008) Dmitri V. Pechkovsky et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extracellular matrix dynamics in development and regenerative medicine

(2008) W. P. Daley et al.   JOURNAL OF CELL SCIENCE

Engineering a Single-Chain Fv Antibody to αvβ6 Integrin Using the Specificity-Determining Loop of a Foot-and-Mouth Disease Virus

(2008) Heide Kogelberg et al.   JOURNAL OF MOLECULAR BIOLOGY

The Biodistribution and Radiation Dosimetry of the Arg-Gly-Asp Peptide 18F-AH111585 in Healthy Volunteers

(2008) B. J. McParland et al.   JOURNAL OF NUCLEAR MEDICINE

Structure of a Complete Integrin Ectodomain in a Physiologic Resting State and Activation and Deactivation by Applied Forces

(2008) Jianghai Zhu et al.   MOLECULAR CELL

Environmental sensing through focal adhesions

(2008) Benjamin Geiger et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Endocytosis and Cancer: an ‘Insider’ Network with Dangerous Liaisons

(2008) Letizia Lanzetti et al.   TRAFFIC

Overexpression of the αvβ6 Integrin in Endometrial Cancer

(2008) Jonathan L. Hecht et al.   APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY

TGF-β1 increases motility and αvβ3 integrin up-regulation via PI3K, Akt and NF-κB-dependent pathway in human chondrosarcoma cells

(2007) Ying-Yi Yeh et al.   BIOCHEMICAL PHARMACOLOGY

Integrin ανβ6 Acts as a Prognostic Indicator in Gastric Carcinoma

(2007) Z.-Y. Zhang et al.   CLINICAL ONCOLOGY

Transmembrane signal transduction of the αIIbβ3 integrin

(2002) Kay E. Gottschalk et al.   PROTEIN SCIENCE