A new role for the PI3K/Akt signaling pathway in the epithelial-mesenchymal transition

ROS-induced epithelial-mesenchymal transition in mammary epithelial cells is mediated by NF-κB-dependent activation of Snail

(2015) Magdalena A. Cichon et al.   Oncotarget

Role of aberrant PI3K pathway activation in gallbladder tumorigenesis

(2015) Andrea Lunardi et al.   Oncotarget

Ribonuclease inhibitor up-regulation inhibits the growth and induces apoptosis in murine melanoma cells through repression of angiogenin and ILK/PI3K/AKT signaling pathway

(2014) Lin Li et al.   BIOCHIMIE

The therapeutic potential of targeting the epithelial–mesenchymal transition in cancer

(2014) Kevin R Ginnebaugh et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Osthole Inhibits Insulin-like Growth Factor-1-Induced Epithelial to Mesenchymal Transition via the Inhibition of PI3K/Akt Signaling Pathway in Human Brain Cancer Cells

(2014) Ying-Chao Lin et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Inhibition of Epithelial to Mesenchymal Transition by E-cadherin Up-regulation via Repression of Slug Transcription and Inhibition of E-cadherin Degradation

(2014) Arghya Adhikary et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reversal Effect of ST6GAL 1 on Multidrug Resistance in Human Leukemia by Regulating the PI3K/Akt Pathway and the Expression of P-gp and MRP1

(2014) Hongye Ma et al.   PLoS One

Overexpression of integrin-linked kinase (ILK) promotes migration and invasion of colorectal cancer cells by inducing epithelial–mesenchymal transition via NF-κB signaling

(2013) Zhaopeng Yan et al.   ACTA HISTOCHEMICA

Epithelial-Mesenchymal Transition Markers in the Differential Diagnosis of Gastroenteropancreatic Neuroendocrine Tumors

(2013) Jose A. Galván et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

Epithelial–mesenchymal transition and cancer stemness: the Twist1–Bmi1 connection

(2013) Kou‑Juey Wu et al.   BIOSCIENCE REPORTS

Cell survival and metastasis regulation by Akt signaling in colorectal cancer

(2013) Ekta Agarwal et al.   CELLULAR SIGNALLING

Regulation of epithelial–mesenchymal and mesenchymal–epithelial transitions by microRNAs

(2013) Samy Lamouille et al.   CURRENT OPINION IN CELL BIOLOGY

Emodin represses TWIST1-induced epithelial–mesenchymal transitions in head and neck squamous cell carcinoma cells by inhibiting the β-catenin and Akt pathways

(2013) Tzong-Der Way et al.   EUROPEAN JOURNAL OF CANCER

TWIST1 promoter methylation is associated with prognosis in tonsillar squamous cell carcinoma

(2013) Mi Jung Kwon et al.   HUMAN PATHOLOGY

A method for in silico identification of SNAIL/SLUG DNA binding potentials to the E-box sequence using molecular dynamics and evolutionary conserved amino acids

(2013) Jeremy W. Prokop et al.   JOURNAL OF MOLECULAR MODELING

Reagents for developmental regulation of Hedgehog signaling

(2013) Cristy Lewis et al.   METHODS

Grape Seed Procyanidin Reversal of P-glycoprotein Associated Multi-Drug Resistance via Down-regulation of NF-κB and MAPK/ERK Mediated YB-1 Activity in A2780/T Cells

(2013) Bo-xin Zhao et al.   PLoS One

miR-200b inhibits TGF-β1-induced epithelial-mesenchymal transition and promotes growth of intestinal epithelial cells

(2013) Y Chen et al.   Cell Death & Disease

miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions

(2012) Helge Siemens et al.   CELL CYCLE

Transcriptional repression ofTWIST1gene by Prospero-related homeobox 1 inhibits invasiveness of hepatocellular carcinoma cells

(2012) Tsung-Ming Chang et al.   FEBS LETTERS

Effects of dexamethasone on the TGF-β1-induced epithelial-to-mesenchymal transition in human peritoneal mesothelial cells

(2012) Yang-Hee Jang et al.   LABORATORY INVESTIGATION

Akt/PKB-Mediated Phosphorylation of Twist1 Promotes Tumor Metastasis via Mediating Cross-Talk between PI3K/Akt and TGF-β Signaling Axes

(2012) Gongda Xue et al.   Cancer Discovery

TWIST and p-Akt immunoexpression in normal oral epithelium, oral dysplasia and in oral squamous cell carcinoma

(2012) B. Santos de Freitas-Silva et al.   Medicina Oral Patologia Oral y Cirugia Bucal

Chemoresistance to 5-fluorouracil induces epithelial–mesenchymal transition via up-regulation of Snail in MCF7 human breast cancer cells

(2011) Weijia Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

E/N-cadherin switch mediates cancer progression via TGF-β-induced epithelial-to-mesenchymal transition in extrahepatic cholangiocarcinoma

(2011) K Araki et al.   BRITISH JOURNAL OF CANCER

Inhibition of tumor growth and vasculogenic mimicry by curcumin through down-regulation of the EphA2/PI3K/MMP pathway in a murine choroidal melanoma model

(2011) Lu-Xia Chen et al.   CANCER BIOLOGY & THERAPY

Sonic Hedgehog Pathway Promotes Metastasis and Lymphangiogenesis via Activation of Akt, EMT, and MMP-9 Pathway in Gastric Cancer

(2011) Y. A. Yoo et al.   CANCER RESEARCH

Metastasis and AKT activation

(2011) Meng Qiao et al.   CELL CYCLE

Tumor necrosis factor-α induces epithelial–mesenchymal transition of renal cell carcinoma cells via a nuclear factor kappa B-independent mechanism

(2011) Sheng-Tang Wu et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Metastatic function of BMP-2 in gastric cancer cells: The role of PI3K/AKT, MAPK, the NF-κB pathway, and MMP-9 expression

(2011) Myoung Hee Kang et al.   EXPERIMENTAL CELL RESEARCH

Recruitment of histone deacetylases HDAC1 and HDAC2 by the transcriptional repressor ZEB1 downregulates E-cadherin expression in pancreatic cancer

(2011) Ali Aghdassi et al.   GUT

Opposite regulation of epithelial-to-mesenchymal transition and cell invasiveness by periostin between prostate and bladder cancer cells

(2011) Hirokazu Inoue   INTERNATIONAL JOURNAL OF ONCOLOGY

Activation of EGFR promotes squamous carcinoma SCC10A cell migration and invasion via inducing EMT-like phenotype change and MMP-9-mediated degradation of E-cadherin

(2011) Jian-Hong Zuo et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Epithelial–mesenchymal transition in chronic liver disease: Fibrogenesis or escape from death?

(2011) Massimo Pinzani   JOURNAL OF HEPATOLOGY

Critical and Reciprocal Regulation of KLF4 and SLUG in Transforming Growth Factor  -Initiated Prostate Cancer Epithelial-Mesenchymal Transition

(2011) Y.-N. Liu et al.   MOLECULAR AND CELLULAR BIOLOGY

Transcription factors that mediate epithelial–mesenchymal transition lead to multidrug resistance by upregulating ABC transporters

(2011) M Saxena et al.   Cell Death & Disease

Slug Confers Resistance to the Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor

(2010) Tzu-Hua Chang et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

NF-κB promotes epithelial–mesenchymal transition, migration and invasion of pancreatic carcinoma cells

(2010) Harald J. Maier et al.   CANCER LETTERS

PKB/AKT phosphorylation of the transcription factor Twist-1 at Ser42 inhibits p53 activity in response to DNA damage

(2010) A Vichalkovski et al.   ONCOGENE

Transforming growth factor-β-induced epithelial–mesenchymal transition facilitates epidermal growth factor-dependent breast cancer progression

(2010) M K Wendt et al.   ONCOGENE

EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer

(2010) A Singh et al.   ONCOGENE

Upregulation of Twist in Gastric Carcinoma Associated with Tumor Invasion and Poor Prognosis

(2010) Guo-Qing Ru et al.   PATHOLOGY & ONCOLOGY RESEARCH

Activation of the PI3K/Akt Pathway Mediates Bone Morphogenetic Protein 2-Induced Invasion of Pancreatic Cancer Cells Panc-1

(2010) Xiong Chen et al.   PATHOLOGY & ONCOLOGY RESEARCH

Sulindac Reverses Aberrant Expression and Localization of β-Catenin in Papillary Thyroid Cancer Cells with the BRAFV600E Mutation

(2010) Nancy L. Cho et al.   THYROID

Slug/SNAI2 regulates cell proliferation and invasiveness of metastatic prostate cancer cell lines

(2010) Modjtaba Emadi Baygi et al.   TUMOR BIOLOGY

Requirement of the Akt/β-Catenin Pathway for Uterine Carcinosarcoma Genesis, Modulating E-Cadherin Expression Through the Transactivation of Slug

(2009) Makoto Saegusa et al.   AMERICAN JOURNAL OF PATHOLOGY

MDR1/P-gp and VEGF Synergistically Enhance the Invasion of Hep-2 Cells with Multidrug Resistance Induced by Taxol

(2009) Li Li et al.   ANNALS OF SURGICAL ONCOLOGY

Epithelial–mesenchymal transition with expression of SNAI1-induced chemoresistance in colorectal cancer

(2009) Hiromitsu Hoshino et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Acquisition of Epithelial-Mesenchymal Transition Phenotype of Gemcitabine-Resistant Pancreatic Cancer Cells Is Linked with Activation of the Notch Signaling Pathway

(2009) Z. Wang et al.   CANCER RESEARCH

Epithelial to Mesenchymal Transition Contributes to Drug Resistance in Pancreatic Cancer

(2009) T. Arumugam et al.   CANCER RESEARCH

A Novel Lung Metastasis Signature Links Wnt Signaling with Cancer Cell Self-Renewal and Epithelial-Mesenchymal Transition in Basal-like Breast Cancer

(2009) Theresa A. DiMeo et al.   CANCER RESEARCH

Epithelial-mesenchymal transition in cancer development and its clinical significance

(2009) Masaaki Iwatsuki et al.   CANCER SCIENCE

Twist1-Mediated Adriamycin-Induced Epithelial-Mesenchymal Transition Relates to Multidrug Resistance and Invasive Potential in Breast Cancer Cells

(2009) Q.-Q. Li et al.   CLINICAL CANCER RESEARCH

Plasticity of cell migration: a multiscale tuning model

(2009) Peter Friedl et al.   JOURNAL OF CELL BIOLOGY

The basics of epithelial-mesenchymal transition

(2009) Raghu Kalluri et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibition of Akt activity induces the mesenchymal-to-epithelial reverting transition with restoring E-cadherin expression in KB and KOSCC-25B oral squamous cell carcinoma cells

(2009) Kyoung-Ok Hong et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Cyclopamine inhibition of human breast cancer cell growth independent of Smoothened (Smo)

(2008) Xiaomei Zhang et al.   BREAST CANCER RESEARCH AND TREATMENT

Twist Promotes Tumor Cell Growth through YB-1 Expression

(2008) M. Shiota et al.   CANCER RESEARCH

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

In memoriam: Dr. Herbert Falk (1924-2008)

(2008) Alan F. Hofmann   HEPATOLOGY

Metastasis and AKT activation

(2008) Shijie Sheng et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Modulating effect of the PI3-kinase inhibitor LY294002 on cisplatin in human pancreatic cancer cells

(2008) Masao Fujiwara et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH