Metabolic control of the Treg/Th17 axis

Glucose Uptake Is Limiting in T Cell Activation and Requires CD28-Mediated Akt-Dependent and Independent Pathways

(2014) S. R. Jacobs et al.   JOURNAL OF IMMUNOLOGY

Tumor-Secreted Lactic Acid Promotes IL-23/IL-17 Proinflammatory Pathway

(2014) H. Shime et al.   JOURNAL OF IMMUNOLOGY

Regulation of Immune Responses by mTOR

(2012) Jonathan D. Powell et al.   Annual Review of Immunology

Recent advances in hypoxia-inducible factor (HIF)-1 inhibitors

(2012) Yan Xia et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Plasticity of Foxp3+ T Cells Reflects Promiscuous Foxp3 Expression in Conventional T Cells but Not Reprogramming of Regulatory T Cells

(2012) Takahisa Miyao et al.   IMMUNITY

Metabolic reprogramming and metabolic dependency in T cells

(2012) Ruoning Wang et al.   IMMUNOLOGICAL REVIEWS

mTOR, metabolism, and the regulation of T-cell differentiation and function

(2012) Adam T. Waickman et al.   IMMUNOLOGICAL REVIEWS

Mammalian Target of Rapamycin Integrates Diverse Inputs To Guide the Outcome of Antigen Recognition in T Cells

(2012) A. T. Waickman et al.   JOURNAL OF IMMUNOLOGY

The Ifng Gene Is Essential for Vdr Gene Expression and Vitamin D3-Mediated Reduction of the Pathogenic T Cell Burden in the Central Nervous System in Experimental Autoimmune Encephalomyelitis, a Multiple Sclerosis Model

(2012) J. A. Spanier et al.   JOURNAL OF IMMUNOLOGY

Enhanced Th17 Differentiation and Aggravated Arthritis in IEX-1-Deficient Mice by Mitochondrial Reactive Oxygen Species-Mediated Signaling

(2012) L. Zhi et al.   JOURNAL OF IMMUNOLOGY

A selective inhibitor reveals PI3Kγ dependence of TH17 cell differentiation

(2012) Giovanna Bergamini et al.   Nature Chemical Biology

Optimal Population of FoxP3+ T Cells in Tumors Requires an Antigen Priming-Dependent Trafficking Receptor Switch

(2012) Chuanwu Wang et al.   PLoS One

Peroxisome proliferator-activated receptor (PPAR)  and -  regulate IFN  and IL-17A production by human T cells in a sex-specific way

(2012) M. A. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear receptor Nr4a1 modulates both regulatory T-cell (Treg) differentiation and clonal deletion

(2012) M. S. Fassett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective Effects of PD-1 on Akt and Ras Pathways Regulate Molecular Components of the Cell Cycle and Inhibit T Cell Proliferation

(2012) N. Patsoukis et al.   Science Signaling

Metabolic pathways in T cell fate and function

(2012) Valerie A. Gerriets et al.   TRENDS IN IMMUNOLOGY

Molecular mechanisms mediating metastasis of hypoxic breast cancer cells

(2012) Gregg L. Semenza   TRENDS IN MOLECULAR MEDICINE

PI3K-Akt-mTORC1-S6K1/2 Axis Controls Th17 Differentiation by Regulating Gfi1 Expression and Nuclear Translocation of RORγ

(2012) Yutaka Kurebayashi et al.   Cell Reports

The Role of the PI3K Signaling Pathway in CD4+ T Cell Differentiation and Function

(2012) Jonathan M. Han et al.   Frontiers in Immunology

Inhibitor of PI3Kγ ameliorates TNBS-induced colitis in mice by affecting the functional activity of CD4+CD25+FoxP3+ regulatory T cells

(2011) RC Dutra et al.   BRITISH JOURNAL OF PHARMACOLOGY

Th17 cells in cancer: help or hindrance?

(2011) Cailin Moira Wilke et al.   CARCINOGENESIS

Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1

(2011) Eric V. Dang et al.   CELL

Activation of Peroxisome Proliferator-Activated Receptor- /-  (PPAR- /- ) Ameliorates Insulin Signaling and Reduces SOCS3 Levels by Inhibiting STAT3 in Interleukin-6-Stimulated Adipocytes

(2011) L. Serrano-Marco et al.   DIABETES

PI3Kγ deficiency delays the onset of experimental autoimmune encephalomyelitis and ameliorates its clinical outcome

(2011) Luciana Berod et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation

(2011) Ruoning Wang et al.   IMMUNITY

Localization of IL-17+Foxp3+ T Cells in Esophageal Cancer

(2011) Chun Huang et al.   IMMUNOLOGICAL INVESTIGATIONS

Dynamic regulation of Th17 differentiation by oxygen concentrations

(2011) A. Ikejiri et al.   INTERNATIONAL IMMUNOLOGY

Converging pathways lead to overproduction of IL-17 in the absence of vitamin D signaling

(2011) Danny Bruce et al.   INTERNATIONAL IMMUNOLOGY

CNI induced Th17/Treg imbalance and susceptibility to renal dysfunction in renal transplantation

(2011) Yi Li et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Ursolic Acid Suppresses Interleukin-17 (IL-17) Production by Selectively Antagonizing the Function of RORγt Protein

(2011) Tao Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis of Digoxin That Antagonizes RORγt Receptor Activity and Suppresses Th17 Cell Differentiation and Interleukin (IL)-17 Production

(2011) Saori Fujita-Sato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Liver X receptor (LXR) mediates negative regulation of mouse and human Th17 differentiation

(2011) Guoliang Cui et al.   JOURNAL OF CLINICAL INVESTIGATION

The requirements for natural Th17 cell development are distinct from those of conventional Th17 cells

(2011) Jiyeon S. Kim et al.   JOURNAL OF EXPERIMENTAL MEDICINE

HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Tregcells

(2011) Lewis Z. Shi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Link between the PDL1 Costimulatory Pathway and Th17 in Fetomaternal Tolerance

(2011) F. D'Addio et al.   JOURNAL OF IMMUNOLOGY

Peroxisome Proliferator-Activated Receptor γ Is Required for CD4 + T Cell-Mediated Lymphopenia-Associated Autoimmunity

(2011) William J. Housley et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: PHLPP Regulates the Development, Function, and Molecular Signaling Pathways of Regulatory T Cells

(2011) S. J. Patterson et al.   JOURNAL OF IMMUNOLOGY

IL-17 + Regulatory T Cells in the Microenvironments of Chronic Inflammation and Cancer

(2011) Ilona Kryczek et al.   JOURNAL OF IMMUNOLOGY

The Liver Kinase B1 Is a Central Regulator of T Cell Development, Activation, and Metabolism

(2011) Nancie J. MacIver et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets

(2011) R. D. Michalek et al.   JOURNAL OF IMMUNOLOGY

New Insights Into the Pathogenesis of Inflammatory Bowel Disease: Transcription Factors Analysis in Bioptic Tissues From Pediatric Patients

(2011) Maria Pierdomenico et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

1,25-Dihydroxyvitamin D3 Ameliorates Th17 Autoimmunity via Transcriptional Modulation of Interleukin-17A

(2011) S. Joshi et al.   MOLECULAR AND CELLULAR BIOLOGY

Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity

(2011) Jun R. Huh et al.   NATURE

Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand

(2011) Laura A. Solt et al.   NATURE

Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells

(2011) Andrea Facciabene et al.   NATURE

The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function

(2011) Kai Yang et al.   NATURE IMMUNOLOGY

Fate mapping of IL-17-producing T cells in inflammatory responses

(2011) Keiji Hirota et al.   NATURE IMMUNOLOGY

The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2

(2011) Greg M Delgoffe et al.   NATURE IMMUNOLOGY

Estrogen-related receptor-  is a metabolic regulator of effector T-cell activation and differentiation

(2011) R. D. Michalek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human TH17 Cells Are Long-Lived Effector Memory Cells

(2011) I. Kryczek et al.   Science Translational Medicine

Inhibition of fatty acid metabolism ameliorates disease activity in an animal model of multiple sclerosis

(2011) Leah P. Shriver et al.   Scientific Reports

HIF-1 mediates pathogenic inflammatory responses to intestinal ischemia-reperfusion injury

(2010) Rena Feinman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Hypoxia-inducible factor plays a gut-injurious role in intestinal ischemia reperfusion injury

(2010) Kolenkode B. Kannan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

AMPK agonist downregulates innate and adaptive immune responses in TNBS-induced murine acute and relapsing colitis

(2010) Aiping Bai et al.   BIOCHEMICAL PHARMACOLOGY

IL-17 Enhances Tumor Development in Carcinogen-Induced Skin Cancer

(2010) L. Wang et al.   CANCER RESEARCH

Th17 and Regulatory T Cells in Mediating and Restraining Inflammation

(2010) Dan R. Littman et al.   CELL

Metabolism in T cell activation and differentiation

(2010) Erika L Pearce   CURRENT OPINION IN IMMUNOLOGY

Estrogen-related receptor α and PGC-1-related coactivator constitute a novel complex mediating the biogenesis of functional mitochondria

(2010) Delphine Mirebeau-Prunier et al.   FEBS Journal

The Mammalian Target of Rapamycin: Linking T Cell Differentiation, Function, and Metabolism

(2010) Jonathan D. Powell et al.   IMMUNITY

The Transcription Factor GATA3 Actively Represses RUNX3 Protein-Regulated Production of Interferon-γ

(2010) Ryoji Yagi et al.   IMMUNITY

The Receptor SIGIRR Suppresses Th17 Cell Proliferation via Inhibition of the Interleukin-1 Receptor Pathway and mTOR Kinase Activation

(2010) Muhammet F. Gulen et al.   IMMUNITY

Epigenetic Instability of Cytokine and Transcription Factor Gene Loci Underlies Plasticity of the T Helper 17 Cell Lineage

(2010) Ryuta Mukasa et al.   IMMUNITY

The PD-1 pathway in tolerance and autoimmunity

(2010) Loise M. Francisco et al.   IMMUNOLOGICAL REVIEWS

Peroxisome proliferator-activated receptor δ agonists inhibit T helper type 1 (Th1) and Th17 responses in experimental allergic encephalomyelitis

(2010) Saravanan Kanakasabai et al.   IMMUNOLOGY

Vitamin D Suppresses Th17 Cytokine Production by Inducing C/EBP Homologous Protein (CHOP) Expression

(2010) Seon Hee Chang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Peroxisome Proliferator-Activated Receptor   and   Agonists Together with TGF-  Convert Human CD4+CD25- T Cells into Functional Foxp3+ Regulatory T Cells

(2010) J. Lei et al.   JOURNAL OF IMMUNOLOGY

Glycogen Synthase Kinase-3 Is an Early Determinant in the Differentiation of Pathogenic Th17 Cells

(2010) E. Beurel et al.   JOURNAL OF IMMUNOLOGY

IDO Upregulates Regulatory T Cells via Tryptophan Catabolite and Suppresses Encephalitogenic T Cell Responses in Experimental Autoimmune Encephalomyelitis

(2010) Y. Yan et al.   JOURNAL OF IMMUNOLOGY

Foxp3+ IL-17+ T cells promote development of cancer-initiating cells in colorectal cancer

(2010) Shaobo Yang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Absence of PI3Kγ leads to increased leukocyte apoptosis and diminished severity of experimental autoimmune encephalomyelitis

(2010) David Henrique Rodrigues et al.   JOURNAL OF NEUROIMMUNOLOGY

Novel Anti-Inflammatory Action of 5-Aminoimidazole-4-carboxamide Ribonucleoside with Protective Effect in Dextran Sulfate Sodium-Induced Acute and Chronic Colitis

(2010) A. Bai et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Hypoxia induces T Helper 17 cell upregulation in cultured peripheral blood mononuclear cells from chronic stage patients of severe cerebral infarction

(2010) YanHong Yin et al.   MICROBIOLOGY AND IMMUNOLOGY

Hypoxia: an alarm signal during intestinal inflammation

(2010) Sean P. Colgan et al.   Nature Reviews Gastroenterology & Hepatology

Negative feedback control of HIF-1 through REDD1-regulated ROS suppresses tumorigenesis

(2010) P. Horak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stability of the Regulatory T Cell Lineage in Vivo

(2010) Y. P. Rubtsov et al.   SCIENCE

Regulation of Immune Responses and Autoimmune Encephalomyelitis by PPARs

(2010) Yuhong Yang et al.   PPAR Research

AMPK-Dependent Metabolic Regulation by PPAR Agonists

(2010) Woo Hyung Lee et al.   PPAR Research

Loss of AMPK exacerbates experimental autoimmune encephalomyelitis disease severity

(2009) Narender Nath et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Indoleamine 2,3-dioxygenase controls conversion of Foxp3+ Tregs to TH17-like cells in tumor-draining lymph nodes

(2009) M. D. Sharma et al.   BLOOD

Heterogeneity and plasticity of T helper cells

(2009) Jinfang Zhu et al.   CELL RESEARCH

Plasticity of CD4+ FoxP3+ T cells

(2009) Xuyu Zhou et al.   CURRENT OPINION IN IMMUNOLOGY

Transcriptional regulatory networks in Th17 cell differentiation

(2009) Liang Zhou et al.   CURRENT OPINION IN IMMUNOLOGY

Insulin Resistance and Altered Systemic Glucose Metabolism in Mice Lacking Nur77

(2009) Lily C. Chao et al.   DIABETES

Regulatory T Cells Reinforce Intestinal Homeostasis

(2009) Michael J. Barnes et al.   IMMUNITY

Plasticity of CD4+ T Cell Lineage Differentiation

(2009) Liang Zhou et al.   IMMUNITY

mTOR: taking cues from the immune microenvironment

(2009) Greg M. Delgoffe et al.   IMMUNOLOGY

Induction of Persistent Colitis by a Human Commensal, Enterotoxigenic Bacteroides fragilis, in Wild-Type C57BL/6 Mice

(2009) K.-J. Rhee et al.   INFECTION AND IMMUNITY

Hsp70 and CHIP Selectively Mediate Ubiquitination and Degradation of Hypoxia-inducible Factor (HIF)-1α but Not HIF-2α

(2009) Weibo Luo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The nuclear receptor PPARγ selectively inhibits Th17 differentiation in a T cell–intrinsic fashion and suppresses CNS autoimmunity

(2009) Luisa Klotz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-17 can promote tumor growth through an IL-6–Stat3 signaling pathway

(2009) Lin Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulation of Th17 Differentiation by Epidermal Fatty Acid-Binding Protein

(2009) B. Li et al.   JOURNAL OF IMMUNOLOGY

Anergic T Cells Are Metabolically Anergic

(2009) Y. Zheng et al.   JOURNAL OF IMMUNOLOGY

Peroxisome Proliferator-Activated Receptor   Agonist Down-Regulates IL-17 Expression in a Murine Model of Allergic Airway Inflammation

(2009) S. J. Park et al.   JOURNAL OF IMMUNOLOGY

IDO Activates Regulatory T Cells and Blocks Their Conversion into Th17-Like T Cells

(2009) B. Baban et al.   JOURNAL OF IMMUNOLOGY

SHIP Regulates the Reciprocal Development of T Regulatory and Th17 Cells

(2009) N. R. Locke et al.   JOURNAL OF IMMUNOLOGY

Liver X receptor agonist regulation of Th17 lymphocyte function in autoimmunity

(2009) Jihong Xu et al.   JOURNAL OF LEUKOCYTE BIOLOGY

PPARγ regulates retinoic acid-mediated DC induction of Tregs

(2009) William J. Housley et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo

(2009) Xuyu Zhou et al.   NATURE IMMUNOLOGY

Infectious tolerance via the consumption of essential amino acids and mTOR signaling

(2009) S. P. Cobbold et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization

(2009) K. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of IL-17-producing FOXP3+ regulatory T cells in humans

(2009) K. S. Voo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Halofuginone Inhibits TH17 Cell Differentiation by Activating the Amino Acid Starvation Response

(2009) M. S. Sundrud et al.   SCIENCE

Regulatory T Cells and Immune Tolerance

(2008) Shimon Sakaguchi et al.   CELL

Nur77 upregulates HIF-α by inhibiting pVHL-mediated degradation

(2008) Bu-Yeon Kim et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Hypoxia-Inducible Factor Augments Experimental Colitis Through an MIF–Dependent Inflammatory Signaling Cascade

(2008) Yatrik M. Shah et al.   GASTROENTEROLOGY

Rosiglitazone for Active Ulcerative Colitis: A Randomized Placebo-Controlled Trial

(2008) James D. Lewis et al.   GASTROENTEROLOGY

Molecular Antagonism and Plasticity of Regulatory and Inflammatory T Cell Programs

(2008) Xuexian O. Yang et al.   IMMUNITY

Differential Regulation of STAT Family Members by Glycogen Synthase Kinase-3

(2008) Eléonore Beurel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Induction of HIF-1α expression by intermittent hypoxia: Involvement of NADPH oxidase, Ca2+signaling, prolyl hydroxylases, and mTOR

(2008) Guoxiang Yuan et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Interdependent roles for hypoxia inducible factor and nuclear factor-κB in hypoxic inflammation

(2008) Cormac T. Taylor   JOURNAL OF PHYSIOLOGY-LONDON

TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function

(2008) Liang Zhou et al.   NATURE

Regulation of TORC1 by Rag GTPases in nutrient response

(2008) Eunjung Kim et al.   NATURE CELL BIOLOGY

Digoxin and other cardiac glycosides inhibit HIF-1  synthesis and block tumor growth

(2008) H. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR

(2008) S. Sauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptional responses to intermittent hypoxia

(2008) Jayasri Nanduri et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE

Regulatory T Cells: Mechanisms of Differentiation and Function

(2007) Steven Z. Josefowicz et al.   Annual Review of Immunology

Mucosal Protection by Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibition

(2007) Andreas Robinson et al.   GASTROENTEROLOGY