Transcriptional activation of RagD GTPase controls mTORC1 and promotes cancer growth

Modelling TFE renal cell carcinoma in mice reveals a critical role of WNT signaling

(2016) Alessia Calcagnì et al.   eLife

Transcriptional control of autophagy–lysosome function drives pancreatic cancer metabolism

(2015) Rushika M. Perera et al.   NATURE

Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB

(2015) Diego L. Medina et al.   NATURE CELL BIOLOGY

Next-Generation Sequencing of Translocation Renal Cell Carcinoma Reveals Novel RNA Splicing Partners and Frequent Mutations of Chromatin-Remodeling Genes

(2014) G. G. Malouf et al.   CLINICAL CANCER RESEARCH

Molecular genetics and cellular features of TFE3 and TFEB fusion kidney cancers

(2014) Eric C. Kauffman et al.   Nature Reviews Urology

The Nutrient-Responsive Transcription Factor TFE3 Promotes Autophagy, Lysosomal Biogenesis, and Clearance of Cellular Debris

(2014) J. A. Martina et al.   Science Signaling

mTOR and the health benefits of exercise

(2014) Kurt Watson et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The Folliculin Tumor Suppressor Is a GAP for the RagC/D GTPases That Signal Amino Acid Levels to mTORC1

(2013) Zhi-Yang Tsun et al.   MOLECULAR CELL

TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop

(2013) Carmine Settembre et al.   NATURE CELL BIOLOGY

Signals from the lysosome: a control centre for cellular clearance and energy metabolism

(2013) Carmine Settembre et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB

(2012) Jose A. Martina et al.   Autophagy

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

(2012) Carmine Settembre et al.   EMBO JOURNAL

Melanoma: from mutations to medicine

(2012) H. Tsao et al.   GENES & DEVELOPMENT

The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis

(2012) A. Roczniak-Ferguson et al.   Science Signaling

Liver autophagy contributes to the maintenance of blood glucose and amino acid levels

(2011) Junji Ezaki et al.   Autophagy

Biology and Clinical Relevance of the Micropthalmia Family of Transcription Factors in Human Cancer

(2011) Rizwan Haq et al.   JOURNAL OF CLINICAL ONCOLOGY

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

mTOR couples cellular nutrient sensing to organismal metabolic homeostasis

(2011) Jessica J. Howell et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Termination of autophagy and reformation of lysosomes regulated by mTOR

(2010) Li Yu et al.   NATURE

Autophagy and Metabolism

(2010) J. D. Rabinowitz et al.   SCIENCE

ERK-regulated differential expression of the Mitf 6a/b splicing isoforms in melanoma

(2009) Aline Primot et al.   Pigment Cell & Melanoma Research

A Gene Network Regulating Lysosomal Biogenesis and Function

(2009) Marco Sardiello et al.   SCIENCE

Regulation of TORC1 by Rag GTPases in nutrient response

(2008) Eunjung Kim et al.   NATURE CELL BIOLOGY

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE