Synthetic Glycans and Glycomimetics: A Promising Alternative to Natural Polysaccharides

Synthesis of 3-O-Sulfated Oligosaccharides to Understand the Relationship between Structures and Functions of Heparan Sulfate

(2017) Zhangjie Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

New Applications of Heparin and Other Glycosaminoglycans

(2017) Marcelo Lima et al.   MOLECULES

Synthetic oligosaccharides can replace animal-sourced low–molecular weight heparins

(2017) Yongmei Xu et al.   Science Translational Medicine

Total synthesis of mycobacterial arabinogalactan containing 92 monosaccharide units

(2017) Yong Wu et al.   Nature Communications

Neutralization of EP217609, a new dual-action FIIa/FXa anticoagulant, by its specific antidote avidin: a phase I study

(2016) P. Gueret et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

First in man study of EP217609, a new long-acting, neutralisable parenteral antithrombotic with a dual mechanism of action

(2016) Pierre Gueret et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Synthesis and amylin receptor activity of glycomimetics of pramlintide using click chemistry

(2016) Lauren R. Yule et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Heparin and related polysaccharides: synthesis using recombinant enzymes and metabolic engineering

(2015) Matthew Suflita et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Recent Developments in Synthetic Carbohydrate-Based Diagnostics, Vaccines, and Therapeutics

(2015) Alberto Fernández-Tejada et al.   CHEMISTRY-A EUROPEAN JOURNAL

EP217609, a neutralisable dual-action FIIa/FXa anticoagulant, with antithrombotic effects in arterial thrombosis

(2015) Ghina Alame et al.   THROMBOSIS AND HAEMOSTASIS

Development and characterization of Haemophilus influenzae type b conjugate vaccine prepared using different polysaccharide chain lengths

(2015) R. Rana et al.   VACCINE

Synthesis of the Heparin-Based Anticoagulant Drug Fondaparinux

(2014) Cheng-Hsiu Chang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis and Evaluation of Di- and Trimeric Hydroxylamine-Based β-(1→3)-Glucan Mimetics

(2014) Angélique Ferry et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthetic oligosaccharides as active pharmaceutical ingredients: Lessons learned from the full synthesis of one heparin derivative on a large scale

(2014) Pierre-Alexandre Driguez et al.   NATURAL PRODUCT REPORTS

Chemoenzymatic synthesis of heparan sulfate and heparin

(2014) Jian Liu et al.   NATURAL PRODUCT REPORTS

Homogeneous low-molecular-weight heparins with reversible anticoagulant activity

(2014) Yongmei Xu et al.   Nature Chemical Biology

Searching for Glycomimetics That Target Protein Misfolding in Rare Diseases: Successes, Failures, and Unexpected Progress Made in Organic Synthesis

(2014) Philippe Compain   SYNLETT

Tailored Glycopolymers as Anticoagulant Heparin Mimetics

(2013) Young In Oh et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of the (1→6)-linked thiodisaccharide of galactofuranose: Inhibitory activity against a β-galactofuranosidase

(2013) Evangelina Repetto et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and Characterization of Linker-Armed Fucose-Based Glycomimetics

(2013) Daniela Doknic et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Development of Vi conjugate – a new generation of typhoid vaccine

(2013) Shousun Chen Szu   Expert Review of Vaccines

Effect of a serogroup A meningococcal conjugate vaccine (PsA–TT) on serogroup A meningococcal meningitis and carriage in Chad: a community study

(2013) DM Daugla et al.   LANCET

Phosphorylation of the Synthetic Hexasaccharide Repeating Unit Is Essential for the Induction of Antibodies to Clostridium difficile PSII Cell Wall Polysaccharide

(2012) Roberto Adamo et al.   ACS Chemical Biology

Multivalency as a Chemical Organization and Action Principle

(2012) Carlo Fasting et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Specificity and selectivity profile of EP217609: a new neutralizable dual-action anticoagulant that targets thrombin and factor Xa

(2011) S. T. Olson et al.   BLOOD

Carbohydrates and Immunology: Synthetic Oligosaccharide Antigens for Vaccine Formulation

(2011) Laura Morelli et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Laminarin Fragments and Evaluation of a β-(1,3) Glucan Hexasaccaride-CRM197Conjugate as Vaccine Candidate againstCandida albicans

(2011) Roberto Adamo et al.   JOURNAL OF CARBOHYDRATE CHEMISTRY

Chemoenzymatic Synthesis of Homogeneous Ultralow Molecular Weight Heparins

(2011) Y. Xu et al.   SCIENCE

Heparin/heparan sulphate-based drugs

(2010) Neha S. Gandhi et al.   DRUG DISCOVERY TODAY

Carbohydrate vaccines: developing sweet solutions to sticky situations?

(2010) Rena D. Astronomo et al.   NATURE REVIEWS DRUG DISCOVERY

Synthesis of Amino-Bridged Oligosaccharide Mimetics

(2009) Janna Neumann et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

A Synthetic Carbohydrate-Protein Conjugate Vaccine Candidate against Shigella flexneri 2a Infection

(2009) A. Phalipon et al.   JOURNAL OF IMMUNOLOGY

Lessons learned from the contamination of heparin

(2009) Haiying Liu et al.   NATURAL PRODUCT REPORTS

Maximising multivalency effects in protein–carbohydrate interactions

(2009) Roland J. Pieters   ORGANIC & BIOMOLECULAR CHEMISTRY

Idraparinux and idrabiotaparinux

(2009) Job Harenberg   Expert Review of Clinical Pharmacology

Identification of the Smallest Structure Capable of Evoking Opsonophagocytic Antibodies against Streptococcus pneumoniae Type 14

(2008) D. Safari et al.   INFECTION AND IMMUNITY

Reversible biotinylated oligosaccharides: a new approach for a better management of anticoagulant therapy

(2008) P. SAVI et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Outbreak of Adverse Reactions Associated with Contaminated Heparin

(2008) David B. Blossom et al.   NEW ENGLAND JOURNAL OF MEDICINE

Contaminated Heparin Associated with Adverse Clinical Events and Activation of the Contact System

(2008) Takashi Kei Kishimoto et al.   NEW ENGLAND JOURNAL OF MEDICINE