Chemoenzymatic synthesis of heparan sulfate and heparin

De novo synthesis of a narrow size distribution low-molecular-weight heparin

(2014) Kasemsiri Chandarajoti et al.   GLYCOBIOLOGY

Chemoenzymatic synthesis and structural characterization of 2-O-sulfated glucuronic acid-containing heparan sulfate hexasaccharides

(2014) Po-Hung Hsieh et al.   GLYCOBIOLOGY

Molecular Mechanism of Substrate Specificity for Heparan Sulfate 2-O-Sulfotransferase

(2014) Chunhui Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fibroblast Growth Factor-based Signaling through Synthetic Heparan Sulfate Blocks Copolymers Studied Using High Cell Density Three-dimensional Cell Printing

(2014) Eric Sterner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synthetic oligosaccharides as active pharmaceutical ingredients: Lessons learned from the full synthesis of one heparin derivative on a large scale

(2014) Pierre-Alexandre Driguez et al.   NATURAL PRODUCT REPORTS

Homogeneous low-molecular-weight heparins with reversible anticoagulant activity

(2014) Yongmei Xu et al.   Nature Chemical Biology

Tailored Design and Synthesis of Heparan Sulfate Oligosaccharide Analogues Using Sequential One-Pot Multienzyme Systems

(2013) Yi Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of a Targeted Library of Heparan Sulfate Hexa- to Dodecasaccharides as Inhibitors of β-Secretase: Potential Therapeutics for Alzheimer’s Disease

(2013) Ralf Schwörer et al.   CHEMISTRY-A EUROPEAN JOURNAL

Toward the chemoenzymatic synthesis of heparan sulfate oligosaccharides: oxidative cleavage of p-nitrophenyl group with ceric ammonium salts

(2013) Chao Cai et al.   TETRAHEDRON LETTERS

Tetrasaccharide iteration synthesis of a heparin-like dodecasaccharide and radiolabelling for in vivo tissue distribution studies

(2013) Steen U. Hansen et al.   Nature Communications

Prevention of VTE in Nonsurgical Patients

(2012) Susan R. Kahn et al.   CHEST

Synthetic heparin

(2012) Robert J Linhardt et al.   CURRENT OPINION IN PHARMACOLOGY

Chemoenzymatic Synthesis of Heparin Oligosaccharides with both Anti-factor Xa and Anti-factor IIa Activities

(2012) Yongmei Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deciphering Mode of Action of Heparanase Using Structurally Defined Oligosaccharides

(2012) Sherket Peterson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Uncovering Biphasic Catalytic Mode of C5-epimerase in Heparan Sulfate Biosynthesis

(2012) Juzheng Sheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Engineering of routes to heparin and related polysaccharides

(2011) Ujjwal Bhaskar et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Enzymatic Placement of 6-O-Sulfo Groups in Heparan Sulfate

(2011) Renpeng Liu et al.   BIOCHEMISTRY

The Dominating Role ofN-Deacetylase/N-Sulfotransferase 1 in Forming Domain Structures in Heparan Sulfate

(2011) Juzheng Sheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Renal Profiles of Anticoagulants

(2011) Sebastian Harder   JOURNAL OF CLINICAL PHARMACOLOGY

Chemoenzymatic Synthesis of Uridine Diphosphate-GlcNAc and Uridine Diphosphate-GalNAc Analogs for the Preparation of Unnatural Glycosaminoglycans

(2011) Sayaka Masuko et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of 3-O-sulfonated heparan sulfate octasaccharides that inhibit the herpes simplex virus type 1 host–cell interaction

(2011) Yu-Peng Hu et al.   Nature Chemistry

Getting the Farm Out of Pharma for Heparin Production

(2011) J. E. Turnbull   SCIENCE

Chemoenzymatic Synthesis of Homogeneous Ultralow Molecular Weight Heparins

(2011) Y. Xu et al.   SCIENCE

Preactivation-Based, One-Pot Combinatorial Synthesis of Heparin-like Hexasaccharides for the Analysis of Heparin-Protein Interactions

(2010) Zhen Wang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Chemoenzymatic Design of Heparan Sulfate Oligosaccharides

(2010) Renpeng Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modular Synthesis of Heparan Sulfate Oligosaccharides for Structure−Activity Relationship Studies

(2009) Sailaja Arungundram et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Design of biologically active heparan sulfate and heparin using an enzyme-based approach

(2009) Sherket Peterson et al.   NATURAL PRODUCT REPORTS

Lessons learned from the contamination of heparin

(2009) Haiying Liu et al.   NATURAL PRODUCT REPORTS

Synthesis of Uridine 5′-diphosphoiduronic Acid: A Potential Substrate for the Chemoenzymatic Synthesis of Heparin

(2008) Michel Weïwer et al.   JOURNAL OF ORGANIC CHEMISTRY