Recent Developments in Synthetic Carbohydrate-Based Diagnostics, Vaccines, and Therapeutics

A guide into glycosciences: How chemistry, biochemistry and biology cooperate to crack the sugar code

(2015) Dolores Solís et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Designing synthetic vaccines for HIV

(2015) Alberto Fernández-Tejada et al.   Expert Review of Vaccines

Semisynthesis of Biologically Active Glycoforms of the Human Cytokine Interleukin 6

(2014) Andreas Reif et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Design, synthesis, and immunologic evaluation of vaccine adjuvant conjugates based on QS-21 and tucaresol

(2014) Alberto Fernández-Tejada et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Chemical Biology Approaches to Designing Defined Carbohydrate Vaccines

(2014) Chakkumkal Anish et al.   CHEMISTRY & BIOLOGY

Antiadhesive Properties of Glycoclusters against Pseudomonas aeruginosa Lung Infection

(2014) Amine M. Boukerb et al.   JOURNAL OF MEDICINAL CHEMISTRY

Chemical Synthesis of the β-Subunit of Human Luteinizing (hLH) and Chorionic Gonadotropin (hCG) Glycoprotein Hormones

(2014) Alberto Fernández-Tejada et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

MUC16 (CA125): tumor biomarker to cancer therapy, a work in progress

(2014) Mildred Felder et al.   Molecular Cancer

Chemoenzymatic synthesis of heparan sulfate and heparin

(2014) Jian Liu et al.   NATURAL PRODUCT REPORTS

A semisynthetic carbohydrate-lipid vaccine that protects against S. pneumoniae in mice

(2014) Marco Cavallari et al.   Nature Chemical Biology

Development of a minimal saponin vaccine adjuvant based on QS-21

(2014) Alberto Fernández-Tejada et al.   Nature Chemistry

Phase 1 Study of the E-Selectin Inhibitor GMI 1070 in Patients with Sickle Cell Anemia

(2014) Ted Wun et al.   PLoS One

Emerging Principles for the Therapeutic Exploitation of Glycosylation

(2014) Martin Dalziel et al.   SCIENCE

Recent Progress in Antitumoral Synthetic Vaccines

(2014) Cristina Nativi et al.   ACS Medicinal Chemistry Letters

Altered Tumor-Cell Glycosylation Promotes Metastasis

(2014) Irina Häuselmann et al.   Frontiers in Oncology

Recent Mechanistic Insights on Glycoconjugate Vaccines and Future Perspectives

(2013) Francesco Berti et al.   ACS Chemical Biology

PET-CT staging of DLBCL accurately identifies and provides new insight into the clinical significance of bone marrow involvement

(2013) A. B. Khan et al.   BLOOD

The development of synthetic antitumour vaccines from mucin glycopeptide antigens

(2013) Nikola Gaidzik et al.   CHEMICAL SOCIETY REVIEWS

Chemical assembly of N-glycoproteins: a refined toolbox to address a ubiquitous posttranslational modification

(2013) Carlo Unverzagt et al.   CHEMICAL SOCIETY REVIEWS

Glycotherapy: New Advances Inspire a Reemergence of Glycans in Medicine

(2013) Jason E. Hudak et al.   CHEMISTRY & BIOLOGY

Synthesis of Multivalent Carbohydrate-Centered Glycoclusters as Nanomolar Ligands of the Bacterial Lectin LecA fromPseudomonas aeruginosa

(2013) Marina L. Gening et al.   CHEMISTRY-A EUROPEAN JOURNAL

Human Galectin-3 Selective and High Affinity Inhibitors. Present State and Future Perspectives

(2013) R. Tellez-Sanz et al.   CURRENT MEDICINAL CHEMISTRY

The carbohydrate switch between pathogenic and immunosuppressive antigen-specific antibodies

(2013) Mattias Collin et al.   EXPERIMENTAL DERMATOLOGY

A Vision for Vaccines Built from Fully Synthetic Tumor-Associated Antigens: From the Laboratory to the Clinic

(2013) Rebecca M. Wilson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemical Synthesis of Highly Congested gp120 V1V2 N-Glycopeptide Antigens for Potential HIV-1-Directed Vaccines

(2013) Baptiste Aussedat et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nanomolar E-Selectin Antagonists with Prolonged Half-Lives by a Fragment-Based Approach

(2013) Jonas Egger et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Glycocalyx engineering reveals a Siglec-based mechanism for NK cell immunoevasion

(2013) Jason E Hudak et al.   Nature Chemical Biology

Therapy of Experimental NASH and Fibrosis with Galectin Inhibitors

(2013) Peter G. Traber et al.   PLoS One

Regression of Fibrosis and Reversal of Cirrhosis in Rats by Galectin Inhibitors in Thioacetamide-Induced Liver Disease

(2013) Peter G. Traber et al.   PLoS One

Recognition of synthetic glycopeptides by HIV-1 broadly neutralizing antibodies and their unmutated ancestors

(2013) S. M. Alam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Carbohydrate-based vaccines with a glycolipid adjuvant for breast cancer

(2013) Y.-L. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Erythropoietin Derived by Chemical Synthesis

(2013) P. Wang et al.   SCIENCE

Carbohydrates and T cells: A sweet twosome

(2013) Fikri Y. Avci et al.   SEMINARS IN IMMUNOLOGY

Glycolipid antigens and autoantibodies in autoimmune neuropathies

(2013) Hugh J. Willison et al.   TRENDS IN IMMUNOLOGY

Synthesis of a well-defined glycoconjugate vaccine by a tyrosine-selective conjugation strategy

(2013) Qi-Ying Hu et al.   Chemical Science

Synthetically defined glycoprotein vaccines: current status and future directions

(2013) Roberto Adamo et al.   Chemical Science

Aminoglycoside Antibiotics in the 21st Century

(2012) Bernd Becker et al.   ACS Chemical Biology

Chemical Synthesis of an Erythropoietin Glycoform Containing a Complex-type Disialyloligosaccharide

(2012) Masumi Murakami et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Multivalent glycoconjugates as anti-pathogenic agents

(2012) Anna Bernardi et al.   CHEMICAL SOCIETY REVIEWS

Development of Aminoglycoside Antibiotics Effective Against Resistant Bacterial Strains

(2012) Lin Yang et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Recent Development in Carbohydrate Based Anticancer Vaccines

(2012) Zhaojun Yin et al.   JOURNAL OF CARBOHYDRATE CHEMISTRY

Synthesis and Preclinical Evaluation of QS-21 Variants Leading to Simplified Vaccine Adjuvants and Mechanistic Probes

(2012) Eric K. Chea et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total Synthesis of the α-Subunit of Human Glycoprotein Hormones: Toward Fully Synthetic Homogeneous Human Follicle-Stimulating Hormone

(2012) Baptiste Aussedat et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemical Synthesis of Homogeneous Human Glycosyl-interferon-β That Exhibits Potent Antitumor Activity in Vivo

(2012) Izumi Sakamoto et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemoenzymatic Glycoengineering of Intact IgG Antibodies for Gain of Functions

(2012) Wei Huang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Development of Aminoglycoside Antibiotics by Carbohydrate Chemistry

(2012) Lina Guo et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Virus-like glycodendrinanoparticles displaying quasi-equivalent nested polyvalency upon glycoprotein platforms potently block viral infection

(2012) Renato Ribeiro-Viana et al.   Nature Communications

Emerging Technologies for Making Glycan-Defined Glycoproteins

(2011) Lai-Xi Wang et al.   ACS Chemical Biology

Probing the Frontiers of Glycoprotein Synthesis: The Fully Elaborated β-Subunit of the Human Follicle-Stimulating Hormone

(2011) Pavel Nagorny et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthetic Antitumor Vaccines Containing MUC1 Glycopeptides with Two Immunodominant Domains-Induction of a Strong Immune Response against Breast Tumor Tissues

(2011) Nikola Gaidzik et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Targeting Siglecs—A novel pharmacological strategy for immuno- and glycotherapy

(2011) Camilla Jandus et al.   BIOCHEMICAL PHARMACOLOGY

Glycans as cancer biomarkers

(2011) Barbara Adamczyk et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Glycans in Magnetic Resonance Imaging: Determinants of Relaxivity to Smart Agents, and Potential Applications in Biomedicine

(2011) Laura Cipolla et al.   CURRENT MEDICINAL CHEMISTRY

Carbohydrates and Immunology: Synthetic Oligosaccharide Antigens for Vaccine Formulation

(2011) Laura Morelli et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Protein Glycoengineering Enabled by the Versatile Synthesis of Aminooxy Glycans and the Genetically Encoded Aldehyde Tag

(2011) Jason E. Hudak et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis and Molecular Recognition Studies of the HNK-1 Trisaccharide and Related Oligosaccharides. The Specificity of Monoclonal Anti-HNK-1 Antibodies as Assessed by Surface Plasmon Resonance and STD NMR

(2011) Yury E. Tsvetkov et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Design of Glycopeptides Used to Investigate Class II MHC Binding and T-Cell Responses Associated with Autoimmune Arthritis

(2011) Ida E. Andersson et al.   PLoS One

Immune recognition of tumor-associated mucin MUC1 is achieved by a fully synthetic aberrantly glycosylated MUC1 tripartite vaccine

(2011) V. Lakshminarayanan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

From lectin structure to functional glycomics: principles of the sugar code

(2011) Hans-Joachim Gabius et al.   TRENDS IN BIOCHEMICAL SCIENCES

Inhibition of DC-SIGN-Mediated HIV Infection by a Linear Trimannoside Mimic in a Tetravalent Presentation

(2010) Sara Sattin et al.   ACS Chemical Biology

Carbohydrate engineered cells for regenerative medicine☆

(2010) Jian Du et al.   ADVANCED DRUG DELIVERY REVIEWS

A Fragment-Based In Situ Combinatorial Approach To Identify High-Affinity Ligands for Unknown Binding Sites

(2010) Sachin V. Shelke et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Glycosylation of Therapeutic Proteins

(2010) Ricardo J. Solá et al.   BIODRUGS

In vivo targeting of B-cell lymphoma with glycan ligands of CD22

(2010) W. C. Chen et al.   BLOOD

GMI-1070, a novel pan-selectin antagonist, reverses acute vascular occlusions in sickle cell mice

(2010) J. Chang et al.   BLOOD

Noninvasive imaging of pancreatic islet inflammation in type 1A diabetes patients

(2010) Jason L. Gaglia et al.   JOURNAL OF CLINICAL INVESTIGATION

Lectin-directed enzyme activated prodrug therapy (LEAPT): Synthesis and evaluation of rhamnose-capped prodrugs

(2010) Philippe Garnier et al.   JOURNAL OF DRUG TARGETING

FimH Antagonists for the Oral Treatment of Urinary Tract Infections: From Design and Synthesis to in Vitro and in Vivo Evaluation

(2010) Tobias Klein et al.   JOURNAL OF MEDICINAL CHEMISTRY

Carbohydrate vaccines: developing sweet solutions to sticky situations?

(2010) Rena D. Astronomo et al.   NATURE REVIEWS DRUG DISCOVERY

A nonself sugar mimic of the HIV glycan shield shows enhanced antigenicity

(2010) K. J. Doores et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multivalent Manno-Glyconanoparticles Inhibit DC-SIGN-Mediated HIV-1 Trans-Infection of Human T Cells

(2009) Olga Martínez-Ávila et al.   CHEMBIOCHEM

Immunotherapy for cancer: synthetic carbohydrate-based vaccines

(2009) Therese Buskas et al.   CHEMICAL COMMUNICATIONS

Pharmacological significance of glycosylation in therapeutic proteins

(2009) Huijuan Li et al.   CURRENT OPINION IN BIOTECHNOLOGY

Inhibitors Against Glycosidases as Medicines

(2009) Tetsuya Kajimoto et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Glycosylation in immune cell trafficking

(2009) Markus Sperandio et al.   IMMUNOLOGICAL REVIEWS

Identification of C-glycoside analogues that display a potent biological activity against murine and human invariant natural killer T cells

(2009) Xiangming Li et al.   IMMUNOLOGY

Synthetic  -(1->6)-Linked N-Acetylated and Nonacetylated Oligoglucosamines Used To Produce Conjugate Vaccines for Bacterial Pathogens

(2009) M. L. Gening et al.   INFECTION AND IMMUNITY

From Synthesis to Biologics: Preclinical Data on a Chemistry Derived Anticancer Vaccine

(2009) Jianglong Zhu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Glycosylation as a strategy to improve antibody-based therapeutics

(2009) Roy Jefferis   NATURE REVIEWS DRUG DISCOVERY

Siglecs as targets for therapy in immune-cell-mediated disease

(2009) Mary K. O’Reilly et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Synthesis of QS-21-Xylose: Establishment of the Immunopotentiating Activity of Synthetic QS-21 Adjuvant with a Melanoma Vaccine

(2008) Kai Deng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of Novel DC-SIGN Ligands with an α-Fucosylamide Anchor

(2008) Gabriele Timpano et al.   CHEMBIOCHEM

Glycoprotein Synthesis: An Update

(2008) David P. Gamblin et al.   CHEMICAL REVIEWS

Carbohydrate arrays as tools for research and diagnostics

(2008) Tim Horlacher et al.   CHEMICAL SOCIETY REVIEWS

Glycomimetics and Glycodendrimers as High Affinity Microbial Anti-adhesins

(2008) Anne Imberty et al.   CHEMISTRY-A EUROPEAN JOURNAL

Glycan arrays: biological and medical applications

(2008) Pi-Hui Liang et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Microbial recognition of human cell surface glycoconjugates

(2008) Anne Imberty et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Recent Developments in Synthetic Oligosaccharide-Based Bacterial Vaccines

(2008) Vince Pozsgay   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Galectins: structure, function and therapeutic potential

(2008) Ri-Yao Yang et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

A Glycoconjugate Antigen Based on the Recognition Motif of a Broadly Neutralizing Human Immunodeficiency Virus Antibody, 2G12, Is Immunogenic but Elicits Antibodies Unable To Bind to the Self Glycans of gp120

(2008) R. D. Astronomo et al.   JOURNAL OF VIROLOGY

Synthetic GPI array to study antitoxic malaria response

(2008) Faustin Kamena et al.   Nature Chemical Biology

Glycan microarray of Globo H and related structures for quantitative analysis of breast cancer

(2008) C.-C. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glyconanoparticles allow pre-symptomatic in vivo imaging of brain disease

(2008) S. I. van Kasteren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An oligosaccharide-based HIV-1 2G12 mimotope vaccine induces carbohydrate-specific antibodies that fail to neutralize HIV-1 virions

(2008) J. G. Joyce et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting the carbohydrates on HIV-1: Interaction of oligomannose dendrons with human monoclonal antibody 2G12 and DC-SIGN

(2008) S.-K. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Imaging the glycome

(2008) S. T. Laughlin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA