Synthesis of α-CF3 and α-CF2H amines via the aminofluorination of fluorinated alkenes

Synthesis of Alkylated Monofluoroalkenes via Fe-Catalyzed Defluorinative Cross-Coupling of Donor Alkenes with gem-Difluoroalkenes

(2018) Ling Yang et al.   ORGANIC LETTERS

“All-Water” Synthesis of β-Amino α,α-Difluoro Ketones from Fluorinated Enol Silyl Ethers and Imines

(2017) Ye-bin Wu et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Metal-Free Three-Component Regioselective Aminofluorination of Styrene Derivatives

(2017) Qiao Zhang et al.   JOURNAL OF ORGANIC CHEMISTRY

Nickel-Catalyzed Defluorinative Reductive Cross-Coupling of gem-Difluoroalkenes with Unactivated Secondary and Tertiary Alkyl Halides

(2017) Xi Lu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Experimental and Theoretical Studies on Rhodium-Catalyzed Coupling of Benzamides with 2,2-Difluorovinyl Tosylate: Diverse Synthesis of Fluorinated Heterocycles

(2017) Jia-Qiang Wu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Molecular basis of USP7 inhibition by selective small-molecule inhibitors

(2017) Andrew P. Turnbull et al.   NATURE

An efficient approach to 3-oxoisoindoline-1-difluoroalkyl derivatives via a metal triflate-catalyzed Mannich/lactamization cascade reaction

(2017) Tingting Chen et al.   NEW JOURNAL OF CHEMISTRY

N-Heterocyclic carbene-catalyzed stereoselective construction of olefinic carbon–sulfur bonds via cross-coupling reaction of gem-difluoroalkenes and thiols

(2017) Zi-Song Cong et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Recent advances in the synthesis and CF functionalization of gem-difluoroalkenes

(2017) Xuxue Zhang et al.   TETRAHEDRON LETTERS

Catalytic asymmetric radical aminoperfluoroalkylation and aminodifluoromethylation of alkenes to versatile enantioenriched-fluoroalkyl amines

(2017) Jin-Shun Lin et al.   Nature Communications

A remote C–C bond cleavage–enabled skeletal reorganization: Access to medium-/large-sized cyclic alkenes

(2017) Lei Li et al.   Science Advances

Copper-Catalyzed Stereoselective Defluorinative Borylation and Silylation of gem -Difluoroalkenes

(2017) Dong-Hang Tan et al.   ADVANCED SYNTHESIS & CATALYSIS

Palladium-Catalyzed Defluorinative Coupling of 1-Aryl-2,2-Difluoroalkenes and Boronic Acids: Stereoselective Synthesis of Monofluorostilbenes

(2016) Richard T. Thornbury et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Oxidative Difunctionalization of Alkenyl MIDA Boronates: A Versatile Platform for Halogenated and Trifluoromethylated α-Boryl Ketones

(2016) Wen-Xin Lv et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Monofluoroalkenylation of Dimethylamino Compounds through Radical-Radical Cross-Coupling

(2016) Jin Xie et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Visible-light-initiated difluoromethylation of arene diazonium tetrafluoroborates

(2016) Ye-bin Wu et al.   CHEMICAL COMMUNICATIONS

Mild and Copper-Free Stereoselective Cyanation of gem -Difluoroalkenes by Using Benzyl Nitrile as a Cyanating Reagent

(2016) Juan Zhang et al.   CHEMISTRY-A EUROPEAN JOURNAL

F– Nucleophilic-Addition-Induced Allylic Alkylation

(2016) Panpan Tian et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Dual-Catalytic Strategy To Direct Asymmetric Radical Aminotrifluoromethylation of Alkenes

(2016) Jin-Shun Lin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Sterically Controlled Cu-Catalyzed or Transition-Metal-Free Cross-Coupling of gem-Difluoroalkenes with Tertiary, Secondary, and Primary Alkyl Grignard Reagents

(2016) Wenpeng Dai et al.   ORGANIC LETTERS

Catalytic, asymmetric difluorination of alkenes to generate difluoromethylated stereocenters

(2016) S. M. Banik et al.   SCIENCE

Michael Addition Catalyzed by Chiral Secondary Amine Phosphoramide Using Fluorinated Silyl Enol Ethers: Formation of Quaternary Carbon Stereocenters

(2015) Jin-Sheng Yu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Applications of Fluorine in Medicinal Chemistry

(2015) Eric P. Gillis et al.   JOURNAL OF MEDICINAL CHEMISTRY

Rhodium-catalysed C(sp2)–C(sp2) bond formation via C–H/C–F activation

(2015) Panpan Tian et al.   Nature Communications

Oxidative Trifluoromethylation and Trifluoromethylthiolation Reactions Using (Trifluoromethyl)trimethylsilane as a Nucleophilic CF3 Source

(2014) Lingling Chu et al.   ACCOUNTS OF CHEMICAL RESEARCH

Highly Efficient “On Water” Catalyst-Free Nucleophilic Addition Reactions Using Difluoroenoxysilanes: Dramatic Fluorine Effects

(2014) Jin-Sheng Yu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Trifluoromethylation of Alkenes with Concomitant Introduction of Additional Functional Groups

(2014) Hiromichi Egami et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Silver-Catalyzed Oxidative Activation of Benzylic CH Bonds for the Synthesis of Difluoromethylated Arenes

(2014) Peng Xu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Electrophilic Trifluoromethylation by Use of Hypervalent Iodine Reagents

(2014) Julie Charpentier et al.   CHEMICAL REVIEWS

gem-Difluoroolefination of Diaryl Ketones and Enolizable Aldehydes with Difluoromethyl 2-Pyridyl Sulfone: New Insights into the Julia-Kocienski Reaction

(2014) Bing Gao et al.   CHEMISTRY-A EUROPEAN JOURNAL

Palladium- and Nickel-Catalyzed Kumada Cross-Coupling Reactions of gem-Difluoroalkenes and Monofluoroalkenes with Grignard Reagents

(2014) Wenpeng Dai et al.   JOURNAL OF ORGANIC CHEMISTRY

Metal-Free, Efficient Oxyfluorination of Olefins for the Synthesis of α-Fluoroketones

(2014) Qiang Yang et al.   ORGANIC LETTERS

Cooperative dual palladium/silver catalyst for direct difluoromethylation of aryl bromides and iodides

(2014) Yang Gu et al.   Nature Communications

AgF-Mediated Fluorinative Homocoupling of gem-Difluoroalkenes

(2013) Bing Gao et al.   ORGANIC LETTERS

A “Renaissance” in Radical Trifluoromethylation

(2012) Armido Studer   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Copper-Mediated Difluoromethylation of (Hetero)aryl Iodides and β-Styryl Halides with Tributyl(difluoromethyl)stannane

(2012) G. K. Surya Prakash et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Copper-Mediated Difluoromethylation of Aryl and Vinyl Iodides

(2012) Patrick S. Fier et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Practical and innate carbon–hydrogen functionalization of heterocycles

(2012) Yuta Fujiwara et al.   NATURE

Asymmetric catalytic Mannich-type reaction of hydrazones with difluoroenoxysilanes using imidazoline-anchored phosphine ligand–zinc(ii) complexes

(2012) Zhiliang Yuan et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A Broadly Applicable Copper Reagent for Trifluoromethylations and Perfluoroalkylations of Aryl Iodides and Bromides

(2011) Hiroyuki Morimoto et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Aromatic Trifluoromethylation with Metal Complexes

(2011) Olesya A. Tomashenko et al.   CHEMICAL REVIEWS

Chiral Phosphoric Acid Catalyzed Enantioselective Synthesis of β-Amino-α,α-difluoro Carbonyl Compounds

(2011) Wataru Kashikura et al.   ORGANIC LETTERS

Fluorinated high-performance polymers: Poly(arylene ether)s and aromatic polyimides containing trifluoromethyl groups

(2010) Mahua G. Dhara et al.   PROGRESS IN POLYMER SCIENCE

Reaction of aldimines and difluoroenoxysilane, an unexpected protocol for the synthesis of 2,2-difluoro-3-hydroxy-1-ones

(2010) Zhi-Liang Yuan et al.   TETRAHEDRON

Nucleophilic (phenylsulfonyl)difluoromethylation of alkyl halides using PhSO2CF2SiMe3: preparation of gem-difluoroalkenes and trifluoromethyl compounds

(2010) Lingui Zhu et al.   TETRAHEDRON LETTERS

Efficient Access to Extended Yagupolskii-Umemoto-Type Reagents: Triflic Acid Catalyzed Intramolecular Cyclization of ortho-Ethynylaryltrifluoromethylsulfanes

(2009) Andrej Matsnev et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

C−F Bond Activation in Organic Synthesis

(2009) Hideki Amii et al.   CHEMICAL REVIEWS

CuBr-Catalyzed Oxidative Difluoromethylation of Tertiary Amines with Difluoroenol Silyl Ethers

(2009) Lingling Chu et al.   ORGANIC LETTERS

α-Trifluoromethylated Carbanion Synthons

(2008) Kenji Uneyama et al.   ACCOUNTS OF CHEMICAL RESEARCH

InX3-catalyzed haloamidation of vinyl arenes: a facile synthesis of α-bromo- and α-fluoroamides

(2008) J.S. Yadav et al.   TETRAHEDRON LETTERS