4.6 Article

Asymmetric catalytic Mannich-type reaction of hydrazones with difluoroenoxysilanes using imidazoline-anchored phosphine ligand-zinc(II) complexes

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 10, Issue 13, Pages 2509-2513

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c2ob07022g

Keywords

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Funding

  1. National Basic Research Program of China [2010CB833302]
  2. National Natural Science Foundation of China [20928001, 21072206, 20472096, 20872162, 20672127, 20821002, 20732008]
  3. Robert A. Welch Foundation [D-1361]
  4. NIH [R21DA031860-01]

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Asymmetric Mannich-type reaction of hydrazones with difluoroenoxysilanes using chiral zinc(II)-imidazoline-phosphine complexes as catalysts have been established, giving the corresponding adducts in good to excellent enantioselectivity and chemical yields under mild conditions.

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