期刊
CHEMICAL COMMUNICATIONS
卷 54, 期 46, 页码 5907-5910出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8cc03364a
关键词
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资金
- National Natural Science Foundation of China [21472250]
- Key Project of Chinese National Programs for Fundamental Research and Development [2016YFA0602900]
- National Science and Technology Major Project of the Ministry of Science and Technology of China [2018ZX09735010]
- 1000-Youth Talents Plan
A novel synthesis of alpha-CF3 and alpha-CF2H amines via the aminofluorination of gem-difluoroalkenes and mono-fluoroalkenes, respectively, is reported. The method employs Selectfluor as an electrophilic fluorine source and acetonitrile as a nitrogen source. Mechanistic studies revealed a single-electron oxidation/fluorine-abstraction/Ritter-type amination pathway. The protocol allowed the synthesis of a broad range of fluorinated amines including those bearing quaternary carbon centers with good efficiency and functional group tolerance.
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