Targeting epigenetics using synthetic lethality in precision medicine

SETD2 indicates favourable prognosis in gastric cancer and suppresses cancer cell proliferation, migration, and invasion

(2018) Ziyi Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SAHA and cisplatin sensitize gastric cancer cells to doxorubicin by induction of DNA damage, apoptosis and perturbation of AMPK-mTOR signalling

(2018) Kwi Shan Seah et al.   EXPERIMENTAL CELL RESEARCH

Phase I combination study of the PARP inhibitor veliparib plus carboplatin and gemcitabine in patients with advanced ovarian cancer and other solid malignancies

(2018) Heidi J. Gray et al.   GYNECOLOGIC ONCOLOGY

BRG1 promotes VEGF-A expression and angiogenesis in human colorectal cancer cells

(2017) Jingqin Lan et al.   EXPERIMENTAL CELL RESEARCH

Utilizing next-generation sequencing in the management of multiple myeloma

(2017) Marta Lionetti et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

LncRNA Structural Characteristics in Epigenetic Regulation

(2017) Chenguang Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Genome Instability and γH2AX

(2017) Anastasios Georgoulis et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Synthetic lethality in DNA repair network: A novel avenue in targeted cancer therapy and combination therapeutics

(2017) Sonali Bhattacharjee et al.   IUBMB LIFE

SETD2 and histone H3 lysine 36 methylation deficiency in advanced systemic mastocytosis

(2017) G Martinelli et al.   LEUKEMIA

AZD6738, A Novel Oral Inhibitor of ATR, Induces Synthetic Lethality with ATM Deficiency in Gastric Cancer Cells

(2017) Ahrum Min et al.   MOLECULAR CANCER THERAPEUTICS

BRCA1–BARD1 promotes RAD51-mediated homologous DNA pairing

(2017) Weixing Zhao et al.   NATURE

ENL links histone acetylation to oncogenic gene expression in acute myeloid leukaemia

(2017) Liling Wan et al.   NATURE

HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures

(2017) Helen Davies et al.   NATURE MEDICINE

Targeting glioma stem cells through combined BMI1 and EZH2 inhibition

(2017) Xun Jin et al.   NATURE MEDICINE

The helicase domain of Polθ counteracts RPA to promote alt-NHEJ

(2017) Pedro A Mateos-Gomez et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A system for detecting high impact-low frequency mutations in primary tumors and metastases

(2017) M Anjanappa et al.   ONCOGENE

PARP inhibitors: Synthetic lethality in the clinic

(2017) Christopher J. Lord et al.   SCIENCE

Loss of SETD2, but not H3K36me3, correlates with aggressive clinicopathological features of clear cell renal cell carcinoma patients

(2017) Lei Liu et al.   BioScience Trends

Co-regulation of transcription by BRG1 and BRM, two mutually exclusive SWI/SNF ATPase subunits

(2017) Jesse R. Raab et al.   Epigenetics & Chromatin

Stable transgenerational epigenetic inheritance requires a DNA methylation-sensing circuit

(2017) Ben P. Williams et al.   Nature Communications

The helicase domain of Polθ counteracts RPA to promote alt-NHEJ

(2017) Pedro A Mateos-Gomez et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Long non-coding RNA PARTICLE bridges histone and DNA methylation

(2017) Valerie Bríd O’Leary et al.   Scientific Reports

Chromatin accessibility underlies synthetic lethality of SWI/SNF subunits in ARID1A-mutant cancers

(2017) Timothy W R Kelso et al.   eLife

Integration of Next-Generation Sequencing to Treat Acute Lymphoblastic Leukemia with Targetable Lesions: The St. Jude Children’s Research Hospital Approach

(2017) Hiroto Inaba et al.   Frontiers in Pediatrics

Clear-cell carcinoma of the ovary

(2016) K. Fujiwara et al.   ANNALS OF ONCOLOGY

Mechanisms of ATP-Dependent Chromatin Remodeling Motors

(2016) Coral Y. Zhou et al.   Annual Review of Biophysics

Atypical Teratoid/Rhabdoid Tumors Are Comprised of Three Epigenetic Subgroups with Distinct Enhancer Landscapes

(2016) Pascal D. Johann et al.   CANCER CELL

LncRNA HOXA11-AS Promotes Proliferation and Invasion of Gastric Cancer by Scaffolding the Chromatin Modification Factors PRC2, LSD1, and DNMT1

(2016) Ming Sun et al.   CANCER RESEARCH

Dual Chromatin and Cytoskeletal Remodeling by SETD2

(2016) In Young Park et al.   CELL

RB localizes to DNA double-strand breaks and promotes DNA end resection and homologous recombination through the recruitment of BRG1

(2016) Renier Vélez-Cruz et al.   GENES & DEVELOPMENT

Human lung adenocarcinoma cell cultures derived from malignant pleural effusions as model system to predict patients chemosensitivity

(2016) Giuseppe Roscilli et al.   Journal of Translational Medicine

Genomic disruption of the histone methyltransferase SETD2 in chronic lymphocytic leukaemia

(2016) H Parker et al.   LEUKEMIA

Methylated α-tubulin antibodies recognize a new microtubule modification on mitotic microtubules

(2016) In Young Park et al.   mAbs

Concurrent ARID1A and ARID1B inactivation in endometrial and ovarian dedifferentiated carcinomas

(2016) Mackenzie Coatham et al.   MODERN PATHOLOGY

Essential Roles for Polymerase θ-Mediated End Joining in the Repair of Chromosome Breaks

(2016) David W. Wyatt et al.   MOLECULAR CELL

Replication fork stability confers chemoresistance in BRCA-deficient cells

(2016) Arnab Ray Chaudhuri et al.   NATURE

The molecular hallmarks of epigenetic control

(2016) C. David Allis et al.   NATURE REVIEWS GENETICS

Synthetic viability by BRCA2 and PARP1/ARTD1 deficiencies

(2016) Xia Ding et al.   Nature Communications

SETD2: an epigenetic modifier with tumor suppressor functionality

(2016) Jun Li et al.   Oncotarget

A synthetic lethal screen identifies ATR-inhibition as a novel therapeutic approach for POLD1-deficient cancers

(2016) Sandra Hocke et al.   Oncotarget

Predicting chemotherapeutic drug combinations through gene network profiling

(2016) Thi Thuy Trang Nguyen et al.   Scientific Reports

Discovery, design, and synthesis of indole-based EZH2 inhibitors

(2015) Victor S. Gehling et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The IGNITE network: a model for genomic medicine implementation and research

(2015) Kristin Wiisanen Weitzel et al.   BMC Medical Genomics

Inhibiting WEE1 Selectively Kills Histone H3K36me3-Deficient Cancers by dNTP Starvation

(2015) Sophia X. Pfister et al.   CANCER CELL

Are pharmacogenomic biomarkers an effective tool to predict taxane toxicity and outcome in breast cancer patients? Literature review

(2015) Francesca De Iuliis et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

The SMARCA2/4 ATPase Domain Surpasses the Bromodomain as a Drug Target in SWI/SNF-Mutant Cancers: Insights from cDNA Rescue and PFI-3 Inhibitor Studies

(2015) Bhavatarini Vangamudi et al.   CANCER RESEARCH

BAP1,PBRM1andSETD2in clear-cell renal cell carcinoma: molecular diagnostics and possible targets for personalized therapies

(2015) Francesco Piva et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Dual loss of the SWI/SNF complex ATPases SMARCA4/BRG1 and SMARCA2/BRM is highly sensitive and specific for small cell carcinoma of the ovary, hypercalcaemic type

(2015) Anthony N Karnezis et al.   JOURNAL OF PATHOLOGY

Differences in Expression of Key DNA Damage Repair Genes after Epigenetic-Induced BRCAness Dictate Synthetic Lethality with PARP1 Inhibition

(2015) A. P. Wiegmans et al.   MOLECULAR CANCER THERAPEUTICS

Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair

(2015) Raphael Ceccaldi et al.   NATURE

Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination

(2015) Pedro A. Mateos-Gomez et al.   NATURE

REV7 counteracts DNA double-strand break resection and affects PARP inhibition

(2015) Guotai Xu et al.   NATURE

EZH2 inhibition sensitizes BRG1 and EGFR mutant lung tumours to TopoII inhibitors

(2015) Christine M. Fillmore et al.   NATURE

Chemical proteomics reveals a γH2AX-53BP1 interaction in the DNA damage response

(2015) Ralph E Kleiner et al.   Nature Chemical Biology

SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2

(2015) Kimberly H Kim et al.   NATURE MEDICINE

Synthetic lethality by targeting EZH2 methyltransferase activity in ARID1A-mutated cancers

(2015) Benjamin G Bitler et al.   NATURE MEDICINE

Mechanism of microhomology-mediated end-joining promoted by human DNA polymerase θ

(2015) Tatiana Kent et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A novel role for the mono-ADP-ribosyltransferase PARP14/ARTD8 in promoting homologous recombination and protecting against replication stress

(2015) Claudia M. Nicolae et al.   NUCLEIC ACIDS RESEARCH

Mechanism of microhomology-mediated end-joining promoted by human DNA polymerase θ

(2015) Tatiana Kent et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mammalian SWI/SNF chromatin remodeling complexes and cancer: Mechanistic insights gained from human genomics

(2015) C. Kadoch et al.   Science Advances

ATR Inhibitors VE-821 and VX-970 Sensitize Cancer Cells to Topoisomerase I Inhibitors by Disabling DNA Replication Initiation and Fork Elongation Responses

(2014) R. Josse et al.   CANCER RESEARCH

Enhanced non-homologous end joining contributes toward synthetic lethality of pathological RAD51C mutants with poly (ADP-ribose) polymerase

(2014) Kumar Somyajit et al.   CARCINOGENESIS

Chromatin-regulating proteins as targets for cancer therapy

(2014) Takahiro Oike et al.   JOURNAL OF RADIATION RESEARCH

Olaparib maintenance therapy in patients with platinum-sensitive relapsed serous ovarian cancer: a preplanned retrospective analysis of outcomes by BRCA status in a randomised phase 2 trial

(2014) Jonathan Ledermann et al.   LANCET ONCOLOGY

A Synthetic Lethal Screen Reveals Enhanced Sensitivity to ATR Inhibitor Treatment in Mantle Cell Lymphoma with ATM Loss-of-Function

(2014) Daniel L. Menezes et al.   MOLECULAR CANCER RESEARCH

ARID1B is a specific vulnerability in ARID1A-mutant cancers

(2014) Katherine C Helming et al.   NATURE MEDICINE

Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers

(2014) G. R. Hoffman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New concepts in DNA methylation

(2014) Albert Jeltsch et al.   TRENDS IN BIOCHEMICAL SCIENCES

Epigenetic marking of sperm by post-translational modification of histones and protamines

(2014) Andrea M Brunner et al.   Epigenetics & Chromatin

Prognostic Significance of Overexpression of EZH2 and H3k27me3 Proteins in Gastric Cancer

(2013) Long-Jun He et al.   Asian Pacific Journal of Cancer Prevention

A Synthetic Lethality-Based Strategy to Treat Cancers Harboring a Genetic Deficiency in the Chromatin Remodeling Factor BRG1

(2013) T. Oike et al.   CANCER RESEARCH

EZH2 Protein Expression Associates with the Early Pathogenesis, Tumor Progression, and Prognosis of Non-Small Cell Lung Carcinoma

(2013) C. Behrens et al.   CLINICAL CANCER RESEARCH

P-glycoprotein and Vacuolar ATPase Synergistically Confer Anthracycline Resistance to Fission Yeast and Human Cells

(2013) Zoey Tay et al.   CURRENT MEDICINAL CHEMISTRY

BRG1 and BRM Chromatin-Remodeling Complexes Regulate the Hypoxia Response by Acting as Coactivators for a Subset of Hypoxia-Inducible Transcription Factor Target Genes

(2013) J. A. Sena et al.   MOLECULAR AND CELLULAR BIOLOGY

Mutational landscape and significance across 12 major cancer types

(2013) Cyriac Kandoth et al.   NATURE

Targeted disruption of the EZH2–EED complex inhibits EZH2-dependent cancer

(2013) Woojin Kim et al.   Nature Chemical Biology

Cellular Robustness Conferred by Genetic Crosstalk Underlies Resistance against Chemotherapeutic Drug Doxorubicin in Fission Yeast

(2013) Zoey Tay et al.   PLoS One

Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2

(2013) S. K. Knutson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of 53BP1 oligomerization in regulating double-strand break repair

(2013) F. Lottersberger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Saccharomyces cerevisiae Genetics Predicts Candidate Therapeutic Genetic Interactions at the Mammalian Replication Fork

(2013) Derek M. van Pel et al.   G3-Genes Genomes Genetics

Lung cancer with loss of BRG1/BRM, shows epithelial mesenchymal transition phenotype and distinct histologic and genetic features

(2012) Daisuke Matsubara et al.   CANCER SCIENCE

A Landscape of Driver Mutations in Melanoma

(2012) Eran Hodis et al.   CELL

Clear cell carcinoma of the ovary: Is there a role of histology-specific treatment?

(2012) Masashi Takano et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Role of genomics on the path to personalized medicine

(2012) Johanne Tremblay et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

ALK alterations in adult renal cell carcinoma: frequency, clinicopathologic features and outcome in a large series of consecutively treated patients

(2012) William R Sukov et al.   MODERN PATHOLOGY

The landscape of cancer genes and mutational processes in breast cancer

(2012) Philip J. Stephens et al.   NATURE

Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations

(2012) Trevor J. Pugh et al.   NATURE

EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations

(2012) Michael T. McCabe et al.   NATURE

A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells

(2012) Sarah K Knutson et al.   Nature Chemical Biology

Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators

(2012) Akihiro Fujimoto et al.   NATURE GENETICS

Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma

(2012) Mark Sausen et al.   NATURE GENETICS

Understanding the language of Lys36 methylation at histone H3

(2012) Eric J. Wagner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation

(2012) W. Qi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of BMI1, a Stem Cell Factor, in Cancer Recurrence and Chemoresistance: Preclinical and Clinical Evidences

(2012) Hifzur Rahman Siddique et al.   STEM CELLS

Up-regulation of enhancer of zeste homolog 2 is associated positively with cyclin D1 overexpression and poor clinical outcome in head and neck squamous cell carcinoma

(2011) Wei Cao et al.   CANCER

RNAi Screening Identifies TAK1 as a Potential Target for the Enhanced Efficacy of Topoisomerase Inhibitors

(2011) S. E. Martin et al.   CURRENT CANCER DRUG TARGETS

Inhibition of the Single Downstream Target BAG1 Activates the Latent Apoptotic Potential of MYC

(2011) X.-Y. Zhang et al.   MOLECULAR AND CELLULAR BIOLOGY

Asf1/HIRA Facilitate Global Histone Deacetylation and Associate with HP1 to Promote Nucleosome Occupancy at Heterochromatic Loci

(2011) Kenichi Yamane et al.   MOLECULAR CELL

Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma

(2011) Ignacio Varela et al.   NATURE

Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR

(2011) Philip M Reaper et al.   Nature Chemical Biology

Enhancer of zeste homolog 2 (EZH2) expression is an independent prognostic factor in renal cell carcinoma

(2010) Nina Wagener et al.   BMC CANCER

Regulation of Tumor Angiogenesis by EZH2

(2010) Chunhua Lu et al.   CANCER CELL

Inhibition of Histone Deacetylase in Cancer Cells Slows Down Replication Forks, Activates Dormant Origins, and Induces DNA Damage

(2010) Chiara Conti et al.   CANCER RESEARCH

Synthetic lethality: General principles, utility and detection using genetic screens in human cells

(2010) Sebastian M.B. Nijman   FEBS LETTERS

Implications of enhancer of zeste homologue 2 expression in pancreatic ductal adenocarcinoma

(2010) Adam D. Toll et al.   HUMAN PATHOLOGY

Small RNAs are on the move

(2010) Daniel H. Chitwood et al.   NATURE

Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes

(2010) Gillian L. Dalgliesh et al.   NATURE

Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes

(2010) Gorica Nikoloski et al.   NATURE GENETICS

Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders

(2010) Thomas Ernst et al.   NATURE GENETICS

ARID1AMutations in Endometriosis-Associated Ovarian Carcinomas

(2010) Kimberly C. Wiegand et al.   NEW ENGLAND JOURNAL OF MEDICINE

Synthesis-dependent microhomology-mediated end joining accounts for multiple types of repair junctions

(2010) Amy Marie Yu et al.   NUCLEIC ACIDS RESEARCH

Frequent Mutations of Chromatin Remodeling Gene ARID1A in Ovarian Clear Cell Carcinoma

(2010) Siân Jones et al.   SCIENCE

Molecular targets of epigenetic regulation and effectors of environmental influences☆☆☆

(2010) Supratim Choudhuri et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The Biology of Chromatin Remodeling Complexes

(2009) Cedric R. Clapier et al.   Annual Review of Biochemistry

Histone deacetylase inhibitors: Potential in cancer therapy

(2009) P.A. Marks et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger

(2009) Gang G. Wang et al.   NATURE

Mechanisms of Polycomb gene silencing: knowns and unknowns

(2009) Jeffrey A. Simon et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Phosphorylation of SDT repeats in the MDC1 N terminus triggers retention of NBS1 at the DNA damage–modified chromatin

(2008) Fredrik Melander et al.   JOURNAL OF CELL BIOLOGY

Cell cycle control of centromeric repeat transcription and heterochromatin assembly

(2008) Ee Sin Chen et al.   NATURE