Human lung adenocarcinoma cell cultures derived from malignant pleural effusions as model system to predict patients chemosensitivity

Heterogeneity of KRAS, NRAS, BRAF and PIK3CA mutations in metastatic colorectal cancer and potential effects on therapy in the CAPRI GOIM trial

(2015) N. Normanno et al.   ANNALS OF ONCOLOGY

ALCHEMIST: Bringing genomic discovery and targeted therapies to early-stage lung cancer

(2015) DE Gerber et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Tumor Genetic Screening Programs: A Call to Action

(2015) David M. Hyman et al.   JOURNAL OF CLINICAL ONCOLOGY

Feasibility of Large-Scale Genomic Testing to Facilitate Enrollment Onto Genomically Matched Clinical Trials

(2015) Funda Meric-Bernstam et al.   JOURNAL OF CLINICAL ONCOLOGY

A Big Bang model of human colorectal tumor growth

(2015) Andrea Sottoriva et al.   NATURE GENETICS

Clinical management of breast cancer heterogeneity

(2015) Dimitrios Zardavas et al.   Nature Reviews Clinical Oncology

Combination therapy with anti-ErbB3 monoclonal antibodies and EGFR TKIs potently inhibits Non-small Cell Lung Cancer

(2015) Alessia Noto et al.   Oncotarget

Poor response to erlotinib in patients with tumors containing baseline EGFR T790M mutations found by routine clinical molecular testing

(2014) H. A. Yu et al.   ANNALS OF ONCOLOGY

Clinical activity of FOLFIRI plus cetuximab according to extended gene mutation status by next-generation sequencing: findings from the CAPRI-GOIM trial

(2014) F. Ciardiello et al.   ANNALS OF ONCOLOGY

Advances in patient-derived tumor xenografts: From target identification to predicting clinical response rates in oncology

(2014) Edward Rosfjord et al.   BIOCHEMICAL PHARMACOLOGY

Clinical outcome according to the level of preexisting epidermal growth factor receptor T790M mutation in patients with lung cancer harboring sensitive epidermal growth factor receptor mutations

(2014) Youngjoo Lee et al.   CANCER

Patient-Derived Ovarian Tumor Xenografts Recapitulate Human Clinicopathology and Genetic Alterations

(2014) F. Ricci et al.   CANCER RESEARCH

Patient-Derived Xenografts from Non-Small Cell Lung Cancer Brain Metastases Are Valuable Translational Platforms for the Development of Personalized Targeted Therapy

(2014) H. W. Lee et al.   CLINICAL CANCER RESEARCH

Patient-derived tumour xenografts as models for breast cancer drug development

(2014) Elisabetta Marangoni et al.   CURRENT OPINION IN ONCOLOGY

Update on systemic therapy of advanced non-small-cell lung cancer

(2014) Tanja Cufer et al.   Expert Review of Anticancer Therapy

Prognostic Impact of Minimal Pleural Effusion in Non–Small-Cell Lung Cancer

(2014) Jeong-Seon Ryu et al.   JOURNAL OF CLINICAL ONCOLOGY

Generation of orthotopic patient-derived xenografts from gastrointestinal stromal tumor

(2014) Jason K Sicklick et al.   Journal of Translational Medicine

Comprehensive molecular profiling of lung adenocarcinoma

(2014) Eric A. Collisson et al.   NATURE

Optimizing lung cancer treatment approaches

(2014) Rafael Rosell et al.   Nature Reviews Clinical Oncology

Influence of Handling Conditions on the Establishment and Propagation of Head and Neck Cancer Patient Derived Xenografts

(2014) Andrew P. Stein et al.   PLoS One

Patient-derived models of acquired resistance can identify effective drug combinations for cancer

(2014) Adam S. Crystal et al.   SCIENCE

Intratumor heterogeneity in localized lung adenocarcinomas delineated by multiregion sequencing

(2014) J. Zhang et al.   SCIENCE

Spatial and temporal diversity in genomic instability processes defines lung cancer evolution

(2014) E. C. de Bruin et al.   SCIENCE

Systems biology of cisplatin resistance: past, present and future

(2014) L Galluzzi et al.   Cell Death & Disease

Patient-Derived Xenograft Models: An Emerging Platform for Translational Cancer Research

(2014) M. Hidalgo et al.   Cancer Discovery

Setting up a wide panel of patient-derived tumor xenografts of non-small cell lung cancer by improving the preanalytical steps

(2014) Marius Ilie et al.   Cancer Medicine

Patient-Derived Tumor Xenografts: Transforming Clinical Samples into Mouse Models

(2013) D. Siolas et al.   CANCER RESEARCH

Extending Survival of Stage IV Non-Small Cell Lung Cancer

(2013) Simona Carnio et al.   SEMINARS IN ONCOLOGY

Non-Small-Cell Lung Cancer: Treatment of Late Stage Disease: Chemotherapeutics and New Frontiers

(2013) Ronald Scheff et al.   SEMINARS IN INTERVENTIONAL RADIOLOGY

Cancer statistics, 2012

(2012) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

The Promise of Patient-Derived Xenografts: The Best Laid Plans of Mice and Men

(2012) S. Kopetz et al.   CLINICAL CANCER RESEARCH

EMT markers in lung adenocarcinoma pleural effusion spheroid cells

(2012) Enrico Giarnieri et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Patient-derived tumour xenografts as models for oncology drug development

(2012) John J. Tentler et al.   Nature Reviews Clinical Oncology

EGFR and KRAS mutations in lung carcinomas in the Dutch population: increased EGFR mutation frequency in malignant pleural effusion of lung adenocarcinoma

(2012) Alexander J. J. Smits et al.   CELLULAR ONCOLOGY

Spheres Derived from Lung Adenocarcinoma Pleural Effusions: Molecular Characterization and Tumor Engraftment

(2011) Rita Mancini et al.   PLoS One

Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method

(2010) T.-C. Chou   CANCER RESEARCH

Chronic cisplatin treatment promotes enhanced damage repair and tumor progression in a mouse model of lung cancer

(2010) T. G. Oliver et al.   GENES & DEVELOPMENT

The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data

(2010) A. McKenna et al.   GENOME RESEARCH

Fast and accurate short read alignment with Burrows-Wheeler transform

(2009) H. Li et al.   BIOINFORMATICS