Negative regulators of cell death pathways in cancer: perspective on biomarkers and targeted therapies

Improved therapeutic efficacy of mammalian expressed-recombinant interferon gamma against ovarian cancer cells

(2017) Ali Razaghi et al.   EXPERIMENTAL CELL RESEARCH

Targeting metabolism and survival in chronic lymphocytic leukemia and Richter syndrome cells by a novel NF-κB inhibitor

(2017) Tiziana Vaisitti et al.   HAEMATOLOGICA

Relevance of necroptosis in cancer

(2017) Najoua Lalaoui et al.   IMMUNOLOGY AND CELL BIOLOGY

Targeting Heat Shock Proteins in Cancer: A Promising Therapeutic Approach

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The TRAIL-Induced Cancer Secretome Promotes a Tumor-Supportive Immune Microenvironment via CCR2

(2017) Torsten Hartwig et al.   MOLECULAR CELL

Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency

(2017) Evangelos Giampazolias et al.   NATURE CELL BIOLOGY

Targeting the differential addiction to anti-apoptotic BCL-2 family for cancer therapy

(2017) Akane Inoue-Yamauchi et al.   Nature Communications

Targeting metabolism and survival in chronic lymphocytic leukemia and Richter syndrome cells by a novel NF-κB inhibitor

(2017) Tiziana Vaisitti et al.   HAEMATOLOGICA

CIMAvax-EGF: A New Therapeutic Vaccine for Advanced Non-Small Cell Lung Cancer Patients

(2017) Danay Saavedra et al.   Frontiers in Immunology

EGFR Family Members’ Regulation of Autophagy Is at a Crossroads of Cell Survival and Death in Cancer

(2017) Elizabeth Henson et al.   Cancers

Immuno-PCR: An ultrasensitive immunoassay for biomolecular detection

(2016) Le Chang et al.   ANALYTICA CHIMICA ACTA

New role of E3 ubiquitin ligase in the regulation of necroptosis

(2016) Jinho Seo et al.   BMB Reports

Targeting cell death signalling in cancer: minimising ‘Collateral damage’

(2016) Joanna L Fox et al.   BRITISH JOURNAL OF CANCER

Clinical study of a survivin long peptide vaccine (SurVaxM) in patients with recurrent malignant glioma

(2016) Robert A. Fenstermaker et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Smac mimetic triggers necroptosis in pancreatic carcinoma cells when caspase activation is blocked

(2016) Sabine Hannes et al.   CANCER LETTERS

Characterization of a c-Rel Inhibitor That Mediates Anticancer Properties in Hematologic Malignancies by Blocking NF-κB–Controlled Oxidative Stress Responses

(2016) Yusuke Shono et al.   CANCER RESEARCH

Cancer therapy in the necroptosis era

(2016) Z Su et al.   CELL DEATH AND DIFFERENTIATION

Ferroptosis: process and function

(2016) Y Xie et al.   CELL DEATH AND DIFFERENTIATION

A Phase III Clinical Trial of the Epidermal Growth Factor Vaccine CIMAvax-EGF as Switch Maintenance Therapy in Advanced Non-Small Cell Lung Cancer Patients

(2016) P. C. Rodriguez et al.   CLINICAL CANCER RESEARCH

Six1 induces protein synthesis signaling expression in duck myoblasts mainly via up-regulation of mTOR

(2016) Haohan Wang et al.   GENETICS AND MOLECULAR BIOLOGY

New Concepts in Cancer Biomarkers: Circulating miRNAs in Liquid Biopsies

(2016) Erika Larrea et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Review of the recombinant human interferon gamma as an immunotherapeutic: Impacts of production platforms and glycosylation

(2016) Ali Razaghi et al.   JOURNAL OF BIOTECHNOLOGY

Expression Profile of BCL-2, BCL-XL, and MCL-1 Predicts Pharmacological Response to the BCL-2 Selective Antagonist Venetoclax in Multiple Myeloma Models

(2016) E. A. Punnoose et al.   MOLECULAR CANCER THERAPEUTICS

Co-operative and Hierarchical Binding of c-FLIP and Caspase-8: A Unified Model Defines How c-FLIP Isoforms Differentially Control Cell Fate

(2016) Michelle A. Hughes et al.   MOLECULAR CELL

CHIP controls necroptosis through ubiquitylation- and lysosome-dependent degradation of RIPK3

(2016) Jinho Seo et al.   NATURE CELL BIOLOGY

Combine and conquer: challenges for targeted therapy combinations in early phase trials

(2016) Juanita S. Lopez et al.   Nature Reviews Clinical Oncology

Ferroptosis is induced following siramesine and lapatinib treatment of breast cancer cells

(2016) S Ma et al.   Cell Death & Disease

Discovery and clinical introduction of first-in-class imipridone ONC201

(2016) Joshua E. Allen et al.   Oncotarget

Prognostic value of the ubiquitin ligase carboxyl terminus of the Hsc70-interacting protein in postmenopausal breast cancer

(2016) Sasagu Kurozumi et al.   Cancer Medicine

NF-κB in cancer therapy

(2015) Feng Li et al.   ARCHIVES OF TOXICOLOGY

The role of Six1 signaling in paclitaxel-dependent apoptosis in MCF-7 cell line

(2015) Marzieh Armat et al.   Bosnian Journal of Basic Medical Sciences

Phase II study of an AKT inhibitor MK2206 in patients with relapsed or refractory lymphoma

(2015) Yasuhiro Oki et al.   BRITISH JOURNAL OF HAEMATOLOGY

Cancer Cell-Autonomous TRAIL-R Signaling Promotes KRAS-Driven Cancer Progression, Invasion, and Metastasis

(2015) Silvia von Karstedt et al.   CANCER CELL

Increased expression of Six1 correlates with progression and prognosis of prostate cancer

(2015) Jun Zeng et al.   Cancer Cell International

Bak apoptotic pores involve a flexible C-terminal region and juxtaposition of the C-terminal transmembrane domains

(2015) S Iyer et al.   CELL DEATH AND DIFFERENTIATION

Cancer stem cells: a potential target for cancer therapy

(2015) Hong Qiu et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

GPX4 and GPX7 over-expression in human hepatocellular carcinoma tissues

(2015) E. Guerriero et al.   EUROPEAN JOURNAL OF HISTOCHEMISTRY

The SIX1-EYA transcriptional complex as a therapeutic target in cancer

(2015) Melanie A Blevins et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Targeting the 5′-AMP-activated protein kinase and related metabolic pathways for the treatment of prostate cancer

(2015) Petra Popovics et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Survivin: A molecular biomarker in cancer

(2015) RD Mittal et al.   INDIAN JOURNAL OF MEDICAL RESEARCH

Akt inhibitors in cancer treatment: The long journey from drug discovery to clinical use (Review)

(2015) GEORGE MIHAI NITULESCU et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

ABT-199 (venetoclax) and BCL-2 inhibitors in clinical development

(2015) Shundong Cang et al.   Journal of Hematology & Oncology

Profile of panitumumab as first-line treatment in patients with wild-type KRAS metastatic colorectal cancer

(2015) Ignacio Garrido-Laguna et al.   OncoTargets and Therapy

The BCL2 Family: Key Mediators of the Apoptotic Response to Targeted Anticancer Therapeutics

(2015) A. N. Hata et al.   Cancer Discovery

NF-κB-Activating Complex Engaged in Response to EGFR Oncogene Inhibition Drives Tumor Cell Survival and Residual Disease in Lung Cancer

(2015) Collin M. Blakely et al.   Cell Reports

Role of AMP-Activated Protein Kinase in Cancer Therapy

(2014) Gauhar Rehman et al.   ARCHIV DER PHARMAZIE

Human heat shock protein-specific cytotoxic T lymphocytes display potent antitumour immunity in multiple myeloma

(2014) Rong Li et al.   BRITISH JOURNAL OF HAEMATOLOGY

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Getting TRAIL back on track for cancer therapy

(2014) J Lemke et al.   CELL DEATH AND DIFFERENTIATION

IFN-γ down-regulates Hsp27 and enhances hyperthermia-induced tumor cell death in vitro and tumor suppression in vivo

(2014) Mariko Oba et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Towards combinatorial targeted therapy in melanoma: From pre-clinical evidence to clinical application (Review)

(2014) GIULIA GRAZIA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Liquid Biopsies: Genotyping Circulating Tumor DNA

(2014) Luis A. Diaz et al.   JOURNAL OF CLINICAL ONCOLOGY

Abstract B102: Targeting the SIX1/EYA transcriptional complex as a potential anti-cancer therapy.

(2014) A. Patrick et al.   MOLECULAR CANCER THERAPEUTICS

GSK3β Overexpression Indicates Poor Prognosis and Its Inhibition Reduces Cell Proliferation and Survival of Non-Small Cell Lung Cancer Cells

(2014) Jing Zeng et al.   PLoS One

Role of cetuximab in first-line treatment of metastatic colorectal cancer

(2014) Miguel Jhonatan Sotelo   WORLD JOURNAL OF GASTROENTEROLOGY

Current and Emerging Biomarkers of Cell Death in Human Disease

(2014) Kongning Li et al.   Biomed Research International

Drug Resistance in Cancer: An Overview

(2014) Genevieve Housman et al.   Cancers

Companion Diagnostics for Targeted Cancer Drugs – Clinical and Regulatory Aspects

(2014) Dana Olsen et al.   Frontiers in Oncology

Review of EGFR TKIs in Metastatic NSCLC, Including Ongoing Trials

(2014) Barbara Melosky   Frontiers in Oncology

Targeting PI3K/Akt/mTOR Signaling in Cancer

(2014) Camillo Porta et al.   Frontiers in Oncology

Expedient Synthesis of Highly Potent Antagonists of Inhibitor of Apoptosis Proteins (IAPs) with Unique Selectivity for ML-IAP

(2013) Mitchell Vamos et al.   ACS Chemical Biology

Application and interpretation of current autophagy inhibitors and activators

(2013) Ya-ping Yang et al.   ACTA PHARMACOLOGICA SINICA

Anoikis molecular pathways and its role in cancer progression

(2013) Paolo Paoli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

EGFR-Mediated Beclin 1 Phosphorylation in Autophagy Suppression, Tumor Progression, and Tumor Chemoresistance

(2013) Yongjie Wei et al.   CELL

Potential Survival Benefit of Anti-Apoptosis Protein: Survivin-Derived Peptide Vaccine with and without Interferon Alpha Therapy for Patients with Advanced or Recurrent Urothelial Cancer—Results from Phase I Clinical Trials

(2013) Toshiaki Tanaka et al.   Clinical & Developmental Immunology

The role of iron and reactive oxygen species in cell death

(2013) Scott J Dixon et al.   Nature Chemical Biology

Heat-shock protein peptide complex–96 vaccination for recurrent glioblastoma: a phase II, single-arm trial

(2013) Orin Bloch et al.   NEURO-ONCOLOGY

Molecular targets for cancer therapy in the PI3K/AKT/mTOR pathway

(2013) Jiri Polivka et al.   PHARMACOLOGY & THERAPEUTICS

Molecularly targeted cancer therapy: some lessons from the past decade

(2013) Min Huang et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Expression of carboxyl terminus of Hsp70-interacting protein (CHIP) indicates poor prognosis in human gallbladder carcinoma

(2013) ZHE LONG LIANG et al.   Oncology Letters

Selective BCL-2 Inhibition by ABT-199 Causes On-Target Cell Death in Acute Myeloid Leukemia

(2013) R. Pan et al.   Cancer Discovery

Targeting Nuclear Factor-Kappa B to Overcome Resistance to Chemotherapy

(2013) P. Godwin et al.   Frontiers in Oncology

Experience with obatoclax mesylate (GX15-070), a small molecule pan-Bcl-2 family antagonist in patients with relapsed or refractory classical Hodgkin lymphoma

(2012) Y. Oki et al.   BLOOD

The roles of FADD in extrinsic apoptosis and necroptosis

(2012) Eun-Woo Lee et al.   BMB Reports

BH3 profiling – Measuring integrated function of the mitochondrial apoptotic pathway to predict cell fate decisions

(2012) Victoria Del Gaizo Moore et al.   CANCER LETTERS

Antibody-Based Immunotherapy of Cancer

(2012) Louis M. Weiner et al.   CELL

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

The role of TRADD in death receptor signaling

(2012) Yelena L. Pobezinskaya et al.   CELL CYCLE

AMPK Is a Negative Regulator of the Warburg Effect and Suppresses Tumor Growth In Vivo

(2012) Brandon Faubert et al.   Cell Metabolism

Phase II Study of Single-Agent Navitoclax (ABT-263) and Biomarker Correlates in Patients with Relapsed Small Cell Lung Cancer

(2012) C. M. Rudin et al.   CLINICAL CANCER RESEARCH

Dual Inhibition of Canonical and Noncanonical NF- B Pathways Demonstrates Significant Antitumor Activities in Multiple Myeloma

(2012) C. Fabre et al.   CLINICAL CANCER RESEARCH

Biomarkers that currently affect clinical practice: EGFR, ALK, MET, KRAS

(2012) M.D. Vincent et al.   Current Oncology

Cancer biomarkers

(2012) N. Lynn Henry et al.   Molecular Oncology

Circumventing Cancer Drug Resistance in the Era of Personalized Medicine

(2012) Levi A. Garraway et al.   Cancer Discovery

IgG-detection devices for the Tus-Ter-lock immuno-PCR diagnostic platform

(2011) Isabelle Morin et al.   ANALYST

Heat shock proteins in oncology: Diagnostic biomarkers or therapeutic targets?

(2011) Ashraf A. Khalil et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Detection of HER2 amplification in circulating free DNA in patients with breast cancer

(2011) K Page et al.   BRITISH JOURNAL OF CANCER

Targeting apoptosis pathways in cancer stem cells

(2011) Michele Signore et al.   CANCER LETTERS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

X-linked inhibitor of apoptosis positive nuclear labeling: a new independent prognostic biomarker of breast invasive ductal carcinoma

(2011) Yutao Zhang et al.   Diagnostic Pathology

FADD Expression as a Prognosticator in Early-Stage Glottic Squamous Cell Carcinoma of the Larynx Treated Primarily With Radiotherapy

(2011) Michiel L. Schrijvers et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

First-in-Man Clinical Trial of the Oral Pan-AKT Inhibitor MK-2206 in Patients With Advanced Solid Tumors

(2011) Timothy A. Yap et al.   JOURNAL OF CLINICAL ONCOLOGY

Apoptosis in cancer: from pathogenesis to treatment

(2011) Rebecca SY Wong   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

A Novel Kinase Inhibitor of FADD Phosphorylation Chemosensitizes through the Inhibition of NF- B

(2011) K. A. Schinske et al.   MOLECULAR CANCER THERAPEUTICS

Targeting c-FLIP in cancer

(2010) Sarah Shirley et al.   CANCER LETTERS

Targeting heat shock proteins in cancer

(2010) Gaëtan Jego et al.   CANCER LETTERS

Nano-Bio-Chip Sensor Platform for Examination of Oral Exfoliative Cytology

(2010) S. E. Weigum et al.   Cancer Prevention Research

Smac mimetics increase cancer cell response to chemotherapeutics in a TNF-α-dependent manner

(2010) B L Probst et al.   CELL DEATH AND DIFFERENTIATION

Negative regulation of autophagy

(2010) C Liang   CELL DEATH AND DIFFERENTIATION

Clinical and Translational Studies of a Phase II Trial of the Novel Oral Akt Inhibitor Perifosine in Relapsed or Relapsed/Refractory Waldenstrom's Macroglobulinemia

(2010) I. M. Ghobrial et al.   CLINICAL CANCER RESEARCH

Trastuzumab

(2010) Karly P. Garnock-Jones et al.   DRUGS

Akt inhibitors in clinical development for the treatment of cancer

(2010) Sumanta Kumar Pal et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Ultrasensitive detection of antibodies using a new Tus–Ter-lock immunoPCR system

(2010) Isabelle Morin et al.   Molecular BioSystems

CD95 promotes tumour growth

(2010) Lina Chen et al.   NATURE

Fas-associated death domain (FADD) is a negative regulator of T-cell receptor-mediated necroptosis

(2010) S. L. Osborn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trastuzumab Sensitizes Ovarian Cancer Cells to EGFR-targeted Therapeutics

(2010) Jason A Wilken et al.   Journal of Ovarian Research

Site-specific covalent attachment of DNA to proteins using a photoactivatable Tus–Ter complex

(2009) Dahdah B. Dahdah et al.   CHEMICAL COMMUNICATIONS

Life and death by death receptors

(2009) Maria Eugenia Guicciardi et al.   FASEB JOURNAL

BNIP3 (Bcl-2 19 kDa Interacting Protein) Acts as Transcriptional Repressor of Apoptosis-Inducing Factor Expression Preventing Cell Death in Human Malignant Gliomas

(2009) T. R. Burton et al.   JOURNAL OF NEUROSCIENCE

Everolimus

(2009) Michael B. Atkins et al.   NATURE REVIEWS DRUG DISCOVERY

Phosphorylation of FADD (Fas-associated death domain protein) at serine 194 is increased in the prefrontal cortex of opiate abusers: Relation to mitogen activated protein kinase, phosphoprotein enriched in astrocytes of 15 kDa, and Akt signaling pathways involved in neuroplasticity

(2009) A. Ramos-Miguel et al.   NEUROSCIENCE

Biomarkers of apoptosis

(2008) T H Ward et al.   BRITISH JOURNAL OF CANCER

Inactivation of NF-κB Components by Covalent Binding of (−)-Dehydroxymethylepoxyquinomicin to Specific Cysteine Residues

(2008) Mizuki Yamamoto et al.   JOURNAL OF MEDICINAL CHEMISTRY