The SIX1-EYA transcriptional complex as a therapeutic target in cancer

Epigenetic silencing of EYA2 in pancreatic adenocarcinomas promotes tumor growth

(2015) Audrey Vincent et al.   Oncotarget

miR-30bregulates migration and invasion of human colorectal cancer via SIX1

(2014) Hui Zhao et al.   BIOCHEMICAL JOURNAL

Allosteric Inhibitors of the Eya2 Phosphatase Are Selective and Inhibit Eya2-mediated Cell Migration

(2014) Aaron B. Krueger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A phosphotyrosine switch determines the antitumor activity of ERβ

(2014) Bin Yuan et al.   JOURNAL OF CLINICAL INVESTIGATION

Chemical, Target, and Bioactive Properties of Allosteric Modulation

(2014) Gerard J. P. van Westen et al.   PLoS Computational Biology

Six1 mediates resistance to paclitaxel in breast cancer cells

(2013) Zhaoming Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibitors of the p53/hdm2 protein–protein interaction—path to the clinic

(2013) Jean-Christophe Carry et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

EYA1 Phosphatase Function Is Essential to Drive Breast Cancer Cell Proliferation through Cyclin D1

(2013) K. Wu et al.   CANCER RESEARCH

Six1 regulates proliferation of Pax7-positive muscle progenitors in zebrafish

(2013) H. Nord et al.   JOURNAL OF CELL SCIENCE

Discovery of RG7388, a Potent and Selective p53–MDM2 Inhibitor in Clinical Development

(2013) Qingjie Ding et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure-function analyses of the human SIX1–EYA2 complex reveal insights into metastasis and BOR syndrome

(2013) Aaron N Patrick et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Six1 Promotes Proliferation of Pancreatic Cancer Cells via Upregulation of Cyclin D1 Expression

(2013) Zhaoming Li et al.   PLoS One

Six1 Regulates MyoD Expression in Adult Muscle Progenitor Cells

(2013) Yubing Liu et al.   PLoS One

Structure-Activity Relationships of Benzbromarone Metabolites and Derivatives as EYA Inhibitory Anti-Angiogenic Agents

(2013) Ram Naresh Pandey et al.   PLoS One

Inhibition of Six1 promotes apoptosis, suppresses proliferation, and migration of osteosarcoma cells

(2013) Liu Hua et al.   TUMOR BIOLOGY

Transcriptional Differences between Normal and Glioma-Derived Glial Progenitor Cells Identify a Core Set of Dysregulated Genes

(2013) Romane M. Auvergne et al.   Cell Reports

The Eyes Absent proteins in development and disease

(2012) Emmanuel Tadjuidje et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Phase II Study of Single-Agent Navitoclax (ABT-263) and Biomarker Correlates in Patients with Relapsed Small Cell Lung Cancer

(2012) C. M. Rudin et al.   CLINICAL CANCER RESEARCH

Small molecule tools for functional interrogation of protein tyrosine phosphatases

(2012) Rongjun He et al.   FEBS Journal

Six1 regulates stem cell repair potential and self-renewal during skeletal muscle regeneration

(2012) Fabien Le Grand et al.   JOURNAL OF CELL BIOLOGY

SIX1 induces lymphangiogenesis and metastasis via upregulation of VEGF-C in mouse models of breast cancer

(2012) Chu-An Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Structure-based de novo design of Eya2 phosphatase inhibitors

(2012) Hwangseo Park et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Six1 and Six1 cofactor expression is altered during early skeletal muscle overload in mice

(2012) Bradley S. Gordon et al.   Journal of Physiological Sciences

Effect of the MDM2 antagonist RG7112 on the P53 pathway in patients with MDM2-amplified, well-differentiated or dedifferentiated liposarcoma: an exploratory proof-of-mechanism study

(2012) Isabelle Ray-Coquard et al.   LANCET ONCOLOGY

EWS/FLI1 Regulates EYA3 in Ewing Sarcoma via Modulation of miRNA-708, Resulting in Increased Cell Survival and Chemoresistance

(2012) T. P. Robin et al.   MOLECULAR CANCER RESEARCH

Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis

(2012) Paul Delgado-Olguín et al.   NATURE GENETICS

SIX1 promotes epithelial–mesenchymal transition in colorectal cancer through ZEB1 activation

(2012) H Ono et al.   ONCOGENE

The EYA Tyrosine Phosphatase Activity Is Pro-Angiogenic and Is Inhibited by Benzbromarone

(2012) Emmanuel Tadjuidje et al.   PLoS One

MLL fusion proteins preferentially regulate a subset of wild-type MLL target genes in the leukemic genome

(2011) Q.-f. Wang et al.   BLOOD

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Structure-Based Virtual Screening Approach to the Discovery of Novel Inhibitors of Eyes Absent 2 Phosphatase with Various Metal Chelating Moieties

(2011) Hwangseo Park et al.   Chemical Biology & Drug Design

Upregulation of Notch2 and Six1 Is Associated with Progression of Early-Stage Lung Adenocarcinoma and a More Aggressive Phenotype at Advanced Stages

(2011) T. Mimae et al.   CLINICAL CANCER RESEARCH

Six1 transcription factor is critical for coordination of epithelial, mesenchymal and vascular morphogenesis in the mammalian lung

(2011) Ahmed H.K. El-Hashash et al.   DEVELOPMENTAL BIOLOGY

Characterization of the threonine-phosphatase of mouse eyes absent 3

(2011) Teruyuki Sano et al.   FEBS LETTERS

Definition and classification of cancer cachexia: an international consensus

(2011) Kenneth Fearon et al.   LANCET ONCOLOGY

Association between Genetic Subgroups of Pancreatic Ductal Adenocarcinoma Defined by High Density 500 K SNP-Arrays and Tumor Histopathology

(2011) María Laura Gutiérrez et al.   PLoS One

Expression and significance of Six1 and Ezrin in cervical cancer tissue

(2011) Jie Tan et al.   TUMOR BIOLOGY

Homeoprotein Six1 Increases TGF-  Type I Receptor and Converts TGF-  Signaling from Suppressive to Supportive for Tumor Growth

(2010) D. S. Micalizzi et al.   CANCER RESEARCH

New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays

(2010) Jonathan B. Baell et al.   JOURNAL OF MEDICINAL CHEMISTRY

MicroRNA-185 suppresses tumor growth and progression by targeting the Six1 oncogene in human cancers

(2010) J S Imam et al.   ONCOGENE

The Eyes Absent phosphatase-transactivator proteins promote proliferation, transformation, migration and invasion of tumor cells

(2010) R N Pandey et al.   ONCOGENE

EYA1 mutations associated with the branchio-oto-renal syndrome result in defective otic development in Xenopus laevis

(2009) Youe Li et al.   BIOLOGY OF THE CELL

Crystal structure of ED-Eya2: insight into dual roles as a protein tyrosine phosphatase and a transcription factor

(2009) Suk-Kyeong Jung et al.   FASEB JOURNAL

Dephosphorylation of the C-terminal Tyrosyl Residue of the DNA Damage-related Histone H2A.X Is Mediated by the Protein Phosphatase Eyes Absent

(2009) Navasona Krishnan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biochemical and Functional Characterization of SixSIX1Branchio-oto-renal Syndrome Mutations

(2009) Aaron N. Patrick et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Six1 expands the mouse mammary epithelial stem/progenitor cell pool and induces mammary tumors that undergo epithelial-mesenchymal transition

(2009) Erica L. McCoy et al.   JOURNAL OF CLINICAL INVESTIGATION

The Six1 homeoprotein induces human mammary carcinoma cells to undergo epithelial-mesenchymal transition and metastasis in mice through increasing TGF-β signaling

(2009) Douglas S. Micalizzi et al.   JOURNAL OF CLINICAL INVESTIGATION

Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions

(2009) Peter J. Cook et al.   NATURE

Six1 Overexpression in Mammary Cells Induces Genomic Instability and Is Sufficient for Malignant Transformation

(2008) R. D. Coletta et al.   CANCER RESEARCH

ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor

(2008) C. Tse et al.   CANCER RESEARCH

The sine oculis homeobox (SIX) family of transcription factors as regulators of development and disease

(2008) J. P. Kumar   CELLULAR AND MOLECULAR LIFE SCIENCES

Branchio-oto-renal syndrome (BOR): novel mutations in theEYA1gene, and a review of the mutational genetics of BOR

(2008) Dana J. Orten et al.   HUMAN MUTATION