Bak apoptotic pores involve a flexible C-terminal region and juxtaposition of the C-terminal transmembrane domains

Regulating cell death at, on, and in membranes

(2014) Xiaoke Chi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Bax targets mitochondria by distinct mechanisms before or during apoptotic cell death: a requirement for VDAC2 or Bak for efficient Bax apoptotic function

(2014) S B Ma et al.   CELL DEATH AND DIFFERENTIATION

Differential retrotranslocation of mitochondrial Bax and Bak

(2014) F. Todt et al.   EMBO JOURNAL

Conformational Rearrangements in the Pro-apoptotic Protein, Bax, as It Inserts into Mitochondria

(2014) Robert F. Gahl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bak Core and Latch Domains Separate during Activation, and Freed Core Domains Form Symmetric Homodimers

(2014) Jason M. Brouwer et al.   MOLECULAR CELL

Structural Model of Active Bax at the Membrane

(2014) Stephanie Bleicken et al.   MOLECULAR CELL

Apoptotic pore formation is associated with in-plane insertion of Bak or Bax central helices into the mitochondrial outer membrane

(2014) Dana Westphal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bax Crystal Structures Reveal How BH3 Domains Activate Bax and Nucleate Its Oligomerization to Induce Apoptosis

(2013) Peter E. Czabotar et al.   CELL

Assembly of the Bak Apoptotic Pore

(2013) Stephen Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Organization of the Mitochondrial Apoptotic BAK Pore

(2013) Sreevidya Aluvila et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proapoptotic Bax and Bak Proteins Form Stable Protein-permeable Pores of Tunable Size

(2013) Stephanie Bleicken et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BID-induced structural changes in BAK promote apoptosis

(2013) Tudor Moldoveanu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Direct activation of full-length proapoptotic BAK

(2013) Elizaveta S. Leshchiner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Process of inducing pores in membranes by melittin

(2013) M.-T. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Where Killers Meet--Permeabilization of the Outer Mitochondrial Membrane during Apoptosis

(2013) T. Bender et al.   Cold Spring Harbor Perspectives in Biology

Bak apoptotic function is not directly regulated by phosphorylation

(2013) V H Tran et al.   Cell Death & Disease

Molecular Basis for Membrane Pore Formation by Bax Protein Carboxyl Terminus

(2012) Suren A. Tatulian et al.   BIOCHEMISTRY

Transmembrane pore formation by the carboxyl terminus of Bax protein

(2012) Pranav Garg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Rational Development of a Cytotoxic Peptide To Trigger Cell Death

(2012) Rebecca J. Boohaker et al.   MOLECULAR PHARMACEUTICS

Translocation of a Bak C-Terminus Mutant from Cytosol to Mitochondria to Mediate Cytochrome c Release: Implications for Bak and Bax Apoptotic Function

(2012) Pedro Eitz Ferrer et al.   PLoS One

µ-Calpain Conversion of Antiapoptotic Bfl-1 (BCL2A1) into a Prodeath Factor Reveals Two Distinct alpha-Helices Inducing Mitochondria-Mediated Apoptosis

(2012) Juan García Valero et al.   PLoS One

VDAC, The early days

(2011) Marco Colombini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Bcl-xL Retrotranslocates Bax from the Mitochondria into the Cytosol

(2011) Frank Edlich et al.   CELL

Bax dimerizes via a symmetric BH3:groove interface during apoptosis

(2011) G Dewson et al.   CELL DEATH AND DIFFERENTIATION

Transient binding of an activator BH3 domain to the Bak BH3-binding groove initiates Bak oligomerization

(2011) Haiming Dai et al.   JOURNAL OF CELL BIOLOGY

Bax-derived membrane-active peptides act as potent and direct inducers of apoptosis in cancer cells

(2011) J. G. Valero et al.   JOURNAL OF CELL SCIENCE

Molecular biology of Bax and Bak activation and action

(2010) Dana Westphal et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Conformational Changes in BAK, a Pore-forming Proapoptotic Bcl-2 Family Member, upon Membrane Insertion and Direct Evidence for the Existence of BH3-BH3 Contact Interface in BAK Homo-oligomers

(2010) Kyoung Joon Oh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BH3 Domains other than Bim and Bid Can Directly Activate Bax/Bak

(2010) Han Du et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Bak Activation by VDAC2 Is Dependent on the Bak Transmembrane Anchor

(2010) Michael Lazarou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondria and cell death: outer membrane permeabilization and beyond

(2010) Stephen W. G. Tait et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural Basis for Dimerization of the BNIP3 Transmembrane Domain,

(2009) Endah S. Sulistijo et al.   BIOCHEMISTRY

The interaction of the Bax C-terminal domain with membranes is influenced by the presence of negatively charged phospholipids

(2009) Alessio Ausili et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

VDAC2 is required for truncated BID-induced mitochondrial apoptosis by recruiting BAK to the mitochondria

(2009) Soumya Sinha Roy et al.   EMBO REPORTS

Molecular Details of Bax Activation, Oligomerization, and Membrane Insertion

(2009) Stephanie Bleicken et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bak Activation for Apoptosis Involves Oligomerization of Dimers via Their α6 Helices

(2009) Grant Dewson et al.   MOLECULAR CELL

The structure of a cytolytic α-helical toxin pore reveals its assembly mechanism

(2009) Marcus Mueller et al.   NATURE

The interaction of the Bax C-terminal domain with negatively charged lipids modifies the secondary structure and changes its way of insertion into membranes

(2008) Alessio Ausili et al.   JOURNAL OF STRUCTURAL BIOLOGY

To Trigger Apoptosis, Bak Exposes Its BH3 Domain and Homodimerizes via BH3:Groove Interactions

(2008) Grant Dewson et al.   MOLECULAR CELL

BAX activation is initiated at a novel interaction site

(2008) Evripidis Gavathiotis et al.   NATURE

X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation

(2008) Nicolas Bocquet et al.   NATURE

The Jpred 3 secondary structure prediction server

(2008) C. Cole et al.   NUCLEIC ACIDS RESEARCH

Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax

(2008) J. I. Fletcher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA