EGFR Family Members’ Regulation of Autophagy Is at a Crossroads of Cell Survival and Death in Cancer

PI3K-AKT-mTOR inhibitors in breast cancers: From tumor cell signaling to clinical trials

(2017) Nandini Dey et al.   PHARMACOLOGY & THERAPEUTICS

Tyrosine kinase receptor EGFR regulates the switch in cancer cells between cell survival and cell death induced by autophagy in hypoxia

(2016) Yongqiang Chen et al.   Autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

Improved transcription and translation with L-leucine stimulation of mTORC1 in Roberts syndrome

(2016) Baoshan Xu et al.   BMC GENOMICS

The PI3K Pathway: Background and Treatment Approaches

(2016) Michael P. Lux et al.   Breast Care

Endocytic control of signaling at the plasma membrane

(2016) Elisa Barbieri et al.   CURRENT OPINION IN CELL BIOLOGY

Autophagic degradation of epidermal growth factor receptor in gefitinib-resistant lung cancer by celastrol

(2016) Su-Wei Xu et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Autophagy inhibition facilitates erlotinib cytotoxicity in lung cancer cells through modulation of endoplasmic reticulum stress

(2016) ZHONGLIANG WANG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

β-Elemene enhances the efficacy of gefitinib on glioblastoma multiforme cells through the inhibition of the EGFR signaling pathway

(2016) Lin Mu et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Lapatinib induces autophagic cell death and differentiation in acute myeloblastic leukemia

(2016) Huey-Lan Huang et al.   OncoTargets and Therapy

ATG9A loss confers resistance to trastuzumab via c-Cbl mediated Her2 degradation

(2016) Joao Nunes et al.   Oncotarget

Identification of breast cancer cell subtypes sensitive to ATG4B inhibition

(2016) Svetlana Bortnik et al.   Oncotarget

The multifaceted role of autophagy in tumor evasion from immune surveillance

(2016) Bassam Janji et al.   Oncotarget

Feedback control of ErbB2 via ERK-mediated phosphorylation of a conserved threonine in the juxtamembrane domain

(2016) Yuki Kawasaki et al.   Scientific Reports

Hijacker of the Antitumor Immune Response: Autophagy Is Showing Its Worst Facet

(2016) Elodie Viry et al.   Frontiers in Oncology

A Kinase-Independent Role for EGF Receptor in Autophagy Initiation

(2015) Xiaojun Tan et al.   CELL

Co-targeting EGFR and Autophagy Impairs Ovarian Cancer Cell Survival during Detachment from the ECM

(2015) Zongyuan Yang et al.   CURRENT CANCER DRUG TARGETS

Autophagy Protects from Trastuzumab-Induced Cytotoxicity in HER2 Overexpressing Breast Tumor Spheroids

(2015) Cristina E. Rodríguez et al.   PLoS One

p130Cas scaffold protein regulates ErbB2 stability by altering breast cancer cell sensitivity to autophagy

(2015) Brigitte Bisaro et al.   Oncotarget

Chloroquine Enhances Gefitinib Cytotoxicity in Gefitinib-Resistant Nonsmall Cell Lung Cancer Cells

(2015) Mei-Chuan Tang et al.   PLoS One

Lapatinib induces autophagic cell death and inhibits growth of human hepatocellular carcinoma

(2015) Yu-Jen Chen et al.   Oncotarget

Mitochondrially localized EGFR is subjected to autophagic regulation and implicated in cell survival

(2014) Xiaojing Yue et al.   Autophagy

Targeting of erbB3 receptor to overcome resistance in cancer treatment

(2014) Jian Ma et al.   Molecular Cancer

Autophagosome-Mediated EGFR Down-Regulation Induced by the CK2 Inhibitor Enhances the Efficacy of EGFR-TKI on EGFR-Mutant Lung Cancer Cells with Resistance by T790M

(2014) Kwang Sup So et al.   PLoS One

EGFR-Mediated Beclin 1 Phosphorylation in Autophagy Suppression, Tumor Progression, and Tumor Chemoresistance

(2013) Yongjie Wei et al.   CELL

EGFR signaling and autophagy dependence for growth, survival, and therapy resistance

(2013) Barry Jutten et al.   CELL CYCLE

Cancer stem-like cell properties are regulated by EGFR/AKT/β-catenin signaling and preferentially inhibited by gefitinib in nasopharyngeal carcinoma

(2013) Lei Ma et al.   FEBS Journal

Interaction between Her2 and Beclin-1 Proteins Underlies a New Mechanism of Reciprocal Regulation

(2013) Jie Han et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy stimulates apoptosis in HER2-overexpressing breast cancers treated by lapatinib

(2013) Xingmei Zhu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Induction of Autophagy Is an Early Response to Gefitinib and a Potential Therapeutic Target in Breast Cancer

(2013) Wieslawa H. Dragowska et al.   PLoS One

Autosis is a Na+,K+-ATPase-regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia-ischemia

(2013) Y. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EGFR overexpressing cells and tumors are dependent on autophagy for growth and survival

(2013) Barry Jutten et al.   RADIOTHERAPY AND ONCOLOGY

NOX4 mediates cytoprotective autophagy induced by the EGFR inhibitor erlotinib in head and neck cancer cells

(2013) Arya Sobhakumari et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

WWOX suppresses autophagy for inducing apoptosis in methotrexate-treated human squamous cell carcinoma

(2013) C-W Tsai et al.   Cell Death & Disease

The anti-malarial chloroquine overcomes Primary resistance and restores sensitivity to Trastuzumab in HER2-positive breast cancer

(2013) Sílvia Cufí et al.   Scientific Reports

EGFR tyrosine kinase inhibition induces autophagy in cancer cells

(2012) Christopher Fung et al.   CANCER BIOLOGY & THERAPY

Blocking p38/ERK crosstalk affects colorectal cancer growth by inducing apoptosis in vitro and in preclinical mouse models

(2012) Fulvio Chiacchiera et al.   CANCER LETTERS

Expression of autophagy-related markers beclin-1, light chain 3A, light chain 3B and p62 according to the molecular subtype of breast cancer

(2012) Junjeong Choi et al.   HISTOPATHOLOGY

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Epidermal growth factor regulates Mcl-1 expression through the MAPK-Elk-1 signalling pathway contributing to cell survival in breast cancer

(2011) E P Booy et al.   ONCOGENE

Differential Sensitivity of ERBB2 Kinase Domain Mutations towards Lapatinib

(2011) Rama Krishna Kancha et al.   PLoS One

The Epidermal Growth Factor Receptor Antibody Cetuximab Induces Autophagy in Cancer Cells by Downregulating HIF-1  and Bcl-2 and Activating the Beclin 1/hVps34 Complex

(2010) X. Li et al.   CANCER RESEARCH

HER-2 Signaling and Inhibition in Breast Cancer

(2009) B. Browne et al.   CURRENT CANCER DRUG TARGETS

Autophagy and tumorigenesis

(2009) Nan Chen et al.   FEBS LETTERS

ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery

(2009) Chang Hwa Jung et al.   MOLECULAR BIOLOGY OF THE CELL

Regulation of Autophagy by Reactive Oxygen Species (ROS): Implications for Cancer Progression and Treatment

(2008) Meghan B. Azad et al.   ANTIOXIDANTS & REDOX SIGNALING

Survival of Cancer Cells Is Maintained by EGFR Independent of Its Kinase Activity

(2008) Zhang Weihua et al.   CANCER CELL

The epidermal growth factor receptor family: Biology driving targeted therapeutics

(2008) M. J. Wieduwilt et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP

(2008) C.-H. Yun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA