Article
Oncology
Yoanna I. Flores Vega, Diana L. Paramo Gonzalez, Sofia C. Alsina Sarmiento, Luis E. Alsina Tul, Iris B. Inguanzo Valdes, Jorge Rodriguez Machado, angel Elejalde Larrinaga, Justo E. Flores Rodriguez, Janet Lamadrid Garcia, Danay Corrales Otero, Ramon Ropero Toirac, Tania Crombet Ramos, Elias A. Gracia Medina
Summary: In Cuba, lung cancer is the leading cause of mortality in both sexes. The majority of non-small cell lung cancer (NSCLC) cases overexpress EGFR and its ligands. CIMAvax-EGF, a therapeutic vaccine, aims to induce antibodies against self-EGF to block the EGF-EGFR interaction. This study evaluated the efficacy and safety of CIMAvax-EGF as maintenance treatment in NSCLC patients.
Article
Oncology
Gisela Maria Suarez, Mauricio Catala, Yadira Pena, Susana Portela, Ana Laura Ane-Kouri, Amnely Gonzalez, Patricia Lorenzo-Luaces, Manuel Diaz, Maria de los A. Molina, Karla Pereira, Jenysbel de la C. Hernandez, Raul Ramos, Mary Carmen Reyes, Nuris Ledon, Zaima Mazorra, Tania Crombet, Agustin Lage, Danay Saavedra
Summary: The administration of BT after chemotherapy in lung cancer patients can improve peripheral lymphocyte subpopulations and enhance the clinical efficacy of immunotherapy.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Tania Crombet Ramos, Orestes Santos Morales, Grace K. Dy, Kalet Leon Monzon, Agustin Lage Davila
Summary: CIMAvax-EGF is a novel approach for treating NSCLC by neutralizing EGF and inhibiting tumor growth, showing potential efficacy. Clinical trials have demonstrated that CIMAvax-EGF can prolong overall survival in advanced NSCLC patients, especially those with higher EGF concentrations.
FRONTIERS IN ONCOLOGY
(2021)
Review
Immunology
Fenge Li, Huancheng Wu, Xueming Du, Yimo Sun, Barbara Nassif Rausseo, Amjad Talukder, Arjun Katailiha, Lama Elzohary, Yupeng Wang, Zhiyu Wang, Gregory Lizee
Summary: The EGFR gene is frequently overexpressed and mutated in various solid tumors, and peptide vaccines targeting mutated EGFR have shown promising clinical efficacy and safety profiles.
Article
Developmental Biology
Shuyu Liu, Dawei Sun, Richard Butler, Emma L. Rawlins
Summary: This study expands multipotent epithelial progenitor cells from human embryonic lungs as organoids and maintains their self-renewing state. The cells exhibit columnar shape, resembling the developing lung tip epithelium. The study identifies the signaling pathways, including FGF7 and integrin signaling, that regulate cell shape and development in human lung progenitors.
Article
Oncology
Rachel Evans, Kelvin Lee, Paul K. Wallace, Mary Reid, Jason Muhitch, Askia Dozier, Circe Mesa, Patricia L. Luaces, Orestes Santos-Morales, Adrienne Groman, Carlos Cedeno, Aileen Cinquino, Daniel T. Fisher, Igor Puzanov, Mateusz Opyrchal, Christos Fountzilas, Tong Dai, Marc Ernstoff, Kristopher Attwood, Alan Hutson, Candace Johnson, Zaima Mazorra, Danay Saavedra, Kalet Leon, Agustin Lage, Tania Crombet, Grace K. Dy
Summary: This study aimed to determine the safety and recommended dose of CIMAvax-EGF in combination with nivolumab for second-line therapy in NSCLC. The combination was found to be safe and tolerable, with a recommended dose of 2.4mg of CIMAvax-EGF. The combination therapy resulted in a greater humoral response to CIMAvax-EGF and objective responses in some patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Ryota Nakamura, Tadaaki Yamada, Kenji Morimoto, Akira Nakao, Yasuhiro Goto, Yuri Ogura, Takayuki Takeda, Chieko Takumi, Keisuke Onoi, Yusuke Chihara, Ryusuke Taniguchi, Takahiro Yamada, Osamu Hiranuma, Satomi Tanaka, Yoshie Morimoto, Masahiro Iwasaku, Shinsaku Tokuda, Yoshiko Kaneko, Junji Uchino, Koichi Takayama
Summary: This study found that response to prior immunochemotherapy was associated with clinical outcomes among patients with advanced NSCLC who received maintenance therapy.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Review
Medicine, General & Internal
Janette Greenhalgh, Angela Boland, Victoria Bates, Fabio Vecchio, Yenal Dundar, Marty Chaplin, John A. Green
Summary: EGFR mutation positive non-small cell lung cancer is more common in women and occurs at a younger age. Treatment with single-agent or combination EGFR therapies shows advantages in improving tumor response rate and prolonging progression-free survival compared to other cytotoxic chemotherapy agents.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Article
Oncology
An-Wen Xiong, Jue-Min Fang, Sheng-Xiang Ren, Wei Li, Jing Wang, Yu Zhao, Guo-You Chen, Qing Xu, Cai-Cun Zhou
Summary: The recombinant EGF-CRM197 therapeutic cancer vaccine is safe, well-tolerated, and can induce a robust neutralizing antibody response in patients with advanced solid tumors, leading to extended progression-free survival.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Kamya Sankar, Alex K. Bryant, Garth W. Strohbehn, Lili Zhao, David Elliott, Drew Moghanaki, Michael J. Kelley, Nithya Ramnath, Michael D. Green
Summary: The addition of durvalumab improves progression-free and overall survival in patients with stage III non-small cell lung cancer, but overall survival is lower in veterans compared to the reference clinical trial population.
Article
Immunology
Gang Li, Sheng Gong, Ning Wang, Xiaojun Yao
Summary: This report discusses a case of a patient with advanced non-small cell lung cancer (NSCLC) and comorbid pulmonary tuberculosis who developed toxic epidermal necrolysis (TEN) after receiving immunotherapy and chemotherapy. The importance of monitoring rare but severe cutaneous toxicities in patients treated with Sintilimab is emphasized.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Xiangwei Xu, Ruya Li, Peizhen Zhu, Penghai Zhang, Jun Chen, Yongsheng Lin, Yinqiao Chen
Summary: This study found that maintenance therapy (MT) is beneficial and tolerable for patients with advanced NSCLC, especially for patients with adenocarcinoma and without distant metastasis. The use of targeted drugs in maintenance therapy significantly prolonged progression-free survival (PFS), and female sex and MT were identified as independent prognostic factors for extended overall survival (OS).
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Wen-Qian Li, Ling-Yu Li, Jin Chai, Jiu-Wei Cui
Summary: Recent cost-effectiveness analysis showed that first-generation EGFR-TKI therapy remains the most cost-effective treatment option for advanced EGFR-mutant NSCLC patients, with potential implications for clinical practice and medical insurance reimbursement policies.
Article
Medicine, General & Internal
Mariano Provencio, Ernest Nadal, Jose L. Gonzalez-Larriba, Alex Martinez-Marti, Reyes Bernabe, Joaquim Bosch-Barrera, Joaquin Casal-Rubio, Virginia Calvo, Amelia Insa, Santiago Ponce, Noemi Reguart, Javier de Castro, Joaquin Mosquera, Manuel Cobo, Andres Aguilar, Guillermo Lopez Vivanco, Carlos Camps, Rafael Lopez-Castro, Teresa Moran, Isidoro Barneto, Delvys Rodriguez-Abreu, Roberto Serna-Blasco, Raquel Benitez, Carlos Aguado de la Rosa, Ramon Palmero, Florentino Hernando-Trancho, Javier Martin-Lopez, Alberto Cruz-Bermudez, Bartomeu Massuti, Atocha Romero
Summary: This study evaluated the efficacy of the neoadjuvant nivolumab plus chemotherapy regimen on operable stage III non-small-cell lung cancer (NSCLC) patients. The results showed that patients receiving the combination therapy had a higher rate of pathological complete response and longer survival, indicating the effectiveness of this treatment approach in this patient population.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Biology
Xiaolong Tang, Lizhi Cheng, Guo Li, Yong-Ming Yan, Fengting Su, Dan-Ling Huang, Shuping Zhang, Zuojun Liu, Minxian Qian, Ji Li, Yong-Xian Cheng, Baohua Liu
Summary: The small molecule compound D6 demonstrates promising efficacy in treating EGFR-TKI resistant NSCLC by targeting the protein-protein interaction between HSP90 and T790M-EGFR, offering a potential alternative strategy to overcome drug resistance.
COMMUNICATIONS BIOLOGY
(2021)
Review
Oncology
Danay Saavedra, Elia Neninger, Camilo Rodriguez, Carmen Viada, Zaima Mazorra, Agustin Lage, Tania Crombet
SEMINARS IN ONCOLOGY
(2018)
Article
Geriatrics & Gerontology
Danay Saavedra, Silvia A. Fuertes, Gisela M. Suarez, Amnely Gonzalez, Patricia Lorenzo-Luaces, Beatriz Garcia, Elisa Aznar, Zaima Mazorra, Tania Crombet, Daniel E. Speiser, Agustin Lage
EXPERIMENTAL GERONTOLOGY
(2019)
Review
Oncology
Tania Crombet Ramos, Braulio Mestre Fernandez, Zaima Mazorra Herrera, Normando E. Iznaga Escobar
FRONTIERS IN ONCOLOGY
(2020)
Review
Oncology
Maria Caridad Rubio, Lizet Sanchez, Gisela Abreu-Ruiz, Walkiria Bermejo-Bencomo, Tania Crombet, Agustin Lage
SEMINARS IN ONCOLOGY
(2020)
Article
Oncology
Patricia Lorenzo-Luaces, Lizet Sanchez, Danay Saavedra, Tania Crombet, Wim Van der Elst, Ariel Alonso, Geert Molenberghs, Agustin Lage
Article
Oncology
Gisela Maria Suarez, Ana Laura Ane-Kouri, Amnely Gonzalez, Patricia Lorenzo-Luaces, Elia Neninger, Eva Elena Salomon, Leamnet Cordero, Mauricio Catala, Nuris Ledon, Karla Pereira, Malkon Guillermo Sanchez, Beatriz Garcia, Tania Crombet, Zaima Mazorra, Danay Saavedra, Agustin Lage
Summary: This study explores the associations among lymphocyte subpopulations, pro-inflammatory cytokines, and epidermal growth factor (EGF) in patients diagnosed with non-small cell lung cancer (NSCLC). The research found decreased naive immune cells and increased effector memory cells in NSCLC patients after chemotherapy, as well as significant correlations between pro-inflammatory cytokines IL-1 beta and TNF alpha. Additionally, associations between EGF serum levels and terminally differentiated CD4(+) T cells, and memory B cells were detected for the first time, highlighting the interconnection between terminally differentiated lymphocytes and pro-inflammatory cytokines.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Letter
Hematology
Armando Caballero Lopez, Carlos Herrera Cartaya, Elibet Chavez Gonzalez, Delvis Gonzalez Reinoso, Jorge Alain Caballero Font, Naivi Sanchez Vera, Mario E. Napoles Lizano, Alexander Vazquez Roque, Alexis Morales Valdera, Tania Crombet Ramos, Julio Betancourt Cervantes
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2021)
Article
Immunology
Lazaro Manuel Filgueira, Julio Betancourt Cervantes, Orlando Adolfo Lovelle, Carlos Herrera, Carlos Figueredo, Jorge Alain Caballero, Naivy Sanchez, Jorge Berrio, Geidy Lorenzo, Meylan Cepeda, Mayra Ramos, Danay Saavedra, Ana Laura Ane-Kouri, Zaima Mazorra, Kalet Leon, Tania Crombet, Armando Caballero
Summary: In COVID-19 patients, inflammation is associated with disease progression. Itolizumab, a monoclonal antibody, has shown to reduce inflammation and immune system activation, with promising results in three severe COVID-19 cases. This anti-inflammatory therapy may help reduce morbidity and mortality associated with COVID-19.
Article
Oncology
Xitlally Popa, Beatriz Garcia, Karla P. Fuentes, Vivian Huerta, Karen Alvarez, Carmen E. Viada, Elia Neninger, Pedro C. Rodriguez, Zuyen Gonzalez, Amnely Gonzalez, Tania Crombet, Zaima Mazorra
Article
Immunology
Armando Caballero, Lazaro M. Filgueira, Julio Betancourt, Naivy Sanchez, Carlos Hidalgo, Alberto Ramirez, Alejandro Martinez, Rolando E. Despaigne, Alberto Escalona, Henrry Diaz, Elio Merino, Lilia M. Ortega, Ulises Castillo, Mayra Ramos, Danay Saavedra, Yanelda Garcia, Geydi Lorenzo, Meylan Cepeda, Maylen Arencibia, Leticia Cabrera, Milagros Domecq, Daymys Estevez, Carmen Valenzuela, Patricia Lorenzo, Lizet Sanchez, Zaima Mazorra, Kalet Leon, Tania Crombet
CLINICAL & TRANSLATIONAL IMMUNOLOGY
(2020)
Article
Geriatrics & Gerontology
Yayquier Diaz, Mayra Ramos-Suzarte, Yordanis Martin, Nestor Antonio Calderon, William Santiago, Orlando Vinet, La O. Yulieski, Jorge Perez Augusto Oyarzabal, Yoan Perez, Geidy Lorenzo, Meylan Cepeda, Danay Saavedra, Zaima Mazorra, Daymys Estevez, Patricia Lorenzo-Luaces, Carmen Valenzuela, Armando Caballero, Kalet Leon, Tania Crombet, Carlos Jorge Hidalgo
Article
Health Care Sciences & Services
Carmen Viada, Carlos Bouza, Martha Fors, Aliuska Frias, Mabel Alvarez, Lazara Garcia, Barbara Wilkinson, Camilo Rodriguez, Tania Crombet, Javier Ballesteros
QUALITY OF LIFE RESEARCH
(2020)
Article
Geriatrics & Gerontology
Danay Saavedra, Ana Laura Ane-Kouri, Naivy Sanchez, Lazaro Manuel Filgueira, Julio Betancourt, Carlos Herrera, Leniel Manso, Elibet Chavez, Armando Caballero, Carlos Hidalgo, Geydi Lorenzo, Meylan Cepeda, Carmen Valenzuela, Mayra Ramos, Kalet Leon, Zaima Mazorra, Tania Crombet