Apoptosis in cancer: from pathogenesis to treatment

Hyperproliferation, cancer, and inflammation in mice expressing a  133p53-like isoform

(2011) T. L. Slatter et al.   BLOOD

P53 in human melanoma fails to regulate target genes associated with apoptosis and the cell cycle and may contribute to proliferation

(2011) Kelly A Avery-Kiejda et al.   BMC CANCER

Multiple BH3 Mimetics Antagonize Antiapoptotic MCL1 Protein by Inducing the Endoplasmic Reticulum Stress Response and Up-regulating BH3-only Protein NOXA

(2011) Tina C. Albershardt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Therapeutic Potential and Molecular Mechanism of a Novel, Potent, Nonpeptide, Smac Mimetic SM-164 in Combination with TRAIL for Cancer Treatment

(2011) J. Lu et al.   MOLECULAR CANCER THERAPEUTICS

Cyclopeptide Smac mimetics as antagonists of IAP proteins

(2010) Haiying Sun et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Adenovirus-mediated transfer of siRNA against survivin enhances the radiosensitivity of human non-small cell lung cancer cells

(2009) C-T Yang et al.   CANCER GENE THERAPY

Bcl-2 Inhibitors: Targeting Mitochondrial Apoptotic Pathways in Cancer Therapy

(2009) M. H. Kang et al.   CLINICAL CANCER RESEARCH

Downregulation of caspase-9 is a frequent event in patients with stage II colorectal cancer and correlates with poor clinical outcome

(2009) X.-G. Shen et al.   Colorectal Disease

Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer

(2009) J. P. Morton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibitor of apoptosis proteins and apoptosis

(2008) Yunbo Wei et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Discovery, In Vivo Activity, and Mechanism of Action of a Small-Molecule p53 Activator

(2008) Sonia Lain et al.   CANCER CELL

IAP-targeted therapies for cancer

(2008) E C LaCasse et al.   ONCOGENE

Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition

(2008) S. Shangary et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeted rescue of a destabilized mutant of p53 by an in silico screened drug

(2008) F. M. Boeckler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA