Targeting α-synuclein as a therapeutic strategy for Parkinson’s disease
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Title
Targeting α-synuclein as a therapeutic strategy for Parkinson’s disease
Authors
Keywords
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Journal
EXPERT OPINION ON THERAPEUTIC TARGETS
Volume 19, Issue 10, Pages 1351-1360
Publisher
Informa Healthcare
Online
2015-07-02
DOI
10.1517/14728222.2015.1062877
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Note: Only part of the references are listed.- Direct visualization of alpha-synuclein oligomers reveals previously undetected pathology in Parkinson’s disease brain
- (2015) Rosalind F. Roberts et al. BRAIN
- Inflammatory and Cell Death Pathways in Brain and Peripheral Blood in Parkinson’s Disease
- (2015) Beatrice Macchi et al. CNS & Neurological Disorders-Drug Targets
- The Prion Hypothesis of Parkinson’s Disease
- (2015) Yaping Chu et al. Current Neurology and Neuroscience Reports
- Behavioural deficits in transgenic mice expressing human truncated (1–120 amino acid) alpha-synuclein
- (2015) Katie Hall et al. EXPERIMENTAL NEUROLOGY
- Could astrocytes be the primary target of an offending agent causing the primary degenerative diseases of the human central nervous system? A hypothesis
- (2015) Roberto E. Sica MEDICAL HYPOTHESES
- FK506 reduces neuroinflammation and dopaminergic neurodegeneration in an α-synuclein-based rat model for Parkinson's disease
- (2015) Anke Van der Perren et al. NEUROBIOLOGY OF AGING
- Ginsenoside Rb1 inhibits fibrillation and toxicity of alpha-synuclein and disaggregates preformed fibrils
- (2015) Mustafa T. Ardah et al. NEUROBIOLOGY OF DISEASE
- Pathogenic Mechanisms of Neurodegeneration in Parkinson Disease
- (2015) Stephen Mullin et al. NEUROLOGIC CLINICS
- Colonic mucosal -synuclein lacks specificity as a biomarker for Parkinson disease
- (2015) N. P. Visanji et al. NEUROLOGY
- Efficient Modification of Alpha-Synuclein Serine 129 by Protein Kinase CK1 Requires Phosphorylation of Tyrosine 125 as a Priming Event
- (2014) Jonas Kosten et al. ACS Chemical Neuroscience
- Amyloidogenic α-synuclein seeds do not invariably induce rapid, widespread pathology in mice
- (2014) Amanda N. Sacino et al. ACTA NEUROPATHOLOGICA
- Next-generation active immunization approach for synucleinopathies: implications for Parkinson’s disease clinical trials
- (2014) Markus Mandler et al. ACTA NEUROPATHOLOGICA
- Exenatide as a potential treatment for patients with Parkinson's disease: First steps into the clinic
- (2014) Thomas Foltynie et al. Alzheimers & Dementia
- The Ubiquitin-Proteasome System in Neurodegeneration
- (2014) Chris McKinnon et al. ANTIOXIDANTS & REDOX SIGNALING
- Targeting alpha-synuclein with a microRNA-embedded silencing vector in the rat substantia nigra: Positive and negative effects
- (2014) Christina E. Khodr et al. BRAIN RESEARCH
- BAG1 is Neuroprotective in In Vivo and In Vitro Models of Parkinson’s Disease
- (2014) Pawel Kermer et al. JOURNAL OF MOLECULAR NEUROSCIENCE
- Reducing C-Terminal-Truncated Alpha-Synuclein by Immunotherapy Attenuates Neurodegeneration and Propagation in Parkinson's Disease-Like Models
- (2014) D. Games et al. JOURNAL OF NEUROSCIENCE
- Presynaptic Alpha-Synuclein Aggregation in a Mouse Model of Parkinson's Disease
- (2014) K. J. Spinelli et al. JOURNAL OF NEUROSCIENCE
- Immunotherapy targeting α-synuclein protofibrils reduced pathology in (Thy-1)-h[A30P] α-synuclein mice
- (2014) Veronica Lindström et al. NEUROBIOLOGY OF DISEASE
- Intracellular processing of disease-associated α-synuclein in the human brain suggests prion-like cell-to-cell spread
- (2014) Gabor G. Kovacs et al. NEUROBIOLOGY OF DISEASE
- CSF biomarkers and clinical progression of Parkinson disease
- (2014) S. Hall et al. NEUROLOGY
- The influence of AAV2-mediated gene transfer of human IL-10 on neurodegeneration and immune response in a murine model of Parkinson's disease
- (2014) Ilona Joniec-Maciejak et al. Pharmacological Reports
- Targeting the Intrinsically Disordered Structural Ensemble of α-Synuclein by Small Molecules as a Potential Therapeutic Strategy for Parkinson’s Disease
- (2014) Gergely Tóth et al. PLoS One
- A Generic Method for Design of Oligomer-Specific Antibodies
- (2014) Kristoffer Brännström et al. PLoS One
- Abrogation of -synuclein-mediated dopaminergic neurodegeneration in LRRK2-deficient rats
- (2014) J. P. L. Daher et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Metformin lowers Ser-129 phosphorylated α-synuclein levels via mTOR-dependent protein phosphatase 2A activation
- (2014) B I Pérez-Revuelta et al. Cell Death & Disease
- Biomarkers in biological fluids for dementia with Lewy bodies
- (2014) Sebastian Schade et al. Alzheimers Research & Therapy
- Evaluating the relationship between amyloid-β and α-synuclein phosphorylated at Ser129 in dementia with Lewy bodies and Parkinson’s disease
- (2014) Marta Swirski et al. Alzheimers Research & Therapy
- α-Synuclein Immunotherapy Blocks Uptake and Templated Propagation of Misfolded α-Synuclein and Neurodegeneration
- (2014) Hien T. Tran et al. Cell Reports
- Vaccination strategies for Parkinson disease
- (2014) Marina Romero-Ramos et al. Human Vaccines & Immunotherapeutics
- Parkinson’s disease-implicated kinases in the brain; insights into disease pathogenesis
- (2014) Nicolas Dzamko et al. Frontiers in Molecular Neuroscience
- Alpha-synuclein spreading in M83 mice brain revealed by detection of pathological α-synuclein by enhanced ELISA
- (2014) Dominique Bétemps et al. Acta Neuropathologica Communications
- Lewy body extracts from Parkinson disease brains trigger α-synuclein pathology and neurodegeneration in mice and monkeys
- (2013) Ariadna Recasens et al. ANNALS OF NEUROLOGY
- Neuroimmunological Processes in Parkinson's Disease and their Relation to α-Synuclein: Microglia as the Referee between Neuronal Processes and Peripheral Immunity
- (2013) Vanesa Sanchez-Guajardo et al. ASN Neuro
- The Role of -Synuclein in Neurodegenerative Diseases: >From Molecular Pathways in Disease to Therapeutic Approaches
- (2013) Karima Al-Mansoori et al. Current Alzheimer Research
- Tackling neurodegenerative diseases: animal models of Alzheimer’s disease and Parkinson’s disease
- (2013) Ahmed A. Raslan et al. Genes & Genomics
- Exenatide and the treatment of patients with Parkinson’s disease
- (2013) Iciar Aviles-Olmos et al. JOURNAL OF CLINICAL INVESTIGATION
- Neural and Immune Mechanisms in the Pathogenesis of Parkinson’s Disease
- (2013) Fabio Blandini Journal of Neuroimmune Pharmacology
- Cerebrospinal fluid biomarkers in Parkinson disease
- (2013) Lucilla Parnetti et al. Nature Reviews Neurology
- Leucine-rich repeat kinase 2 modulates cyclooxygenase 2 and the inflammatory response in idiopathic and genetic Parkinson's disease
- (2013) Rakel Lopez de Maturana et al. NEUROBIOLOGY OF AGING
- -Synuclein in cutaneous autonomic nerves
- (2013) N. Wang et al. NEUROLOGY
- Intrabodies as Neuroprotective Therapeutics
- (2013) Anne Messer et al. Neurotherapeutics
- Immunotherapy for neurodegenerative diseases: Focus on α-synucleinopathies
- (2013) Elvira Valera et al. PHARMACOLOGY & THERAPEUTICS
- Triggering of Inflammasome by Aggregated α–Synuclein, an Inflammatory Response in Synucleinopathies
- (2013) Gaia Codolo et al. PLoS One
- Human α4β2 Nicotinic Acetylcholine Receptor as a Novel Target of Oligomeric α-Synuclein
- (2013) Qiang Liu et al. PLoS One
- What’s to like about the prion-like hypothesis for the spreading of aggregated α-synuclein in Parkinson disease?
- (2013) Christopher J.R. Dunning et al. Prion
- Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia
- (2013) Changyoun Kim et al. Nature Communications
- S100B is increased in Parkinson’s disease and ablation protects against MPTP-induced toxicity through the RAGE and TNF-α pathway
- (2012) Kinnari Sathe et al. BRAIN
- The Role of Phosphorylation in Synucleinopathies: Focus on Parkinsons Disease
- (2012) Nadia Cavallarin et al. CNS & Neurological Disorders-Drug Targets
- Comparison of the behavioural and histological characteristics of the 6-OHDA and α-synuclein rat models of Parkinson's disease
- (2012) M. Decressac et al. EXPERIMENTAL NEUROLOGY
- Targeting intracellular and extracellular alpha-synuclein as a therapeutic strategy in Parkinson's disease and other synucleinopathies
- (2012) Kostas Vekrellis et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia
- (2012) Lisa Fellner et al. GLIA
- Antibody-Aided Clearance of Extracellular -Synuclein Prevents Cell-to-Cell Aggregate Transmission
- (2012) E.-J. Bae et al. JOURNAL OF NEUROSCIENCE
- The many faces of α-synuclein: from structure and toxicity to therapeutic target
- (2012) Hilal A. Lashuel et al. NATURE REVIEWS NEUROSCIENCE
- Lewy pathology is not the first sign of degeneration in vulnerable neurons in Parkinson disease
- (2012) J. M. Milber et al. NEUROLOGY
- Long-term polarization of microglia upon α-synuclein overexpression in nonhuman primates
- (2012) P. Barkholt et al. NEUROSCIENCE
- Rational design of potent domain antibody inhibitors of amyloid fibril assembly
- (2012) A. R. A. Ladiwala et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Emerging roles of microglial activation and non-motor symptoms in Parkinson's disease
- (2012) Karlijn J. Doorn et al. PROGRESS IN NEUROBIOLOGY
- α-Synuclein phosphorylation as a therapeutic target in Parkinson’s disease
- (2012) Steven P. Braithwaite et al. REVIEWS IN THE NEUROSCIENCES
- An alpha-synuclein AAV gene silencing vector ameliorates a behavioral deficit in a rat model of Parkinson's disease, but displays toxicity in dopamine neurons
- (2011) Christina E. Khodr et al. BRAIN RESEARCH
- α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation
- (2011) Tim Bartels et al. NATURE
- Alpha-synuclein release by neurons activates the inflammatory response in a microglial cell line
- (2011) Lydia Alvarez-Erviti et al. NEUROSCIENCE RESEARCH
- Physiology of Microglia
- (2011) Helmut Kettenmann et al. PHYSIOLOGICAL REVIEWS
- Passive Immunization Reduces Behavioral and Neuropathological Deficits in an Alpha-Synuclein Transgenic Model of Lewy Body Disease
- (2011) Eliezer Masliah et al. PLoS One
- Antibodies against Alpha-Synuclein Reduce Oligomerization in Living Cells
- (2011) Thomas Näsström et al. PLoS One
- Direct Transfer of α-Synuclein from Neuron to Astroglia Causes Inflammatory Responses in Synucleinopathies
- (2010) He-Jin Lee et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Inhibition of FK506 Binding Proteins Reduces -Synuclein Aggregation and Parkinson's Disease-Like Pathology
- (2010) M. Gerard et al. JOURNAL OF NEUROSCIENCE
- Delayed Dominant-Negative TNF Gene Therapy Halts Progressive Loss of Nigral Dopaminergic Neurons in a Rat Model of Parkinson's Disease
- (2010) Ashley S Harms et al. MOLECULAR THERAPY
- Caspase activation precedes and leads to tangles
- (2010) Alix de Calignon et al. NATURE
- Cell-to-cell transmission of non-prion protein aggregates
- (2010) Seung-Jae Lee et al. Nature Reviews Neurology
- Thymulin related peptide attenuates inflammation in the brain induced by intracerebroventricular endotoxin injection
- (2010) Bared Safieh-Garabedian et al. NEUROPHARMACOLOGY
- Molecular interaction of α-synuclein with tubulin influences on the polymerization of microtubule in vitro and structure of microtubule in cells
- (2009) R. M. Zhou et al. MOLECULAR BIOLOGY REPORTS
- Alterations in corticostriatal synaptic plasticity in mice overexpressing human α-synuclein
- (2009) J.B. Watson et al. NEUROSCIENCE
- Dissecting the potential molecular mechanisms underlying α-synuclein cell-to-cell transfer in Parkinson's disease
- (2009) Elodie Angot et al. PARKINSONISM & RELATED DISORDERS
- Inclusion formation and neuronal cell death through neuron-to-neuron transmission of -synuclein
- (2009) P. Desplats et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- α-Synuclein aggregation alters tyrosine hydroxylase phosphorylation and immunoreactivity: Lessons from viral transduction of knockout mice
- (2008) Tshianda N.M. Alerte et al. NEUROSCIENCE LETTERS
- Glial reactions in Parkinson's disease
- (2007) Patrick L. McGeer et al. MOVEMENT DISORDERS
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