Tackling neurodegenerative diseases: animal models of Alzheimer’s disease and Parkinson’s disease

Loss of Bace2 in zebrafish affects melanocyte migration and is distinct from Bace1 knock out phenotypes

(2013) Frauke van Bebber et al.   JOURNAL OF NEUROCHEMISTRY

Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease

(2013) Seung Woo Cho et al.   NATURE BIOTECHNOLOGY

RNA-Guided Human Genome Engineering via Cas9

(2013) P. Mali et al.   SCIENCE

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

Drosophila melanogaster in the Study of Human Neurodegeneration

(2012) Frank Hirth   CNS & Neurological Disorders-Drug Targets

Modeling Neurodegeneration in Zebrafish

(2011) Yanwei Xi et al.   Current Neurology and Neuroscience Reports

Zebrafish neurotransmitter systems as potential pharmacological and toxicological targets

(2011) E.P. Rico et al.   NEUROTOXICOLOGY AND TERATOLOGY

Swimming into the Future of Drug Discovery:In VivoChemical Screens in Zebrafish

(2010) Teresa V. Bowman et al.   ACS Chemical Biology

Novel Research Horizons for Presenilins and γ-Secretases in Cell Biology and Disease

(2010) Bart De Strooper et al.   Annual Review of Cell and Developmental Biology

Impaired dopaminergic neuron development and locomotor function in zebrafish with loss ofpink1function

(2010) Yanwei Xi et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Enhanced Striatal Dopamine Transmission and Motor Performance with LRRK2 Overexpression in Mice Is Eliminated by Familial Parkinson's Disease Mutation G2019S

(2010) X. Li et al.   JOURNAL OF NEUROSCIENCE

Genome editing with engineered zinc finger nucleases

(2010) Fyodor D. Urnov et al.   NATURE REVIEWS GENETICS

Parkin Is Protective against Proteotoxic Stress in a Transgenic Zebrafish Model

(2010) Mareike E. Fett et al.   PLoS One

Deletion of the WD40 Domain of LRRK2 in Zebrafish Causes Parkinsonism-Like Loss of Neurons and Locomotive Defect

(2010) Donglai Sheng et al.   PLoS Genetics

The genetics of Parkinson's syndromes: a critical review

(2009) John Hardy et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Amyloid precursor protein is required for convergent-extension movements during Zebrafish development

(2009) Powrnima Joshi et al.   DEVELOPMENTAL BIOLOGY

Independent and cooperative action of Psen2 with Psen1 in zebrafish embryos

(2009) Svanhild Nornes et al.   EXPERIMENTAL CELL RESEARCH

Aβ exacerbates the neuronal dysfunction caused by human tau expression in a Drosophila model of Alzheimer's disease

(2009) James Folwell et al.   EXPERIMENTAL NEUROLOGY

A zebrafish model of tauopathy allows in vivo imaging of neuronal cell death and drug evaluation

(2009) Dominik Paquet et al.   JOURNAL OF CLINICAL INVESTIGATION

Bacterial Artificial Chromosome Transgenic Mice Expressing a Truncated Mutant Parkin Exhibit Age-Dependent Hypokinetic Motor Deficits, Dopaminergic Neuron Degeneration, and Accumulation of Proteinase K-Resistant  -Synuclein

(2009) X.-H. Lu et al.   JOURNAL OF NEUROSCIENCE

LRRK2 Modulates Vulnerability to Mitochondrial Dysfunction in Caenorhabditis elegans

(2009) S. Saha et al.   JOURNAL OF NEUROSCIENCE

Evidence for a common pathway linking neurodegenerative diseases

(2009) Joshua M Shulman et al.   NATURE GENETICS

Mutant LRRK2 R1441G BAC transgenic mice recapitulate cardinal features of Parkinson's disease

(2009) Yanping Li et al.   NATURE NEUROSCIENCE

Parkinson Phenotype in Aged PINK1-Deficient Mice Is Accompanied by Progressive Mitochondrial Dysfunction in Absence of Neurodegeneration

(2009) Suzana Gispert et al.   PLoS One

The amyloid cascade hypothesis

(2008) Amos D. Korczyn   Alzheimers & Dementia

The invertebrate microtubule-associated protein PTL-1 functions in mechanosensation and development in Caenorhabditis elegans

(2008) Patricia Gordon et al.   DEVELOPMENT GENES AND EVOLUTION

Olfactory deficits in mice overexpressing human wildtype -synuclein

(2008) Sheila M. Fleming et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Amyloid precursor protein-induced axonopathies are independent of amyloid-β peptides

(2008) Gorazd B. Stokin et al.   HUMAN MOLECULAR GENETICS

Neurotoxic effects induced by the Drosophila amyloid-β peptide suggest a conserved toxic function

(2008) Katia Carmine-Simmen et al.   NEUROBIOLOGY OF DISEASE

Impairments in remote memory stabilization precede hippocampal synaptic and cognitive failures in 5XFAD Alzheimer mouse model

(2008) Ryoichi Kimura et al.   NEUROBIOLOGY OF DISEASE

Invited Article: Nervous system pathology in sporadic Parkinson disease

(2008) H. Braak et al.   NEUROLOGY

Aβ42 Mutants with Different Aggregation Profiles Induce Distinct Pathologies in Drosophila

(2008) Koichi Iijima et al.   PLoS One

Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress

(2008) C. A. Gautier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microtubule-associated protein tau in development, degeneration and protection of neurons

(2008) Jian-Zhi Wang et al.   PROGRESS IN NEUROBIOLOGY

A Caenorhabditis elegans model of tau hyperphosphorylation: Induction of developmental defects by transgenic overexpression of Alzheimer's disease-like modified tau

(2007) Roland Brandt et al.   NEUROBIOLOGY OF AGING