Thinking small: towards microRNA-based therapeutics for anxiety disorders

Long-term safety and efficacy of microRNA-targeted therapy in chronic hepatitis C patients

(2014) Meike H. van der Ree et al.   ANTIVIRAL RESEARCH

Mechanisms to medicines: elucidating neural and molecular substrates of fear extinction to identify novel treatments for anxiety disorders

(2014) Olena Bukalo et al.   BRITISH JOURNAL OF PHARMACOLOGY

Environmental enrichment modulates glucocorticoid receptor expression and reduces anxiety in Indian field male mouse Mus booduga through up-regulation of microRNA-124a

(2014) Ragu Varman Durairaj et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Serum microRNA expression signatures identified from genome-wide microRNA profiling serve as novel noninvasive biomarkers for diagnosis and recurrence of bladder cancer

(2014) Xiumei Jiang et al.   INTERNATIONAL JOURNAL OF CANCER

Serum and amygdala microRNA signatures of posttraumatic stress: Fear correlation and biomarker potential

(2014) Nagaraja S. Balakathiresan et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Anxiety Disorders in Primary Care

(2014) Heidi Combs et al.   MEDICAL CLINICS OF NORTH AMERICA

Global CNS Transduction of Adult Mice by Intravenously Delivered rAAVrh.8 and rAAVrh.10 and Nonhuman Primates by rAAVrh.10

(2014) Bin Yang et al.   MOLECULAR THERAPY

miR-1202 is a primate-specific and brain-enriched microRNA involved in major depression and antidepressant treatment

(2014) Juan Pablo Lopez et al.   NATURE MEDICINE

Evaluation of quantitative miRNA expression platforms in the microRNA quality control (miRQC) study

(2014) Pieter Mestdagh et al.   NATURE METHODS

Amygdala-Dependent Fear Memory Consolidation via miR-34a and Notch Signaling

(2014) Brian George Dias et al.   NEURON

MicroRNA 135 Is Essential for Chronic Stress Resiliency, Antidepressant Efficacy, and Intact Serotonergic Activity

(2014) Orna Issler et al.   NEURON

Basal microRNA expression patterns in reward circuitry of selectively bred high-responder and low-responder rats vary by brain region and genotype

(2014) David E. Hamilton et al.   PHYSIOLOGICAL GENOMICS

Neurobehavioral, neuropathological and biochemical profiles in a novel mouse model of co-morbid post-traumatic stress disorder and mild traumatic brain injury

(2014) Joseph O. Ojo et al.   Frontiers in Behavioral Neuroscience

miRNA Expression Profiles in Cerebrospinal Fluid and Blood of Patients with Acute Ischemic Stroke

(2014) Sofie Sølvsten Sørensen et al.   Translational Stroke Research

When less is more - microRNAs and psychiatric disorders

(2013) E. Kolshus et al.   ACTA PSYCHIATRICA SCANDINAVICA

Circulating MicroRNAs: A Novel Class of Potential Biomarkers for Diagnosing and Prognosing Central Nervous System Diseases

(2013) Xue-Feng Jin et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Anxiolytic drug discovery: what are the novel approaches and how can we improve them?

(2013) Adam Michael Stewart et al.   Expert Opinion on Drug Discovery

microRNAs as novel antidepressant targets: converging effects of ketamine and electroconvulsive shock therapy in the rat hippocampus

(2013) Richard M. O'Connor et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Progress in microRNA delivery

(2013) Yu Zhang et al.   JOURNAL OF CONTROLLED RELEASE

MicroRNA-182 Regulates Amygdala-Dependent Memory Formation

(2013) E. M. Griggs et al.   JOURNAL OF NEUROSCIENCE

50 years of hurdles and hope in anxiolytic drug discovery

(2013) Guy Griebel et al.   NATURE REVIEWS DRUG DISCOVERY

MicroRNAs and other non-coding RNAs as targets for anticancer drug development

(2013) Hui Ling et al.   NATURE REVIEWS DRUG DISCOVERY

Treatment of HCV Infection by Targeting MicroRNA

(2013) Harry L.A. Janssen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Acute Stress Alters Amygdala microRNA miR-135a and miR-124 Expression: Inferences for Corticosteroid Dependent Stress Response

(2013) Cecilia Mannironi et al.   PLoS One

Chronic Academic Stress Increases a Group of microRNAs in Peripheral Blood

(2013) Manami Honda et al.   PLoS One

Translational Approaches to Anxiety: Focus on Genetics, Fear Extinction and Brain Imaging

(2013) Angelika Erhardt et al.   Current Psychiatry Reports

The origin, function, and diagnostic potential of extracellular microRNAs in human body fluids

(2013) Hongwei Liang et al.   Wiley Interdisciplinary Reviews-RNA

Systemic Delivery of Tyrosine-Mutant AAV Vectors Results in Robust Transduction of Neurons in Adult Mice

(2013) Asako Iida et al.   Biomed Research International

MicroRNAs as biomarkers for CNS disease

(2013) Pooja Rao et al.   Frontiers in Molecular Neuroscience

Therapeutic Delivery of MicroRNA-29b by Cationic Lipoplexes for Lung Cancer

(2013) Yun Wu et al.   Molecular Therapy-Nucleic Acids

Therapeutic Action of Fluoxetine is Associated with a Reduction in Prefrontal Cortical miR-1971 Expression Levels in a Mouse Model of Posttraumatic Stress Disorder

(2013) Ulrike Schmidt et al.   Frontiers in Psychiatry

MicroRNA-target interactions: new insights from genome-wide approaches

(2012) Dooyoung Lee et al.   Annals of the New York Academy of Sciences

Genetic variation in hippocampal microRNA expression differences in C57BL/6 J X DBA/2 J (BXD) recombinant inbred mouse strains

(2012) Michael J Parsons et al.   BMC GENOMICS

Hippocampal microRNA-132 mediates stress-inducible cognitive deficits through its acetylcholinesterase target

(2012) G. Shaltiel et al.   Brain Structure & Function

Clinical Applications for microRNAs in Cancer

(2012) S P Nana-Sinkam et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Blood microRNA changes in depressed patients during antidepressant treatment

(2012) Luisella Bocchio-Chiavetto et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Lost in translation. New unexplored avenues for neuropsychopharmacology: epigenetics and microRNAs

(2012) Daniela Tardito et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Identification of seven serum microRNAs from a genome-wide serum microRNA expression profile as potential noninvasive biomarkers for malignant astrocytomas

(2012) Cuihua Yang et al.   INTERNATIONAL JOURNAL OF CANCER

Micro-Managing the Circadian Clock: The Role of microRNAs in Biological Timekeeping

(2012) Neel Mehta et al.   JOURNAL OF MOLECULAR BIOLOGY

Environmental enrichment upregulates micro-RNA-183 and alters acetylcholinesterase splice variants to reduce anxiety-like behavior in the little Indian field mouse (Mus booduga)

(2012) Durairaj Ragu Varman et al.   JOURNAL OF NEUROSCIENCE RESEARCH

microRNAs in cancer management

(2012) Yi W Kong et al.   LANCET ONCOLOGY

Lifetime experiences, the brain and personalized medicine: An integrative perspective

(2012) Bruce S. McEwen et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Allele-specific FKBP5 DNA demethylation mediates gene–childhood trauma interactions

(2012) Torsten Klengel et al.   NATURE NEUROSCIENCE

MicroRNA profiling: approaches and considerations

(2012) Colin C. Pritchard et al.   NATURE REVIEWS GENETICS

Regulated microRNAs in the CSF of patients with multiple sclerosis: A case-control study

(2012) A. Haghikia et al.   NEUROLOGY

MicroRNAs miR-144/144* and miR-16 in peripheral blood are potential biomarkers for naturalistic stress in healthy Japanese medical students

(2012) Sakurako Katsuura et al.   NEUROSCIENCE LETTERS

Secreted microRNAs: a new form of intercellular communication

(2012) Xi Chen et al.   TRENDS IN CELL BIOLOGY

MiR-122 in hepatic function and liver diseases

(2012) Jun Hu et al.   Protein & Cell

The Path to microRNA Therapeutics in Psychiatric and Neurodegenerative Disorders

(2012) Anthony W. S. Chan et al.   Frontiers in Genetics

High resolution of microRNA signatures in human whole saliva

(2011) Rushi S. Patel et al.   ARCHIVES OF ORAL BIOLOGY

The age of anxiety: role of animal models of anxiolytic action in drug discovery

(2011) John F Cryan et al.   BRITISH JOURNAL OF PHARMACOLOGY

Blood Cell Origin of Circulating MicroRNAs: A Cautionary Note for Cancer Biomarker Studies

(2011) C. C. Pritchard et al.   Cancer Prevention Research

microRNA-34c is a novel target to treat dementias

(2011) Athanasios Zovoilis et al.   EMBO JOURNAL

MicroRNA therapeutics

(2011) J A Broderick et al.   GENE THERAPY

MicroRNA expression in rat brain exposed to repeated inescapable shock: differential alterations in learned helplessness vs. non-learned helplessness

(2011) Neil R. Smalheiser et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

microRNA as Repressors of Stress-Induced Anxiety: The Case of Amygdalar miR-34

(2011) S. Haramati et al.   JOURNAL OF NEUROSCIENCE

Role of microRNAs in central nervous system development and pathology

(2011) Karla F. Meza-Sosa et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Little things on which happiness depends: microRNAs as novel therapeutic targets for the treatment of anxiety and depression

(2011) R M O'Connor et al.   MOLECULAR PSYCHIATRY

Extracellular microRNA: A new source of biomarkers

(2011) Alton Etheridge et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

MicroRNA history: Discovery, recent applications, and next frontiers

(2011) Maria I. Almeida et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

The brain-specific microRNA miR-128b regulates the formation of fear-extinction memory

(2011) Quan Lin et al.   NATURE NEUROSCIENCE

Non-coding RNAs in human disease

(2011) Manel Esteller   NATURE REVIEWS GENETICS

The GABA system in anxiety and depression and its therapeutic potential

(2011) Hanns Möhler   NEUROPHARMACOLOGY

The involvement of FK506-binding protein 51 (FKBP5) in the behavioral and neuroendocrine effects of chronic social defeat stress

(2011) Jakob Hartmann et al.   NEUROPHARMACOLOGY

Increased sensitivity to the effects of chronic social defeat stress in an innately anxious mouse strain

(2011) H.M. Savignac et al.   NEUROSCIENCE

MicroRNAs: Meta-controllers of gene expression in synaptic activity emerge as genetic and diagnostic markers of human disease

(2011) Stephanie Ceman et al.   PHARMACOLOGY & THERAPEUTICS

Behavioural consequences of two chronic psychosocial stress paradigms: Anxiety without depression

(2011) David A. Slattery et al.   PSYCHONEUROENDOCRINOLOGY

Chronic non-invasive corticosterone administration abolishes the diurnal pattern of tph2 expression

(2011) Nina C. Donner et al.   PSYCHONEUROENDOCRINOLOGY

Posttranscriptional Upregulation by MicroRNAs

(2011) Shobha Vasudevan   Wiley Interdisciplinary Reviews-RNA

Convergent functional genomics of anxiety disorders: translational identification of genes, biomarkers, pathways and mechanisms

(2011) H Le-Niculescu et al.   Translational Psychiatry

Human microRNAs miR-22, miR-138-2, miR-148a, and miR-488 Are Associated with Panic Disorder and Regulate Several Anxiety Candidate Genes and Related Pathways

(2010) Margarita Muiños-Gimeno et al.   BIOLOGICAL PSYCHIATRY

RNA mechanisms in CNS systems and disorders

(2010) Kai-Christian Sonntag et al.   BRAIN RESEARCH

MicroRNA dysregulation in psychiatric disease

(2010) Brooke H. Miller et al.   BRAIN RESEARCH

Childhood adversities and adult psychopathology in the WHO World Mental Health Surveys

(2010) Ronald C. Kessler et al.   BRITISH JOURNAL OF PSYCHIATRY

Circulating microRNAs: Association with disease and potential use as biomarkers

(2010) Glen Reid et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

A five-microRNA signature identified from genome-wide serum microRNA expression profiling serves as a fingerprint for gastric cancer diagnosis

(2010) Rui Liu et al.   EUROPEAN JOURNAL OF CANCER

Metabotropic glutamate receptor 7: At the interface of cognition and emotion

(2010) Richard M. O'Connor et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The Pharmacologic Treatment of Anxiety Disorders

(2010) Lakshmi N. Ravindran et al.   JOURNAL OF CLINICAL PSYCHIATRY

Serum Response Factor Promotes Resilience to Chronic Social Stress through the Induction of  FosB

(2010) V. Vialou et al.   JOURNAL OF NEUROSCIENCE

Early Life Stress Enhances Behavioral Vulnerability to Stress through the Activation of REST4-Mediated Gene Transcription in the Medial Prefrontal Cortex of Rodents

(2010) S. Uchida et al.   JOURNAL OF NEUROSCIENCE

Animal models of neuropsychiatric disorders

(2010) Eric J Nestler et al.   NATURE NEUROSCIENCE

Animal models of depression and anxiety: What do they tell us about human condition?

(2010) I.D. Neumann et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Stress induces region specific alterations in microRNAs expression in mice

(2009) Arianna Rinaldi et al.   BEHAVIOURAL BRAIN RESEARCH

Pharmacology of epigenetics in brain disorders

(2009) Pritika Narayan et al.   BRITISH JOURNAL OF PHARMACOLOGY

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

Changes in Brain MicroRNAs Contribute to Cholinergic Stress Reactions

(2009) Ari Meerson et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Imaging genetics of anxiety disorders

(2009) Katharina Domschke et al.   NEUROIMAGE

Genetics of anxiety and trauma-related disorders

(2009) S.D. Norrholm et al.   NEUROSCIENCE

A single anti-microRNA antisense oligodeoxyribonucleotide (AMO) targeting multiple microRNAs offers an improved approach for microRNA interference

(2009) Yanjie Lu et al.   NUCLEIC ACIDS RESEARCH

The role of FKBP5, a co-chaperone of the glucocorticoid receptor in the pathogenesis and therapy of affective and anxiety disorders

(2009) Elisabeth B. Binder   PSYCHONEUROENDOCRINOLOGY

Using hippocampal microRNA expression differences between mouse inbred strains to characterise miRNA function

(2008) Michael J. Parsons et al.   MAMMALIAN GENOME

LNA-mediated microRNA silencing in non-human primates

(2008) Joacim Elmén et al.   NATURE

Evidence for Selective microRNAs and Their Effectors as Common Long-Term Targets for the Actions of Mood Stabilizers

(2008) Rulun Zhou et al.   NEUROPSYCHOPHARMACOLOGY

Circulating microRNAs as stable blood-based markers for cancer detection

(2008) P. S. Mitchell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteomic profiling of exosomes: Current perspectives

(2008) Richard J. Simpson et al.   PROTEOMICS